Research Topics
| A L OaklanderSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
Research Grants
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Detail Information
Publications
Small-fiber neuropathy: answering the burning questionsEzekiel Fink
Department of Anesthesiology, Neurology, and Neuropathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Sci Aging Knowledge Environ 2006:pe7. 2006..Infrequently, the underlying cause of small-fiber dysfunction is identified and disease-modifying therapy can be instituted. More commonly, the treatments for small-fiber neuropathy involve symptomatic treatment of neuropathic pain...- Patients with Ehlers Danlos syndrome and CRPS: a possible association?Joan M Stoler
Genetics and Teratology Unit, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Pain 123:204-9. 2006..We review the clinical presentation of the different Ehlers Danlos syndromes and provide clinical criteria that can be used to screen CRPS patients for EDS for clinical or research purposes... - The density of remaining nerve endings in human skin with and without postherpetic neuralgia after shinglesA L Oaklander
Department of Neurological Surgery, Johns Hopkins Medical Institutions, Boston, MA, USA
Pain 92:139-45. 2001.... - Intractable postherpetic itch and cutaneous deafferentation after facial shinglesAnne Louise Oaklander
Neuropathic Pain Study Group, Department of Anesthesiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Pain 96:9-12. 2002.... - Evidence of focal small-fiber axonal degeneration in complex regional pain syndrome-I (reflex sympathetic dystrophy)Anne Louise Oaklander
Nerve Injury Unit, Departments of Anesthesiology, Neurology, and Neuropathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Pain 120:235-43. 2006..These results support the hypothesis that CRPS-I is specifically associated with post-traumatic focal MDNI affecting nociceptive small-fibers. This type of nerve injury will remain undetected in most clinical settings... - Common neuropathic itch syndromesAnne Louise Oaklander
Nerve Injury Unit, Department of Neurology, Massachusetts General Hospital, Boston, 02114, USA
Acta Derm Venereol 92:118-25. 2012..This review summarizes current knowledge, admittedly incomplete, on neuropathic itch caused by diseases of the brain, spinal cord, cranial or spinal nerve-roots, and peripheral nerves... - Neuropathic itchAnne Louise Oaklander
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Semin Cutan Med Surg 30:87-92. 2011..Current treatment recommendations include local or systemic administration of inhibitors of neuronal excitability (especially local anesthetics) and barriers to reduce scratching... - Is reflex sympathetic dystrophy/complex regional pain syndrome type I a small-fiber neuropathy?Anne Louise Oaklander
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Ann Neurol 65:629-38. 2009..Restoring the interest of neurologists in RSD/CRPS should improve patient care and broaden our knowledge of small-fiber functions... - Mechanisms of pain and itch caused by herpes zoster (shingles)Anne Louise Oaklander
Departments of Neurology and Pathology, Massachusetts General Hospital, Harvard Medical School, 275 Charles Street, Boston, MA 02114, USA
J Pain 9:S10-8. 2008..Their prevalence makes highly powered studies feasible. Funding and organization are the current bottlenecks... - Cutaneous innervation: form and functionAnne Louise Oaklander
Department of Anesthesiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Am Acad Dermatol 53:1027-37. 2005..We review the innervation of the skin and update readers about recent neuroscientific discoveries... - Pregabalin-withdrawal encephalopathy and splenial edema: a link to high-altitude illness?Anne Louise Oaklander
Nerve Injury Unit, Department of Anesthesiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Ann Neurol 58:309-12. 2005..The similarity of this syndrome to high-altitude cerebral edema suggests a possible common pathophysiology and offers potential therapies... - Progression of dystonia in complex regional pain syndromeAnne Louise Oaklander
Massachusetts General Hospital, 55 Fruit Street, Clinics 3, Boston, MA 02114, USA
Neurology 63:751. 2004 - Unilateral nerve injury produces bilateral loss of distal innervationAnne Louise Oaklander
Nerve Injury Unit, Department of Anesthesiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Ann Neurol 55:639-44. 2004..They discredit the practice of using tissues contralateral to an injury to provide normative controls and suggest the possibility of rapid, transmedian postinjury signals between homologous mirror-image neurons... - Herpes zoster itch: preliminary epidemiologic dataAnne Louise Oaklander
Nerve Injury Unit, Department of Anesthesiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Pain 4:338-43. 2003..These findings indicate a need for research on zoster-associated itch, including prospective studies on frequency, impact, and treatment... - Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 16-2004. A 76-year-old woman with numbness and pain in the feet and legsAnthony A Amato
Department of Neurology, Division of Neuromuscular Medicine, Brigham and Women's Hospital, Boston, USA
N Engl J Med 350:2181-9. 2004 - Number of Langerhans immune cells in painful and non-painful human skin after shinglesAnne Louise Oaklander
Department of Neurosurgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Arch Dermatol Res 294:529-35. 2003.... - Endoneurial pathology of the needlestick-nerve-injury model of Complex Regional Pain Syndrome, including rats with and without pain behaviorsM M Klein
Departments of Neurology and Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States
Eur J Pain 16:28-37. 2012..Spread of pathological changes to nearby ipsilateral and contralateral nerves might potentially contribute to extraterritorial pain in CRPS... - Effects of distal nerve injuries on dorsal-horn neurons and glia: relationships between lesion size and mechanical hyperalgesiaJ W Lee
Departments of Neurology and Pathology, Massachusetts General Hospital, Harvard Medical School, 275 Charles Street, Warren 310, Boston, MA 02114, USA
Neuroscience 158:904-14. 2009..However, the presence of similar dorsal-horn changes in rats without pain behaviors suggests that not all transcellular responses to axotomy are pain-specific... - Neuropathic pain associated with non-surgical treatment of breast cancerBeth F Jung
Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 604, Rochester, NY 14642, USA
Pain 118:10-4. 2005 - Single-agent bortezomib in previously untreated multiple myeloma: efficacy, characterization of peripheral neuropathy, and molecular correlations with response and neuropathyPaul G Richardson
Dana Farber Cancer Institute, 44 Binney St, Dana 1B02, Boston, MA 02115, USA
J Clin Oncol 27:3518-25. 2009..Baseline myeloma-associated neuropathy seems more common than previously reported, and bortezomib-associated neuropathy, although a common toxicity, is reversible in most patients... - Postherpetic neuralgia after shingles: an under-recognized cause of chronic vulvar painAnne Louise Oaklander
Neuropathic Pain Study Group, Departments of Anesthesiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Obstet Gynecol 99:625-8. 2002..The possibility of postherpetic neuralgia must be considered in women with unexplained vulvar dysesthesia... - Needlestick distal nerve injury in rats models symptoms of complex regional pain syndromeSandra M Siegel
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Anesth Analg 105:1820-9, table of contents. 2007..Therefore, we, prospectively investigated whether DNIs are sufficient to cause CRPS-like abnormalities in animals. We used needlestick, a cause of human CRPS, to evaluate lesion-size effects... - A retrospective analysis of reasons for reoperation following initially successful peripheral nerve stimulationKelly Ishizuka
Department of Neurological Surgery, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
J Neurosurg 106:388-90. 2007..The authors investigated the causes for surgical reexploration in patients with complex regional pain syndrome Type II who received initial relief of pain from implantation of a peripheral nerve stimulator (PNS)... - Recommendations for the management of herpes zosterRobert H Dworkin
Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA
Clin Infect Dis 44:S1-26. 2007..Specific recommendations for the use of these medications are provided. In addition, suggestions are made for treatments that, when used in combination with antiviral therapy, may further reduce pain and other complications of HZ... - Central neuropathic itch from spinal-cord cavernous hemangioma: a human case, a possible animal model, and hypotheses about pathogenesisDennis Daniel Dey
Anesthesia, Neurology and Pathology, Massachusetts General Hospital, 55 Fruit St, Clinics 3, Boston, MA 02114, USA
Pain 113:233-7. 2005..Study of quisqualate-injected rats may provide leads towards new treatments for neuropathic itch... - Complex regional pain syndrome: a review of evidence-supported treatment optionsE Daniela Hord
Massachusetts General Hospital, 55 Fruit Street, Clinics 3, Boston, MA 02114, USA
Curr Pain Headache Rep 7:188-96. 2003..Other treatments with encouraging published results (eg, neural stimulators) are not used often enough. We hope to encourage clinicians to rely more on evidence-supported treatments for complex regional pain syndrome... - Defining a treatable cause of erythromelalgia: acute adolescent autoimmune small-fiber axonopathyJoshua Paticoff
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Anesth Analg 104:438-41. 2007..Similarities to other cases allowed us to tentatively characterize a new treatable cause of erythromelalgia; acute adolescent autoimmune small-fiber axonopathy. In this report we evaluate various options for diagnosis and treatment... - Diagnosis and assessment of pain associated with herpes zoster and postherpetic neuralgiaRobert H Dworkin
Department of Anesthesiology and Neurology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
J Pain 9:S37-44. 2008..PERSPECTIVE: Comprehensive assessments of pain are necessary for clinical research on the epidemiology, natural history, pathophysiologic mechanisms, treatment, and prevention of pain in herpes zoster and PHN... - Congenital insensitivity to pain: an updateElna M Nagasako
Washington University School of Medicine, St. Louis, MO, USA
Pain 101:213-9. 2003 - Response to "Pain" editorial re: Oaklander et al. (2006)Anne Louise Oaklander
Pain 123:217-8. 2006 - Reply to Prilipko et alAnne Louise Oaklander
Ann Neurol 59:724-5. 2006
Research Grants
- Neurite density in skin as a marker for neuropathic painAnne Louise Oaklander; Fiscal Year: 2005..abstract_text> ..