Research Topics
| A MajewskaSummaryAffiliation: Massachusetts Institute of Technology Country: USA Publications
| Collaborators
|
Detail Information
Publications
Topology of gap junction networks in C. elegansA Majewska
Department of Biological Sciences, Columbia University, New York, NY 10027, USA
J Theor Biol 212:155-67. 2001..Finally, we notice that the function of some gap junctions appears linked to their precise location on the neuronal processes. We propose that the location of the gap junctions within the neuron determines their functional role...
Motility of dendritic spines in visual cortex in vivo: changes during the critical period and effects of visual deprivationAnia Majewska
Department of Brain and Cognitive Sciences, Picower Center for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 100:16024-9. 2003..We conclude that spine motility might be involved in critical-period plasticity and that reduction of activity during the critical period enhances spine dynamics...
Mechanisms of calcium decay kinetics in hippocampal spines: role of spine calcium pumps and calcium diffusion through the spine neck in biochemical compartmentalizationA Majewska
Department of Biological Sciences, Columbia University, New York, New York 10027, USA
J Neurosci 20:1722-34. 2000..We conclude that dendritic spines have calcium pumps and that their density and kinetics, together with the morphology of the spine neck, determine the time during which the spine compartmentalizes calcium...
Regulation of spine calcium dynamics by rapid spine motilityA Majewska
Department of Biological Sciences, Columbia University, New York, New York 10027, USA
J Neurosci 20:8262-8. 2000..Our results demonstrate that the spine's ability to compartmentalize calcium is constantly changing...
Developmental regulation of spine motility in the mammalian central nervous systemA Dunaevsky
Department of Pathology, Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Proc Natl Acad Sci U S A 96:13438-43. 1999..We hypothesize that this basal motility of dendritic protrusions is intrinsic to the neuron and underlies the heightened plasticity found in developing CNS...
From form to function: calcium compartmentalization in dendritic spinesR Yuste
Dept of Biological Sciences, Columbia University, 1212 Amsterdam Avenue, Box 2435, New York, New York 10027, USA
Nat Neurosci 3:653-9. 2000..These studies highlight the richness and heterogeneity of pathways that regulate calcium accumulations in spines and the close relationship between the morphology and function of the spine...
A custom-made two-photon microscope and deconvolution systemA Majewska
Department of Biological Sciences, Columbia University, New York, NY 10027, USA
Pflugers Arch 441:398-408. 2000..Images obtained with this system can be deconvolved with the Estimation Maximization algorithm using the program XCOSM (freeware available at: http://www.ibc.wustl.edu/bcl/ xcosm/)...
On the function of dendritic spinesR Yuste
Department of Biological Sciences, Columbia University, New York, NY 10027, USA
Neuroscientist 7:387-95. 2001..Spines therefore would play a crucial circuit role, remarkably analogous to synaptic matrix elements of associative neural networks. This model highlights the economical, yet elegant, design of CNS circuits...
Dendritic spine dynamics are regulated by monocular deprivation and extracellular matrix degradationSerkan Oray
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Neuron 44:1021-30. 2004..Further, monocular deprivation occludes a subsequent effect of matrix degradation, suggesting that this mechanism is active in vivo to permit structural remodeling during ocular dominance plasticity...
Effects of synaptic activity on dendritic spine motility of developing cortical layer v pyramidal neuronsSerkan Oray
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Cereb Cortex 16:730-41. 2006....
In vivo two-photon imaging reveals a role of arc in enhancing orientation specificity in visual cortexKuan Hong Wang
Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Cell 126:389-402. 2006..These results suggest a physiological function of Arc in enhancing the overall orientation specificity of visual cortical neurons during the post-eye-opening life of an animal...
