Research Topics
| Rochelle P WalenskySummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Detail Information
Publications
The impact of the President's Emergency Plan for AIDS Relief (PEPfAR) beyond HIV and why it remains essentialRochelle P Walensky
Divisions of 1Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Clin Infect Dis 50:272-5. 2010..We further address the substantial impact PEPfAR has achieved in general and more specifically toward improving maternal and child health and why continued PEPfAR investment remains essential...- When to start antiretroviral therapy in resource-limited settingsRochelle P Walensky
Massachusetts General Hospital, Brigham and Women s Hospital, Harvard University Medical School, Harvard School of Public Health, and Boston University School of Public Health, Boston, Massachusetts 02114, USA
Ann Intern Med 151:157-66. 2009..The results of international clinical trials that are assessing when to initiate antiretroviral therapy (ART) will not be available for several years... - Intensive tuberculosis screening for HIV-infected patients starting antiretroviral therapy in Durban, South AfricaIngrid V Bassett
Division of Infectious Disease, Massachusetts General Hospital, Boston, Massachusetts, USA
Clin Infect Dis 51:823-9. 2010..Our objective was to assess the yield and cost of a more intensive tuberculosis screening in HIV-infected patients starting antiretroviral therapy (ART) in Durban, South Africa... - The clinical impact and cost-effectiveness of routine, voluntary HIV screening in South AfricaRochelle P Walensky
Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
J Acquir Immune Defic Syndr 56:26-35. 2011..Although 900,000 HIV-infected South Africans receive antiretroviral therapy, the majority of South Africans with HIV remain undiagnosed... - Scaling up antiretroviral therapy in South Africa: the impact of speed on survivalRochelle P Walensky
The Divisions of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
J Infect Dis 197:1324-32. 2008..Only 33% of eligible human immunodeficiency virus (HIV)-infected patients in South Africa receive antiretroviral therapy (ART). We sought to estimate the impact of alternative ART scale-up scenarios on patient outcomes from 2007-2012... - Cost-effectiveness of preventing loss to follow-up in HIV treatment programs: a Côte d'Ivoire appraisalElena Losina
Division of General Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America
PLoS Med 6:e1000173. 2009..Our objective was to project the clinical impact and cost-effectiveness of interventions to prevent LTFU from HIV care in West Africa... - Loss to follow-up and mortality among HIV-infected people co-infected with TB at ART initiation in Durban, South AfricaIngrid V Bassett
Division of Infectious Disease, Massachusetts General Hospital, Boston, USA
J Acquir Immune Defic Syndr 59:25-30. 2012..To quantify the impact of tuberculosis (TB) co-infection on death and loss to follow-up (LTFU) 12 months after entry into an ART program... - Resource utilization and cost-effectiveness of counselor- vs. provider-based rapid point-of-care HIV screening in the emergency departmentRochelle P Walensky
Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America
PLoS ONE 6:e25575. 2011..Routine HIV screening in emergency department (ED) settings may require dedicated personnel. We evaluated the outcomes, costs and cost-effectiveness of HIV screening when offered by either a member of the ED staff or by an HIV counselor... - Test and treat DC: forecasting the impact of a comprehensive HIV strategy in Washington DCRochelle P Walensky
Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Clin Infect Dis 51:392-400. 2010..We forecast outcomes of this approach if implemented in Washington DC... - Racial and sex disparities in life expectancy losses among HIV-infected persons in the united states: impact of risk behavior, late initiation, and early discontinuation of antiretroviral therapyElena Losina
Divisions of General Medicine, Department of Medicine, MA 02114, USA
Clin Infect Dis 49:1570-8. 2009.... - Clinical impact and cost-effectiveness of antiretroviral therapy in India: starting criteria and second-line therapyKenneth A Freedberg
Divisions of General Medicine and Infectious Disease and the Partners AIDS Research Center, Massachusetts General Hospital, Boston, MA, USA
AIDS 21:S117-28. 2007..India has more than 5.7 million people infected with human immunodeficiency virus (HIV). In 2004, the Indian government began providing antiretroviral therapy (ART), and there are now an estimated 56 500 people receiving ART... - Loss to care and death before antiretroviral therapy in Durban, South AfricaIngrid V Bassett
Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA
J Acquir Immune Defic Syndr 51:135-9. 2009..To examine the loss to care and mortality rates before starting antiretroviral therapy (ART) among ART eligible HIV-infected patients in Durban, South Africa. Design: Retrospective cohort study... - Predictors of mortality in patients initiating antiretroviral therapy in Durban, South AfricaBisola O Ojikutu
Harvard Center for AIDS Research CFAR and Division of AIDS, Harvard Medical School, and Division of Infectious Disease, Massachusetts General Hospital, Boston, MA, USA
S Afr Med J 98:204-8. 2008..To identify predictors of mortality in patients initiating antiretroviral therapy (ART) in Durban, South Africa... - Who starts antiretroviral therapy in Durban, South Africa?... not everyone who shouldIngrid V Bassett
Division of Infectious Disease, Massachusetts General Hospital, Boston, MA 02114, USA
AIDS 24:S37-44. 2010..To evaluate rates of antiretroviral therapy (ART) initiation within 12 months of a new HIV diagnosis in Durban, South Africa... - Counselor- versus provider-based HIV screening in the emergency department: results from the universal screening for HIV infection in the emergency room (USHER) randomized controlled trialRochelle P Walensky
Division of Infectious Diseases and General Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
Ann Emerg Med 58:S126-32.e1-4. 2011..We compare rates of rapid HIV testing, test offer, and acceptance in an urban emergency department (ED) when conducted by dedicated HIV counselors versus current members of the ED staff... - Cost-effectiveness of tenofovir as first-line antiretroviral therapy in IndiaMelissa A Bender
Divisions of General Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
Clin Infect Dis 50:416-25. 2010..We evaluated the clinical outcomes and cost-effectiveness of first-line ART using tenofovir in India, compared with current practice using stavudine or zidovudine... - WHO 2010 guidelines for prevention of mother-to-child HIV transmission in Zimbabwe: modeling clinical outcomes in infants and mothersAndrea L Ciaranello
Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America
PLoS ONE 6:e20224. 2011..The Zimbabwean national prevention of mother-to-child HIV transmission (PMTCT) program provided primarily single-dose nevirapine (sdNVP) from 2002-2009 and is currently replacing sdNVP with more effective antiretroviral (ARV) regimens... - HIV testing rates and outcomes in a South African community, 2001-2006: implications for expanded screening policiesMichael D April
Harvard Medical School, Boston, MA, USA
J Acquir Immune Defic Syndr 51:310-6. 2009..Revised World Health Organization recommendations seek to increase HIV testing. We assessed the need for expanded testing in South Africa by examining current testing and treatment trends among a high prevalence population... - Improving outcomes in state AIDS drug assistance programsBenjamin P Linas
Divisions of General Medicine, Massachusetts General Hospital, Boston, MA 02115, USA
J Acquir Immune Defic Syndr 51:513-21. 2009..State AIDS Drug Assistance Programs (ADAPs) provide antiretroviral medications to patients with no access to medications. Resource constraints limit the ability of many ADAPs to meet demand for services... - Factors associated with refusal of rapid HIV testing in an emergency departmentMary L Pisculli
Division of Infectious Disease, Brigham and Women s Hospital, Boston, MA, USA
AIDS Behav 15:734-42. 2011..Enrollment during morning hours was also associated with an increased risk of refusal. Increased educational efforts to convey the rationale and benefits of universal screening may improve testing uptake among these groups... - Scaling up the 2010 World Health Organization HIV Treatment Guidelines in resource-limited settings: a model-based analysisRochelle P Walensky
Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
PLoS Med 7:e1000382. 2010..This paper considers what to do first in resource-limited settings where immediate implementation of all of the WHO recommendations is not feasible... - The "ART" of linkage: pre-treatment loss to care after HIV diagnosis at two PEPFAR sites in Durban, South AfricaElena Losina
Division of General Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America
PLoS ONE 5:e9538. 2010..Our objective was to determine PTLC in newly identified HIV-infected individuals in South Africa... - Patient satisfaction with rapid HIV testing in the emergency departmentLaurel Donnell-Fink
Department of Orthopedic Surgery, Brigham and Women s Hospital, Boston, MA 02114, USA
Ann Emerg Med 58:S49-52. 2011..This investigation assesses patient satisfaction with rapid HIV testing in the emergency department (ED) of an urban tertiary academic medical center... - Projected survival gains from revising state laws requiring written opt-in consent for HIV testingMichael D April
Division of General Medicine, MGH, 50 Staniford St, 9th Fl, Boston, MA 02114, USA
J Gen Intern Med 26:661-7. 2011..Although the Centers for Disease Control and Prevention recommends HIV testing in all settings unless patients refuse (opt-out consent), many state laws require written opt-in consent... - Effectiveness of pediatric antiretroviral therapy in resource-limited settings: a systematic review and meta-analysisAndrea L Ciaranello
The Division of Infectious Disease, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Clin Infect Dis 49:1915-27. 2009..We sought to derive pooled estimates of the 12-month rate of virologic suppression (HIV RNA, <400 copies/mL) and gain in CD4 cell percentage (DeltaCD4%) for children initiating ART in resource-limited settings... - Antiretroviral drugs for preventing mother-to-child transmission of HIV in sub-Saharan Africa: balancing efficacy and infant toxicityAndrea L Ciaranello
Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
AIDS 22:2359-69. 2008..We sought to identify the currently recommended regimen to prevent mother-to-child transmission that optimally balances risks of pediatric HIV infection and neurologic mitochondrial toxicity... - HIV drug resistance surveillance for prioritizing treatment in resource-limited settingsRochelle P Walensky
Division of Infectious Disease, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
AIDS 21:973-82. 2007..Sentinel testing programs for HIV drug resistance in resource-limited settings can inform policy on antiretroviral therapy (ART) and drug sequencing... - What will it take to eliminate pediatric HIV? Reaching WHO target rates of mother-to-child HIV transmission in Zimbabwe: a model-based analysisAndrea L Ciaranello
Division of Infectious Disease, Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, Massachusetts, USA
PLoS Med 9:e1001156. 2012..We investigated uptake of prevention of MTCT (PMTCT) services, infant feeding recommendations, and specific drug regimens necessary to achieve this goal in Zimbabwe... - Loss to follow-up in a community clinic in South Africa--roles of gender, pregnancy and CD4 countBingxia Wang
Division of General Medicine, Department of Medicine, Massachusetts General Hospital, Boston, Mass, USA
S Afr Med J 101:253-7. 2011..Faith-based organisations have expanded antiretroviral therapy (ART) in community clinics across South Africa. Loss to follow-up (LTFU), however, limits the potential individual and population treatment benefits and optimal care... - Cost-effectiveness of HIV interventions: from cohort studies and clinical trials to policyRochelle P Walensky
Harvard Medical School, Boston, MA, USA
Top HIV Med 17:130-4. 2009..This article is a summary of a presentation made by Rochelle P. Walensky, MD, MPH, at the International AIDS Society-USA Chicago program held in May 2009. The original presentation is available as a Webcast at www.iasusa.org... - Impact of obesity and knee osteoarthritis on morbidity and mortality in older AmericansElena Losina
Brigham and Women s Hospital, Boston University School of Public Health, Massachusetts General Hospital, USA
Ann Intern Med 154:217-26. 2011..Obesity and knee osteoarthritis are among the most frequent chronic conditions affecting Americans aged 50 to 84 years... - Cost-effectiveness of laboratory monitoring in sub-Saharan Africa: a review of the current literatureRochelle P Walensky
Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Clin Infect Dis 51:85-92. 2010.... - Emergency provider attitudes and barriers to universal HIV testing in the emergency departmentChristian Arbelaez
Department of Emergency Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Emerg Med 42:7-14. 2012..The Centers for Disease Control and Prevention (CDC) recently published recommendations for routine, voluntary human immunodeficiency virus (HIV) testing of adults in all health care settings, including the emergency department (ED)... - Early infant HIV-1 diagnosis programs in resource-limited settings: opportunities for improved outcomes and more cost-effective interventionsAndrea L Ciaranello
Division of Infectious Disease, Massachusetts General Hospital, and Center for AIDS Research, Harvard Medical School, Boston, MA, USA
BMC Med 9:59. 2011.... - Routine voluntary HIV testing in Durban, South Africa: the experience from an outpatient departmentIngrid V Bassett
Division of Infectious Disease, Massachusetts General Hospital, Boston, MA 02114, USA
J Acquir Immune Defic Syndr 46:181-6. 2007..To evaluate the yield of a routine voluntary HIV testing program compared with traditional provider-referred voluntary counseling and testing (VCT) in a hospital-affiliated outpatient department (OPD) in Durban, South Africa... - Integrating HIV screening into routine health care in resource-limited settingsIngrid V Bassett
Division of Infectious Disease, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Clin Infect Dis 50:S77-84. 2010..We review the benefits of knowledge of HIV serostatus and evidence from multiple countries surrounding the successes and pitfalls of provider-initiated testing in health care and home-based settings... - First-line antiretroviral therapy after single-dose nevirapine exposure in South Africa: a cost-effectiveness analysis of the OCTANE trialAndrea L Ciaranello
Division of Infectious Disease, Massachusetts General Hospital, Boston, 02114, USA
AIDS 25:479-92. 2011..nevirapine-based antiretroviral therapy (ART) among women previously exposed to single-dose nevirapine to prevent mother-to-child HIV transmission. However, lopinavir/ritonavir is 12 times costlier than nevirapine... - Home testing for HIV infection in resource-limited settingsIshani Ganguli
Division of General Medicine, Massachusetts General Hospital, 9th Floor, Boston, MA 02114, USA
Curr HIV/AIDS Rep 6:217-23. 2009..Home testing is showing promising early results in some high-prevalence, resource-limited settings. This article reviews the mechanisms and literature to date of this door-to-door approach... - Cost-effectiveness of HIV testing and treatment in the United StatesRochelle P Walensky
Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Clin Infect Dis 45:S248-54. 2007..This article reviews the methods and results of cost-effectiveness studies in the United States and articulates why routine, voluntary HIV testing is not only of crucial public health importance but also economically justified... - Cost-effectiveness of total knee arthroplasty in the United States: patient risk and hospital volumeElena Losina
Department of Orthopedic Surgery, Orthopedic and Arthritis Center for Outcomes Research, Brigham and Women s Hospital, Boston, MA 02115, USA
Arch Intern Med 169:1113-21; discussion 1121-2. 2009..However, to our knowledge, the cost-effectiveness of TKA and the influences of hospital volume and patient risk on TKA cost-effectiveness have not been investigated in the United States... - Access to medications and medical care after participation in HIV clinical trials: a systematic review of trial protocols and informed consent documentsAndrea L Ciaranello
Division of Infectious Disease, Massachusetts General Hospital, Boston, MA 02114, USA
HIV Clin Trials 10:13-24. 2009..We describe the frequency with which these posttrial services are described in the protocols and informed consent forms (ICFs) of antiretroviral drug (ARV) trials... - Cost-effectiveness analysis and HIV screening: the emergency medicine perspectiveHeather Hsu
Harvard Medical School, Boston, MA, USA
Ann Emerg Med 58:S145-50. 2011..We specifically describe the incremental cost-effectiveness ratio--its calculation, the derivation of ratio components, and the interpretation of these ratios... - The effect of antiretroviral therapy on secondary transmission of HIV among men who have sex with menAlethea W McCormick
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Clin Infect Dis 44:1115-22. 2007..However, the potential reduction in secondary transmission associated with ART may be offset by the longer duration of infectiousness... - HIV/AIDS: AIDS Drug Assistance Programs in the era of routine HIV testingIngrid V Bassett
Division of Infectious Disease, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Clin Infect Dis 47:695-701. 2008.... - Projecting the clinical benefits and risks of using efavirenz-containing antiretroviral therapy regimens in women of childbearing ageEric N Ouattara
PAC CI Program, CHU de Treichville, Abidjan, Cote d Ivoire
AIDS 26:625-34. 2012..To project the outcomes of using either efavirenz or nevirapine as part of initial antiretroviral therapy (ART) in women of childbearing age in Côte d'Ivoire... - Revising expectations from rapid HIV tests in the emergency departmentRochelle P Walensky
Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Ann Intern Med 149:153-60. 2008..Expanded HIV screening efforts in the United States have increased the use of rapid HIV tests in emergency departments. The reported sensitivity and specificity of rapid HIV tests exceed 99%... - Visual screening for malignant melanoma: a cost-effectiveness analysisElena Losina
Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
Arch Dermatol 143:21-8. 2007..To evaluate the cost-effectiveness of various melanoma screening strategies proposed in the United States... - HIV Self-testing and the Missing LinkageRochelle P Walensky
Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America
PLoS Med 8:e1001101. 2011.... - Optimizing resource allocation in United States AIDS drug assistance programsBenjamin P Linas
Division of General Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Clin Infect Dis 43:1357-64. 2006..We hypothesized that CD4 cell count-based ADAP eligibility would improve ADAP outcomes, allowing them to serve more-diverse patient populations and to prioritize persons who are at greatest risk of HIV-related mortality... - Quantifying the risks and benefits of efavirenz use in HIV-infected women of childbearing age in the USAH E Hsu
Harvard Medical School, Boston, MA, USA
HIV Med 12:97-108. 2011..The aim of the study was to quantify the benefits (life expectancy gains) and risks (efavirenz-related teratogenicity) associated with using efavirenz in HIV-infected women of childbearing age in the USA...