Research Topics
Genomes and Genes
Species | Elizabeth KarlsonSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Publications
Epidemiology: Interpreting studies of interactions between RA risk factorsElizabeth W Karlson
Section of Clinical Sciences, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Nat Rev Rheumatol 6:72-3. 2010..As recent epidemiological evidence shows, deciphering these interactions demands consideration of the analytical approach used...- Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smokingKaren H Costenbader
Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Arthritis Res Ther 10:R52. 2008..We investigated whether polymorphisms in these genes were associated with RA in Caucasian women included in two large prospective cohorts, adjusting for confounding factors and testing for interactions with smoking... - Epstein-Barr virus and rheumatoid arthritis: is there a link?Karen H Costenbader
Brigham and Women s Hospital, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Arthritis Res Ther 8:204. 2006..In latent and replicating forms, it has immunomodulating actions that could play a role in the development of this autoimmune disease. The evidence linking Epstein-Barr virus and rheumatoid arthritis is reviewed... - The relationship between disease activity, sleep, psychiatric distress and pain sensitivity in rheumatoid arthritis: a cross-sectional studyYvonne C Lee
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, 75 Francis Street, PBB B3, Boston, MA 02115, USA
Arthritis Res Ther 11:R160. 2009..The etiology of RA pain is likely multifactorial, including both inflammatory and non-inflammatory components. In this study, we examine the association between disease activity, sleep, psychiatric distress and pain sensitivity in RA... - Protein, iron, and meat consumption and risk for rheumatoid arthritis: a prospective cohort studyElizabeth Benito-Garcia
Section of Clinical Sciences, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, Francis Street, Boston, Massachusetts 02115, USA
Arthritis Res Ther 9:R16. 2007..We were unable to confirm that there is an association between protein or meat and risk for RA in this large female cohort. Iron was also not associated with RA in this cohort... - High sensitivity, specificity and predictive value of the Connective Tissue Disease Screening Questionnaire among urban African-American womenE W Karlson
Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Lupus 14:832-6. 2005..These results suggest that the CSQ has adequate sensitivity and specificity and could be used in population studies to screen African-American women for SLE... - A prospective study of androgen levels, hormone-related genes and risk of rheumatoid arthritisElizabeth W Karlson
Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Arthritis Res Ther 11:R97. 2009.... - Biomarkers of inflammation and development of rheumatoid arthritis in women from two prospective cohort studiesElizabeth W Karlson
Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Arthritis Rheum 60:641-52. 2009..To examine the association of biomarkers of inflammation with preclinical rheumatoid arthritis (RA)... - Effect of glutathione S-transferase polymorphisms and proximity to hazardous waste sites on time to systemic lupus erythematosus diagnosis: results from the Roxbury lupus projectElizabeth W Karlson
Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Arthritis Rheum 56:244-54. 2007..Our goal was to assess association of residential proximity to hazardous waste sites and genetic variation in 3 glutathione Stransferase (GST) genes (GSTM1, GSTT1, and GSTP1) with age at diagnosis of SLE... - Gene-environment interaction between HLA-DRB1 shared epitope and heavy cigarette smoking in predicting incident rheumatoid arthritisE W Karlson
Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA
Ann Rheum Dis 69:54-60. 2010..To address the effect of dosage, a case-control study nested within two prospective cohorts to determine the interaction between heavy smoking and the HLA-SE was conducted... - Associations between human leukocyte antigen, PTPN22, CTLA4 genotypes and rheumatoid arthritis phenotypes of autoantibody status, age at diagnosis and erosions in a large cohort studyE W Karlson
Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Ann Rheum Dis 67:358-63. 2008..HLA-DRB1 shared epitope (HLA-SE), PTPN22 and CTLA4 alleles are associated with cyclic citrullinated peptide (CCP) and rheumatoid arthritis (RA)... - Vitamin E in the primary prevention of rheumatoid arthritis: the Women's Health StudyElizabeth W Karlson
Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Arthritis Rheum 59:1589-95. 2008..Vitamin E supplements may reduce the risk of developing rheumatoid arthritis (RA) through antioxidant effects. Although previous observational studies have investigated this question, no randomized trial data are available... - Serologic evaluations of women exposed to breast implantsE W Karlson
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Rheumatol 28:1523-30. 2001..We conducted laboratory tests in a large number of women with and without breast implants, and in diabetic patients with presumed silicone exposure via insulin syringes... - Do breast-feeding and other reproductive factors influence future risk of rheumatoid arthritis? Results from the Nurses' Health StudyElizabeth W Karlson
Brigham and Women s Hospital, Harvard Medical School, and Harvard School of Public Health, 75 Francis Street, Boston, MA 02115, USA
Arthritis Rheum 50:3458-67. 2004.... - Coffee consumption and risk of rheumatoid arthritisElizabeth W Karlson
Harvard Medical School, and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Arthritis Rheum 48:3055-60. 2003..We studied whether coffee, decaffeinated coffee, total coffee, tea, or overall caffeine consumption was associated with the risk of RA, using the Nurses' Health Study, a longitudinal cohort study of 121,701 women... - Total hip replacement due to osteoarthritis: the importance of age, obesity, and other modifiable risk factorsElizabeth W Karlson
Division of Rheumatology, Immunology, and Allergy, Robert B Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Boston, Massachusetts, USA
Am J Med 114:93-8. 2003..In the Nurses' Health Study, higher body mass index and older age significantly increased the risk of total hip replacement due to osteoarthritis. Part of this risk appeared to be established early in life... - Cumulative association of 22 genetic variants with seropositive rheumatoid arthritis riskElizabeth W Karlson
75 Francis Street, Boston, MA 02115, USA
Ann Rheum Dis 69:1077-85. 2010..This study examined whether a cumulative score based on 22 validated genetic risk alleles for seropositive RA would identify high-risk, asymptomatic individuals who might benefit from preventive interventions... - A randomized clinical trial of a psychoeducational intervention to improve outcomes in systemic lupus erythematosusElizabeth W Karlson
Brigham and Women s Hospital, and Robert B Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Boston, Massachusetts 02115, USA
Arthritis Rheum 50:1832-41. 2004..The goal of this study was to evaluate in a randomized controlled trial a theory-based intervention to improve patient self-efficacy and partner support to manage SLE... - Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk scorePhilip L De Jager
Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women s Hospital, Boston, MA 02115, USA
Lancet Neurol 8:1111-9. 2009..We investigated the usefulness of an aggregate measure of risk of MS that is based on genetic susceptibility loci. We also assessed the added effect of environmental risk factors that are associated with susceptibility for MS... - Environmental influences on risk for rheumatoid arthritisKatherine P Liao
Brigham and Women s Hospital, Boston, Massachusetts 02141, USA
Curr Opin Rheumatol 21:279-83. 2009..This review is timely given the expanding information on treatment, pathogenesis and genetic risk factors for RA... - Antioxidants and other novel cardiovascular risk factors in subjects with rheumatoid arthritis in a large population samplePaola de Pablo
Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Arthritis Rheum 57:953-62. 2007..To compare antioxidants and other novel and traditional cardiovascular disease (CVD) risk factors in participants with rheumatoid arthritis (RA) and non-RA controls in a large population sample... - Genetic basis of autoantibody positive and negative rheumatoid arthritis risk in a multi-ethnic cohort derived from electronic health recordsFina Kurreeman
Division of Rheumatology, Immunology, and Allergy and Division of Genetics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA
Am J Hum Genet 88:57-69. 2011.... - Factors determining participation in prevention trials among systemic lupus erythematosus patients: a qualitative studyKaren H Costenbader
Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Arthritis Rheum 57:49-55. 2007..Our goal was to determine factors that patients with SLE consider in deciding about participating in prevention trials, to uncover concerns about SLE trials, and to investigate how study design and purpose affect participation decisions... - Antioxidant intake and risks of rheumatoid arthritis and systemic lupus erythematosus in womenKaren H Costenbader
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Am J Epidemiol 172:205-16. 2010..In these large, prospective cohorts of women, antioxidant intake was not associated with the risk of developing either rheumatoid arthritis or systemic lupus erythematosus... - Effect of interactions of glutathione S-transferase T1, M1, and P1 and HMOX1 gene promoter polymorphisms with heavy smoking on the risk of rheumatoid arthritisBrendan T Keenan
Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Arthritis Rheum 62:3196-210. 2010..This study was undertaken to examine the impact of gene-smoking interactions on susceptibility to rheumatoid arthritis (RA)... - Alcohol consumption and markers of inflammation in women with preclinical rheumatoid arthritisBing Lu
Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Arthritis Rheum 62:3554-9. 2010..To examine the association between alcohol consumption and markers of inflammation in preclinical rheumatoid arthritis (RA)... - Investigation of candidate polymorphisms and disease activity in rheumatoid arthritis patients on methotrexateYvonne C Lee
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Rheumatology (Oxford) 48:613-7. 2009..We examined the association between candidate single nucleotide polymorphisms (SNPs) and disease activity in RA patients on MTX... - Specific association of type 1 diabetes mellitus with anti-cyclic citrullinated peptide-positive rheumatoid arthritisKatherine P Liao
Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, MA 02114, USA
Arthritis Rheum 60:653-60. 2009..In this study, the strength and nature of this association were investigated at the population level in a Swedish case-control cohort... - Low-dose aspirin in the primary prevention of rheumatoid arthritis: the Women's Health StudyNancy A Shadick
Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Arthritis Care Res (Hoboken) 62:545-50. 2010..Previous randomized trial data have demonstrated a beneficial effect of low-dose aspirin in reducing other inflammatory diseases, such as asthma and colorectal adenomas, but no trial has evaluated the role of aspirin in RA prevention... - Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis riskSoumya Raychaudhuri
Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
Nat Genet 41:1313-8. 2009..0008 replication, P = 4 x 10(-6) overall) and FCGR2A (rs12746613, P = 0.0022 replication, P = 2 x 10(-5) overall). Many of these loci are also associated to other immunologic diseases... - Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapyJing Cui
Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Arthritis Rheum 62:1849-61. 2010..The aim of the present study was to test established RA genetic risk factors to determine whether the same alleles also influence the response to anti-TNF therapy... - Genome-wide association study of determinants of anti-cyclic citrullinated peptide antibody titer in adults with rheumatoid arthritisJing Cui
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Mol Med 15:136-43. 2009..We identified a SNP in moderate linkage disequilibrium (LD) with HLA-DR3, which may influence anti-CCP titer independently of the HLA-SE... - Systemic lupus erythematosus and the risk of cardiovascular disease: results from the nurses' health studyA Elisabeth Hak
Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Arthritis Rheum 61:1396-402. 2009..Systemic lupus erythematosus (SLE) has been associated with an increased risk of cardiovascular disease. However, prospective population-based data addressing this association have been lacking... - The PRL -1149 G/T polymorphism and rheumatoid arthritis susceptibilityYvonne C Lee
Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Arthritis Rheum 60:1250-4. 2009..The aim of this study was to determine the role of the PRL -1149 G/T polymorphism (rs1341239) in rheumatoid arthritis (RA) susceptibility... - Geographic variation in rheumatoid arthritis incidence among women in the United StatesKaren H Costenbader
Section of Clinical Sciences, Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
Arch Intern Med 168:1664-70. 2008..The geographic variation in rheumatoid arthritis (RA) incidence in the United States is unknown... - Perinatal factors and adult-onset lupusJulia F Simard
Department of Epidemiology, Harvard University School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
Arthritis Rheum 59:1155-61. 2008..Therefore, we evaluated the role of birth weight, being breastfed, and preterm birth on the incidence of SLE in participants in the Nurses' Health Study (NHS) and the Nurses' Health Study II (NHSII)... - Barriers to a trial of atherosclerosis prevention in systemic lupus erythematosusKaren H Costenbader
Brigham and Women s Hospital, Boston, MA 02115, USA
Arthritis Rheum 53:718-23. 2005..We describe our experience in recruiting and retaining patients with SLE in this trial... - Obesity, weight change, hypertension, diuretic use, and risk of gout in men: the health professionals follow-up studyHyon K Choi
Rheumatology Unit, Department of Medicine, Massachusetts General Hospital, MA 02114, USA
Arch Intern Med 165:742-8. 2005..Similarly, both hypertension and diuretic use have been considered risk factors for gout; however, their independent contributions have not been established prospectively... - Cardiac risk factor awareness and management in patients with systemic lupus erythematosusKaren H Costenbader
Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
Arthritis Rheum 51:983-8. 2004..To assess awareness and management of traditional cardiac risk factors (CRFs) in patients with systemic lupus erythematosus (SLE) and physicians... - Cardiovascular risk factors in women with and without rheumatoid arthritisDaniel H Solomon
Division of Pharmacoepidemiology, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street, Boston, MA 02120, USA
Arthritis Rheum 50:3444-9. 2004..The risk of cardiovascular disease (CVD) is increased in patients with rheumatoid arthritis (RA). The objective of this study was to examine the distribution of known CVD risk factors and biomarkers of CVD in women with and without RA... - Cardiovascular care and cancer screening in female nurses with and without rheumatoid arthritisDaniel H Solomon
Division of Pharmacoepidemiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
Arthritis Rheum 51:429-32. 2004..To compare frequencies of cancer screening and cardiovascular treatments aimed at reducing acute myocardial infarction in women with and without rheumatoid arthritis (RA)... - Alcohol intake and risk of incident gout in men: a prospective studyHyon K Choi
Rheumatology Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Lancet 363:1277-81. 2004..Additionally, potential differences in risk of gout posed by different alcoholic beverages have not been assessed... - Cigarette smoking and the risk of systemic lupus erythematosus: a meta-analysisKaren H Costenbader
Robert B Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Arthritis Rheum 50:849-57. 2004..We performed an extensive search of the medical literature for all studies examining this relationship, and performed a meta-analysis to arrive at a more precise estimate of effect... - Purine-rich foods, dairy and protein intake, and the risk of gout in menHyon K Choi
Rheumatology Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
N Engl J Med 350:1093-103. 2004..Similarly, the possibility that the consumption of dairy products has a role in protecting against gout has been raised by metabolic studies. We prospectively investigated the association of these dietary factors with new cases of gout... - Cardiovascular morbidity and mortality in women diagnosed with rheumatoid arthritisDaniel H Solomon
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
Circulation 107:1303-7. 2003..Rheumatoid arthritis may be associated with an increased risk of cardiovascular disease. We compared the incidence rates of myocardial infarction and stroke in subjects with and without rheumatoid arthritis... - Cigarette smoking and systemic lupus erythematosus: a smoking gun?Karen H Costenbader
Brigham and Women s Hospital, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Boston, MA 02115, USA
Autoimmunity 38:541-7. 2005..5 [95% CI 1.09, 2.08]), but no increased risk associated with past smoking. The strengths and weaknesses of these data and potential implications are discussed... - A pravastatin dose-escalation study in systemic lupus erythematosusKaren H Costenbader
Division of Rheumatology, Immunology, and Allergy, Section of Clinical Sciences, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
Rheumatol Int 27:1071-7. 2007..Pravastatin reduced LDL and total cholesterol levels approximately the same degree observed in normal individuals, but the effect appeared blunted in those on modest doses of glucocorticoids and those with higher BMI... - Reproductive and menopausal factors and risk of systemic lupus erythematosus in womenKaren H Costenbader
Robert B Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Brigham and Women s Hospital, and Harvard School of Public Health, Boston, Massachusetts 02115, USA
Arthritis Rheum 56:1251-62. 2007..This study was carried out to examine associations between female reproductive and menopausal factors and the development of SLE... - C-reactive protein in the prediction of rheumatoid arthritis in womenNancy A Shadick
Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Arch Intern Med 166:2490-4. 2006..The purpose of this study was to examine whether levels of C-reactive protein (CRP), a sensitive marker of disease activity in rheumatoid arthritis (RA), are associated with increased risk of subsequent RA... - Smoking intensity, duration, and cessation, and the risk of rheumatoid arthritis in womenKaren H Costenbader
Division of Rheumatology, Immunology, and Allergy, Robert B Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
Am J Med 119:503.e1-9. 2006.... - Two independent alleles at 6q23 associated with risk of rheumatoid arthritisRobert M Plenge
Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
Nat Genet 39:1477-82. 2007..We show that these two SNP associations are statistically independent, are each reproducible in the comparison of our data and WTCCC data, and define risk and protective haplotypes for rheumatoid arthritis at 6q23... - Atherosclerotic vascular disease in systemic lupus erythematosusMatthew H Liang
Department of Medicine, Robert B Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, USA
J Natl Med Assoc 94:813-9. 2002..The study of the best and most effective means to prevent ASVD in SLE and in African Americans with SLE and in African Americans with SLE should be a major priority... - Early life factors and adult-onset rheumatoid arthritisJulia F Simard
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
J Rheumatol 37:32-7. 2010..We investigated the association of preterm birth and being breastfed with the incidence of rheumatoid arthritis (RA) in 2 large prospective cohorts... - Occupational silica and solvent exposures and risk of systemic lupus erythematosus in urban womenAxel Finckh
Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Arthritis Rheum 54:3648-54. 2006..To assess the risk of systemic lupus erythematosus (SLE) associated with occupational exposure to silica dust and organic solvents in an urban population... - Comparison of threshold cutpoints and continuous measures of anti-cyclic citrullinated peptide antibodies in predicting future rheumatoid arthritisLori B Chibnik
Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
J Rheumatol 36:706-11. 2009..While the anti-CCP level is commonly dichotomized for clinical use, the best threshold for and utility of the titer as a continuous variable to predict development of RA are uncertain... - Expression of CD44 variant isoforms CD44v3 and CD44v6 is increased on T cells from patients with systemic lupus erythematosus and is correlated with disease activityJose C Crispin
Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Arthritis Rheum 62:1431-7. 2010.... - Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk lociEli A Stahl
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
Nat Genet 42:508-14. 2010..An additional 11 SNPs replicated at P < 0.05, many of which are validated autoimmune risk alleles, suggesting that most represent genuine rheumatoid arthritis risk alleles... - Electronic medical records for discovery research in rheumatoid arthritisKatherine P Liao
Brigham and Women s Hospital, Boston, Massachusetts, USA
Arthritis Care Res (Hoboken) 62:1120-7. 2010..We assessed whether a classification algorithm incorporating narrative EMR data (typed physician notes) more accurately classifies subjects with rheumatoid arthritis (RA) compared with an algorithm using codified EMR data alone... - Exposure to traffic pollution and increased risk of rheumatoid arthritisJaime E Hart
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Environ Health Perspect 117:1065-9. 2009..Particulate air pollution, especially of traffic origin, has been linked to systemic inflammation in many studies... - Experience with etanercept in an academic medical center: are infection rates increased?Kristine Phillips
Robert B. Brigham Multipurpose Arthritis and Musculoskeletal Diseases Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Arthritis Rheum 47:17-21. 2002..Serious infections occurred in this patient population. Our results underscore the value of long-term observation under the conditions of clinical practice beyond controlled clinical trials... - Development and initial validation of a self-assessed lupus organ damage instrumentKaren H Costenbader
Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts
Arthritis Care Res (Hoboken) 62:559-68. 2010..Trained physicians must complete it, thus limiting utility where this is impossible... - Defining lupus cases for clinical studies: the Boston weighted criteria for the classification of systemic lupus erythematosusKaren H Costenbader
Robert B. Brigham Arthritis and Musculoskeletal Disease Clinical Research Center, Boston, Massachusetts, USA
J Rheumatol 29:2545-50. 2002..This reflects the inclusion of patients with objective findings of SLE but less than 4 ACR criteria. Our Boston Criteria system could minimize selection bias and increase the generalizability of clinical SLE studies... - Interaction between smoking, the shared epitope, and anti-cyclic citrullinated peptide: a mixed picture in three large North American rheumatoid arthritis cohortsHye Soon Lee
Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, New York 11030, USA
Arthritis Rheum 56:1745-53. 2007..In an effort to confirm this interaction between smoking and shared epitope alleles, we performed a case-only analysis of 3 North American RA cohorts... - Common variants at CD40 and other loci confer risk of rheumatoid arthritisSoumya Raychaudhuri
Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
Nat Genet 40:1216-23. 2008..1 x 10(-7) overall), CDK6 (rs42041, P = 0.010 replication, P = 4.0 x 10(-6) overall), PRKCQ (rs4750316, P = 0.0078 replication, P = 4.4 x 10(-6) overall), and KIF5A-PIP4K2C (rs1678542, P = 0.0026 replication, P = 8.8 x 10(-8) overall)... - Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4Robert M Plenge
Broad Institute of MIT and Harvard, Cambridge, MA, USA
Am J Hum Genet 77:1044-60. 2005....
Research Grants
- ANTIOXIDANTS AND FEMALE HORMONES IN THE ETIOLOGY OF RAElizabeth Karlson; Fiscal Year: 2002..RA will be confirmed by a screening questionnaire regarding rheumatic symptoms and review of medical records. The study will identify potentially modifiable risk factors for primary prevention of RA. ..
- Clinical Risk Prediction Modeling in Rheumatoid ArthritisElizabeth Karlson; Fiscal Year: 2009..This information will be used to develop personally tailored physical activity counseling to promote health and reduce cardiovascular risk of patients with RA. ..
- Hormone, cytokine, and genetic risks for RA in womenElizabeth Karlson; Fiscal Year: 2007..Ultimately, this study could lead to the identification of potential targets for therapeutic interventions to treat RA or to reduce the risk of this serious autoimmune disease. ..
- Genetic Predictors of Early Atherosclerosis in SLEElizabeth Karlson; Fiscal Year: 2007..abstract_text> ..
- Clinical Risk Prediction Modeling in Rheumatoid ArthritisElizabeth W Karlson; Fiscal Year: 2010..This information will be used to develop personally tailored physical activity counseling to promote health and reduce cardiovascular risk of patients with RA. ..