Research Topics
Species | A NassarSummaryAffiliation: Mayo Clinic Country: USA Publications
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Publications
Image cytometric validation of breast carcinoma markers (ER, HER2 and MIB-1) using tissue microarrays: rabbit monoclonal vs. FDA-approved antibodiesAziza Nassar
Department of Pathology, Mayo Clinic, Rochester, Minnesota 55902, USA
Anal Quant Cytol Histol 32:192-200. 2010..To use the ACIS III (Dako, Carpinteria, California, U.S.A.) with tissue microarrays (TMAs) to compare rabbit monoclonal antibodies (RMab) for ER, HER2, and MIB-1 with FDA-approved monoclonal (FMab) and polyclonal (FPab) antibodies...- Trainable immunohistochemical HER2/neu image analysis: a multisite performance study using 260 breast tissue specimensAziza Nassar
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
Arch Pathol Lab Med 135:896-902. 2011.... - Reading immunohistochemical slides on a computer monitor--a multisite performance study using 180 HER2-stained breast carcinomasAziza Nassar
Mayo Clinic, Rochester, MN, USA
Appl Immunohistochem Mol Morphol 19:212-7. 2011..ScanScope XT instrument and the Spectrum digital pathology information management system to conventional manual microscopy (MM)... - A new immunohistochemical ER/PR image analysis system: a multisite performance studyAziza Nassar
Department of Pathology, Mayo Clinic, Rochester, MN, USA
Appl Immunohistochem Mol Morphol 19:195-202. 2011..A multisite study was conducted to assess the performance of Aperio's IHC IA solution for estrogen receptor (ER) and progesterone receptor (PR)... - Diagnostic utility of snail in metaplastic breast carcinomaAziza Nassar
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
Diagn Pathol 5:76. 2010..and overall survival. A combination of p63, OSCAR and WS-KER are useful in its work-up. On the other hand, Snail is neither a diagnostic nor a prognostic marker for MBC... - Core needle biopsy versus fine needle aspiration biopsy in breast--a historical perspective and opportunities in the modern eraAziza Nassar
Division of Anatomic Pathology, Mayo Clinic, Rochester, MN 55902, USA
Diagn Cytopathol 39:380-8. 2011..In this review, the advantages, disadvantages, and inherent limitations of breast FNA and CNB, and new advanced techniques are discussed... - Intratumoral heterogeneity of immunohistochemical marker expression in breast carcinoma: a tissue microarray-based studyAziza Nassar
Division of Anatomic Pathology, Mayo Clinic, Rochester, MN 55905, USA
Appl Immunohistochem Mol Morphol 18:433-41. 2010..A negative result does not exclude the expression of these markers in the remainder of the tumor. E-cad (positive in ductal carcinomas) and EGFR lacked heterogeneity... - Estimation of hormone receptor status and HER2 in cytologic cell blocks from breast cancer using the novel rabbit monoclonal antibodies (SP1, SP2, and SP3)Aziza Nassar
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55902, USA
Diagn Cytopathol 37:865-70. 2009..Both are as sensitive as their FDA-approved clones. SP3, on the other hand, is superior to HercepTest for detecting HER2 overexpression, with an excellent concordance with FISH... - Utility of glypican-3 and survivin in differentiating hepatocellular carcinoma from benign and preneoplastic hepatic lesions and metastatic carcinomas in liver fine-needle aspiration biopsiesA Nassar
Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
Diagn Cytopathol 37:629-35. 2009..Our data supports the potentially significant diagnostic utility of GPC-3 in FNABs in differentiating primary malignant from benign and preneoplastic liver lesions, and metastatic carcinomas... - Significance of intramammary lymph nodes in the staging of breast cancer: correlation with tumor characteristics and outcomeAziza Nassar
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA
Breast J 14:147-52. 2008..350; and overall survival p = 0.138). IntraMLN metastasis is a poor prognostic marker but not an independent predictor of poor outcome in patients with breast carcinoma... - Comparison of p16INK4A and Hybrid Capture 2 human papillomavirus testing as adjunctive tests in liquid-based gynecologic SurePath preparationsAziza Nassar
Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
Diagn Cytopathol 36:142-8. 2008..001). Using liquid-based cytology specimens, HCII is a more sensitive test than p16(INK4a) for detection of abnormal cytology. HCII has a higher PPV than p16(INK4a) for identifying CIN II/III... - Evaluation of new monoclonal antibodies in detection of estrogen receptor, progesterone receptor, and Her2 protein expression in breast carcinoma cell block sections using conventional microscopy and quantitative image analysisK Z Hanley
Department of Pathology and Laboratory Medicine, Emory University Hospital, Atlanta, Georgia, USA
Diagn Cytopathol 37:251-7. 2009..For Her2 overexpression, RMab proved to be superior to HerFDA and showed excellent agreement with FISH results with both quantitative detection methods... - Clinician's guide to imaging and pathologic findings in benign breast diseaseLonzetta Neal
Division of General Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
Mayo Clin Proc 85:274-9. 2010..This article provides insight into and understanding of breast imaging and biopsy techniques and of histologic findings as a means to timely and appropriate decision making and action by the patient and her health care professional... - Automated cellular imaging system III for assessing HER2 status in breast cancer specimens: development of a standardized scoring method that correlates with FISHDouglas M Minot
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
Am J Clin Pathol 132:133-8. 2009..The EQD method may more accurately identify FISH-amplified HER2 cases with fewer 2+ cases that would be "reflexed" to FISH compared with the manual method... - Extranodal Rosai-Dorfman disease of the kidney and coexistent poorly differentiated prostatic adenocarcinomaLara Harik
Department of Pathology, Emory University Hospital, School of Medicine, Atlanta, GA 30322, USA
Arch Pathol Lab Med 130:1223-6. 2006..Isolated involvement of the kidney by Rosai-Dorfman disease is very rare. The combination of prostatic adenocarcinoma and isolated extranodal Rosai-Dorfman disease of the kidney makes this case unique... - Novel breast tissue feature strongly associated with risk of breast cancerKevin P McKian
Department of Oncology, Mayo Clinic Cancer Center, Mayo Graduate School of Medical Education, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
J Clin Oncol 27:5893-8. 2009..Breast lobules are the anatomic sites of origin of breast cancer. As women age, these lobular structures should regress, which results in reduced breast cancer risk. However, this does not occur in all women... - Detecting high-grade cervical disease on ASC-H cytology: role of BD ProEx C and Digene Hybrid Capture II HPV DNA testingMomin T Siddiqui
Department of Pathology, Emory University Hospital, Atlanta, GA 30322, USA
Am J Clin Pathol 130:765-70. 2008..8% and for hr-HPV was 71.1%, whereas specificity values were 82.4% and 64.7%, respectively. BD ProEx C has potential as a marker for detection of high-grade disease in patients with ASC-H cytologic results... - Diagnostic utility of D2-40 and podoplanin in effusion cell blocksRitu Bhalla
Department of Pathology, Emory Univeristy Hospital, Atlanta, GA 30322, USA
Diagn Cytopathol 35:342-7. 2007..Since these markers are extremely helpful in differentiating epithelioid mesothelioma from metastatic adenocarcinoma, they shall be a valuable addition to the battery of markers used to differentiate the two entities... - Identification of a broad coverage HLA-DR degenerate epitope pool derived from carcinoembryonic antigenLavakumar Karyampudi
Department of Immunology, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Cancer Immunol Immunother 59:161-71. 2010..Patients with breast or ovarian cancer demonstrate pre-existent immune responses to the tumor antigen CEA. The degenerate pool of CEA peptides may be useful for augmenting CD4 T cell immunity... - HMGA2 gene expression analysis performed on cytologic smears to distinguish benign from malignant thyroid nodulesPaul J Lappinga
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
Cancer Cytopathol 118:287-97. 2010.... - ProEx C immunocytochemistry and high-risk human papillomavirus DNA testing in papanicolaou tests with atypical squamous cell (ASC-US) cytology: correlation study with histologic biopsyMomin T Siddiqui
Department of Pathology and Laboratory Medicine, Emory University Hospital, Atlanta, Georgia 30322, USA
Arch Pathol Lab Med 132:1648-52. 2008..ProEx C detects 2 such molecular markers, minichromosome maintenance protein 2 and topoisomerase II, which are associated with abnormal cell cycle regulation... - COX-2 expression in invasive breast cancer: correlation with prognostic parameters and outcomeAziza Nassar
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Appl Immunohistochem Mol Morphol 15:255-9. 2007..The therapeutic value of COX-2 inhibitors in COX-2 positive breast cancer patients requires further investigation... - Survivin and caspase-3 expression in breast cancer: correlation with prognostic parameters, proliferation, angiogenesis, and outcomeAziza Nassar
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Appl Immunohistochem Mol Morphol 16:113-20. 2008..We used a breast cancer tissue microarray to assess survivin and caspase-3 expression in breast cancer and to correlate both markers with proliferation (MIB-1), angiogenesis (CD31), and prognosis... - Homozygous deletion of SMAD4 in breast cancer cell lines and invasive ductal carcinomasDiansheng Zhong
The Winship Cancer Institute, Emory University, Atlanta, Georgia 30322, USA
Cancer Biol Ther 5:601-7. 2006.... - Utility of alpha-methylacyl coenzyme A racemase (p504s antibody) as a diagnostic immunohistochemical marker for cancerAziza Nassar
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Appl Immunohistochem Mol Morphol 13:252-5. 2005..It may be a useful adjunct to an immunohistochemical panel employed in the differential diagnosis of colon versus ovarian and breast carcinoma; the latter two infrequently express AMACR... - Value of histiocyte detection in Pap smears for predicting endometrial pathology. An institutional experienceAziza Nassar
Department of Pathology and Laboratory Medicine, Emory University, 1364 Clifton Road, N E, Room H 174, Atlanta, Georgia 30324, USA
Acta Cytol 47:762-7. 2003..To determine the clinical implications of the finding of histiocytes in Pap smears in 1 patient population... - Carcinoma showing thymuslike element of the thyroidAziza Nassar
Acta Cytol 47:313-5. 2003