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Genomes and GenesSpecies | S W GuoSummaryAffiliation: Medical College of Wisconsin Country: USA Publications
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Publications
Gene-environment interactions and the affected-sib-pair designsS W Guo
The M McGee National Research Center for Juvenile Diabetes, Department of Pediatrics, Medical College of Wisconsin, Milwaukee 53226 0509, USA
Hum Hered 50:271-85. 2000..Above all, a genetic model involving both genetic and environmental factors behaves differently from a single-locus genetic model...- The link between exposure to dioxin and endometriosis: a critical reappraisal of primate dataSun Wei Guo
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 0509, USA
Gynecol Obstet Invest 57:157-73. 2004..Weighing all converging evidence, it seems that there are no solid, credible data available at this moment to support the hypothesis that dioxin exposure may lead to the development of endometriosis... - Preferential transmission of type 1 diabetes from parents to offspring: fact or artifact?Sun Wei Guo
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Genet Epidemiol 23:323-34. 2002.... - The prevalence of endometriosis in women with chronic pelvic painSun Wei Guo
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisc 53226 0509, USA
Gynecol Obstet Invest 62:121-30. 2006..Such an astounding variation or heterogeneity raises the question whether it is appropriate to use a single prevalence of endometriosis for all women with CPP... - Nuclear factor-kappab (NF-kappaB): an unsuspected major culprit in the pathogenesis of endometriosis that is still at large?Sun Wei Guo
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226 0509, USA
Gynecol Obstet Invest 63:71-97. 2007..Further research is warranted to precisely delineate the roles of NF-kappaB in the pathogenesis of endometriosis and to indict and convict its aiders and abettors... - Sources of heterogeneities in estimating the prevalence of endometriosis in infertile and previously fertile womenSun Wei Guo
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 0509, USA
Fertil Steril 86:1584-95. 2006..To identify possible sources of heterogeneity in estimates of the prevalence of endometriosis in previously fertile women and in women with infertility... - Two unsuccessful clinical trials on endometriosis and a few lessons learnedSun Wei Guo
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226 0509, USA
Gynecol Obstet Invest 64:24-35. 2007.... - Does higher concordance in monozygotic twins than in dizygotic twins suggest a genetic component?S W Guo
Max McGee National Research Center for Juvenile Diabetes, Department of Pediatrics and Division of Biostatistics, Medical College of Wisconsin, Milwaukee, Wisc, USA
Hum Hered 51:121-32. 2001..This may serve as a sobering antidote to the uncritical reliance on twin studies without examining the validity of the underlying assumptions... - Gene-environment interaction and the mapping of complex traits: some statistical models and their implicationsS W Guo
The M McGee National Research Center for Juvenile Diabetes, Department of Pediatrics, Medical College of Wisconsin, Milwaukee 53226 0509, USA
Hum Hered 50:286-303. 2000..Thus their use as indicators of the genetic basis of complex diseases is cast into doubt... - Meta-analysis of vitamin D receptor polymorphisms and type 1 diabetes: a HuGE review of genetic association studiesSun Wei Guo
Department of Pediatrics and the Max McGee Research Center for Juvenile Diabetes, Medical College of Wisconsin, Children s Research Institute, Children s Hospital of Wisconsin, Milwaukee, 53226 0509, USA
Am J Epidemiol 164:711-24. 2006..In fact, a reanalysis of previously published data (McDermott et al., Diabetologia 1997;40:971-5) indicated no evidence of an association as reported... - Laterality and asymmetry of endometriotic lesionsSun Wei Guo
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 0509, USA
Fertil Steril 89:33-41. 2008..To identify possible sources of heterogeneities in the estimation of the proportion of bilateral cases and of left-sided cases of endometriotic lesions... - Familial aggregation of environmental risk factors and familial aggregation of diseaseS W Guo
Institute of Human Genetics and Division of Epidemiology, University of Minnesota, Minneapolis, USA
Am J Epidemiol 151:1121-31. 2000..In view of this, there is a need to examine carefully the roles of multiple environmental risk factors in disease familiality... - Estimating the age of mutant disease alleles based on linkage disequilibriumS W Guo
Division of Epidemiology, University of Minnesota, Minneapolis 55454 1015, USA
Hum Hered 47:315-37. 1997..The former data set allows us to trace the origin and dispersion of the most common mutation for cystic fibrosis. The latter provides an opportunity to examine whether all mutations for these diseases have the same age... - Inflation of sibling recurrence-risk ratio, due to ascertainment bias and/or overreportingS W Guo
Institute of Human Genetics, University of Minnesota, Minneapolis, MN 55454 1015, USA
Am J Hum Genet 63:252-8. 1998..This is particularly important if one uses lambdaS for exclusion mapping, for discrimination between different genetic models, and for association studies, since these practices hinge tightly on an accurate estimation of lambdaS... - Inhibition of proliferation of endometrial stromal cells by trichostatin A, RU486, CDB-2914, N-acetylcysteine, and ICI 182780Yan Wu
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226-0509, USA
Gynecol Obstet Invest 62:193-205. 2006..HDACIs may be promising therapeutics in treating endometriosis due to their antiproliferative effects as well as the potential to restore gene dysregulation through chromatin remodeling... - Quantitative quality control in microarray image processing and data acquisitionX Wang
Max McGee National Research Center for Juvenile Diabetes, Medical College and Children s Hospital of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Nucleic Acids Res 29:E75-5. 2001..Based on these studies, we discuss the potential of quantitative quality control for microarray data and the possibility of filtering and normalizing microarray data using a quality metrics-dependent scheme... - Glutathione S-transferases M1/T1 gene polymorphisms and endometriosis: a meta-analysis of genetic association studiesSun Wei Guo
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226 0509, USA
Mol Hum Reprod 11:729-43. 2005..However, even this estimate should be viewed with a large grain of salt, because the estimate could easily lose its statistical significance if there is a realistic 69-80% publication probability... - The association of endometriosis risk and genetic polymorphisms involving dioxin detoxification enzymes: a systematic reviewSun Wei Guo
Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Road, MS 756, Milwaukee, WI 53226 0509, USA
Eur J Obstet Gynecol Reprod Biol 124:134-43. 2006..However, there is no strong indication that CYP1A1 MspI polymorphism is consistently associated with endometriosis. For NAT2 polymorphisms, there is no evidence that it is associated with endometriosis... - Association of endometriosis risk and genetic polymorphisms involving sex steroid biosynthesis and their receptors: a meta-analysisSun Wei Guo
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226 0509, USA
Gynecol Obstet Invest 61:90-105. 2006..In future association studies, it may be productive to put more thought to study design, execution, and data analysis... - Conditions to ensure competitive hybridization in two-color microarray: a theoretical and experimental analysisYoumin Wang
Department of Pediatrics, Medical College of Wisconsin, Children s Hospital of Wisconsin, Milwaukee 53226, USA
Biotechniques 32:1342-6. 2002..The method of validation is easily implemented to ensure data reliability by two-color microarray... - Three color cDNA microarrays: quantitative assessment through the use of fluorescein-labeled probesMartin J Hessner
The Max McGee National Research Center for Juvenile Diabetes, The Medical College of Wisconsin and Children s Hospital of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Nucleic Acids Res 31:e14. 2003..80, P < 0.001) was observed. We therefore conclude that slide selection based upon prehybridization quality scores will greatly benefit the ability to generate reliable gene expression data... - Threshold distributions of phenylthiocarbamide (PTC) in the Chinese populationS W Guo
Institute of Human Genetics, University of Minnesota, Minneapolis 55454 1015, USA
Ann N Y Acad Sci 855:810-2. 1998..Several authors had previously reported PTC data on Chinese living outside China. Our data are, to our knowledge, the first ever collected from the Chinese population within China... - Promoter hypermethylation of progesterone receptor isoform B (PR-B) in endometriosisYan Wu
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 0509, USA
Epigenetics 1:106-11. 2006..This perspective should potentially open up new avenues for the delineation of pathogenesis of endometriosis, and might also lead to novel ways to treat the disease through reversing aberrant methylation via pharmacological means... - Prolonged stimulation with tumor necrosis factor-alpha induced partial methylation at PR-B promoter in immortalized epithelial-like endometriotic cellsYan Wu
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
Fertil Steril 90:234-7. 2008.... - Linkage disequilibrium measures for fine-scale mapping: a comparisonS W Guo
Division of Epidemiology, University of Minnesota, Minneapolis 55454 1015, USA
Hum Hered 47:301-14. 1997..The initial incomplete linkage disequilibrium could render all measures useless. These expected values also show clearly why in Devlin and Risch's simulation some measures performed very badly under certain circumstances... - Modeling the maternal-age dependency of reproductive failure and genetic fitnessC J Zheng
Division of Environmental and Occupational Health, University of Minnesota, Minneapolis 55455, USA
Evol Dev 2:203-7. 2000.... - The genetics of phenylthiocarbamide perceptionS W Guo
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, USA
Ann Hum Biol 28:111-42. 2001..The development of methods to identify these genes will provide a good stepping-stone between single-gene disorders and polygenic traits... - Suppression of IL-1beta-induced COX-2 expression by trichostatin A (TSA) in human endometrial stromal cellsYan Wu
Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Road, MS 756, Milwaukee, WI 53226 0509, USA
Eur J Obstet Gynecol Reprod Biol 135:88-93. 2007.... - Genomic alterations in the endometrium may be a proximate cause for endometriosisSun-Wei Guo
Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Road, MS 756, Milwaukee, WI 53226-0509, USA
Eur J Obstet Gynecol Reprod Biol 116:89-99. 2004..This is consistent with numerous reports that the endometrium of women with endometriosis differ from those of women without. Our finding suggests that genomic alterations in the endometrium may be a proximate cause for endometriosis... - Aberrant expression of deoxyribonucleic acid methyltransferases DNMT1, DNMT3A, and DNMT3B in women with endometriosisYan Wu
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 0509, USA
Fertil Steril 87:24-32. 2007..The aim of this study was to determine gene expression levels of DNMT1, DNMT3A, and DNMT3B, the three genes coding for DNA methyltransferases that are responsible for methylation... - Trichostatin A, a histone deacetylase inhibitor, attenuates invasiveness and reactivates E-cadherin expression in immortalized endometriotic cellsYan Wu
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226 0509, USA
Reprod Sci 14:374-82. 2007.... - Aberrant methylation at HOXA10 may be responsible for its aberrant expression in the endometrium of patients with endometriosisYan Wu
Department of Pediatrics, Medical College of Wisconsin, Milwaikee 53226 0509, USA
Am J Obstet Gynecol 193:371-80. 2005..In the endometrium of women with endometriosis, its expression is reduced. The aim of this study was to determine whether the observed aberrant expression of HOXA10 is caused by aberrant methylation of the gene... - Genomic alterations in ectopic and eutopic endometria of women with endometriosisYan Wu
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisc. 53226-0509, USA
Gynecol Obstet Invest 62:148-59. 2006..The identified genomic alterations should help to zero in genes involved in the pathogenesis of endometriosis in future studies... - Resolution of clonal origins for endometriotic lesions using laser capture microdissection and the human androgen receptor (HUMARA) assayYan Wu
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226-0509, USA
Fertil Steril 79:710-7. 2003.... - Transcriptional characterizations of differences between eutopic and ectopic endometriumYan Wu
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226-0509, USA
Endocrinology 147:232-46. 2006..The identification of these genes and their associated pathways provides new insight. Our findings will stimulate future investigations on molecular genetic mechanisms underlying the pathogenesis of endometriosis... - Reconstructing cellular lineages in endometrial cellsYan Wu
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 0509, USA
Fertil Steril 89:481-4. 2008.... - Histone deacetylase inhibitors trichostatin A and valproic acid induce cell cycle arrest and p21 expression in immortalized human endometrial stromal cellsYan Wu
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Eur J Obstet Gynecol Reprod Biol 137:198-203. 2008.... - Statistical methods for detecting genomic alterations through array-based comparative genomic hybridization (CGH)Yuedong Wang
Department of Statistics and Applied Probability, University of California, Santa Barbara, California 93106, USA
Front Biosci 9:540-9. 2004..We apply the proposed methods to the identification of genomic alterations in endometrium in women with endometriosis... - The knockdown of progesterone receptor isoform B (PR-B) promotes proliferation in immortalized endometrial stromal cellsYan Wu
Taussig Cancer Center, Center for Hematology and Oncology Molecular Therapeutics, Cleveland, Ohio, USA
Fertil Steril 90:1320-3. 2008..This suggests that PR-B knockdown might be responsible, at least in part, for increased proliferation and resistance to apoptosis as seen in the eutopic and ectopic endometrium of women with endometriosis... - The best-fit model for endometriosisSun-Wei Guo
Fertil Steril 80:232; author reply 232-3. 2003 - The search for genetic variants predisposing women to endometriosisWen Di
Institute of Obstetric and Gynecologic Research, Shanghai Jiao Tong University School of Medicine, Renji Hospital, Shanghai, China
Curr Opin Obstet Gynecol 19:395-401. 2007.... - A system-wide analysis of differentially expressed genes in ectopic and eutopic endometriumJonathan D Wren
Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, 825 N E 13th Street, Oklahoma City, OK 73104 5005, USA
Hum Reprod 22:2093-102. 2007..Thus, it is difficult to see 'the big picture' without first integrating these multiple, heterogeneous sources of high-quality information for analysis... - Patterns of and risk factors for recurrence in women with ovarian endometriomasXishi Liu
Department of Gynecology, Shanghai OB GYN Hospital, Shanghai, China
Obstet Gynecol 109:1411-20. 2007..To identify risk factors for and the patterns of recurrence of endometrioma and of dysmenorrhea in women with ovarian endometrioma... - A pilot study on the off-label use of valproic acid to treat adenomyosisXishi Liu
Department of Gynecology, Shanghai Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China
Fertil Steril 89:246-50. 2008..We found that by the end of the 3-month treatment, all three recruited patients reported complete disappearance of dysmenorrhea, with an average of one-third reduction in uterus size... - Sibling recurrence risk ratio as a measure of genetic effect: caveat emptor!Sun-Wei Guo
Am J Hum Genet 70:818-9. 2002 - Capsaicin inhibits proliferation of endometriotic cells in vitroYan Wu
Taussig Cancer Center, Center for Hematology and Oncology Molecular Therapeutics, Cleveland, Ohio, USA
Gynecol Obstet Invest 66:59-62. 2008..In addition, endometriotic cells are more sensitive to capsaicin treatment than immortalized endometrial cells, suggesting that capsaicin may be an admissible drug candidate for treating endometriosis...