Igor Ulitsky

..A full list of the predicted mRNA functions is available at http://acgt.cs.tau.ac.il/fame/...

..Here we present a novel method, which combines genetic interaction data together with diverse genomic data, to quantitatively impute these missing interactions. We also present data on almost 190,000 novel interactions...

..Protein interaction networks can potentially be used to overcome these problems...

..The results of each analysis step can be visualized in a number of ways. The complete protocol can be executed in approximately 1 h...

..Finally, using stem-cell expression profiles, we identify three miRNA families with pivotal roles in human embryogenesis...

..Many of the QTLs found by both methods are not directly implied in pH homeostasis but have more general, and often regulatory, roles...

..By summarizing prior knowledge and providing visual and computational aids, it helps the expert explore and understand her system better...

..Recent studies have shown that the analysis of expression data can be improved by its integration with protein interaction networks, but the performance of these analyses has been hampered by the uneven quality of the interaction data...

..Our findings suggest that miR-135b serves as a cellular effector, involved in regulating some of the differences between the cochlear and vestibular hair cells...

..To further explore the effect of the mutation on global gene expression in the brain, we conducted a wide-scale transcriptome analysis of the first three critical postnatal weeks...

..The complete database and the individual maps are freely exportable in several formats. The database is accompanied by a stand-alone software tool for analysis and dynamic visualization of pathways...

..Our results support some previous hypotheses regarding the molecular pathways underlying diversity of breast tumors and suggest novel ones...

..We show how the resulting map of modules provides clues for the elucidation of function both at the level of individual genes and at the level of functional modules...

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..Our analysis of models and pivots sheds light on the organization of the cellular machinery as well as on the roles of individual proteins...

..The assimilation, visualization and interpretation of these data have become a major challenge in biological research, and once met, will greatly boost our ability to understand cell functioning on a systems level...

..Although a broad variety of interesting approaches has been developed, further progress in the field will depend on systematic evaluation of the methods and their dissemination in the biological community...