E L Hohmann

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi Nontyphoidal salmonellosis
    E L Hohmann
    Infectious Diseases Division, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Infect Dis 32:263-9. 2001
  2. ncbi Intestinal alkaline phosphatase preserves the normal homeostasis of gut microbiota
    M S Malo
    Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
    Gut 59:1476-84. 2010
  3. ncbi Comparison of rectal swabs with fecal cultures for detection of Salmonella typhimurium in adult volunteers
    Camille N Kotton
    Infectious Disease Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Diagn Microbiol Infect Dis 56:123-6. 2006
  4. ncbi Listeriosis during pregnancy: a case series and review of 222 cases
    Eleftherios Mylonakis
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA
    Medicine (Baltimore) 81:260-9. 2002
  5. ncbi Enteric pathogens as vaccine vectors for foreign antigen delivery
    Camille N Kotton
    Infectious Diseases Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Infect Immun 72:5535-47. 2004
  6. ncbi Killed but metabolically active Salmonella typhimurium: application of a new technology to an old vector
    Alexander J Lankowski
    Infectious Diseases Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Infect Dis 195:1203-11. 2007
  7. ncbi Comparative proteomic analysis of the PhoP regulon in Salmonella enterica serovar Typhi versus Typhimurium
    Richelle C Charles
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA
    PLoS ONE 4:e6994. 2009
  8. ncbi The International LAM Registry: a component of an innovative web-based clinician, researcher, and patient-driven rare disease research platform
    Michael Nurok
    Division of Surgical Critical Care, Cardiac and Thoracic Anesthesia, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Lymphat Res Biol 8:81-7. 2010
  9. ncbi Safety and shedding of an attenuated strain of Listeria monocytogenes with a deletion of actA/plcB in adult volunteers: a dose escalation study of oral inoculation
    Haroula Angelakopoulos
    Infectious Diseases Division, Massachusetts General Hospital, Boston, Massachussetts 02114, USA
    Infect Immun 70:3592-601. 2002
  10. ncbi Safety and immunogenicity of attenuated Salmonella enterica serovar Typhimurium delivering an HIV-1 Gag antigen via the Salmonella Type III secretion system
    Camille N Kotton
    Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, GRJ 504, Boston, MA 02114, USA
    Vaccine 24:6216-24. 2006

Research Grants

  1. Human Studies of Attenuated Salmonella Vectors
    Elizabeth Hohmann; Fiscal Year: 2007
  2. Human studies of Listeria monocytogenes vectors
    Elizabeth Hohmann; Fiscal Year: 2006
  3. PHOP/PHOQ DELETED S TYPHI VACCINE STRAINS
    Elizabeth Hohmann; Fiscal Year: 2002

Detail Information

Publications11

  1. ncbi Nontyphoidal salmonellosis
    E L Hohmann
    Infectious Diseases Division, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Infect Dis 32:263-9. 2001
    ..The current report presents a brief overview of the problems and trends associated with salmonellosis that are of interest to the infectious diseases clinician...
  2. ncbi Intestinal alkaline phosphatase preserves the normal homeostasis of gut microbiota
    M S Malo
    Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
    Gut 59:1476-84. 2010
    ..In this study the role of IAP in the preservation of the normal homeostasis of the gut microbiota was investigated...
  3. ncbi Comparison of rectal swabs with fecal cultures for detection of Salmonella typhimurium in adult volunteers
    Camille N Kotton
    Infectious Disease Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Diagn Microbiol Infect Dis 56:123-6. 2006
    ..When compared with fecal culture, rectal swabs were 64% sensitive and 90% specific. Rectal swabs are of moderate diagnostic utility for detection of Salmonella and may be useful when collection of fecal samples is impractical...
  4. ncbi Listeriosis during pregnancy: a case series and review of 222 cases
    Eleftherios Mylonakis
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA
    Medicine (Baltimore) 81:260-9. 2002
  5. ncbi Enteric pathogens as vaccine vectors for foreign antigen delivery
    Camille N Kotton
    Infectious Diseases Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Infect Immun 72:5535-47. 2004
  6. ncbi Killed but metabolically active Salmonella typhimurium: application of a new technology to an old vector
    Alexander J Lankowski
    Infectious Diseases Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Infect Dis 195:1203-11. 2007
    ..Because the parental strain has previously been found to elicit strong immune responses to Salmonella antigens, we propose CKS362 as a prototype strain to test the immunogenicity of KBMA organisms in humans...
  7. ncbi Comparative proteomic analysis of the PhoP regulon in Salmonella enterica serovar Typhi versus Typhimurium
    Richelle C Charles
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA
    PLoS ONE 4:e6994. 2009
    ..The PhoP regulon is a well studied two component (PhoP/Q) coordinately regulated network of genes whose expression is required for intracellular survival of S. enterica...
  8. ncbi The International LAM Registry: a component of an innovative web-based clinician, researcher, and patient-driven rare disease research platform
    Michael Nurok
    Division of Surgical Critical Care, Cardiac and Thoracic Anesthesia, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Lymphat Res Biol 8:81-7. 2010
    ..A relative inability to capture a sufficiently large patient population in any one geographic location has traditionally limited research into rare diseases...
  9. ncbi Safety and shedding of an attenuated strain of Listeria monocytogenes with a deletion of actA/plcB in adult volunteers: a dose escalation study of oral inoculation
    Haroula Angelakopoulos
    Infectious Diseases Division, Massachusetts General Hospital, Boston, Massachussetts 02114, USA
    Infect Immun 70:3592-601. 2002
    ..Attenuated L. monocytogenes can be studied in adult volunteers without serious long-term health sequelae...
  10. ncbi Safety and immunogenicity of attenuated Salmonella enterica serovar Typhimurium delivering an HIV-1 Gag antigen via the Salmonella Type III secretion system
    Camille N Kotton
    Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, GRJ 504, Boston, MA 02114, USA
    Vaccine 24:6216-24. 2006
    ..CONCLUSIONS: Although immunogenicity of the HIV antigen needs augmentation, the attenuated Salmonella strain proved to be an excellent platform for vaccine development...
  11. ncbi Identification of specific targets for the gut mucosal defense factor intestinal alkaline phosphatase
    Kathryn T Chen
    Dept of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Am J Physiol Gastrointest Liver Physiol 299:G467-75. 2010
    ..IAP likely targets these bacterially derived molecules in its role as a gut mucosal defense factor...

Research Grants13

  1. Human Studies of Attenuated Salmonella Vectors
    Elizabeth Hohmann; Fiscal Year: 2007
    ..The major goal of the project is to provide practical safety and immunogenicity data in humans which will help efficiently direct development of live bacterial vectors. ..
  2. Human studies of Listeria monocytogenes vectors
    Elizabeth Hohmann; Fiscal Year: 2006
    ..These studies will provide important data on the feasibility and utility of using Listeria monocytogenes vectors in humans. ..
  3. PHOP/PHOQ DELETED S TYPHI VACCINE STRAINS
    Elizabeth Hohmann; Fiscal Year: 2002
    ..These studies are designed to provide novel human safety and immunogenicity data which is vital to the clinical development of live bacterial vaccine vectors. ..