Research Topics
Species | Ajay SinghSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
| Collaborators
|
Detail Information
Publications
Predictors of the response to treatment in anemic hemodialysis patients with high serum ferritin and low transferrin saturationA K Singh
Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Kidney Int 71:1163-71. 2007..We conclude that none of the studied markers is a good predictor of response to anemia treatment in this patient sub-population...
Is there a deleterious effect of erythropoietin in end-stage renal disease?Ajay K Singh
Renal Division, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Kidney Int 80:569-71. 2011..Cotter and colleagues report that exposure to high dosages of ESA in patients with diabetes is associated with increased risk...
Correction of anemia with epoetin alfa in chronic kidney diseaseAjay K Singh
Renal Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
N Engl J Med 355:2085-98. 2006..Recombinant human erythropoietin (epoetin alfa) is indicated for the correction of anemia associated with this condition. However, the optimal level of hemoglobin correction is not defined...
The controversy surrounding hemoglobin and erythropoiesis-stimulating agents: what should we do now?Ajay K Singh
Renal Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Am J Kidney Dis 52:S5-13. 2008..Managing the anemia of CKD in the era of the hemoglobin level and ESA controversy has required aiming for appropriate hemoglobin levels, using the lowest effective ESA dose, and better managing the problem of ESA hyporesponsiveness...
Hemoglobin control, ESA resistance, and regular low-dose IV iron therapy: a review of the evidenceAjay Singh
Renal Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Semin Dial 22:64-9. 2009..This article reviews factors that affect Hb control, with a focus on management practices (e.g., regular low-dose administration of IV iron) that can help improve anemia management...
Resolved: Targeting a higher hemoglobin is associated with greater risk in patients with CKD anemia: proAjay K Singh
Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Am Soc Nephrol 20:1436-41. 2009..The debate here reflects a look back on the tension produced by confusing data and outcomes. Is it the target hemoglobin per se or the high doses of erythropoietin in subsets of resistant patients that is the problem? You decide...
Diabetes, anemia and CKD: Why TREAT?Ajay K Singh
Renal Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Curr Diab Rep 10:291-6. 2010..Furthermore, there was an inconsistent and modest improvement in health-related quality of life. TREAT raises questions about whether anemia in type 2 diabetic patients should be treated and under what circumstances...
What is causing the mortality in treating the anemia of chronic kidney disease: erythropoietin dose or hemoglobin level?Ajay K Singh
Renal Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Curr Opin Nephrol Hypertens 19:420-4. 2010..This article examines the potential mechanisms underlying adverse risk observed in four randomized controlled trials of anemia correction in chronic kidney disease (CKD) patients...
Anemia of chronic kidney disease: CHOIR and the FDAAjay K Singh
Renal Division, Brigham and Women's Hospital, Boston, MA 02115, USA
Nat Clin Pract Nephrol 3:406-7. 2007
Immunopathogenesis of the antiphospholipid antibody syndrome: an updateA K Singh
Renal Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Curr Opin Nephrol Hypertens 10:355-8. 2001....
Does correction of anemia slow the progression of chronic kidney disease?Ajay K Singh
Renal Division, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA
Nat Clin Pract Nephrol 3:638-9. 2007
MR imaging of the acute abdomen and pelvis: acute appendicitis and beyondAjay Singh
Department of Radiology, University of Massachusetts Memorial Medical Center, Worcester, MA, USA
Radiographics 27:1419-31. 2007....
A 39-year-old pregnant woman with polyuria and hypomagnesemiaS B Ahmed
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, PBB-3, RA-126E, Boston, MA 02115, USA
Kidney Int 69:938-41. 2006
Crossed fused ectopia of the kidneysT V Patel
Renal Division, Brigham and Women's Hospital, Boston, Massachusettes, USA
Kidney Int 73:662. 2008
Hematuria in a patient with class IV lupus nephritisB V Mittal
Renal Division, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA
Kidney Int 70:1182-6. 2006
Safety of ferumoxytol in patients with anemia and CKDAjay Singh
Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Am J Kidney Dis 52:907-15. 2008..The main objective of this study was to assess the safety of ferumoxytol for the treatment of patients with CKD stages 1 to 5 and 5D...
Potential applications of outpatient nesiritide infusions in patients with advanced heart failure and concomitant renal insufficiency (from the Follow-Up Serial Infusions of Nesiritide [FUSION I] trial)Clyde W Yancy
Department of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas, and Renal Division, Brigham and Women s Hospital, Boston, MA, USA
Am J Cardiol 98:226-9. 2006..Further study is warranted to test the validity of this finding...
Magnetic resonance of acute appendicitis: pearls and pitfallsMichael Lam
Department of Radiology, University of Massachusetts Memorial Medical Center, Worcester, MA, USA
Curr Probl Diagn Radiol 37:57-66. 2008..In the following review, the role of magnetic resonance in the diagnosis of appendicitis will be discussed...
Serum amyloid P inhibits fibrosis through Fc gamma R-dependent monocyte-macrophage regulation in vivoAna P Castano
Laboratory of Inflammation Research, Harvard Institutes of Medicine, 4 Blackfan Circle, Boston, MA 02115, USA
Sci Transl Med 1:5ra13. 2009..These studies uncover previously unidentified roles for Fc gamma receptors in sterile inflammation and highlight serum amyloid P as a potential antifibrotic therapy through local generation of interleukin-10...
Uremic pruritusS R Keithi-Reddy
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Kidney Int 72:373-7. 2007
Gangrenous cholecystitis: prediction with CT imagingA K Singh
Division of Abdominal Imaging and Interventional Radiology, Massachusetts General Hospital, White 270, 55 Fruit Street, Boston, MA 02114, USA
Abdom Imaging 30:218-21. 2005..The pattern of gallbladder mucosal enhancement on CT can be used as a reliable criterion for distinguishing acute, uncomplicated cholecystitis from gangrenous cholecystitis...
Analgesic nephropathyN Vadivel
Renal Division, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
Kidney Int 72:517-20. 2007
Accepting prospective kidney donors with asymptomatic urinary abnormalities: are we shooting in the dark?N Vadivel
Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
Kidney Int 71:173-7. 2007
Lithium toxicity: a double-edged swordM P Alexander
Renal Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA
Kidney Int 73:233-7. 2008
Cytokine gene expression in the MRL/lpr model of lupus nephritisS Lemay
New England Medical Center, Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA
Kidney Int 50:85-93. 1996....
Tuberculous peritonitis: a race against timeN Vadivel
Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Kidney Int 70:969-72. 2006
Omental infarct: CT imaging featuresA K Singh
Division of Abdominal Imaging and Interventional Emergency Radiology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Abdom Imaging 31:549-54. 2006..The aim of this study is to describe contrast-enhanced computed tomographic (CT) features of acute omental infarction and to study the evolutionary changes on follow-up CT imaging...
Diffuse vascular calcification in a dialysis patientS P Surana
Renal Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA
Kidney Int 73:890-4. 2008
New approaches to the treatment of calcium and phosphorus abnormalities in patients on hemodialysisK Uhlig
Division of Nephrology, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
Curr Opin Nephrol Hypertens 10:793-8. 2001..We provide an algorithm for the management of calcium and phosphorus abnormalities, based on newer recommendations for tighter calcium and phosphorus control with a lower target for the calcium x phosphorus product...
Cardiac arrest: abdominal CT imaging featuresA K Singh
Division of Abdominal Imaging and Interventional Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
Abdom Imaging 29:177-9. 2004..The thoracic findings were reflux of contrast into the coronary sinus, nonopacificaton of the left ventricle with intravenous contrast, and lack of cardiac motion artifact...
Associations between demographic factors and provider structures on cost and length of stay for hemodialysis patients with vascular access failureLouis Brenner
Renal Division, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Clin J Am Soc Nephrol 1:455-61. 2006..It is concluded that gender and racial factors may influence VAF care. Over time, more VAF episodes are being treated in outpatient settings. Case management may lead to more outpatient treatment and shorter inpatient treatment of VAF...
Outcomes of renal transplantation for recipients with lupus nephritis: analysis of the Organ Procurement and Transplantation Network databaseSuphamai Bunnapradist
Transplantation 82:612-8. 2006..Outcomes were similar regardless of type of calcineurin inhibitor, induction therapy, and time on dialysis. We conclude that lupus transplant recipients have outcomes generally equivalent to non-lupus transplant recipients...
Dropped gallstones and surgical clips after cholecystectomy: CT assessmentAjay K Singh
University of Massachusetts Memorial Medical Center, Worcester, USA
J Comput Assist Tomogr 31:758-62. 2007..To describe the spectrum of computed tomographic (CT) findings in patients with dropped gallstones or dropped surgical clips after cholecystectomy...
Ferric gluconate reduces epoetin requirements in hemodialysis patients with elevated ferritinToros Kapoian
Department of Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
J Am Soc Nephrol 19:372-9. 2008..73, P = 0.041). In conclusion, ferric gluconate maintains hemoglobin and allows lower epoetin doses in anemic hemodialysis patients with low TSAT and ferritin levels up to 1200 ng/ml...
Prevention of intravenous contrast-induced nephropathy in hospital inpatientsRahul Kakkar
Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA
Crit Pathw Cardiol 7:1-4. 2008..On the basis of the recently published clinical trial data and guidelines from the major radiologic societies, we developed an algorithmic approach to CIN prophylaxis in hospital inpatients...
Giant colonic diverticulum: percutaneous computed tomography-guided treatmentAjay K Singh
Department of Radiology, University of Massachusetts Memorial Medical Center, Worcester, MA 01655, USA
J Comput Assist Tomogr 32:204-6. 2008..In patients with inflamed giant colonic diverticulum, the percutaneous approach may be useful in treatment of diverticulitis and avoiding a staged Hartmann procedure with end colostomy...
The optimal hemoglobin in dialysis patients- a critical reviewAjay K Singh
Semin Dial 21:1-6. 2008..We also suggest that the current reimbursement system for erythropoiesis stimulating agent treatment potentially encourages unsafe overtreatment...
Is it time to reconsider subcutaneous administration of epoetin?Tejas V Patel
Brigham and Women s Hospital s renal Division at the Harvard Medical School, Boston, MA, USA
Nephrol News Issues 21:57, 59, 63-4 passim. 2007..In this article, the advantages and disadvantages of the subcutaneous route are reviewed...
Neoplastic iliopsoas masses in oncology patients: CT findingsAjay K Singh
Department of Radiology, University of Massachusetts Medical Center, Worcester, MA, USA
Abdom Imaging 33:493-7. 2008..The detection of an iliopsoas mass warrants a careful search for gluteal muscles and subcutaneous metastases...
Hemoglobin maintenance with use of extended dosing of epoetin alfa in patients with diabetes and anemia of chronic kidney diseaseRobert Provenzano
Division of Nephrology, St John Hospital and Medical Center, Detroit, Michigan 48236, USA
Endocr Pract 13:251-9. 2007..To compare the efficacy of extended epoetin alfa dosing in maintaining hemoglobin (Hb) concentrations in patients with and without diabetes as the primary cause of chronic kidney disease...
Rationale--Trial to Reduce Cardiovascular Events with Aranesp Therapy (TREAT): evolving the management of cardiovascular risk in patients with chronic kidney diseaseT-Christian H Mix
Department of Development and Medical Affairs, Amgen Inc, Thousand Oaks, Calif, USA
Am Heart J 149:408-13. 2005..TREAT will provide data that are critical to evolution of the management of cardiovascular risk in this high-risk population...
CT appearance of acute appendagitisAjay K Singh
Division of Abdominal Imaging and Interventional Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
AJR Am J Roentgenol 183:1303-7. 2004..The most common finding on CT is a fat-density oval lesion with surrounding inflammation on the anterior aspect of the sigmoid colon. The changes on CT are not predictable in the 2-week to 6-month window...
Imaging of inflammatory bowel disease: CT and MRMichael Zalis
Department of Abdominal Imaging and Interventional Radiology, Massachusetts General Hospital, Boston 02114, USA
Dig Dis 22:56-62. 2004....
Acute epiploic appendagitis in hernia sac: CT appearanceAjay K Singh
Division of Abdominal Imaging and Interventional Radiology, Wh 270, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
Emerg Radiol 11:226-7. 2005..The contrast-enhanced CT findings of the inflammation of appendices epiploicae of the transverse colon were diagnostic in this case...
Acute epiploic appendagitis and its mimicsAjay K Singh
Department of Radiology, University of Massachusetts Medical Center, Worcester, MA 01605, USA
Radiographics 25:1521-34. 2005..Recognition of these conditions on CT images will allow appropriate management of acute abdominal pain and may help to prevent unnecessary surgery...
The benefits of IV iron therapy in treating anemia in patients with renal disease and comorbid cardiovascular diseaseAjay K Singh
Renal Division Brigham and Women's Hospital, Boston, MA, USA
Nephrol Nurs J 32:199-206; quiz 207-8. 2005..Therefore, the nephrology nurse should have an increased awareness of the link between anemia and renal/cardiac disease as well as available treatment options...
The role of kidney biopsy in the management of lupus nephritisBharati Mittal
Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Curr Opin Nephrol Hypertens 14:1-8. 2005....
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 36-2003. A 68-year-old woman with impaired renal functionAjay K Singh
Renal Division, Department of Medicine, Brigham and Women's Hospital, USA
N Engl J Med 349:2055-63. 2003
A comparison of prediction equations for estimating glomerular filtration rate in adults without kidney diseaseJulie Lin
Renal Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Am Soc Nephrol 14:2573-80. 2003..Further studies are needed to derive and assess GFR prediction equations in people with normal or mildly impaired renal function...
Ferric gluconate is highly efficacious in anemic hemodialysis patients with high serum ferritin and low transferrin saturation: results of the Dialysis Patients' Response to IV Iron with Elevated Ferritin (DRIVE) StudyDaniel W Coyne
Washington University School of Medicine, 660 S Euclid Avenue, Campus Box 8129, St Louis, MO 63110, USA
J Am Soc Nephrol 18:975-84. 2007..Administration of ferric gluconate (125 mg for eight treatments) is superior to no iron therapy in anemic dialysis patients receiving adequate epoetin dosages and have a ferritin 500 to 1200 ng/ml and TSAT <or=25%...
Anaemia of CKD--the CHOIR study revisitedAjay K Singh
Nephrol Dial Transplant 22:1806-10. 2007
Tc-99m ciprofloxacin scans for detection of tubercular bone infectionRajnish Sharma
Department of Nuclear Medicine, Institute of Nuclear Medicine and Allied Sciences INMAS, Lucknow Road, Delhi 110054, India
Clin Nucl Med 32:367-70. 2007..Delayed 24 hour scans were found useful to differentiate between inflammatory and infective lesions. The aim of this study was to evaluate the usefulness of the Tc-99m ciprofloxacin scan as a means to detect tubercular bone disease...
The FDA black box for EPO: what should nephrologists do?Ajay K Singh
Renal Division, Brigham and Women's Hospital, Boston, USA
Nephrol News Issues 21:55-6, 58-9. 2007
Cholecystocolonic fistula: serial CT imaging featuresAjay K Singh
Division of Abdominal Imaging and Interventional Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
Emerg Radiol 10:301-2. 2004..It is rare for the fistulous communication to occur between gallbladder and the colon. We describe the serial imaging findings, which were diagnostic of this condition...
Bouveret's syndrome: appearance on CT and upper gastrointestinal radiography before and after stone obturationAjay K Singh
Department of Diagnostic Radiology, William Beaumont Hospital, 3601 W. 13 Mile Rd, Royal Oak, MI 48073, USA
AJR Am J Roentgenol 181:828-30. 2003
Pancreatoduodenectomy: imaging and image-guided interventional treatmentAjay K Singh
Division of Abdominal Imaging and Interventional Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
Semin Ultrasound CT MR 25:252-60. 2004..Identification of the normal postoperative anatomy is crucial to correctly interpreting CT scans for short-term complications and long-term tumor recurrence...
Complications of chronic kidney disease: anemia, mineral metabolism, and cardiovascular diseaseShona Pendse
Renal Division, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Med Clin North Am 89:549-61. 2005..Substantive trial data are sorely need to provide the definitive evidence that effective treatment of these complications results in better outcomes...
Fournier gangrene: role of imagingRobin B Levenson
Department of Radiology, University of Massachusetts Memorial Medical Center, 55 Lake Avenue N, Worcester, MA 01655, USA
Radiographics 28:519-28. 2008..An awareness of the CT features of Fournier gangrene is imperative for prompt diagnosis and effective treatment planning...
The nephrology quiz and questionnaire: 2006Ronald J Falk
University of North Carolina Kidney Center, 7024 Burnett-Womack Building, Campus Box #7155, Chapel Hill, NC 27599-7155, USA
Clin J Am Soc Nephrol 2:1375-88. 2007
The target hemoglobin in patients with chronic kidney diseaseAjay K Singh
Brigham and Women's Hospital, Boston, and Harvard Medical School, MA, USA
Nephrol News Issues 20:29-30. 2006
Imaging-guided catheter drainage of abdominal collections with fistulous pancreaticobiliary communicationAjay K Singh
Division of Abdominal Imaging, University of Massachusetts Memorial Medical Center, 55 Lake Avenue North, Worcester, MA 01655, USA
AJR Am J Roentgenol 187:1591-6. 2006..The success rate is significantly better for collections with biliary communication than for those with pancreatic communication...
Reducing versus discontinuing erythropoietin at high hemoglobin levelsDaniel E Weiner
Division of Nephrology, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
J Am Soc Nephrol 18:3184-91. 2007....
Anemia of chronic kidney diseaseAjay K Singh
Clin J Am Soc Nephrol 3:3-6. 2008
Uncertainty in the treatment of anemia in chronic kidney diseaseMarc A Pfeffer
Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA
Rev Cardiovasc Med 6:S35-41. 2005..This article reviews the rationale and design features for these trials...
Omental infarct: an unusual CT appearance after superior mesenteric artery occlusionAjay K Singh
Division of Abdominal Imaging and Interventional Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
Emerg Radiol 10:276-8. 2004..We report a case of omental infarct resulting from superior mesenteric artery occlusion, which had an unusual appearance on computed tomography...
Dropped appendicolith: CT findings and implications for managementAjay K Singh
Department of Radiology, University of Massachusetts Memorial Medical Center, Worcester, MA, USA
AJR Am J Roentgenol 190:707-11. 2008..CT-guided drainage can be used to manage abscesses associated with dropped appendicolith in selected cases...
Diagnosis of mandibular osteomyelitis in probable coexisting tumor recurrence: role of Tc-99m ciprofloxacin imagingBaljinder Singh
Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Clin Nucl Med 33:525-7. 2008..A follow-up Tc-99m ciprofloxacin scan after debridement and 8 weeks of antibiotic treatment showed no focus of tracer concentration in the region of the mandible...
