Research Topics
| Robert L OwensSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Detail Information
Publications
Upper airway function in the pathogenesis of obstructive sleep apnea: a review of the current literatureRobert L Owens
Pulmonary and Critical Care Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Curr Opin Pulm Med 14:519-24. 2008..However, recent work has focused on the function, rather than structure alone, of the upper airway...
Is the way to man's heart (and lung) through the abdomen?Robert L Owens
Sleep Disorders Research Program, Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Crit Care 13:199. 2009..However, their work raises several questions for clinicians and researchers regarding the pathophysiology and management of IAP...
The influence of end-expiratory lung volume on measurements of pharyngeal collapsibilityRobert L Owens
Sleep Disorders Research Program, Div of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Appl Physiol 108:445-51. 2010..Changes in lung volume alter Pcrit substantially. This work supports a role for lung volume in the pathogenesis of OSA, and lung volume changes should be a consideration during assessment of pharyngeal mechanics...
Sleep-disordered breathing and COPD: the overlap syndromeRobert L Owens
Sleep Disorders Research Program, Brigham and Women s Hospital, Boston, MA 02115, USA
Respir Care 55:1333-44; discussion 1344-6. 2010..Treatment currently consists of continuous positive airway pressure, and oxygen as needed. Noninvasive ventilation may be helpful in overlap syndrome patients, but this has not yet been well studied...
Acetazolamide improves loop gain but not the other physiological traits causing obstructive sleep apnoeaBradley A Edwards
Sleep Disorders Research Program, Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
J Physiol 590:1199-211. 2012..Identification of patients who may benefit from reductions in LG alone or in combination with other therapies to alter the remaining traits may facilitate pharmacological resolution of OSA in the future...
A method for measuring and modeling the physiological traits causing obstructive sleep apneaAndrew Wellman
221 Longwood Ave, 036 BLI, Boston, MA 02115, USA
J Appl Physiol 110:1627-37. 2011..This technique could conceivably be used clinically to define a patient's physiology and guide therapy based on the traits...
Obstructive airway disease and obstructive sleep apnea: effect of pulmonary functionBhavneesh Sharma
Division of Sleep Medicine, Harvard Medical School Brigham and Women s Hospital, Boston, MA 02115, USA
Lung 189:37-41. 2011..However, the high prevalence of OSA in OAD patients appears to be due to obesity, and reduced pulmonary function is not an independent risk factor for OSA...
What is central sleep apnea?Atul Malhotra
Division of Sleep, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Respir Care 55:1168-78. 2010..A paucity of research exists in this area, emphasizing the opportunities for young investigators who are interested in this field...
Influencing the decline of lung function in COPD: use of pharmacotherapyEkaterina S Gladysheva
Harvard Combined Pulmonary and Critical Care Fellowship, Harvard Medical School, Boston, MA, USA
Int J Chron Obstruct Pulmon Dis 5:153-64. 2010..A variety of newer classes of medications may help target other pathophysiologically important pathways, and could be used in the future to prevent lung function decline in COPD...
Eszopiclone increases the respiratory arousal threshold and lowers the apnoea/hypopnoea index in obstructive sleep apnoea patients with a low arousal thresholdDanny J Eckert
Sleep Disorders Program, Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Clin Sci (Lond) 120:505-14. 2011..However, additional treatment strategies are probably required to achieve elimination of apnoea...
Effect of the chest wall on pressure-volume curve analysis of acute respiratory distress syndrome lungsRobert L Owens
Departments of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Crit Care Med 36:2980-5. 2008..We sought to quantify the effect of the chest wall by considering the chest wall and lung in series...
Do newer monitors of exhaled gases, mechanics, and esophageal pressure add value?Robert L Owens
Department of Medicine, Pulmonary and Critical Care Unit, Cox 2, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
Clin Chest Med 29:297-312, vi-vii. 2008..The authors explore the concepts, benefits, difficulties, and relevant clinical trials of each...
