Paul B Yu

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi Bone morphogenetic protein (BMP) type II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary artery smooth muscle cells
    Paul B Yu
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Biol Chem 280:24443-50. 2005
  2. ncbi Bone morphogenetic protein (BMP) type II receptor is required for BMP-mediated growth arrest and differentiation in pulmonary artery smooth muscle cells
    Paul B Yu
    Cardiovascular Research Center and Anesthesia Center for Critical Care Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 283:3877-88. 2008
  3. ncbi Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism
    Paul B Yu
    Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 02129, USA
    Nat Chem Biol 4:33-41. 2008
  4. ncbi Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4
    Yin Xia
    Program in Membrane Biology and the Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    J Biol Chem 282:18129-40. 2007
  5. ncbi Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation
    Andrea U Steinbicker
    Department of Anesthesia, Harvard Medical School, Boston, MA, USA
    Blood 117:4915-23. 2011
  6. ncbi BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia
    Hideyuki Beppu
    Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Am J Physiol Lung Cell Mol Physiol 287:L1241-7. 2004
  7. ncbi Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice
    Andrea U Steinbicker
    Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Blood 118:4224-30. 2011
  8. ncbi Images in cardiovascular medicine. Left atrial-esophageal fistula after pulmonary vein isolation: a cautionary tale
    Leon M Ptaszek
    Cardiac Arrhythmia Service, Massachusetts General Hospital, 55 Fruit Street, GRB 109, Boston, MA 02114, USA
    Circulation 115:e432-3. 2007
  9. ncbi Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors
    Gregory D Cuny
    Laboratory for Drug Discovery in Neurodegeneration, Harvard NeuroDiscovery Center, Brigham and Women s Hospital and Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA
    Bioorg Med Chem Lett 18:4388-92. 2008

Research Grants

  1. The role of the BMP type II receptor in vascular function
    Paul Yu; Fiscal Year: 2007
  2. Molecular and cellular mechanisms of heterotopic ossification
    Paul B Yu; Fiscal Year: 2010

Collaborators

Detail Information

Publications9

  1. ncbi Bone morphogenetic protein (BMP) type II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary artery smooth muscle cells
    Paul B Yu
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Biol Chem 280:24443-50. 2005
    ..These findings suggest that disruption of Bmpr2 leads to the net gain of signaling by some, but not all, BMP ligands via the activation of ActRIIa...
  2. ncbi Bone morphogenetic protein (BMP) type II receptor is required for BMP-mediated growth arrest and differentiation in pulmonary artery smooth muscle cells
    Paul B Yu
    Cardiovascular Research Center and Anesthesia Center for Critical Care Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 283:3877-88. 2008
    ..These data suggest that sustained BMP pathway activation, such as that mediated by BMPRII, is necessary for growth and differentiation control in vascular smooth muscle...
  3. ncbi Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism
    Paul B Yu
    Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 02129, USA
    Nat Chem Biol 4:33-41. 2008
    ..These findings suggest an essential physiological role for hepatic BMP signaling in iron-hepcidin homeostasis...
  4. ncbi Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4
    Yin Xia
    Program in Membrane Biology and the Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    J Biol Chem 282:18129-40. 2007
    ..These findings suggest that RGMa facilitates the use of ActRIIA by endogenous BMP2 and BMP4 ligands that otherwise prefer signaling via BMPRII and that increased utilization of ActRIIA leads to generation of an enhanced BMP signal...
  5. ncbi Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation
    Andrea U Steinbicker
    Department of Anesthesia, Harvard Medical School, Boston, MA, USA
    Blood 117:4915-23. 2011
    ..Our studies support the concept that BMP and IL-6 act together to regulate iron homeostasis and suggest that inhibition of BMP signaling may be an effective strategy for the treatment of anemia of inflammation...
  6. ncbi BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia
    Hideyuki Beppu
    Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Am J Physiol Lung Cell Mol Physiol 287:L1241-7. 2004
    ..Our results suggest that, in mice, mutation of one copy of the BMPR-II gene causes pulmonary hypertension but impairs the ability of the pulmonary vasculature to remodel in response to prolonged hypoxic breathing...
  7. ncbi Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice
    Andrea U Steinbicker
    Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Blood 118:4224-30. 2011
    ....
  8. ncbi Images in cardiovascular medicine. Left atrial-esophageal fistula after pulmonary vein isolation: a cautionary tale
    Leon M Ptaszek
    Cardiac Arrhythmia Service, Massachusetts General Hospital, 55 Fruit Street, GRB 109, Boston, MA 02114, USA
    Circulation 115:e432-3. 2007
  9. ncbi Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors
    Gregory D Cuny
    Laboratory for Drug Discovery in Neurodegeneration, Harvard NeuroDiscovery Center, Brigham and Women s Hospital and Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA
    Bioorg Med Chem Lett 18:4388-92. 2008
    ..g., plasma t(1/2)=1.6h) following intraperitoneal administration in mice. These studies provide useful molecular probes for examining the in vivo pharmacology of BMP signaling inhibition...

Research Grants3

  1. The role of the BMP type II receptor in vascular function
    Paul Yu; Fiscal Year: 2007
    ..This study examines in mice how a receptor for bone morphogenetic proteins (BMPR2) coordinates the function of blood vessel cells, and how abnormal function of BMPR2 may lead to disorders of the circulation. (End of Abstract) ..
  2. Molecular and cellular mechanisms of heterotopic ossification
    Paul B Yu; Fiscal Year: 2010
    ..These mechanisms have relevance to a broader set of conditions in which inflammation and injury appear to lead to abnormal ossification in autoimmune, cardiac, and vascular disease. ..