Research Topics
Species | A N VallejoSummaryAffiliation: Mayo Clinic Country: USA Publications
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Detail Information
Publications
Modulation of CD28 expression: distinct regulatory pathways during activation and replicative senescenceA N Vallejo
Division of Rheumatology, Department of Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
J Immunol 162:6572-9. 1999..In vivo expanded CD4+CD28null and CD8+CD28null T cells uniformly lack alpha- and beta-bound complexes, resembling the pattern seen in chronically activated cells and not of senescent cells...- Biology of T lymphocytesAbbe N Vallejo
Departments of Medicine and Immunology, Guggenheim 401, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Rheum Dis Clin North Am 30:135-57. 2004..How we translate the cellular and molecular details of this regulation into innovation and development of therapies for disease management remains a fundamental, but exciting, challenge... - Molecular basis for the loss of CD28 expression in senescent T cellsAbbe N Vallejo
Department of Medicine and Immunology, Mayo Clinic, Rochester, Minnesota 55905, USA
J Biol Chem 277:46940-9. 2002..The present data also provide evidence for INR-regulated transcription that is independent of the known components of the basal transcription complex... - T-cell senescence: a culprit of immune abnormalities in chronic inflammation and persistent infectionAbbe N Vallejo
Division of Rheumatology, Department of Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
Trends Mol Med 10:119-24. 2004..Indeed, studies on the molecular basis for the loss of CD28 are already providing information on methods to functionally rescue senescent T cells... - Clonality and longevity of CD4+CD28null T cells are associated with defects in apoptotic pathwaysA N Vallejo
Departments of Medicine and Immunology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
J Immunol 165:6301-7. 2000.... - Functional disruption of the CD28 gene transcriptional initiator in senescent T cellsA N Vallejo
Departments of Medicine and Immunology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
J Biol Chem 276:2565-70. 2001..Rather, initiators can have a direct role in regulating the expression of specific genes. The gain or loss of initiator activity can be an important determinant of cell phenotypes... - Central role of thrombospondin-1 in the activation and clonal expansion of inflammatory T cellsA N Vallejo
Division of Rheumatology, Department of Internal Medicine, Mayo Clinic Foundation, Rochester, MN 55905, USA
J Immunol 164:2947-54. 2000.... - Down-regulation of CD28 expression by TNF-alphaE Bryl
Department of Medicine and Immunology, Mayo Clinic, Rochester, MN 55905, USA
J Immunol 167:3231-8. 2001..These results demonstrate that TNF-alpha directly influences CD28 gene transcription. We propose that the emergence of CD4(+)CD28(null) T cells in vivo is facilitated by increased production of TNF-alpha... - Molecular fingerprint of interferon-gamma signaling in unstable anginaG Liuzzo
Department of Medicine, Mayo Clinic and Foundation, Rochester, Minnesota, USA
Circulation 103:1509-14. 2001..IFN-gamma may derive from stimulated T lymphocytes, which implicates specific immune responses in the pathogenesis of acute coronary syndromes... - CD28 extinction in human T cells: altered functions and the program of T-cell senescenceAbbe N Vallejo
Department of Pediatrics, University of Pittsburgh School of Medicine, Division of Rheumatology, Children s Hospital of Pittsburgh, PA 15213, USA
Immunol Rev 205:158-69. 2005..Dissection of the machinery regulating CD28 expression is paving the way in elucidating the molecular events leading to immune senescence as well as providing clues into the functional rejuvenation of senescent T cells... - Distinct transcriptional control mechanisms of killer immunoglobulin-like receptors in natural killer (NK) and in T cellsJing Xu
Department of Medicine, Lowance Center for Human Immunology, Emory School of Medicine, Atlanta, Georgia 30322, USA
J Biol Chem 280:24277-85. 2005..We suggest that the regulated expression of KIRs in T cells profoundly influences peripheral tolerance and antigen-specific immune responses... - Tumor necrosis factor-alpha and CD80 modulate CD28 expression through a similar mechanism of T-cell receptor-independent inhibition of transcriptionDorothy E Lewis
Department of Immunology, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 279:29130-8. 2004..T cell lines with transient expression of CD28 are invaluable in the dissection of the biochemical processes involved in the transactivation of the CD28 INR, the silencing of which is a key event in the ontogenesis of senescent T cells... - CD28 loss in senescent CD4+ T cells: reversal by interleukin-12 stimulationKenneth J Warrington
Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
Blood 101:3543-9. 2003..The re-expressed CD28 was functional and restored the ability of CD4(+)CD28(null) T cells to express CD25 and CD40 ligand. Our data suggest that IL-12 may, in part, functionally rescue senescent CD4(+) T cells... - Synoviocyte-mediated expansion of inflammatory T cells in rheumatoid synovitis is dependent on CD47-thrombospondin 1 interactionAbbe N Vallejo
Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
J Immunol 171:1732-40. 2003..Because TSP1 is abundantly expressed in the rheumatoid synovium, CD47-TSP1 interaction is proposed to be a key component of an FLS/T cell regulatory circuit that perpetuates the inflammatory process in the rheumatoid joint... - The ontogeny and fate of NK cells marked by permanent DNA rearrangementsKristy Pilbeam
Department of Immunology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15261, USA
J Immunol 180:1432-41. 2008.... - Plasmacytoid dendritic cells in inflamed muscle of patients with juvenile dermatomyositisConsuelo M López De Padilla
Mayo Clinic College of Medicine, Rochester, Minnesota, USA
Arthritis Rheum 56:1658-68. 2007..To examine whether dendritic cells (DCs) are constituents of muscle inflammation in juvenile dermatomyositis (DM)... - Age-dependent alterations of the T cell repertoire and functional diversity of T cells of the agedAbbe N Vallejo
Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Immunol Res 36:221-8. 2006..Understanding the biology of NKR+ T cells will be pivotal to the development of strategies to enhance immunity in the elderly... - Immune remodeling: lessons from repertoire alterations during chronological aging and in immune-mediated diseaseAbbe N Vallejo
Departments of Pediatrics and Immunology, University of Pittsburgh School of Medicine, 3460 Fifth Avenue, Pittsburgh, PA 15213, USA
Trends Mol Med 13:94-102. 2007.... - CD56-expressing T cells that have features of senescence are expanded in rheumatoid arthritisJoshua J Michel
Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Arthritis Rheum 56:43-57. 2007..T cells deficient in CD28 expression have been implicated in the pathogenesis of rheumatoid arthritis (RA). Given that CD28-null T cells are functionally heterogeneous, we undertook this study to screen for novel receptors on these cells... - Modulation of CD28 expression with anti-tumor necrosis factor alpha therapy in rheumatoid arthritisEwa Bryl
Mayo Clinic College of Medicine, Rochester, Minnesota, USA
Arthritis Rheum 52:2996-3003. 2005..CONCLUSION: Overproduction of TNFalpha in RA induces a global down-regulation of CD28 in CD4+ T cells and may cause reduced sensitivity to costimulatory signals in T cell responses... - Diversity of NKR expression in aging T cells and in T cells of the aged: the new frontier into the exploration of protective immunity in the elderlySameem Abedin
Division of Rheumatology, Children's Hospital of Pittsburgh, PA 15213, USA
Exp Gerontol 40:537-48. 2005..We suggest that appreciation of the functional diversity of these unusual NK-like T cells is central to the creative development of new strategies to enhance protective immunity in the aged... - The influence of age on T cell generation and TCR diversityKeith Naylor
Department of Medicine, Mayo Clinic and Graduate School, Rochester, MN 55905, USA
J Immunol 174:7446-52. 2005..The collapse in CD4 T cell diversity during the seventh and eighth decades indicates substantial T cell loss and implies that therapeutic measures to improve vaccine responses will have to include strategies for T cell replenishment... - Induction of CD56 and TCR-independent activation of T cells with agingBonnie H Lemster
Department of Pediatrics, University of Pittsburgh, PA 15213, USA
J Immunol 180:1979-90. 2008..CD56(+) T cells are unique effectors capable of mediating TCR-independent immune cascades that could be harnessed to enhance protective immunity in the elderly...