Research Topics
Genomes and Genes | Yasunori HayashiSummaryAffiliation: Massachusetts Institute of Technology Country: USA Publications
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Publications
Dendritic spine geometry: functional implication and regulationYasunori Hayashi
RIKEN MIT Neuroscience Research Center, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Neuron 46:529-32. 2005..Here we review recent evidence suggesting that the geometry of dendritic spines controls postsynaptic calcium signaling and is bidirectionally regulated during synaptic plasticity...- Synaptic accumulation of PSD-95 and synaptic function regulated by phosphorylation of serine-295 of PSD-95Myung Jong Kim
The Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Neuron 56:488-502. 2007..The data suggest that synaptic strength can be regulated by phosphorylation-dephosphorylation of ser-295 of PSD-95 and that synaptic depression requires the dephosphorylation of ser-295... - Visualization of synaptic Ca2+ /calmodulin-dependent protein kinase II activity in living neuronsKeizo Takao
RIKEN-Massachusetts Institute of Technology (MIT) Neuroscience Research Center, The Picower Center for Learning and Memory, Department of Brain and Cognitive Sciences, MIT, Cambridge, Massachusetts 02139, USA
J Neurosci 25:3107-12. 2005..In combination with two-photon microscopy, we demonstrate that Camuialpha can be used to observe temporal and spatial regulation of CaMKII activity in living neurons... - Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95-neuroliginKensuke Futai
RIKEN MIT Neuroscience Research Center, The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
Nat Neurosci 10:186-95. 2007..Presynaptic beta-neurexin serves as a likely presynaptic mediator of this effect. Our results indicate that trans-synaptic protein-protein interactions can link postsynaptic and presynaptic function... - The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapsesZheng Li
The Picower Center for Learning and Memory, RIKEN-MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Cell 119:873-87. 2004..Reciprocally, synaptic activity modulates the motility and fusion/fission balance of mitochondria and controls mitochondrial distribution in dendrites... - QZ1 and QZ2: rapid, reversible quinoline-derivatized fluoresceins for sensing biological Zn(II)Elizabeth M Nolan
Department of Chemistry, Cambridge, Massachusetts Institute of Technology, 02139, USA
J Am Chem Soc 127:16812-23. 2005..Because of its weaker affinity for Zn(II), QZ2 responds to higher concentrations of intracellular Zn(II) than members of the ZP family, illustrating that binding affinity is an important parameter for Zn(II) detection in vivo... - The postsynaptic density proteins Homer and Shank form a polymeric network structureMariko Kato Hayashi
RIKEN MIT Neuroscience Research Center, The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Cell 137:159-71. 2009..We propose that the Homer-Shank complex serves as a structural framework and as an assembly platform for other PSD proteins... - The role of CaMKII as an F-actin-bundling protein crucial for maintenance of dendritic spine structureKen ichi Okamoto
RIKEN MIT Neuroscience Research Center, The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 104:6418-23. 2007..This finding indicates that CaMKII serves as a central signaling molecule in both functional and structural changes during synaptic plasticity... - Visualization of F-actin and G-actin equilibrium using fluorescence resonance energy transfer (FRET) in cultured cells and neurons in slicesKen-Ichi Okamoto
RIKEN-MIT Neuroscience Research Center, The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 46-4243A, 43 Vassar Street, Cambridge, Massachusetts 02139, USA
Nat Protoc 1:911-9. 2006..Our protocol provides the first direct method for looking at the dynamic equilibrium between F-actin and G-actin in intact cells... - Targeting quantum dots to surface proteins in living cells with biotin ligaseMark Howarth
Department of Chemistry, The Picower Center for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 102:7583-8. 2005..We performed time-lapse imaging of single QDs bound to AMPA receptors in neurons, and we compared the trafficking of different AMPA receptor subunits by using two-color pulse-chase labeling... - Tetrameric hub structure of postsynaptic scaffolding protein homerMariko Kato Hayashi
RIKEN-MIT Neuroscience Research Center, The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Neurosci 26:8492-501. 2006..Our results provide the first insight into the structure of native Homer protein as a tetramer and the functional significance conferred by that structure... - Quaternary structure, protein dynamics, and synaptic function of SAP97 controlled by L27 domain interactionsTerunaga Nakagawa
The Picower Center for Learning and Memory, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Neuron 44:453-67. 2004..Thus SAP97 has a broader role than its close relative, PSD-95, in the maintenance of synaptic function... - Functional dynamics of Polo-like kinase 1 at the centrosomeKazuhiro Kishi
David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Mol Cell Biol 29:3134-50. 2009..These results indicate that mitotic progression and control of mitotic reentry after DNA damage resides, at least in part, on the dynamic behavior of Plk1... - Experience-dependent regulation of CaMKII activity within single visual cortex synapses in vivoAmanda F Mower
The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 108:21241-6. 2011..Synapses that are eliminated in deprived eye domains have low basal CaMKII activity, implying a protective role for activated CaMKII against synapse elimination... - ZP8, a neuronal zinc sensor with improved dynamic range; imaging zinc in hippocampal slices with two-photon microscopyChristopher J Chang
Department of Chemistry, Picower Center for Learning and Memory, RIKEN-MIT Neuroscience Research Center, and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Inorg Chem 43:6774-9. 2004.... - Genetic ablation of NMDA receptor subunit NR3B in mouse reveals motoneuronal and nonmotoneuronal phenotypesStephan Niemann
RIKEN MIT Neuroscience Research Center, The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Eur J Neurosci 26:1407-20. 2007..This work is the first reporting of the functional significance of NR3B in vivo and may give insight into the contribution of genetic variability of NR3B in the phenotypic heterogeneity among human population... - Genetically encoded probe for fluorescence lifetime imaging of CaMKII activityShowming Kwok
RIKEN MIT Neuroscience Research Center, The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue 46 4243A, Cambridge, MA 02139, USA
Biochem Biophys Res Commun 369:519-25. 2008..These FLIM versions of Camui could be useful for elucidating the function of CaMKII both in vitro and in vivo... - Rapid and persistent modulation of actin dynamics regulates postsynaptic reorganization underlying bidirectional plasticityKen ichi Okamoto
RIKEN MIT Neuroscience Research Center, The Picower Center for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Nat Neurosci 7:1104-12. 2004..This bidirectional regulation of actin is actively involved in protein assembly and disassembly and provides a substrate for bidirectional synaptic plasticity... - Entrapment of migrating hippocampal neural cells in three-dimensional peptide nanofiber scaffoldCarlos E Semino
Center for Biomedical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
Tissue Eng 10:643-55. 2004..This simple method may be useful not only in developing technology for neural progenitor cell isolation and enrichment in vitro, but also for expanding cells for cell-based therapies of regenerative medicine... - NR2 to NR3B subunit switchover of NMDA receptors in early postnatal motoneuronsMasahiro Fukaya
Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
Eur J Neurosci 21:1432-6. 2005..Therefore, the major regulatory subunit of NMDA receptors is likely to switch from NR2 to NR3B in somatic motoneurons during the early postnatal period... - Brain-derived neurotrophic factor signal enhances and maintains the expression of AMPA receptor-associated PDZ proteins in developing cortical neuronsHussam Jourdi
Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, 951 8585, Japan
Dev Biol 263:216-30. 2003..This work reveals a novel function of BDNF in postsynaptic development by regulating the PDZ protein expression... - Inhibition of dendritic spine morphogenesis and synaptic transmission by activity-inducible protein Homer1aCarlo Sala
Consiglio Nazionale delle Ricerche Institute of Neuroscience, Cellular and Molecular Pharmacology, Department of Pharmacology, University of Milan, 20129 Milan, Italy
J Neurosci 23:6327-37. 2003..Because Homer1a expression is induced by synaptic activity, our results suggest that this splice variant of Homer operates in a negative feedback loop to regulate the structure and function of synapses in an activity-dependent manner...
Research Grants
- Mutational Analysis of Motoneuron Specific NMDA-R in ALSYasunori Hayashi; Fiscal Year: 2004..abstract_text> ..