Research Topics
| S J MentzerSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
Research Grants
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Detail Information
Publications
CD34+ progenitor to endothelial cell transition in post-pneumonectomy angiogenesisKenji Chamoto
Division of Thoracic Surgery, Brigham and Women s Hospital, Room 259, Boston, MA 02115, USA
Am J Respir Cell Mol Biol 46:283-9. 2012..We conclude that blood-borne CD34(+) endothelial progenitor cells, characterized by active cell division and an amplified transcriptional signature, transition into resident endothelial cells during compensatory lung growth...- Angiogenesis gene expression in murine endothelial cells during post-pneumonectomy lung growthMiao Lin
Laboratory of Adaptive and Regenerative Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Respir Res 12:98. 2011..These findings indicate that a network of gene interactions contributes to angiogenesis during compensatory lung growth... - Epstein--Barr virus post-transplant lymphoproliferative disease and virus-specific therapy: pharmacological re-activation of viral target genes with arginine butyrateS J Mentzer
Division of Thoracic Surgery, Department of Surgery, Brigham and Women s Hospital, and the Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Transpl Infect Dis 3:177-85. 2001..Additional patient accrual is sought for further evaluation of this therapy... - Optimizing the selection of surgical candidates for lung volume reduction surgerySteven J Mentzer
Division of Thoracic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Semin Thorac Cardiovasc Surg 19:151-6. 2007..Finally, a preoperative conditioning program can provide an additional screening process to identify patients physically and emotionally prepared for surgery... - Surgical palliative care in thoracic diseasesSteven J Mentzer
Division of Thoracic Surgery, Department of Surgery, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Room 259, Boston, MA 02115, USA
Surg Clin North Am 85:315-28. 2005..Minimally invasive surgical interventions, such as the use of video thoracoscopy, can relieve dyspnea effectively and improve the quality of life for patients who have end stage thoracic disease... - Blood flow shapes intravascular pillar geometry in the chick chorioallantoic membraneGrace S Lee
Laboratory of Adaptive and Regenerative Biology, Brigham and Women s Hospital, Harvard Medical School, Boston MA, USA
J Angiogenes Res 2:11. 2010..We conclude that mechanical forces produced by blood flow have both a limiting and permissive influence on pillar development in the chick chorioallantoic membrane... - Causes of allograft dysfunction after single lung transplantation for emphysema: extrinsic restriction versus intrinsic obstruction. Brigham and Women's Hospital Lung Transplantation GroupM L Moy
Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
J Heart Lung Transplant 18:986-93. 1999..Determination of the mechanism of allograft dysfunction may allow the selection of an appropriate subset of patients who would benefit from LVRS... - Induction of the Epstein-Barr virus thymidine kinase gene with concomitant nucleoside antivirals as a therapeutic strategy for Epstein-Barr virus-associated malignanciesD V Faller
Cancer Research Center and Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Curr Opin Oncol 13:360-7. 2001..This virus-targeted antitumor strategy may provide a new therapeutic approach to EBV-associated neoplasms... - Interpreting improvement in expiratory flows after lung volume reduction surgery in terms of flow limitation theoryE P Ingenito
Division of Pulmonary and Critical Care Medicine and Thoracic Surgery, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Am J Respir Crit Care Med 163:1074-80. 2001.... - Model of functional restriction in chronic obstructive pulmonary disease, transplantation, and lung reduction surgeryS H Loring
Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Division of Pulmonary Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Am J Respir Crit Care Med 160:821-8. 1999..Surgical reduction of the native emphysematous lung after single lung transplantation can reduce functional restriction of the transplant and thereby improve its function... - New surgical options for elderly lung cancer patientsM T Jaklitsch
Division of Thoracic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Chest 116:480S-485S. 1999..Age alone should not be a contradiction to thoracic surgical interventions when video thoracoscopy is performed as treatment... - Treatment of patients with lung cancer and severe emphysemaS J Mentzer
Department of Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
Chest 116:477S-479S. 1999..Early results of combined LVRS and lung cancer resections suggest a favorable outcome in carefully selected patients... - Surveillance transbronchial lung biopsies: implication for survival after lung transplantationS J Swanson
Lung Transplant Program, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
J Thorac Cardiovasc Surg 119:27-37. 2000..We wished to determine whether early rejection after lung transplantation as assessed by surveillance transbronchial biopsy predicts for survival... - Transthoracic esophagectomy with radical mediastinal and abdominal lymph node dissection and cervical esophagogastrostomy for esophageal carcinomaS J Swanson
Division of Thoracic Surgery, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Ann Thorac Surg 72:1918-24; discussion 1924-5. 2001..The technique includes right thoracotomy, laparotomy, and cervical esophagogastrostomy (total thoracic esophagectomy) with radical mediastinal and abdominal lymph node dissection... - Bronchoscopic volume reduction: a safe and effective alternative to surgical therapy for emphysemaE P Ingenito
Brigham and Women s Hospital, Department of Pulmonary and Critical Care Medicine, 75 Francis Street, Boston, MA 02115, USA
Am J Respir Crit Care Med 164:295-301. 2001..BVR has the potential for simplifying volume reduction, extending indications, and reducing morbidity, mortality, and costs in humans... - Physiological characterization of variability in response to lung volume reduction surgeryEdward P Ingenito
Division of Pulmonary and Critical Care Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
J Appl Physiol 94:20-30. 2003..Among nonresponders, recoil pressure increased out of proportion to reduced volume, such that no increase in vital capacity or improvement in FEV(1) occurred... - Prevention, early detection, and management of complications after 328 consecutive extrapleural pneumonectomiesDavid J Sugarbaker
Division of Thoracic Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
J Thorac Cardiovasc Surg 128:138-46. 2004..Complications after extrapleural pneumonectomy were further analyzed to elucidate means of prevention, early detection, and treatment... - Respiratory impedance following bronchoscopic or surgical lung volume reduction for emphysemaEdward P Ingenito
Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Respiration 72:406-17. 2005..Understanding the differential effects of surgical volume reduction therapy (LVRS) and BLVR on lung and chest wall physiology will assist physicians in selecting an optimal approach for patients... - Modified T-tube repair of delayed esophageal perforation results in a low mortality rate similar to that seen with acute perforationsPhilip A Linden
Division of Thoracic Surgery, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Ann Thorac Surg 83:1129-33. 2007..We present a large series of patients requiring operative treatment of esophageal perforations with attention to an infrequently used method of dealing with delayed intrathoracic perforations... - Ambulatory monitoring of cumulative free-living activityMarilyn L Moy
Brigham and Women's Hospital, Pulmonary and Critical Care Medicine, 75 Francis Street, Boston, MA 02115, USA
IEEE Eng Med Biol Mag 22:89-95. 2003 - Comparison of physiological and radiological screening for lung volume reduction surgeryE P Ingenito
Department of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Am J Respir Crit Care Med 163:1068-73. 2001..ULPR helps identify patients with He disease that improves with surgery, despite unfavorable G(Li)... - Sources of graft restriction after single lung transplantation for emphysemaStephen H Loring
Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass, USA
J Thorac Cardiovasc Surg 134:204-9. 2007..We sought to determine the contributions of donor-recipient size matching, postoperative native lung hyperinflation, and postoperative chest wall volume reduction to graft restriction after transplantation... - Soluble and surface-bound immunoglobulin triggers human monocyte activation and hydrogen peroxide releaseS J Mentzer
Division of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115
Exp Hematol 18:812-7. 1990..Comparable H2O2 release was observed whether the Ig was in surface-bound or soluble form. These data support an important role for Fc receptors in the acquisition of cytotoxic potential by human MO... - Pneumonectomy after chemoradiation: the Dana-Farber Cancer Institute/Brigham and Women's Hospital experienceAaron M Allen
Department of Radiation Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Boston, MA 02115, USA
Cancer 112:1106-13. 2008..The current study was conducted to examine the outcomes of pneumonectomy after induction chemoradiotherapy in patients with locally advanced nonsmall cell lung cancer (NSCLC)... - Relationship between a history of antecedent cancer and the probability of malignancy for a solitary pulmonary noduleCarlos M Mery
Division of Thoracic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
Chest 125:2175-81. 2004..Metastases from previous cancer account for almost half of SPNs seen among patients in this subgroup. Diagnosis depends on the histology of previous malignancies, smoking history, age, and size of the SPN... - Effect of shear stress on efferent lymph-derived lymphocytes in contact with activated endothelial monolayersX Li
Laboratory of lmmunophysiology, The Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
In Vitro Cell Dev Biol Anim 37:599-605. 2001..of the order of 20 dyn/cm2, are too high to permit adhesion and transmigration of migratory lymphocytes. Additional mechanisnis must be present in vivo to facilitate lymphocyte transmigration in the inflammatory microcircu-.. - Interactions of blood cell constituents: experimental investigation and computational modeling by discrete particle dynamics algorithmN Filipovic
Molecular and Integrative Physiological Sciences, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
Microvasc Res 75:279-84. 2008..It is demonstrated that the DPD analysis offers the capability of simulating the time-dependent binding of platelets. We conclude that this model provides a new approach for studying the interaction among blood constituents... - Cell adhesion molecule expression in the sheep thymusT Zhao
Laboratory of Immunophysiology, The Dana-Farber Cancer Institute, Harvard Surgical Research Laboratories, Harvard Medical School, 02115, Boston, MA, USA
Dev Comp Immunol 25:519-30. 2001..These studies of thymocyte membrane molecule expression should facilitate future investigations of sheep intrathymic development and T lymphocyte immigration... - Spatial variation of plasma flow in the oxazolone-stimulated microcirculationC A West
Laboratory of Immunophysiology, Dana-Farber Cancer Institute and Harvard Surgical Research Laboratories, Harvard Medical School, 75 Francis Street, Boston MA 02115, USA
Inflamm Res 51:572-8. 2002..001). CONCLUSIONS: These results indicate that the oxazolone-stimulated adaptations of the inflammatory microcirculation include both microvascular dilatation and the redistribution of plasma flow... - Stochastic regulation of cell migration from the efferent lymph to oxazolone-stimulated skinC A West
Laboratory of Immunophysiology, Dana-Farber Cancer Institute, Harvard Surgical Research Laboratories, Harvard Medical School, Boston, MA 02115, USA
J Immunol 166:1517-23. 2001..8-fold more prevalent in the skin than the contralateral control cells. These results suggest that the in situ immune response generally mirrors the frequency of recruitable lymphocytes in the peripheral blood... - Aldehyde fixation of thiol-reactive fluorescent cytoplasmic probes for tracking cell migrationC A West
Laboratory of Immunophysiology, The Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA
J Histochem Cytochem 49:511-8. 2001..With these fixatives, both the CMFDA and CMTMR fluorescent dyes permitted sufficient anatomic resolution for reliable localization in long-term cell tracking studies... - Cytolytic peptides induce biphasic permeability changes in mammalian cell membranesM Su
Laboratory of Immunophysiology, Dana-Farber Cancer Institute, Room G09, JFB, 44 Binney Street, Boston, MA 02115, USA
J Immunol Methods 252:63-71. 2001.... - Combined antegrade and retrograde dilation: a new endoscopic technique in the management of complex esophageal obstructionR Bueno
Division of Thoracic Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Gastrointest Endosc 54:368-72. 2001..All strictures were dilated and no perforations occurred. CONCLUSIONS: Combined antegrade and retrograde dilation is a safe and effective technique for dilation of complex obstructing esophageal lesions... - Focal topographic changes in inflammatory microcirculation associated with lymphocyte slowing and transmigrationC A West
Laboratory of Immunophysiology, Harvard Surgical Research Laboratories, The Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Physiol Heart Circ Physiol 281:H1742-50. 2001..Results suggest that structural adaptations in inflammatory microcirculation represented by focal topographic changes may contribute to regulation of tissue entry by recirculating lymphocytes... - Sequential thoracic metastasectomy prolongs survival by re-establishing local control within the chestM T Jaklitsch
Division of Thoracic Surgery, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA
J Thorac Cardiovasc Surg 121:657-67. 2001..CONCLUSIONS: Multiple attempts to re-establish intrathoracic control of metastatic disease is justified in carefully selected patients, but the magnitude of benefit decays with each subsequent attempt... - Vascular microarchitecture of murine colitis-associated lymphoid angiogenesisAslihan Turhan
Laboratory of Adaptive and Regenerative Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Anat Rec (Hoboken) 292:621-32. 2009..We conclude that the development of ectopic lymphoid tissue requires significant structural remodeling of the stromal microcirculation. A feature of permissive tissues may be the capacity for lymphoid angiogenesis... - Outcomes of patients with stage III nonsmall cell lung cancer treated with chemotherapy and radiation with and without surgeryHale B Caglar
Department of Radiation Oncology Dana Farber Cancer Institute Brigham and Women s Hospital, Boston, Massachusetts 02215, USA
Cancer 115:4156-66. 2009..The objective of this study was to identify the factors associated with improved outcome after treatment for stage III nonsmall cell lung cancer (NSCLC)... - Hierarchical clustering of monoclonal antibody reactivity patterns in nonhuman speciesJuan Pablo Pratt
Laboratory of Immunophysiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Cytometry A 75:734-42. 2009..We conclude that our computational algorithm is a potentially useful tool for both Mab classification and molecular taxonomy in nonhuman experimental systems... - Computational flow dynamics in a geometric model of intussusceptive angiogenesisNenad Filipovic
Molecular and Integrative Physiological Sciences, Harvard School of Public Health, Boston, MA 02115, USA
Microvasc Res 78:286-93. 2009..We conclude that the intraluminal flow fields demonstrate sufficient spatial resolution and dynamic range to participate in the regulation of intussusceptive angiogenesis... - Murine microvideo endoscopy of the colonic microcirculationDino J Ravnic
Department of Surgery, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Surg Res 142:97-103. 2007..We conclude that natural orifice endoscopy is a useful method for the minimally invasive longitudinal assessment of the colonic mucosal microcirculation... - Factors predicting poor survival after resection of stage IA non-small cell lung cancerMichael Y Chang
Division of Thoracic Surgery, Brigham and Women s Hospital, Harvard Medical School, and Boston VA Healthcare, Harvard School of Public Health, Boston, Mass, USA
J Thorac Cardiovasc Surg 134:850-6. 2007..Using a national cancer registry, we determined the postoperative survival of patients with stage IA non-small cell lung cancer in the United States from 1988 to 1997 and identified factors that affect survival... - Osteomalacia associated with a fibroblast growth factor-23 secreting chest wall tumorSubroto Paul
Division of Thoracic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass 02115, USA
J Thorac Cardiovasc Surg 134:803-5. 2007 - Biochemical changes in the efferent lymph plasma after oxazolone stimulationCharles A West
Laboratory of Immunophysiology, Dana-Farber Cancer Institute, Surgical Research Laboratories, Harvard Medical School, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA
Dev Comp Immunol 26:111-9. 2002..These selective biochemical changes in the efferent lymph appeared to reflect the dynamics of lymphocyte activation within the lymph node as well as provide a practical measure of the lymph node response to antigen stimulation... - The murine bronchopulmonary microcirculation in hapten-induced inflammationDino J Ravnic
Division of Thoracic Surgery, Brigham and Women s Hospital, Boston, Mass 02115, USA
J Thorac Cardiovasc Surg 133:97-103. 2007..The clinical observation of central bronchial artery hypertrophy in chronic lung inflammation suggests the possibility that the bronchial circulation may also participate in adaptive responses in peripheral lung inflammation... - Structural adaptations in the murine colon microcirculation associated with hapten-induced inflammationDino J Ravnic
Laboratory of Immunophysiology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Gut 56:518-23. 2007..Blood flowing across the vascular endothelium creates wall shear stress, dependent on velocity of flow and vessel geometry, that tends to disrupt lymphocyte-endothelial cell adhesion... - Vessel painting of the microcirculation using fluorescent lipophilic tracersDino J Ravnic
Laboratory of Immunophysiology, Department of Surgery, Brigham and Women's Hospital, Harvard Surgical Research Laboratories, Harvard Medical School, Room 259, 75 Francis Street, Boston, MA 02115, USA
Microvasc Res 70:90-6. 2005..These studies suggest the utility of fluorescent vessel painting as a complementary technique to corrosion casting in the morphometric study of the microcirculation... - Outcomes and cost-effectiveness of alternative staging strategies for non-small-cell lung cancerNestor F Esnaola
Department of Surgery, Brigham and Women s Hospital, Harvard School of Public Health, Boston, MA, USA
J Clin Oncol 20:263-73. 2002..To identify the optimal strategy for staging the mediastinum of patients with known non-small-cell lung cancer (NSCLC), stratified by tumor (T) classification... - Stimulation of regional lymphatic and blood flow by epicutaneous oxazoloneChufa He
Laboratory of Immunophysiology, Dana-Farber Cancer Institute, Department of Surgery, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
J Appl Physiol 93:966-73. 2002.... - Dynamic deformation of migratory efferent lymph-derived cells "trapped" in the inflammatory microcirculationMei Su
Harvard Surgical Research Laboratories, Harvard Medical School, Boston, Massachusetts, USA
J Cell Physiol 194:54-62. 2003..When "trapping" does occur, the shape changes and sustained cell movement facilitated by excess cell membrane may contribute to the return of the "trapped cells" into the flow stream... - Microangiectasias: structural regulators of lymphocyte transmigrationTimothy W Secomb
Department of Physiology, University of Arizona, Tucson, AZ 85724, USA
Proc Natl Acad Sci U S A 100:7231-4. 2003..These findings support the hypothesis that a preparatory step to lymphocyte transmigration involves structural adaptations in the inflammatory microcirculation...
Research Grants
- Adult Tissue Morphogenesis: Functinoal Regulation of Intussusceptive AntiogenesisSteven Mentzer; Fiscal Year: 2009..The development of techniques and methods that can rapidly expand blood supply to injured tissue will have a significant impact on regenerative medicine and tissue engineering. ..
- Physiology of Systemic and Pulmonary MicroangiectasiasSteven Mentzer; Fiscal Year: 2006..abstract_text> ..
- Microangiectasia Regulation of Lymphocyte MigrationSteven Mentzer; Fiscal Year: 2006..abstract_text> ..
- LYMPHOCYTE RECRUITMENT IN LUNG TRANSPLANTATIONSteven Mentzer; Fiscal Year: 2000....
- Adult Tissue Morphogenesis: Functinoal Regulation of Intussusceptive AntiogenesisSteven J Mentzer; Fiscal Year: 2010..The development of techniques and methods that can rapidly expand blood supply to injured tissue will have a significant impact on regenerative medicine and tissue engineering. ..