David Kallmes

..Spine X-rays will be obtained at the end of the study (month 12) to determine subsequent fracture rates. Our co-primary outcomes are the modified Roland score and pain numerical rating scale at 1 month...

..Our aim was to review the literature regarding stent-assisted coil embolization of acutely ruptured intracranial aneurysms to determine the safety and efficacy of this treatment option...

..Randomized trials evaluating endovascular therapy are currently underway. The results of these trials will present us with both new answers and new questions...

..We report a preclinical study of a second-generation endoluminal device (Pipeline Embolization Device [PED-2] for aneurysmal occlusion and compare the PED-2 with its first-generation predecessor (PED-1)...

..80). Intravertebral clefts are not associated with bisphosphonate therapy. If these clefts indicate osteonecrosis, then bisphosphonate therapy does not appear to be associated with vertebral osteonecrosis...

..Vertebroplasty is commonly used to treat painful, osteoporotic vertebral compression fractures...

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..Our aim was to report baseline characteristics for the Investigational Vertebroplasty Efficacy and Safety Trial (INVEST), a randomized blinded controlled study of vertebroplasty...

..Dense matrix deposition is commonly seen with collagen-based coils. This contrasts with low rates of progressive thrombosis and high rates of loose matrix deposition seen with platinum coils...

..To evaluate the periprocedural outcome after carotid artery stenting with embolic brain protection (EBP+) versus without embolic brain protection (EBP-)...

..No cases of pneumothorax were noted. CONCLUSION: Transpedicular vertebroplasty is readily and safely performed using 11-gauge needles in the mid- and upper thoracic regions, yielding excellent pain relief and low complication rates...

..CONCLUSION: Antecedent venography does not significantly improve the effectiveness or safety of percutaneous vertebroplasty performed by qualified, experienced operators...

..In each of these cases, the HES allowed rapid, short-segment occlusion...

..CONCLUSION: The clinical outcomes of the patients within this case series suggest that repeat percutaneous vertebroplasty performed at previously treated vertebral levels for recurrent pain offer therapeutic benefit...

..Hypotheses included: (1) fibroblast-coated (FBC) platinum coils can improve angiographic results after embolization; and (2) FBC platinum coils can accelerate histological healing of embolized aneurysms...

..An important issue is determining immediate vs long-term risk regarding treatment effectiveness and durability. This issue emphasizes the importance of long-term follow-up in patients after surgical and endovascular procedures...

..and mechanisms of cerebral infarction and TIA are possible? (4) What is the prevalence of each potential etiology? (5) What treatments are available for this etiology? (6) What tests and studies are useful to evaluate this etiology?..

..We report the angiographic and histologic findings of the new, hybrid device used to treat experimental aneurysms in rabbits...

..Densely packed rabbit aneurysms demonstrate reproducible histologic evolution: early fibrin coverage, delayed spindle-cell coverage, delayed intraaneurysmal thrombus resorption, and occasional coil compaction...

..Two representative cases are presented that illustrate the ability of targeted cement deposition and flexible site selection with this technique...

..0 +/- 1.7 and 7.5 +/- 2.2 mm; P > .05). CONCLUSION: The neck size of elastase-induced aneurysm models in rabbits can be controlled by adjusting the position of the inflated balloon...

..A better understanding of predictors of aneurysm detection in familial IA may allow more targeted aneurysm screening strategies...

..More important, the RDQ provides an easily administered, well-validated, back pain-specific outcome measure that could be adopted to assess vertebroplasty outcomes...

..The suture-mediated Perclose ProGlide device is intended for use with 5F to 8F sheaths. We describe the use of the ProGlide device with 9F sheaths in acute stroke treatment using the Merci retrieval device...

..Thrombolytic therapy is generally given intravenously in the first 3 h and up to 6 h via the intraarterial route for pharmacological clot disruption. The maximum time-frame for mechanical thrombectomy devices has yet to be determined...

..Vertebral augmentation may be able to help many of these patients, although opportunities exist to optimize management strategies with respect to the other factors that influence long-term outcomes in this patient population...

..Relatively short incubation (eg, 10 minutes) and 25% elastase can be used to create rabbit aneurysms, especially if dilatation of adjacent parent arteries is to be avoided...

..007), although the mean difference was negligible (0.6%). CONCLUSION: We find no generalized association between PMMA injection during percutaneous vertebroplasty and systemic cardiovascular derangement...

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..To retrospectively evaluate the complications of diagnostic cerebral catheter angiography in 19,826 consecutive patients...

..First- and second-fractures are not associated with greater incidence of aortic injury. Thus, the previous axiom that first- and second-rib fractures should result in increased examination for aortic injury may not hold true...

..Our study suggests that it may be important for radiologists to assess the arterial anatomy of the C1-C2 region before performing C1-C2 puncture...

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..The current series examines the use of MicroNester pushable coils (Cook Medical, Bloomington, IN) as a low-cost and effective adjunct to detachable coils in the treatment of selected neurovascular pathologies...

..However, total dose per injection was equivalent between groups because of significantly longer injection duration for the injection device cohort...

..In conclusion, the CAD scheme showed good accuracy and may have application in improving the sensitivity of aneurysm detection on MR images...

..To perform a detailed analysis of blinding efficacy in the Investigational Vertebroplasty Efficacy and Safety Trial (INVEST) to determine any factors associated with patient unblinding...

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..Future directions of these modalities, including carotid plaque imaging, are also discussed...

..Vertebroplasty administered earlier in hospitalization also leads to greater decreases in analgesic requirements...

..We hypothesized that serial measurements of DWI infarct volume would be predictive of functional outcome after ischemic stroke...

..To determine whether the reported pain severity changed significantly on the basis of specific types of pain questions posed to patients with spine augmentation...

..We evaluated a large administrative database to determine the effect of age on outcomes in patients treated for unruptured cerebral aneurysm...

..The morbidity and mortality rates are substantial for perforations caused by coils and microcatheters, whereas they seem to be much lower for perforations caused by microguidewires...

..To compare gene expression patterns between well-healed and poorly healed aneurysms following coil embolization in a rabbit model...

..We report on a patient with a large symptomatic CBT treated surgically with the aid of mandibular subluxation and preoperative embolization...

..Understanding of the normal and variant anatomy of the rabbit will aid investigators who use the rabbit model for endovascular research...

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..The aim of the present study was to understand the mechanism of apoptosis in aneurysms embolized with platinum coils in the rabbit model of elastase-induced aneurysms...

..Neointimal thickness and area were not statistically significantly different between groups. CONCLUSIONS: Type 1 collagen stent-grafts demonstrate excellent hemocompatibility and biocompatibility in small-diameter vessels in rabbits...

..All relevant vessels can be accessed from the radial artery for diagnostic studies. Interventions in the right vertebral and carotid systems are facilitated by the transradial approach...

..Other factors, such as MR evidence of edema or increased uptake on bone scan, should be weighed considerably in the decision to treat a patient...

..The Matrix group showed an increase in inflammation and coil compaction compared with HydroCoils and platinum coils...

..05). CONCLUSION: The results indicate that more consistent aneurysm diameters can be created using the modified technique...

..There is no report regarding patency of elastase-induced aneurysms for more than a 2-year period. Our aim was to report aneurysm patency rates up to 5 years in the elastase-induced aneurysm model in rabbits...

..To identify and define clinical associations and radiologic findings of posterior reversible encephalopathy syndrome (PRES)...

..CONCLUSION: Potential clinical complications can be avoided by early recognition of thrombus at the coil-parent artery interface and by administering appropriate medical therapy...

..Finally, the current state of evidence in support of the efficacy of vertebroplasty are discussed, with particular attention to the need for ongoing clinical trials...

..The purpose of this study was to evaluate the association between hemodynamic forces and markers of vascular remodeling in elastase-induced saccular aneurysms in rabbits...

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..The HES provided substantially improved volumetric packing of the aneurysm lumen relative to standard platinum coils (73% vs. 32%; P=.0001)...

..We demonstrate the technical success of this system by presenting a patient whose endovascular treatment would have otherwise been impossible without a "buddy" wire...

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..This technique is considered beneficial for studying the molecular mechanisms of aneurysm healing after coiling...

..To determine if operator variability, prior vertebroplasty experience, or acquired vertebroplasty experience affects clinical outcomes...

..The Hirsch Index (H index) is widely applied as a metric of scientific productivity. The purpose of this study was to evaluate the role of self-citation on the H index in academic radiology...

..To evaluate the outcomes of carotid artery stenting (CAS) and open surgical repair (OR) for treatment of radiation-induced carotid stenosis (RICS)...

..The elastase-induced aneurysm model in rabbits is more suitable than sidewall swine aneurysms for testing of modified devices aimed at improving intra-aneurysmal fibrosis...

..We present a catheter technique that utilizes a 5F system for the purpose of balloon-assisted coiling in the setting of intracranial aneurysms...

..CONCLUSION: The results of this study suggest that hMSC and BMP-9 ex vivo gene therapy may be useful in inducing spinal fusion as well as other related procedures and certainly warrants further clinical development...

..CONCLUSION: The patient radiation dose for 3D RA is significantly lower than for biplanar DSA, by nearly a factor of 4 in peak skin dose and 40% lower in cumulative incident dose...

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..311, P = 0.086 and P = 0.258, respectively). IVDSA appears to be an alternative method for evaluating elastase-induced aneurysms in rabbits...

..This program will enhance health by preventing the catastrophic events resulting from spontaneous rupture of intracranial aneurysms. ..

..This program will enhance health by preventing the catastrophic events resulting from spontaneous rupture of intracranial aneurysms. ..

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..Successful implementation of this research program will advance the field of genetic and tissue engineering and will improve the care of patients harboring life-threatening cerebral aneurysms. ..

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..This program will enhance health by preventing the catastrophic events resulting from spontaneous rupture of intracranial aneurysms. ..