Research Topics
Genomes and Genes | Jason C DugasSummaryAffiliation: Massachusetts Institute of Technology Country: USA Publications
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Publications
Odorant receptor gene regulation: implications from genomic organizationErica Kratz
Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720, USA
Trends Genet 18:29-34. 2002..Here, we address the evolutionary expansion of odorant receptor genes and the role genomic organization of these genes might have in their tightly regulated expression...- Functional genomic analysis of oligodendrocyte differentiationJason C Dugas
Department of Neurobiology, Stanford University School of Medicine, Stanford, California 94305, USA
J Neurosci 26:10967-83. 2006.... - A crucial role for p57(Kip2) in the intracellular timer that controls oligodendrocyte differentiationJason C Dugas
Department of Neurobiology, Stanford University School of Medicine, Stanford, California 94305 5125, USA
J Neurosci 27:6185-96. 2007..These findings reveal a novel part of the mechanism by which OPCs measure time and are likely to extend to similar timers in many other precursor cell types... - Dicer1 and miR-219 Are required for normal oligodendrocyte differentiation and myelinationJason C Dugas
Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305 5125, USA
Neuron 65:597-611. 2010..Together, these findings show that miR-219 plays a critical role in coupling differentiation to proliferation arrest in the OL lineage, enabling the rapid transition from proliferating OPCs to myelinating OLs... - MicroRNAs in oligodendrocyte and Schwann cell differentiationJason C Dugas
Department of Neurobiology, Stanford University, Stanford, Calif 94305 5125, USA
Dev Neurosci 33:14-20. 2011..In this review, we will discuss how individual miRNAs regulate these various processes, and also how miRNA production in general is required for several stages of myelin generation and maintenance... - Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelinationBen Emery
Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305 5125, USA
Cell 138:172-85. 2009..These findings establish MRF as a critical transcriptional regulator essential for oligodendrocyte maturation and CNS myelination... - Disease gene candidates revealed by expression profiling of retinal ganglion cell developmentJack T Wang
Department of Neurobiology, Stanford University School of Medicine, Stanford, California 94305, USA
J Neurosci 27:8593-603. 2007..Consistent with this hypothesis, we found that CYP1B1 overexpression potentiates RGC survival... - A novel purification method for CNS projection neurons leads to the identification of brain vascular cells as a source of trophic support for corticospinal motor neuronsJason C Dugas
Department of Neurobiology, Stanford University School of Medicine, Stanford, California 94305 5125
J Neurosci 28:8294-305. 2008.... - Peroxisome proliferator-activated receptor delta limits the expansion of pathogenic Th cells during central nervous system autoimmunityShannon E Dunn
Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA
J Exp Med 207:1599-608. 2010..Collectively, these findings suggest that PPAR-delta serves as an important molecular brake for the control of autoimmune inflammation...