Research Topics
Genomes and Genes | Jeremy ChienSummaryAffiliation: Mayo Clinic Country: USA Publications
| Collaborators
|
Detail Information
Publications
Downregulation of HtrA1 promotes resistance to anoikis and peritoneal dissemination of ovarian cancer cellsXiaoping He
Department of Laboratory Medicine and Experimental Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
Cancer Res 70:3109-18. 2010....- Analysis of gene expression in stage I serous tumors identifies critical pathways altered in ovarian cancerJeremy Chien
Division of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Gynecol Oncol 114:3-11. 2009..The objective of this study was to characterize differentially expressed genes in high-grade stage I serous carcinoma of the ovary... - Identification of tubulins as substrates of serine protease HtrA1 by mixture-based oriented peptide library screeningJeremy Chien
Department of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
J Cell Biochem 107:253-63. 2009..These results provide initial insights into substrate identification and functional characterization of HtrA1 in pathogenesis of various diseases... - Loss of HSulf-1 expression enhances autocrine signaling mediated by amphiregulin in breast cancerKeishi Narita
Department of Laboratory Medicine and Experimental Pathology, Mayo Clinic Cancer Center, Rochester, MN 55905, USA
J Biol Chem 282:14413-20. 2007..These data suggest a potential role of HSulf-1 down-regulation in mammary carcinogenesis... - Serine protease HtrA1 associates with microtubules and inhibits cell migrationJeremy Chien
Experimental Pathology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
Mol Cell Biol 29:4177-87. 2009..These results offer an original identification of HtrA1 as a microtubule-associated protein and provide initial mechanistic insights into the role of HtrA1 in the regulation of cell motility by modulating microtubule stability... - HSulf-1 modulates FGF2- and hypoxia-mediated migration and invasion of breast cancer cellsAshwani Khurana
Department of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Cancer Res 71:2152-61. 2011..03 and P ? 0.0001, respectively). Collectively, these results reveal an important link between loss of HSulf-1 under hypoxic microenvironment and increased growth factor signaling, cell migration, and invasion... - HSulf-1 inhibits angiogenesis and tumorigenesis in vivoKeishi Narita
Department of Experimental Pathology, Mayo Clinic Cancer Center, Rochester, Minnesota 55905, USA
Cancer Res 66:6025-32. 2006..Collectively, these observations provide the first evidence of a novel mechanism by which HSulf-1 modulates the function of heparan sulfate binding VEGF165 in proliferation and angiogenesis... - A candidate tumor suppressor HtrA1 is downregulated in ovarian cancerJeremy Chien
Mayo Clinic Cancer Center and Department of Experimental Pathology, Mayo Clinic, Rochester, MN 55905, USA
Oncogene 23:1636-44. 2004..These observations raise the possibility of HtrA1 as a candidate tumor suppressor involved in promoting serine-protease-mediated cell death and that downregulation of HtrA1 in ovarian cancer may contribute to malignant phenotype... - Epigenetic silencing of TCEAL7 (Bex4) in ovarian cancerJeremy Chien
Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic Foundation, 200 First Street, SW Rochester, MN 55905, USA
Oncogene 24:5089-100. 2005..These data implicate TCEAL7 as a cell death regulatory protein that is frequently inactivated in ovarian cancers, and suggest that it may function as a tumor suppressor... - HSulf-1 modulates HGF-mediated tumor cell invasion and signaling in head and neck squamous carcinomaJin-Ping Lai
Division of Gastroenterology and Hepatology, Mayo Clinic Cancer Center, Mayo Clinic and Foundation, Rochester, MN 55905, USA
Oncogene 23:1439-47. 2004.... - High temperature requirement A3 (HtrA3) promotes etoposide- and cisplatin-induced cytotoxicity in lung cancer cell linesDaniah Beleford
Department of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
J Biol Chem 285:12011-27. 2010.... - HtrA1 sensitizes ovarian cancer cells to cisplatin-induced cytotoxicity by targeting XIAP for degradationXiaoping He
Department of Laboratory Medicine and Experimental Pathology, Mayo Clinic College of Medicine, Rochester, MN, USA
Int J Cancer 130:1029-35. 2012.... - Loss of HSulf-1 up-regulates heparin-binding growth factor signaling in cancerJinping Lai
Mayo Clinic Cancer Center, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
J Biol Chem 278:23107-17. 2003..Collectively, these observations provide evidence that HSulf-1 modulates signaling by heparin-binding growth factors, and HSulf-1 down-regulation represents a novel mechanism by which cancer cells can enhance growth factor signaling... - Serine protease HtrA1 modulates chemotherapy-induced cytotoxicityJeremy Chien
Department of Laboratory Medicine and Experimental Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA, Medical Oncology Unit and Department of Histopathology, San Salvatore Hospital, Pesaro, Italy
J Clin Invest 116:1994-2004. 2006.... - Assessment of hepatocyte growth factor in ovarian cancer mortalityEllen L Goode
Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Cancer Epidemiol Biomarkers Prev 20:1638-48. 2011..Invasive ovarian cancer is a significant cause of gynecologic cancer mortality... - Heterozygous ATR mutations in mismatch repair-deficient cancer cells have functional significanceKriste A Lewis
Department of Obstetrics and Gynecology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
Cancer Res 65:7091-5. 2005..These findings imply that ATR mutations play an important role in the development and clinical behavior of a subset of microsatellite instability-positive endometrial, colon, and stomach cancers... - Identification of underexpressed genes in early- and late-stage primary ovarian tumors by suppression subtraction hybridizationViji Shridhar
Department of Experimental Pathology, Division of Laboratory Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
Cancer Res 62:262-70. 2002..In conclusion, our analysis has identified down-regulated genes, which map to known as well as novel regions of deletions and may represent potential candidate tumor suppressor genes involved in ovarian cancer... - DIXDC1 isoform, l-DIXDC1, is a novel filamentous actin-binding proteinXianshu Wang
Department of Laboratory Medicine and Pathology, Mayo Clinic Mayo Medical School, Rochester, MN 55905, USA
Biochem Biophys Res Commun 347:22-30. 2006....