Research Topics
| J MaoSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
Research Grants
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Detail Information
Publications
Glutamate transporter: an unexpected target for some antibioticsJianren Mao
Mol Pain 1:5. 2005..These findings indicate that positive promoters of GT expression may have a unique role in neuroprotection through regulating GT expression. This is also encouraging in search for new pharmacological tools for pain management...- Systemic lidocaine for neuropathic pain reliefJ Mao
MGH Pain Center, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
Pain 87:7-17. 2000..The thoughtful use of lidocaine therapy and the potential application of subtype-specific sodium channel blockers could provide better management of distinctive neuropathic pain symptoms... - Opioid-induced abnormal pain sensitivityJianren Mao
MGH Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, 02114, USA
Curr Pain Headache Rep 10:67-70. 2006..Their converging effects may be part of the mechanisms leading to the reduced opioid analgesic efficacy in chronic opioid therapy... - Combination drug therapy for chronic pain: a call for more clinical studiesJianren Mao
MGHCenter for Translational Pain Research, Department of Anesthesia, Harvard Medical School, Boston, MA 02114, USA
J Pain 12:157-66. 2011..PERSPECTIVE: More preclinical, clinical, and translational studies are needed to improve the efficacy of combination drug therapy that is an integral part of a comprehensive approach to the management of chronic pain... - Central glucocorticoid receptor: a new role in the cellular mechanisms of neuropathic painJianren Mao
Pain Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Rev Neurosci 16:233-8. 2005 - Translational pain research: achievements and challengesJianren Mao
MGH Center for Translational Pain Research, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
J Pain 10:1001-11. 2009..As translational pain research emerges as an important field in pain medicine, it will play a unique role in improving clinical pain management through coordinated bidirectional research approaches between bedside and bench... - Neuronal apoptosis associated with morphine tolerance: evidence for an opioid-induced neurotoxic mechanismJianren Mao
Massachusetts General Hospital Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
J Neurosci 22:7650-61. 2002..These results indicate an opioid-induced neurotoxic consequence regulated by the NMDAR-caspase pathway, a mechanism that may have clinical implications in opioid therapy and substance abuse... - Translational pain research: bridging the gap between basic and clinical researchJianren Mao
Department of Anesthesia and Critical Care, MGH Pain Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Pain 97:183-7. 2002 - Opioid-induced abnormal pain sensitivity: implications in clinical opioid therapyJianren Mao
MGH Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Pain 100:213-7. 2002 - Chronic morphine induces downregulation of spinal glutamate transporters: implications in morphine tolerance and abnormal pain sensitivityJianren Mao
Massachusetts General Hospital Pain Center and Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
J Neurosci 22:8312-23. 2002..These results indicate that spinal GTs may contribute to the neural mechanisms of morphine tolerance and associated abnormal pain sensitivity by means of regulating regional glutamate homeostasis... - Spinal cord neuroplasticity following repeated opioid exposure and its relation to pathological painJ Mao
MGH Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
Ann N Y Acad Sci 933:175-84. 2001..These observations may help understand mechanisms of chemical intolerance and multiple chemical sensitivity as well as have significant clinical implications in pain management with opioid analgesics... - Central glucocorticoid receptors modulate the expression of spinal cannabinoid receptors induced by chronic morphine exposureGrewo Lim
Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, Boston, MA 02114, USA
Brain Res 1059:20-7. 2005..These results indicate that the expression of spinal CBRs was altered following repeated morphine exposure and regulated by the activation of central GRs... - Inhibition of the ubiquitin-proteasome activity prevents glutamate transporter degradation and morphine toleranceLiling Yang
MGH Center for Translational Pain Research, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, WACC 324, 15 Parkman Street, Boston, MA 02114, USA
Pain 140:472-8. 2008..The possible relationship between MG-132-mediated regulation of glutamate transporters, ubiquitin-proteasome system, and the cellular mechanisms of morphine tolerance is discussed in light of these findings... - Central glucocorticoid receptors modulate the expression and function of spinal NMDA receptors after peripheral nerve injuryShuxing Wang
Pain Research Group, Massachusetts General Hospital Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
J Neurosci 25:488-95. 2005..These data suggest that interactions between central GRs and NMDARs through genomic and nongenomic regulation may be an important mechanism critical to neuropathic pain behaviors in rats... - cAMP and protein kinase A contribute to the downregulation of spinal glutamate transporters after chronic morphineGrewo Lim
Pain Research Group, MGH Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Neurosci Lett 376:9-13. 2005.... - Expression of central glucocorticoid receptors after peripheral nerve injury contributes to neuropathic pain behaviors in ratsShuxing Wang
Pain Research Group, Massachusetts General Hospital Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
J Neurosci 24:8595-605. 2004..These findings indicate a central role of neuronal GRs in the mechanisms of neuropathic pain behaviors in rats and suggest a potential role for GR antagonists in clinical management of neuropathic pain... - Expression of spinal NMDA receptor and PKCgamma after chronic morphine is regulated by spinal glucocorticoid receptorGrewo Lim
Pain Research Group, Division of Pain Medicine, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
J Neurosci 25:11145-54. 2005..The data suggest that genomic interaction among spinal GR, NMDAR, and PKCgamma may be an important mechanism that contributes to the development of morphine tolerance... - Altered expression and uptake activity of spinal glutamate transporters after nerve injury contribute to the pathogenesis of neuropathic pain in ratsBackil Sung
Massachusetts General Hospital Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
J Neurosci 23:2899-910. 2003.... - A differential diagnosis of hyperalgesia, toxicity, and withdrawal from intrathecal morphine infusionAneesh Singla
Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Anesth Analg 105:1816-9, table of contents. 2007..This report demonstrates the complexity of treating patients with long-term continuous intrathecal opioids when modest adjustment of the intrathecal cocktail results in a paradoxical clinical course... - A survey of selected physician views on acupuncture in pain managementLucy Chen
MGH Center for Translational Pain Research, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Pain Med 11:530-4. 2010..To collect information on the role of acupuncture in pain management from pain physicians and referral physicians who manage clinical pain conditions... - A combined effect of dextromethorphan and melatonin on neuropathic pain behavior in ratsShuxing Wang
MGH Center for Translational Pain Research, Department of Anesthesia and Critical Care, WACC 324, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Brain Res 1288:42-9. 2009..These results suggest that a combination of melatonin with a clinically available NMDA receptor antagonist might be more effective than either drug alone for the treatment of neuropathic pain... - Pain and opioid addiction: what is the connection?Adam J Carinci
Division of Pain Medicine, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Curr Pain Headache Rep 14:17-21. 2010..The connection between chronic pain and opioid addiction is a complex interplay between psychological, epidemiological, and neurobiological factors. Herein, we explore this critical relationship... - Activity of adenylyl cyclase and protein kinase A contributes to morphine-induced spinal apoptosisGrewo Lim
Pain Research Group, Division of Pain Medicine, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Suite WACC 324, 15 Parkman Street, Boston, MA 02114, USA
Neurosci Lett 389:104-8. 2005..The results indicate that the spinal AC and PKA pathway through intracellular MAPK may be contributory to the cellular mechanisms of morphine-induced apoptosis... - A rat model of unilateral hindpaw burn injury: slowly developing rightwards shift of the morphine dose-response curveShuxing Wang
Pain Research Group, MGH Pain Center, WACC 324, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, Boston, MA 02114, USA
Pain 116:87-95. 2005.... - Upregulation of spinal cannabinoid-1-receptors following nerve injury enhances the effects of Win 55,212-2 on neuropathic pain behaviors in ratsGrewo Lim
Department of Anesthesia and Critical Care, MGH Pain Center, WACC 324, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, Boston, MA 02114, USA
Pain 105:275-83. 2003..These results indicate that upregulation of spinal CB1Rs following peripheral nerve injury may contribute to the therapeutic effects of exogenous cannabinoids on neuropathic pain... - Opioid therapy for chronic painJane C Ballantyne
Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
N Engl J Med 349:1943-53. 2003 - Opioid tolerance and neuroplasticityJianren Mao
Pain Research Group, MGH Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Novartis Found Symp 261:181-6; discussion 187-93. 2004..The converging effects of these cellular mechanisms would significantly reduce the opioid analgesic efficacy. The current evidence also suggests new approaches for improving the clinical use of opioid analgesics... - Spinal glucocorticoid receptors contribute to the development of morphine tolerance in ratsGrewo Lim
Pain Research Group, MGH Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, Boston, MA 02114, USA
Anesthesiology 102:832-7. 2005..CONCLUSIONS: The results indicate an important role of spinal GRs in the cellular mechanisms of morphine tolerance in rats and may have significant implications in clinical opioid therapy... - Evidence for a long-term influence on morphine tolerance after previous morphine exposure: role of neuronal glucocorticoid receptorsGrewo Lim
Pain Research Group, MGH Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02116, USA
Pain 114:81-92. 2005..These findings may have significant implications in clinical opioid therapy and substance abuse... - Spinal leptin contributes to the pathogenesis of neuropathic pain in rodentsGrewo Lim
MGH Center for Translational Pain Research, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Clin Invest 119:295-304. 2009..Our findings reveal a critical role for spinal leptin in the pathogenesis of neuropathic pain and suggest what we believe to be a novel form of nonneuronal and neuronal interactions in the mechanisms of pathological pain... - Exacerbated mechanical allodynia in rats with depression-like behaviorQing Zeng
MGH Center for Translational Pain Research, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Brain Res 1200:27-38. 2008.... - Altered quantitative sensory testing outcome in subjects with opioid therapyLucy Chen
MGH Center for Translational Pain Research, Department of Anesthesia and Critical Care, WACC 324, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Pain 143:65-70. 2009..The data suggest that QST may be a useful tool in the clinical assessment of OIH... - Regulation of the trigeminal NR1 subunit expression induced by inflammation of the temporomandibular joint region in ratsShuxing Wang
MGH Center for Translational Pain Research, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, WACC 324, Boston, MA 02114, USA
Pain 141:97-103. 2009.... - Opioid tolerance and hyperalgesiaGrace Chang
Massachusetts General Hospital Pain Center, Division of Pain Medicine, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Med Clin North Am 91:199-211. 2007..This article will review updated information from both clinical and preclinical studies regarding opioid-induced hyperalgesia, tolerance, and dependence. The implications of these issues in clinical opioid therapy also will be discussed... - Animal models of acute surgical painHyangin Kim
Department of Anesthesia and Critical Care, Massachusetts General Hospital Center for Translational Pain Research, Harvard Medical School, Boston, MA, USA
Methods Mol Biol 617:31-9. 2010..Preclinical studies using these models have provided insights into the mechanisms and causes of acute surgical pain as well as the treatment options to control postsurgical pain... - Downregulation of spinal glutamate transporter EAAC1 following nerve injury is regulated by central glucocorticoid receptors in ratsShuxing Wang
Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, WACC 324, Boston, 02114, USA
Pain 120:78-85. 2006.... - Morphine induces ubiquitin-proteasome activity and glutamate transporter degradationLiling Yang
MGH Center for Translational Pain Research, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, 75 Parkman Street, Boston, MA 02114, USA
J Biol Chem 283:21703-13. 2008.... - Altered spinal arachidonic acid turnover after peripheral nerve injury regulates regional glutamate concentration and neuropathic pain behaviors in ratsBackil Sung
Pain Research Group, Division of Pain Medicine, WACC 324, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, Boston, MA 02114, USA
Pain 131:121-31. 2007..These data suggest that regulating spinal AA turnover may be a useful approach to improving the clinical management of neuropathic pain... - Central glucocorticoid receptors regulate the upregulation of spinal cannabinoid-1 receptors after peripheral nerve injury in ratsShuxing Wang
MGH Center for Translational Pain Research, Division of Pain Medicine, WACC 324, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, Boston, MA 02114, USA
Pain 131:96-105. 2007.... - The intravenous ketamine test: a predictive response tool for oral dextromethorphan treatment in neuropathic painSteven P Cohen
Pain Management Center, 550 North Broadway, Suite 301, Baltimore, MD 21205, USA
Anesth Analg 99:1753-9, table of contents. 2004..More research is needed to determine the ideal candidates for such a test, and the optimal dose and cutoff value for the response to ketamine... - Time-dependent effect of epidural steroid on pain behavior induced by chronic compression of dorsal root ganglion in ratsXiaoping Gu
Department of Anesthesiology, Drum Tower Hospital, Medical Department of Nanjing University, Nanjing 210008, People s Republic of China
Brain Res 1174:39-46. 2007..These results indicate that the effect of epidural steroid on radicular pain may be time-dependent. Clinical implications for epidural steroid treatment are discussed in light of these preclinical findings... - Intrathecal midazolam regulates spinal AMPA receptor expression and function after nerve injury in ratsJeongae Lim
Department of Anesthesia and Pain Medicine, Konkuk University, Seoul, Korea
Brain Res 1123:80-8. 2006..These results indicate that modulation of spinal AMPA receptor expression and function by the GABAergic activity may serve as a mechanism contributory to the spinal nociceptive processing... - The intravenous ketamine test predicts subsequent response to an oral dextromethorphan treatment regimen in fibromyalgia patientsSteven P Cohen
Pain Management Division, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
J Pain 7:391-8. 2006..Considering the refractory nature of fibromyalgia to conventional pain treatments, the IV ketamine test might enhance patient care by saving time and reducing unnecessary treatment trials... - The effect of opioid dose and treatment duration on the perception of a painful standardized clinical stimulusSteven P Cohen
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21029, USA
Reg Anesth Pain Med 33:199-206. 2008..g., surgery. The primary objective of this study is to delineate the effect of opioid dose and treatment duration on pain intensity and unpleasantness ratings following a standardized clinical pain stimulus... - A rat model of radicular pain induced by chronic compression of lumbar dorsal root ganglion with SURGIFLOXiaoping Gu
Department of Anesthesiology, Drum Tower Hospital, Nanjing, People s Republic of China
Anesthesiology 108:113-21. 2008..The authors report a modified rat model of radicular pain that could mimic a subset of clinical radicular pain conditions induced by the soft tissue compression on dorsal root ganglion...
Research Grants
- OPIOID-INDUCED PAIN SENSITIVITY: CLINICAL DIAGNOSIS AND MANAGEMENTJianren Mao; Fiscal Year: 2007....
- COMORBIDITY BETWEEN DEPRESSION AND OROFACIAL PAINJianren Mao; Fiscal Year: 2007....
- COMORBIDITY BETWEEN DEPRESSION AND OROFACIAL PAINJianren Mao; Fiscal Year: 2009....
- Central Mechanisms of Orofacial PainJianren Mao; Fiscal Year: 2009..The outcome of this study could lead to the development of new therapeutic tools to treat often intractable and debilitating clinical orofacial pain. ..
- OPIOID-INDUCED PAIN SENSITIVITY: CLINICAL DIAGNOSIS AND MANAGEMENTJianren Mao; Fiscal Year: 2010....
- COMORBIDITY BETWEEN DEPRESSION AND OROFACIAL PAINJianren Mao; Fiscal Year: 2010....
- Glutamate Uptake & the Pathogenesis of Neuropathic PainJianren Mao; Fiscal Year: 2007..abstract_text> ..
- Cellular Mechanisms of Hyperalgesia and Opioid ToleranceJianren Mao; Fiscal Year: 2005....
- Neuropathic Pain Modulation by CannabinoidsJianren Mao; Fiscal Year: 2006..A better understanding of cannabinoid actions in neuropathic pain states could open a new avenue to developing novel pharmacological tools for the improved management of often intractable and debilitating neuropathic pain syndromes. ..
- Central Mechanisms of Orofacial PainJianren Mao; Fiscal Year: 2010..The outcome of this study could lead to the development of new therapeutic tools to treat often intractable and debilitating clinical orofacial pain. ..