Research Topics
| Susan FaganSummaryAffiliation: Medical College of Georgia Country: USA Publications
Research Grants
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Detail Information
Publications
Delayed minocycline inhibits ischemia-activated matrix metalloproteinases 2 and 9 after experimental strokeLivia S Machado
Program in Clinical and Experimental Therapeutics, Clinical Pharmacy Department, College of Pharmacy, University of Georgia, Augusta, GA, USA
BMC Neurosci 7:56. 2006..Minocycline inhibits inflammation, apoptosis and extracellular matrix degradation. In this study we investigated whether delayed minocycline inhibits brain MMPs activated by ischemia in a model of temporary occlusion in Wistar rats...- Effect of neutrophil depletion on gelatinase expression, edema formation and hemorrhagic transformation after focal ischemic strokeAlex K Harris
Program in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, Georgia, USA
BMC Neurosci 6:49. 2005..While gelatinase (MMP-2 and -9) activity is increased after focal ischemia/reperfusion injury in the brain, the relative contribution of neutrophils to the MMP activity and to the development of hemorrhagic transformation remains unknown... - Low dose intravenous minocycline is neuroprotective after middle cerebral artery occlusion-reperfusion in ratsLin Xu
Department of Neurology, Medical College of Georgia, Augusta GA, 30912, USA
BMC Neurol 4:7. 2004.... - Hypertension after experimental cerebral ischemia: candesartan provides neurovascular protectionSusan C Fagan
Program in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, Georgia 30912 2450, USA
J Hypertens 24:535-9. 2006..After ischemic stroke, hypertension increases the risk of recurrence, hemorrhage and fatal cerebral edema, but blood pressure (BP) lowering in the acute stroke period is controversial due to fears of infarct extension and worsened outcomes... - Urgent need for secondary stroke prevention after transient ischemic attackSusan C Fagan
Clinical and Administrative Pharmacy, University of Georgia College of Pharmacy, Augusta, Georgia 30912 2450, USA
Consult Pharm 23:131-40. 2008..To review symptom awareness, diagnostic techniques, and therapeutic interventions for the recognition and treatment of transient ischemic attack (TIA) and to discuss secondary stroke prevention after TIA... - Tactics for vascular protection after acute ischemic strokeSusan C Fagan
Program in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, Georgia 30912 2450, USA
Pharmacotherapy 25:387-95. 2005..Vascular protection represents a new field to be explored in acute ischemic stroke in order to develop new approaches to therapeutic intervention... - Targets for vascular protection after acute ischemic strokeSusan C Fagan
Program in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Athens, GA 30912 2450, USA
Stroke 35:2220-5. 2004..The purpose of this review is to identify the pathophysiologic processes involved in vascular damage after ischemia, which may lead to strategies to provide vascular protection in ischemic stroke patients... - Optimal delivery of minocycline to the brain: implication for human studies of acute neuroprotectionSusan C Fagan
Program in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA 30912 2450, USA
Exp Neurol 186:248-51. 2004.... - Drug repurposing for drug development in strokeSusan C Fagan
College of Pharmacy, University of Georgia, Augusta, Georgia 30912, USA
Pharmacotherapy 30:51S-4S. 2010..In fact, vascular protection with the angiotensin II receptor blocker candesartan has already been demonstrated in a clinical trial of acute ischemic stroke... - Role of angiotensin-converting-enzyme inhibitors in stroke preventionSusan C Fagan
Department of Clinical and Administrative Pharmacy, University of Georgia, Department of Neurology, Medical College of Georgia (MCG, Neuroscience Service Line, Veterans Affairs Medical Center (VAMC, Augusta, GA, USA
Am J Health Syst Pharm 60:788-93. 2003 - Hemorrhagic transformation is related to the duration of occlusion and treatment with tissue plasminogen activator in a nonembolic stroke modelSusan C Fagan
Department of Neurology, Medical College of Georgia, Veteran s Affairs Medical Center, Augusta, GA, USA
Neurol Res 25:377-82. 2003..001) and without HT (p < 0.001), but only in animals with durations of occlusion of 2 h or more. Duration of occlusion is an important predictor of HT in transient MCAO in the rat and is closely associated with EBA expression... - Blood pressure lowering after experimental cerebral ischemia provides neurovascular protectionHazem F Elewa
Program in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta 30912 2450, USA
J Hypertens 25:855-9. 2007..These results could be either mediated by BP lowering or a BP-independent cerebrovascular protective effect... - Minocycline to improve neurologic outcome in stroke (MINOS): a dose-finding studySusan C Fagan
Departmentof Neurology, College of Pharmacy, University of Georgia, Medical College of Georgia, Augusta, GA 30912, USA
Stroke 41:2283-7. 2010..Minocycline is a promising anti-inflammatory and protease inhibitor that is effective in multiple preclinical stroke models. We conducted an early phase trial of intravenous minocycline in acute ischemic stroke... - Candesartan augments ischemia-induced proangiogenic state and results in sustained improvement after strokeAnna Kozak
University of Georgia College of Pharmacy, Veterans Administration Medical Center, Augusta, GA 30912 2450, USA
Stroke 40:1870-6. 2009..We now examine effects of candesartan on proangiogenic factors and 7-day outcomes using the same treatment paradigm... - Minocycline and tissue-type plasminogen activator for stroke: assessment of interaction potentialLivia S Machado
Department of Clinical and Administrative Pharmacy, University of Georgia College of Pharmacy, Augusta, GA 30912 2450, USA
Stroke 40:3028-33. 2009..This study aimed to determine the effect of minocycline on t-PA clot lysis and t-PA-induced hemorrhage formation after ischemia... - Early atorvastatin reduces hemorrhage after acute cerebral ischemia in diabetic ratsHazem F Elewa
Program in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, Georgia 30912 2450, USA
J Pharmacol Exp Ther 330:532-40. 2009..0007). We concluded that atorvastatin is a vascular protective agent after experimental ischemic stroke, especially in diabetes... - Adaptive cerebral neovascularization in a model of type 2 diabetes: relevance to focal cerebral ischemiaWeiguo Li
Department of Physiology, Medical College of Georgia, Augusta, Georgia, USA
Diabetes 59:228-35. 2010..However, how diabetes influences cerebral neovascularization is not clear. Our aim was to determine diabetes-mediated changes in the cerebrovasculature and its impact on the short-term outcome of cerebral ischemia... - Increased hemorrhagic transformation and altered infarct size and localization after experimental stroke in a rat model type 2 diabetesAdviye Ergul
Program in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, USA
BMC Neurol 7:33. 2007..Diabetes is a risk factor for stroke as well as poor outcome of stroke. The current study tested the hypothesis that diabetes-induced changes in the cerebral vasculature increase the risk of HT and augment ischemic injury... - Hyperglycemia, diabetes and stroke: focus on the cerebrovasculatureAdviye Ergul
Department of Physiology, Medical College of Georgia, Augusta, GA 30912, USA
Vascul Pharmacol 51:44-9. 2009..Here, we review the impact of diabetes and acute hyperglycemia on experimental stroke with an emphasis on cerebrovasculature structure and function. The relevance to clinical evidence is also discussed... - Single slice method for quantification of hemorrhagic transformation using direct ELISAHend M Hilali
College of Pharmacy, University of Georgia, Augusta, GA, USA
Neurol Res 26:93-8. 2004..This allows two essential variables in experimental stroke research to be assessed on the same slice, leaving the rest of the brain available for other analysis... - Minocycline for short-term neuroprotectionHazem F Elewa
Program in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Athens, Georgia 30912, USA
Pharmacotherapy 26:515-21. 2006..Minocycline is ready for clinical trials of acute neurologic injury... - Acute blood-brain barrier opening in experimentally induced focal cerebral ischemia is preferentially identified by quantitative magnetization transfer imagingRobert A Knight
Department of Neurology, Henry Ford Health Sciences Center, Detroit, MI 48202, USA
Magn Reson Med 54:822-32. 2005..6 demarcates leakage of small molecules such as Gd-DTPA and AIB across the BBB. As to clinical relevance, the quantitation of MT parameters in acute stroke may enable the early detection of areas of BBB opening and potential HT... - SDF-1 (CXCL12) is upregulated in the ischemic penumbra following stroke: association with bone marrow cell homing to injuryWilliam D Hill
Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, Georgia 30912 2000, USA
J Neuropathol Exp Neurol 63:84-96. 2004..These findings suggest SDF-1 is important in the homing of bone marrow-derived cells, especially monocytes, to areas of ischemic injury... - Type 2 diabetes causes remodeling of cerebrovasculature via differential regulation of matrix metalloproteinases and collagen synthesis: role of endothelin-1Alex K Harris
Medical College of Georgia, Clinical Pharmacy CJ-1020, Augusta, GA 30912, USA
Diabetes 54:2638-44. 2005..Augmented cerebrovascular remodeling may contribute to an increased risk of stroke in diabetes, and ET(A) receptor antagonism may offer a novel therapeutic target... - Tracking trends in secondary stroke prevention strategiesJody L Carswell
Medical College of Georgia Health, Augusta, GA, USA
Ann Pharmacother 38:215-9. 2004..CONCLUSIONS: The dedicated stroke service was able to effectively translate emerging evidence and guidelines into practice and significantly change the use of prescribed medications for secondary stroke prevention... - Quantitation and localization of blood-to-brain influx by magnetic resonance imaging and quantitative autoradiography in a model of transient focal ischemiaRobert A Knight
Department of Neurology, Henry Ford Health Sciences Center, Detroit, MI 48202, USA
Magn Reson Med 54:813-21. 2005..1 +/- 3.3 x 10(-3) and 6.8 +/- 3.5 x 10(-3) ml.g(-1) . min(-1), respectively). In most instances, Gd-DTPA MRI accurately localized areas of BBB opening... - Oxidative stress and cardiovascular disease: antioxidants and unresolved issuesKamakshi Sachidanandam
Program in Clinical and Experimental Therapeutics, University of Georgia College of Pharmacy
Cardiovasc Drug Rev 23:115-32. 2005.... - Drug repurposing for drug development in strokeSusan C Fagan
Program in Clinical and Experimental Therapeutics, University of Georgia College of Pharmacy, Augusta, GA, USA
Rev Neurol Dis 7:S3-6. 2010..Repurposing of safe, older drugs provides a lower risk alternative. Vascular protection with candesartan is one such approach... - Repurposing an old drug to improve the use and safety of tissue plasminogen activator for acute ischemic stroke: minocyclineDavid C Hess
Department of Neurology, Medical College of Georgia, Augusta, GA, USA
Rev Neurol Dis 7:S7-13. 2010..Minocycline is also an anti-inflammatory agent and inhibits poly (ADP-ribose) polymerase-1. Minocycline has been safe and well tolerated in the clinical trials conducted to date... - Vascular protection in diabetic stroke: role of matrix metalloprotease-dependent vascular remodelingMostafa M Elgebaly
Department of Clinical Pharmacy, Program in Clinical and Experimental Therapeutics, University of Georgia, College of Pharmacy, Augusta, Georgia, USA
J Cereb Blood Flow Metab 30:1928-38. 2010..Metformin and minocycline offer vascular protection, which has important clinical implications for diabetes patients who are at a fourfold to sixfold higher risk for stroke... - Diverse effects of statins on angiogenesis: new therapeutic avenuesHazem F Elewa
Program in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA 30912 2450, USA
Pharmacotherapy 30:169-76. 2010..Statins are safe, orally available agents that may acquire novel therapeutic indications through their angiogenic modulating effects... - Association of serial biochemical markers with acute ischemic stroke: the National Institute of Neurological Disorders and Stroke recombinant tissue plasminogen activator Stroke StudyEdward C Jauch
Department of Emergency Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267 0769, USA
Stroke 37:2508-13. 2006..These biochemical markers, myelin basic protein (MBP), neuron-specific enolase (NSE), S100beta, and soluble thrombomodulin, were studied for an association with initial stroke severity, infarct volume, and functional outcome... - New perspectives on the pharmacotherapy of ischemic strokeJ Chris Bradberry
School of Pharmacy and Health Professions, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA
J Am Pharm Assoc (2003) 44:S46-56; quiz S56-7. 2004..To provide an overview of the impact of ischemic stroke and the steps that can be taken to reduce its burden through greater awareness of the disease, improved diagnosis and better treatment, with emphasis on the use of antiplatelet agents... - Vascular protection with candesartan after experimental acute stroke in hypertensive rats: a dose-response studyWieslaw Kozak
Institute of General and Molecular Biology, Nicolas Copernicus University, Torun, Poland
J Pharmacol Exp Ther 326:773-82. 2008..Low doses of candesartan provide neurovascular protection after stroke in SHRs. Caution is warranted because acute stroke increases the sensitivity to BP lowering, which, in turn, increases the likelihood of overshooting... - Atopic dermatitis is associated with a decrement in health-related quality of lifeGwendoline Kiebert
MEDTAP International, 7101 Wisconsin Avenue, Suite 600, Bethesda, MD 20814, USA
Int J Dermatol 41:151-8. 2002..Atopic dermatitis has as large an impact on HRQL as several chronic conditions and other dermatologic conditions...
Research Grants
- Vascular Protection in Acute Ischemic StrokeSusan Fagan; Fiscal Year: 2005..Collectively, the successful completion of the research summarized in this proposal can be expected to contribute to the development of methods to make reperfusion safer, and therefore more accessible, to human stroke patients. ..
- Mechanisms of Vascular Protection after Acute StrokeSusan C Fagan; Fiscal Year: 2010..This project will determine the mechanisms of vascular protection after stroke and develop a medication treatment likely to work in stroke patients. ..