Research Topics
Genomes and Genes | B D HumphreysSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Publications
Imaging of podocyte foot processes by fluorescence microscopyIvica Grgic
Brigham and Women s Hospital, Harvard Institutes of Medicine, Room 550, 4 Blackfan Circle, Boston, MA 02115
J Am Soc Nephrol 23:785-91. 2012..In summary, using this method of genetic labeling and conventional fluorescence microscopy to visualize podocyte foot processes will complement electron microscopy and facilitate the analysis of podocytes and their precursors in vivo...- Origin of new cells in the adult kidney: results from genetic labeling techniquesJeremy S Duffield
Department of Medicine, Renal Division, Brigham and Women s Hospital, and Harvard Stem Cell Institute, Boston, Massachusetts, USA
Kidney Int 79:494-501. 2011.... - Intrinsic epithelial cells repair the kidney after injuryBenjamin D Humphreys
Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Institutes of Medicine, Room 550, 4 Blackfan Circle, Boston, MA 02115, USA
Cell Stem Cell 2:284-91. 2008..These results indicate that regeneration by surviving tubular epithelial cells is the predominant mechanism of repair after ischemic tubular injury in the adult mammalian kidney... - Mesenchymal stem cells in acute kidney injuryBenjamin D Humphreys
Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Annu Rev Med 59:311-25. 2008..This review summarizes current knowledge and identifies gaps in our understanding of MSC biology that will need to be filled in order to translate recent discoveries into therapies for AKI in humans... - Repair of injured proximal tubule does not involve specialized progenitorsBenjamin D Humphreys
Renal Division, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 108:9226-31. 2011..Thus, nonlethally injured cells repopulate the kidney epithelium after injury in the absence of any specialized progenitor cell population... - The contribution of adult stem cells to renal repairBenjamin D Humphreys
Renal Division, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Harvard Stem Cell Institute and Harvard MIT Division of Health Sciences and Technology, Boston, MA 02115, USA
Nephrol Ther 3:3-10. 2007..The identification of adult renal epithelial progenitor cells will ultimately determine the future direction of renal regenerative medicine... - Renal stem cells in recovery from acute kidney injuryB D Humphreys
Renal Division, Brigham and Women s Hospital, Boston, MA, USA
Minerva Urol Nefrol 58:329-37. 2006..In this review we focus on our current understanding of the potential role of renal and extrarenal stem cells in repair of the adult kidney and highlight some of the controversies in this field... - Characterization and Fate of Telomerase-expressing Epithelia during Kidney RepairJie Song
Harvard Institutes of Medicine, Room 554, 4 Blackfan Circle, Boston, MA 02115
J Am Soc Nephrol 22:2256-65. 2011..In summary, these data suggest that cells expressing telomerase reverse transcriptase are not a progenitor-cell population, and they do not play a direct role in kidney repair... - Acetaminophen-induced anion gap metabolic acidosis and 5-oxoprolinuria (pyroglutamic aciduria) acquired in hospitalBenjamin D Humphreys
Department of Medicine, Renal Division, Brigham and Women s Hospital, Boston, MA, USA
Am J Kidney Dis 46:143-6. 2005.... - Renal stem cells in recovery from acute kidney injuryB D Humphreys
Renal Division, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
Minerva Urol Nefrol 58:13-21. 2006..In this review we focus on our current understanding of the potential role of renal and extrarenal stem cells in repair of the adult kidney and highlight some of the controversies in this field... - Minimal-change nephrotic syndrome in a hematopoietic stem-cell transplant recipientBenjamin D Humphreys
Harvard Medical School, Boston, MA 02115, USA
Nat Clin Pract Nephrol 2:535-9; quiz 540. 2006..After 5 days, she developed fatigue with progressive weight gain and edema, and 14 days after immunization she presented with anasarca and was found to have acute renal failure and nephrotic proteinuria... - Cediranib, an oral inhibitor of vascular endothelial growth factor receptor kinases, is an active drug in recurrent epithelial ovarian, fallopian tube, and peritoneal cancerUrsula A Matulonis
Department of Medical Oncology, Dana Farber Cancer Institute, MA 02115, USA
J Clin Oncol 27:5601-6. 2009..Cediranib is an oral tyrosine kinase inhibitor (TKI) of vascular endothelial growth factor receptor (VEGFR) -1, VEGFR-2, VEGFR-3, and c-kit... - CSF-1 signals directly to renal tubular epithelial cells to mediate repair in miceJulia Menke
Laboratory of Molecular Autoimmune Disease, Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
J Clin Invest 119:2330-42. 2009..Taken together, these data suggest that CSF-1 mediates renal repair by both a macrophage-dependent mechanism and direct autocrine/paracrine action on TECs... - Rapid development of hypertension and proteinuria with cediranib, an oral vascular endothelial growth factor receptor inhibitorEmily S Robinson
Channing Laboratory, 3rd Floor, 181 Longwood Avenue, Boston, MA 02115, USA
Clin J Am Soc Nephrol 5:477-83. 2010..In this phase II study of cediranib (AZD2171) for recurrent epithelial ovarian cancer, the time course and severity of BP changes and proteinuria were characterized... - The spectrum of kidney involvement in lymphoma: a case report and review of the literatureLisa J Cohen
Nephrology Division, Brigham and Women s Hospital, Boston, MA, USA
Am J Kidney Dis 56:1191-6. 2010..We discuss a case of non-Hodgkin lymphoma and associated kidney failure from several distinct malignancy-related mechanisms and review the spectrum of lymphoma-related kidney involvement... - Adverse renal and metabolic effects associated with oral sodium phosphate bowel preparationEliot C Heher
Department of Medicine, Division of Nephrology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Clin J Am Soc Nephrol 3:1494-503. 2008..This review summarizes current knowledge about the renal complications of OSP, risk factors for its development, and the pathophysiology of acute and chronic kidney damage in nephrocalcinosis... - Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cellsTakaharu Ichimura
Renal Division, Brigham and Women s Hospital, Harvard Institutes of Medicine, Room 550, 4 Blackfan Circle, Boston, Massachusetts 02115, USA
J Clin Invest 118:1657-68. 2008..Thus, KIM-1 is the first nonmyeloid phosphatidylserine receptor identified to our knowledge that transforms epithelial cells into semiprofessional phagocytes... - Kidney disease associated with plasma cell dyscrasiasEliot C Heher
Massachusetts General Hospital, Boston, 02114, USA
Blood 116:1397-404. 2010..The role of stem cell transplantation, plasma exchange, and kidney transplantation in the management of patients with paraprotein-related kidney disease continues to evolve... - Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosisBenjamin D Humphreys
Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Pathol 176:85-97. 2010..These data indicate that therapeutic strategies directly targeting pericyte differentiation in vivo may productively impact fibrotic kidney disease... - Renal injury is a third hit promoting rapid development of adult polycystic kidney diseaseAyumi Takakura
Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 4 Blackfan Circle, Boston, MA 02115, USA
Hum Mol Genet 18:2523-31. 2009..These data demonstrate, for the first time, a role for polycystin-1 in kidney injury and repair and indicate that renal injury constitutes a 'third hit' resulting in rapid cyst formation in adulthood... - Rapid development of hypertension by sorafenib: toxicity or target?Benjamin D Humphreys
Renal Division, Brigham and Women s Hospital, Boston, Massachusetts, USA
Clin Cancer Res 15:5947-9. 2009..Blood pressure rises on the first day of treatment, facilitating design and interpretation of future trials aiming to correlate blood pressure changes with clinical outcomes... - Suppression of the nitric oxide pathway in metastatic renal cell carcinoma patients receiving vascular endothelial growth factor-signaling inhibitorsEmily S Robinson
Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
Hypertension 56:1131-6. 2010..Prospective studies are needed to explore whether these biomarkers may be useful predictors of efficacy in patients receiving VEGF-targeted therapies... - Renal failure associated with cancer and its treatment: an updateBenjamin D Humphreys
Renal Division, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA
J Am Soc Nephrol 16:151-61. 2005 - Shedding of the urinary biomarker kidney injury molecule-1 (KIM-1) is regulated by MAP kinases and juxtamembrane regionZhiwei Zhang
Renal Division, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, and Harvard Massachusetts Institute of Technology Division of Health Sciences and Technology, Boston, Massachusetts, USA
J Am Soc Nephrol 18:2704-14. 2007..Mutagenesis studies demonstrated that the juxtamembrane secondary structure, not the primary amino acid sequence, was critical to the cleavage of KIM-1... - Gemcitabine-associated thrombotic microangiopathyBenjamin D Humphreys
Renal Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
Cancer 100:2664-70. 2004..31% vs. 0.015%). Seven of nine patients developed new or exacerbated hypertension, which could be a useful early identifier of patients with gemcitabine-associated TMA syndromes...
Research Grants
- Kim-1 in Renal Epithelial Cell Motility and AdhesionBENJAMIN HUMPHREYS; Fiscal Year: 2005..The proposed studies will have great relevance in understanding the molecular mechanisms of renal regeneration and renal cell cancer invasion and metastasis. ..
- Kidney Injury Molecule-1 in Renal FibrosisBENJAMIN HUMPHREYS; Fiscal Year: 2007..These studies could validate Kim-1 as a therapeutic target in renal fibrosis and are therefore of great public health interest ..
- Hedgehog Signaling in Kidney Homeostasis and RepairBenjamin D Humphreys; Fiscal Year: 2010..Drugs are now being developed to modulate this pathway, so these studies might identify a new use for such drugs in treating kidney fibrosis which remains a tremendous problem in the United States and worldwide. ..