Research Topics
Species | P James B DyckSummaryAffiliation: Mayo Clinic Country: USA Publications
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Detail Information
Publications
Non-diabetic lumbosacral radiculoplexus neuropathy: natural history, outcome and comparison with the diabetic varietyP J Dyck
Peripheral Neuropathy Research Laboratory, Department of Neurology, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA
Brain 124:1197-207. 2001..We infer an autoimmune basis for LSRPN and emphasize the need for controlled trials of immune-modulating therapy...
Diabetic and nondiabetic lumbosacral radiculoplexus neuropathies: new insights into pathophysiology and treatmentP James B Dyck
Peripheral Neuropathy Research Laboratory, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
Muscle Nerve 25:477-91. 2002..It is likely that DLRPN and LRPN are immune-mediated neuropathies that should be separated from chronic inflammatory demyelinating polyneuropathy and from systemic necrotizing vasculitis...
Primary amyloidosis presenting as upper limb multiple mononeuropathiesJennifer A Tracy
Peripheral Neuropathy Research Laboratory, Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
Muscle Nerve 41:710-5. 2010..Recognition that light chain amyloidosis may be the cause of a multiple mononeuropathy pattern adds to the differential diagnosis of this clinical phenotype...
Microvasculitis in diabetic lumbosacral radiculoplexus neuropathyJennifer A Tracy
Peripheral Neuropathy Research Laboratory, Mayo Clinic, Rochester, MN 55905, USA
J Clin Neuromuscul Dis 11:44-8. 2009..This case illustrates the typical clinical, electrophysiologic, and pathologic features of diabetic lumbosacral radiculoplexus neuropathy and the utility of nerve biopsy to judge ongoing disease activity...
Mass spectrometric-based proteomic analysis of amyloid neuropathy type in nerve tissueChristopher J Klein
Department of Neurology Peripheral Nerve Laboratory, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Arch Neurol 68:195-9. 2011..To determine the specific type of amyloid from nerve biopsies using laser microdissection (LMD) and mass spectrometric (MS)-based proteomic analysis...
Post-surgical inflammatory neuropathyNathan P Staff
Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Brain 133:2866-80. 2010....
Signs and symptoms versus nerve conduction studies to diagnose diabetic sensorimotor polyneuropathy: Cl vs. NPhys trialPeter J Dyck
Peripheral Neuropathy Research Laboratory, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
Muscle Nerve 42:157-64. 2010..Study physician dx from signs and symptoms were excessively variable, often overestimating DSPN. Specific approaches to improving clinical proficiency should be tested...
Auto-immune polyradiculoneuropathy and a novel IgG biomarker in workers exposed to aerosolized porcine brainJennifer A Tracy
Peripheral Neuropathy Research Laboratory, Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
J Peripher Nerv Syst 16:34-7. 2011....
Impaired glycemia and diabetic polyneuropathy: the OC IG SurveyPeter J Dyck
Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
Diabetes Care 35:584-91. 2012....
Longitudinal study of intraneural perineurioma--a benign, focal hypertrophic neuropathy of youthMichelle L Mauermann
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
Brain 132:2265-76. 2009..Because intensive evaluation is needed for diagnosis, intraneural perineurioma is probably under-recognized...
Isolated amyloidosis presenting with lumbosacral radiculoplexopathy: description of two cases and pathogenic reviewShafeeq S Ladha
Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
J Peripher Nerv Syst 11:346-52. 2006..The limited literature and experience among other cases is described...
Disseminated sporotrichosis presenting with granulomatous inflammatory multiple mononeuropathiesMichelle L Mauermann
Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, Minnesota 55905, USA
Muscle Nerve 36:866-72. 2007..Based on clinical and pathological features, the mechanism of neuropathy may have been due to either direct nerve infection or a bystander effect of inflammatory/immune damage or, perhaps more likely, to both mechanisms...
HIV lumbosacral radiculoplexus neuropathy mimicking lymphoma: diffuse infiltrative lymphocytosis syndrome (DILS) restricted to nerve?Nizar Chahin
Peripheral Neuropathy Research Laboratory, Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
Muscle Nerve 41:276-82. 2010..Symptoms, signs, and repeat biopsy improved with antiretroviral treatment. The presentation and treatment response suggest that this case is localized DILS...
Inflammatory mediators in diabetic and non-diabetic lumbosacral radiculoplexus neuropathyNobutoshi Kawamura
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
Acta Neuropathol 115:231-9. 2008..Up-regulated inflammatory mediators may be immunotherapeutic targets in these two conditions...
Inflammatory pseudotumor of nerve: clinicopathological characteristics and a potential therapyMichelle L Mauermann
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
J Peripher Nerv Syst 15:216-26. 2010..The primary pathophysiology is unknown but the inflammation and response to treatment suggests that there may be an immune component...
Adult polyglucosan body disease: case description of an expanding genetic and clinical syndromeChristopher J Klein
Department of Neurology, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, Minnesota 55905, USA
Muscle Nerve 29:323-8. 2004..These findings expand the clinical and genetic spectrum of APBD. Factors other than mutation of the expressed GBE gene may cause enzyme deficiency and varied expression and development of APBD...
Monotonicity of nerve tests in diabetes: subclinical nerve dysfunction precedes diagnosis of polyneuropathyPeter J Dyck
Department of Neurology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, Minnesota 55905, USA
Diabetes Care 28:2192-200. 2005..The objective of this study was to test whether monotone worsening of nerve function, attributable to diabetes, can be demonstrated before criteria for diabetic sensorimotor polyneuropathy (DSPN) have been met. Which nerve tests are best?..
Hypertrophy of the nerve roots of the cauda equina as a paraneoplastic manifestation of lymphomaNeeraj Kumar
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
Arch Neurol 62:1776-7. 2005
History of standard scoring, notation, and summation of neuromuscular signs. A current survey and recommendationPeter J Dyck
Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
J Peripher Nerv Syst 10:158-73. 2005..representing increasing impairment based on the judgment of percentage abnormality with corrections made for age, sex, physical fitness, and physical characteristics...
Individual attributes versus composite scores of nerve conduction abnormality: sensitivity, reproducibility, and concordance with impairmentPeter J Dyck
Peripheral Neuropathy Research Laboratory, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA
Muscle Nerve 27:202-10. 2003..We conclude that, with the availability of microprocessors and normative databases, electromyographers may increasingly seek to express nerve conduction abnormality also as composite scores of individual or several nerves...
SEPT9 mutations and a conserved 17q25 sequence in sporadic and hereditary brachial plexus neuropathyChristopher J Klein
Peripheral Neuropathy Research Laboratory, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
Arch Neurol 66:238-43. 2009..These mutations were not found in North American kindreds with H-BPN with a conserved 500-kilobase sequence of DNA at the 17q25 chromosomal region (where SEPT9 localizes) where a founder mutation has been suggested...
Neoplastic lumbosacral radiculoplexopathy in prostate cancer by direct perineural spread: an unusual entityShafeeq S Ladha
Department of Neurology, Mayo Clinic, Scottsdale, Arizona, USA
Muscle Nerve 34:659-65. 2006..The probable etiology of tumor spreading along prostatic nerves into the lumbosacral plexus (i.e., perineural spread) is discussed as are the potential mechanisms for this unusual mode of cancer dissemination...
Meralgia paresthetica: relation to obesity, advanced age, and diabetes mellitusThomas J Parisi
Department of Graduate Medicine, Mayo Medical School, 200 First Street SW, Rochester, MN 55905, USA
Neurology 77:1538-42. 2011..To determine the incidence of meralgia paresthetica (MP) and its relationship to diabetes mellitus (DM) and obesity...
Vasculitic neuropathiesTed M Burns
Department of Neurology, University of Virginia, Charlottesville, VA 22908, USA
Neurol Clin 25:89-113. 2007..Steroids and cytotoxic agents have been the mainstay of therapy for most forms of vasculitic neuropathy. Dosing, potential side effects, and management recommendations of conventional therapies are provided...
A 46-year-old man with numbness and shock-like sensations in hands, feet, and jawDavid W Polston
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
Lancet Neurol 3:63-7. 2004
Immune trigeminal sensory neuropathy with esophageal achalasia: improvement with long-term immunotherapyJuan J Figueroa
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
Muscle Nerve 43:289-93. 2011..We suggest that the patient's deficits, including achalasia, were due to an immune-mediated sensory and autonomic neuropathy and that, in such cases, pathologic studies of the great auricular nerve may be diagnostically informative...
Investigations and treatment of chronic inflammatory demyelinating polyradiculoneuropathy and other inflammatory demyelinating polyneuropathiesJennifer A Tracy
Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
Curr Opin Neurol 23:242-8. 2010..The evaluation of demyelinating polyneuropathies and the data for treatment of inflammatory demyelinating peripheral neuropathies, particularly chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), will be discussed...
Hemi-meningitis: A focal sign heralding a multisystem necrotizing vasculitisDean M Wingerchuk
Department of Neurology, 13400 E Shea Blvd, Scottsdale, AZ 85259, USA
Neurology 70:2014. 2008
An outbreak of neurological autoimmunity with polyradiculoneuropathy in workers exposed to aerosolised porcine neural tissue: a descriptive studyDaniel H LaChance
Department of Neurology, Mayo Clinic, Rochester, MN, USA Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
Lancet Neurol 9:55-66. 2010..We aimed to describe the pathogenic and immunological characteristics of this illness...
Modeling chronic glycemic exposure variables as correlates and predictors of microvascular complications of diabetesPeter J Dyck
Mayo Clinic College of Medicine, Department of Neurology, 200 First St SW, Rochester, MN 55905, USA
Diabetes Care 29:2282-8. 2006..Specifically, we test whether combinations of components correlate and predict complications better than individual components...
Does impaired glucose metabolism cause polyneuropathy? Review of previous studies and design of a prospective controlled population-based studyPeter J Dyck
Peripheral Neuropathy Research Laboratory, Mayo Clinic, Rochester, MN 55905, USA
Muscle Nerve 36:536-41. 2007..Here we review previous studies, list the reasons that the issue needs further study, and outline a study now in progress to address the question more definitively...
The Paclitaxel acute pain syndrome: sensitization of nociceptors as the putative mechanismCharles L Loprinzi
Division of Medical Oncology, Mayo Clinic College of Medicine, Rochester, MN, USA
Cancer J 13:399-403. 2007..Herein, we characterize the clinical characteristics of this syndrome using detailed patient interviews and consider the putative mechanism(s) for these symptoms...
Electronic case-report forms of symptoms and impairments of peripheral neuropathyPeter J Dyck
Peripheral Neuropathy Research Center, Mayo Clinic and Mayo Foundation, Rochester, MN, USA
Can J Neurol Sci 29:258-66. 2002....
The spectrum of diabetic neuropathiesJennifer A Tracy
Peripheral Neuropathy Research Laboratory, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Phys Med Rehabil Clin N Am 19:1-26, v. 2008..It discusses the symmetrical neuropathies, particularly generalized diabetic polyneuropathy, and then the focal or asymmetrical types of diabetes-associated neuropathy...
An update on the classification and treatment of vasculitic neuropathyGreg A Schaublin
Department of Neurology, University of Virginia Health Sciences, Charlottesville, VA 22908, USA
Lancet Neurol 4:853-65. 2005..Future trials should compare commonly used treatment regimens and better establish the efficacy of newer, potentially safer, treatments...
Diabetic neuropathies. Classification, clinical features, and pathophysiological basisMichael Sinnreich
Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
Neurologist 11:63-79. 2005..We have tried to include epidemiological data where available, as well as histopathology of nerve in several diabetic neuropathies...
Identification of transthyretin variants by sequential proteomic and genomic analysisH Robert Bergen
WM Keck FT-ICR Mass Spectrometry Laboratory, Mayo Proteomics Research Center, Mayo Clinic College of Medicine, Rochester, MN, USA
Clin Chem 50:1544-52. 2004..This method correctly identified all previously known variants and also identified a novel variant, Val94Ala...
Ornithine transcarbamylase deficiency presenting as encephalopathy during adulthood following bariatric surgeryWilliam T Hu
Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
Arch Neurol 64:126-8. 2007..Whereas nutritional deficiencies are the most common cause of neurological symptoms, the unmasking of previously subclinical metabolic disorders can also lead to significant morbidity...
A 16-year-old girl with progressive weakness of the left legAngelika F Hahn
Department of Clinical Neurological Sciences, University of Western Ontario, Canada
Neurology 69:84-90. 2007
Hemorrhagic polyneuropathy in idiopathic thrombocytopenic purpuraJoon-Shik Moon
J Peripher Nerv Syst 12:286-9. 2007
Multifocal motor neuropathy: pathologic alterations at the site of conduction blockBruce V Taylor
Department of Neurology, Royal Hobart Hospital, Hobart Tasmania, Australia
J Neuropathol Exp Neurol 63:129-37. 2004....
Two causes of demyelinating neuropathy in one patient: CMT1A and POEMS syndromeNizar Chahin
Can J Neurol Sci 34:380-5. 2007
