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Genomes and GenesSpecies | Kristin B HighlandSummaryAffiliation: Medical University of South Carolina Country: USA Publications
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Publications
New developments in scleroderma interstitial lung diseaseKristin B Highland
Division of Pulmonary, Critical Care, Allergy and Clinical Immunology, Medical University of South Carolina, Charleston, SC 29425, USA
Curr Opin Rheumatol 17:737-45. 2005....- The spectrum of scleroderma lung diseaseKristin B Highland
Division of Pulmonary Critical Care, Allergy, and Sleep Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Semin Respir Crit Care Med 28:418-29. 2007..For each manifestation we outline the current knowledge of etiology, risk factors, diagnosis, treatment, and prognosis. We also discuss the current state of lung transplantation in this population... - Pulmonary arterial hypertensionKristin B Highland
Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Am J Med Sci 335:40-5. 2008..Multiple effective therapies now exist for pulmonary arterial hypertension, and thus early diagnosis and referral will translate into meaningful survival and better lives for our patients... - Inhaled corticosteroids in chronic obstructive pulmonary disease: is there a long-term benefit?Kristin B Highland
Division of Pulmonary, Critical Care, Allergy and Clinical Immunology, Medical University of South Carolina, Charleston, South Carolina, USA
Curr Opin Pulm Med 10:113-9. 2004..Experts disagree about the benefits and harms of ICS for patients with COPD, yet a majority of patients with COPD are being treated with inhaled corticosteroids. This is a review of the most recent literature on this subject... - Treatment of pulmonary arterial hypertension: a preliminary decision analysisKristin B Highland
Division of Pulmonary, Critical Care, Allergy, and Clinical Immunology, Medical University of South Carolina, 96 Jonathan Lucas Street, Suite 812 CSB, Charleston, SC 29425, USA
Chest 124:2087-92. 2003..Clinicians must chose between very different therapies without the availability of comparison studies. We constructed a "virtual" clinical trial to help inform these treatment choices... - Long-term effects of inhaled corticosteroids on FEV1 in patients with chronic obstructive pulmonary disease. A meta-analysisKristin B Highland
Division of Pulmonary, Critical Care, Allergy and Clinical Immunology, Medical University of South Carolina, 96 Jonathan Lucas Street, 812 CSB, Box 250623, Charleston, South Carolina 29425, USA
Ann Intern Med 138:969-73. 2003..There is no consensus on the effectiveness of inhaled corticosteroids for the treatment of chronic obstructive pulmonary disease (COPD)... - Down-regulation of collagen and connective tissue growth factor expression with hepatocyte growth factor in lung fibroblasts from white scleroderma patients via two signaling pathwaysGalina S Bogatkevich
Medical University of South Carolina, Charleston, SC 29425, USA
Arthritis Rheum 56:3468-77. 2007..To study the mechanisms by which hepatocyte growth factor (HGF) down-regulates collagen and connective tissue growth factor (CTGF) in scleroderma (systemic sclerosis [SSc]) lung fibroblasts... - Interstitial lung disease in the patient who has connective tissue diseaseCharlie Strange
Division of Pulmonary and Critical Care Medicine, Medical University of South Carolina, 96 Jonathan Lucas Street, 812 CSB, Charleston, SC 29425, USA
Clin Chest Med 25:549-59, vii. 2004..Additionally, the challenge of finding the patient who has occult connective tissue disease in an interstitial lung disease clinic is discussed... - A "story" of a woman with cystic fibrosisKristin B Highland
Division of Pulmonary and Critical Care Medicine, Allergy and Clinical Immunology, Medical University of South Carolina, Charleston, SC 29425, USA
Chest 121:1704-7. 2002..Such knowledge is likely to result in less harm to the patient through unnecessary testing and treatment... - Chronic dyspnea and severe obstruction after pneumonectomy: postpneumonectomy syndromeMeena Kalluri
Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Am J Med Sci 336:530-1. 2008..Postpneumonectomy syndrome is treated by surgical repositioning of the mediastinum. Knowledge of the clinical and radiological features will enable prompt diagnosis and appropriate treatment... - Impairment of the antifibrotic effect of hepatocyte growth factor in lung fibroblasts from African Americans: possible role in systemic sclerosisGalina S Bogatkevich
Medical University of South Carolina, Charleston 29425, USA
Arthritis Rheum 56:2432-42. 2007..To compare the composition of cytokines in African American and Caucasian patients with systemic sclerosis (SSc; scleroderma) and in healthy individuals, particularly the expression and function of hepatocyte growth factor (HGF)... - Pulmonary hypertension in interstitial lung diseaseCharlie Strange
Division of Pulmonary and Critical Care Medicine, Allergy and Clinical Immunology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Curr Opin Pulm Med 11:452-5. 2005..Antifibrotic therapies for interstitial lung disease remain unproved; therefore, some interest has been focused on treating the pulmonary vascular impairment these diseases... - Clinical aspects of lung involvement: lessons from idiopathic pulmonary fibrosis and the scleroderma lung studyKristin B Highland
Division of Rheumatology and Immunology, Medical University of South Carolina, 96 Jonathan Lucas Street, Suite 912 CSB, Charleston, SC 29425, USA
Curr Rheumatol Rep 7:135-41. 2005..A randomized controlled trial, the Scleroderma Lung Study (SLS), will be completed in 2005; the outcome of the SLS should define the efficacy of daily oral cyclophosphamide for SSc-ILD patients with alveolitis defined by BALF and HRCT... - Pleural effusion in interstitial lung diseaseKristin B Highland
Division of Pulmonary Critical Care Medicine and Allergy, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Curr Opin Pulm Med 10:390-6. 2004..SUMMARY: Pleural effusions occur in patients with various forms of interstitial lung disease. The effusions require a clinical evaluation to exclude complications of therapy and coexisting conditions unrelated to the underlying ILD... - The PPAR? Agonist Rosiglitazone Is Antifibrotic for Scleroderma Lung Fibroblasts: Mechanisms of Action and Differential Racial EffectsGalina S Bogatkevich
Division of Rheumatology and Immunology, Medical University of South Carolina, 96 Jonathan Lucas Street, Suite 912, Charleston, SC 29425 6370, USA
Pulm Med 2012:545172. 2012..Differential therapeutic effects might be anticipated especially relative to racial differences and the functional expression of the c-Met receptor... - Chronic obstructive pulmonary disease in geriatric critical careJohn E Heffner
Pulmonary Divison, 812 CSB, Medical University of South Carolina, 96 Jonathan Lucas Street, P O Box 250623, Charleston, SC 29425, USA
Crit Care Clin 19:713-27. 2003..Most patients survive hospitalization in the ICU for an episode of respiratory failure. The severity of the underlying lung disease, however, underlies the poor outcomes of patients in terms of postdischarge survival and quality of life... - Clinical profile of anti-PL-12 autoantibody. Cohort study and review of the literatureMeena Kalluri
Division of Pulmonary and Critical Care Medicine, Allergy, and Sleep Medicine, Medical University of South Carolina, Charleston, SC, USA
Chest 135:1550-6. 2009..The purpose of this study was to examine the clinical profile of anti-PL-12, an antisynthetase autoantibody directed against alanyl-transfer RNA synthetase... - Critical care challenges in the adult ECMO patientSarah E Gay
Duke University School of Nursing, Durham, North Carolina, USA
Dimens Crit Care Nurs 24:157-62; quiz 163-4. 2005..Although ECMO is not new to the intensive care unit setting, it is usually considered a last resort measure in the adult population. ECMO may save a life and present an awarding challenge to the intensive care unit nurse... - Sitaxsentan for the treatment of pulmonary arterial hypertension: a 1-year, prospective, open-label observation of outcome and survivalRaymond L Benza
University of Alabama at Birmingham, 1900 University Blvd, Tinsley Harrison Towers, Room 328A, Birmingham, AL 35294, USA
Chest 134:775-82. 2008..Long-term efficacy evaluations are needed to guide therapeutic management. The purpose of this study is to present 1-year observational data with two endothelin antagonists, sitaxsentan and bosentan, in a prospective, open-label study...