Johan Flygare

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. ncbi Gene therapy of Diamond Blackfan anemia CD34(+) cells leads to improved erythroid development and engraftment following transplantation
    Johan Flygare
    Department of Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University Hospital, Lund, Sweden
    Exp Hematol 36:1428-35. 2008
  2. ncbi Ribosomal protein S19 deficiency leads to reduced proliferation and increased apoptosis but does not affect terminal erythroid differentiation in a cell line model of Diamond-Blackfan anemia
    Koich Miyake
    Molecular Medicine and Gene Therapy, Lund University, BMC A12, 221 84, Lund, Sweden
    Stem Cells 26:323-9. 2008
  3. ncbi Human RPS19, the gene mutated in Diamond-Blackfan anemia, encodes a ribosomal protein required for the maturation of 40S ribosomal subunits
    Johan Flygare
    Department of Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University Hospital, Sweden
    Blood 109:980-6. 2007
  4. ncbi Mice with ribosomal protein S19 deficiency develop bone marrow failure and symptoms like patients with Diamond-Blackfan anemia
    Pekka Jaako
    Molecular Medicine and Gene Therapy, Lund Strategic Center for Stem Cell Biology, Lund University, Lund, Sweden
    Blood 118:6087-96. 2011
  5. ncbi Endoglin is not critical for hematopoietic stem cell engraftment and reconstitution but regulates adult erythroid development
    Jennifer L Moody
    Molecular Medicine and Gene Therapy, Institute of Laboratory Medicine, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University Hospital, Lund, Sweden
    Stem Cells 25:2809-19. 2007
  6. ncbi Diamond-Blackfan anemia: erythropoiesis lost in translation
    Johan Flygare
    Department of Molecular Medicine and Gene Therapy, Institute of Molecular Medicine, and Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, A12 221 84 Lund, Sweden
    Blood 109:3152-4. 2007
  7. ncbi From stem cell to erythroblast: regulation of red cell production at multiple levels by multiple hormones
    Harvey Lodish
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    IUBMB Life 62:492-6. 2010
  8. ncbi Deficiency of ribosomal protein S19 in CD34+ cells generated by siRNA blocks erythroid development and mimics defects seen in Diamond-Blackfan anemia
    Johan Flygare
    Molecular Medicine and Gene Therapy, Institute of Laboratory Medicine and The Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden
    Blood 105:4627-34. 2005

Collaborators

Detail Information

Publications8

  1. ncbi Gene therapy of Diamond Blackfan anemia CD34(+) cells leads to improved erythroid development and engraftment following transplantation
    Johan Flygare
    Department of Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University Hospital, Lund, Sweden
    Exp Hematol 36:1428-35. 2008
    ..We further determined if high level of RPS19 expression is required for correction...
  2. ncbi Ribosomal protein S19 deficiency leads to reduced proliferation and increased apoptosis but does not affect terminal erythroid differentiation in a cell line model of Diamond-Blackfan anemia
    Koich Miyake
    Molecular Medicine and Gene Therapy, Lund University, BMC A12, 221 84, Lund, Sweden
    Stem Cells 26:323-9. 2008
    ..These findings indicate that RPS19 deficiency causes apoptosis and accelerated loss of erythroid progenitors in RPS19-deficient DBA...
  3. ncbi Human RPS19, the gene mutated in Diamond-Blackfan anemia, encodes a ribosomal protein required for the maturation of 40S ribosomal subunits
    Johan Flygare
    Department of Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University Hospital, Sweden
    Blood 109:980-6. 2007
    ..This defect was observed to a lesser extent in CD34+ cells from patients with DBA who have mutations in RPS19...
  4. ncbi Mice with ribosomal protein S19 deficiency develop bone marrow failure and symptoms like patients with Diamond-Blackfan anemia
    Pekka Jaako
    Molecular Medicine and Gene Therapy, Lund Strategic Center for Stem Cell Biology, Lund University, Lund, Sweden
    Blood 118:6087-96. 2011
    ..This study demonstrates the feasibility of transgenic RNA interference to generate mouse models for human diseases caused by haploinsufficient expression of a gene...
  5. ncbi Endoglin is not critical for hematopoietic stem cell engraftment and reconstitution but regulates adult erythroid development
    Jennifer L Moody
    Molecular Medicine and Gene Therapy, Institute of Laboratory Medicine, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University Hospital, Lund, Sweden
    Stem Cells 25:2809-19. 2007
    ....
  6. ncbi Diamond-Blackfan anemia: erythropoiesis lost in translation
    Johan Flygare
    Department of Molecular Medicine and Gene Therapy, Institute of Molecular Medicine, and Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, A12 221 84 Lund, Sweden
    Blood 109:3152-4. 2007
    ..Recent studies and emerging findings suggest that a malfunctioning translational machinery may be a cause of anemia in patients with DBA...
  7. ncbi From stem cell to erythroblast: regulation of red cell production at multiple levels by multiple hormones
    Harvey Lodish
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    IUBMB Life 62:492-6. 2010
    ....
  8. ncbi Deficiency of ribosomal protein S19 in CD34+ cells generated by siRNA blocks erythroid development and mimics defects seen in Diamond-Blackfan anemia
    Johan Flygare
    Molecular Medicine and Gene Therapy, Institute of Laboratory Medicine and The Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden
    Blood 105:4627-34. 2005
    ..This study shows for the first time that RPS19 silencing decreases the proliferative capacity of hematopoietic progenitors and leads to a defect in erythroid development...