Research Topics
Species | Kimmie NgSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Detail Information
Publications
Vitamin D receptor expression is associated with PIK3CA and KRAS mutations in colorectal cancerShoko Kure
Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
Cancer Epidemiol Biomarkers Prev 18:2765-72. 2009..Our data support potential interactions between the VDR, RAS-MAPK and PI3K-AKT pathways, and possible influence by KRAS or PIK3CA mutation on therapy or chemoprevention targeting VDR...- Relationship between statin use and colon cancer recurrence and survival: results from CALGB 89803Kimmie Ng
Department of Medical Oncology, Dana Farber Cancer Institute, 450 Brookline Ave, Boston, MA 02215, USA
J Natl Cancer Inst 103:1540-51. 2011..Although preclinical and epidemiological data suggest that statins may have antineoplastic properties, the impact of statin use on patient survival after a curative resection of stage III colon cancer is unknown... - Vitamin D status in patients with stage IV colorectal cancer: findings from Intergroup trial N9741Kimmie Ng
Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
J Clin Oncol 29:1599-606. 2011.... - Adjuvant and neoadjuvant approaches in gastric cancerKimmie Ng
Dana Farber Cancer Institute, Boston, MA 02115, USA
Cancer J 13:168-74. 2007.... - Multivitamin use is not associated with cancer recurrence or survival in patients with stage III colon cancer: findings from CALGB 89803Kimmie Ng
Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
J Clin Oncol 28:4354-63. 2010..Multivitamin use is widespread in the United States, especially among patients with cancer. However, the influence of multivitamin supplementation on cancer recurrence and death after a curative resection of colon cancer is unknown... - Circulating 25-hydroxyvitamin d levels and survival in patients with colorectal cancerKimmie Ng
Division of Medical Oncology, Dana Farber Cancer Institute Boston, MA 02115, USA
J Clin Oncol 26:2984-91. 2008..Higher plasma 25-hydroxyvitamin D(3) (25(OH)D) levels are associated with a decreased incidence of colorectal cancer, but the influence of plasma 25(OH)D on the outcome of patients with established colorectal cancer is unknown... - Insulin, the insulin-like growth factor axis, and mortality in patients with nonmetastatic colorectal cancerBrian M Wolpin
Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
J Clin Oncol 27:176-85. 2009..Excess energy balance leads to increased circulating insulin and depressed levels of circulating insulin-like growth factor binding protein (IGFBP) -1, which promote cancer cell growth in preclinical models... - Interaction of molecular markers and physical activity on mortality in patients with colon cancerJeffrey A Meyerhardt
Dana Farber Cancer Institute, Boston, MA 02115, USA
Clin Cancer Res 15:5931-6. 2009..Physical activity in colon cancer survivors has been associated with lower cancer recurrences and improved survival. Whether molecular features of the tumor portend more or less likelihood for benefit from exercise is unknown... - Predictive and prognostic roles of BRAF mutation in stage III colon cancer: results from intergroup trial CALGB 89803Shuji Ogino
Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02215, USA
Clin Cancer Res 18:890-900. 2012..irinotecan (CPT11), FU and LV (IFL); CALGB 89803]. Cox proportional hazards model was used to assess the prognostic role of BRAF mutation, adjusting for clinical features, adjuvant chemotherapy arm, and MSI status... - Reported behavior of eating anything at anytime and risk of colorectal cancer in womenYing Bao
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Int J Cancer 130:1395-400. 2012..05). In conclusion, reports of eating anything at anytime are associated with an increased risk of colorectal cancer in this large prospective cohort study, independent of other potential risk factors for colorectal cancer... - PTGER2 overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotypeYoshifumi Baba
Department of Medical Oncology, Dana FarberCancer Institute and Harvard Medical School, Boston, Massachusetts, USA
Cancer Epidemiol Biomarkers Prev 19:822-31. 2010..However, the prognostic significance of PTGER2 expression or its relationship with MSI, CIMP, LINE-1 hypomethylation, or PTGS2 (COX-2) remains uncertain... - Plasma 25-hydroxyvitamin D and risk of pancreatic cancerBrian M Wolpin
Department of Medical Oncology, Dana Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA
Cancer Epidemiol Biomarkers Prev 21:82-91. 2012..Laboratory studies suggest that vitamin D may inhibit pancreatic cancer cell growth. However, epidemiologic studies of vitamin D and pancreatic cancer risk have been conflicting... - Prediagnostic plasma folate and the risk of death in patients with colorectal cancerBrian M Wolpin
Department of MedicalOncology, Dana Farber Cancer Institute, Boston, MA, USA
J Clin Oncol 26:3222-8. 2008..Therefore, high priority has been given to research investigating the influence of folate on cancer progression in patients with colorectal cancer... - Dietary insulin load, dietary insulin index, and colorectal cancerYing Bao
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 19:3020-6. 2010..On the basis of a novel insulin index for individual foods, we estimated insulin demand for overall diets and assessed its association with colorectal cancer in the Nurses' Health Study and Health Professionals Follow-up Study... - Statin use and colorectal cancer risk according to molecular subtypes in two large prospective cohort studiesJung Eun Lee
Department of Food and Nutrition, Sookmyung Women s University, Seoul, Korea
Cancer Prev Res (Phila) 4:1808-15. 2011..Current statin use was not associated with risk of overall colorectal cancer. The possibility that statin use may be associated with lower risk of rectal cancer or KRAS wild-type colorectal cancer requires further confirmation... - Targeting the epidermal growth factor receptor in metastatic colorectal cancerKimmie Ng
Massachusetts General Hospital Cancer Center, 55 Fruit Street, Boston, MA 02114, USA
Crit Rev Oncol Hematol 65:8-20. 2008..Novel strategies of targeting the EGFR pathway to improve efficacy, as well as ongoing research in identifying molecular predictors of response to anti-EGFR agents, will also be reviewed... - Efficacy and safety of single-agent pertuzumab (rhuMAb 2C4), a human epidermal growth factor receptor dimerization inhibitor, in castration-resistant prostate cancer after progression from taxane-based therapyDavid B Agus
Cedars Sinai Prostate Cancer Center, Los Angeles, CA 90048, USA
J Clin Oncol 25:675-81. 2007..The aim of this single-arm phase II clinical study was to assess the efficacy and safety of single-agent pertuzumab in castration-resistant prostate cancer (CRPC) patients who had experienced progression after prior chemotherapy... - Clinical activity of pertuzumab (rhuMAb 2C4), a HER dimerization inhibitor, in advanced ovarian cancer: potential predictive relationship with tumor HER2 activation statusMichael S Gordon
Arizona Cancer Center, Tuscon and Scottsdale, AZ, USA
J Clin Oncol 24:4324-32. 2006..CONCLUSION: Pertuzumab is well tolerated with a RR of 4.3% in heavily-pretreated OC patients. Further studies on pHER2 as a diagnostic are warranted... - Detection of proximal adenomatous polyps with screening sigmoidoscopy: a systematic review and meta-analysis of screening colonoscopyJames D Lewis
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Dr, Seventh Floor Blockley Hall, Philadelphia, PA 19104 6021, USA
Arch Intern Med 163:413-20. 2003..To address this, we performed a systematic review and meta-analysis of screening colonoscopy studies...