Jörg Dietrich

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi Chemotherapy associated central nervous system damage
    Jörg Dietrich
    Department of Neurology, MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street Yawkey 9E, Boston, Massachusetts 02114, USA
    Adv Exp Med Biol 678:77-85. 2010
  2. ncbi Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system
    Ruolan Han
    Department of Biomedical Genetics and University of Rochester Stem Cell and Regenerative Medicine Institute, University of Rochester Medical Center, Elmwood Avenue, Rochester, NY 14642, USA
    J Biol 7:12. 2008
  3. ncbi Mechanisms of Disease: the role of stem cells in the biology and treatment of gliomas
    Jörg Dietrich
    Department of Neurology, Brigham and Women s Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA
    Nat Clin Pract Oncol 5:393-404. 2008
  4. ncbi CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo
    Joerg Dietrich
    Department of Biomedical Genetics, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Biol 5:22. 2006
  5. ncbi Glioma stem cell signaling: therapeutic opportunities and challenges
    Jörg Dietrich
    Massachusetts General Hospital, 55 Fruit Street, Yawkey 9E, Boston, MA 02114, USA
    Expert Rev Anticancer Ther 10:709-22. 2010
  6. ncbi Clinical patterns and biological correlates of cognitive dysfunction associated with cancer therapy
    Jörg Dietrich
    Department of Neurology, Division of Neuro Oncology, Stephen E and Catherine Pappas Center for Neuro Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Oncologist 13:1285-95. 2008
  7. ncbi Mathematical and experimental approaches to identify and predict the effects of chemotherapy on neuroglial precursors
    Ollivier Hyrien
    Department of Biostatistics and Computational Biology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Cancer Res 70:10051-9. 2010
  8. ncbi EIF2B5 mutations compromise GFAP+ astrocyte generation in vanishing white matter leukodystrophy
    Jörg Dietrich
    Department of Biomedical Genetics, Aab Institute, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Nat Med 11:277-83. 2005
  9. ncbi Cediranib: profile of a novel anti-angiogenic agent in patients with glioblastoma
    Jörg Dietrich
    Stephen E and Catherine Pappas Center for Neuro Oncology, Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA
    Expert Opin Investig Drugs 18:1549-57. 2009
  10. ncbi Developing concepts in neural stem cells
    Joerg Dietrich
    Dept of Biomedical Genetics, University of Rochester, 601 Elmwood Avenue, Box 633, Rochester, NY 14642, USA
    Trends Neurosci 25:129-31. 2002

Collaborators

Detail Information

Publications18

  1. ncbi Chemotherapy associated central nervous system damage
    Jörg Dietrich
    Department of Neurology, MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street Yawkey 9E, Boston, Massachusetts 02114, USA
    Adv Exp Med Biol 678:77-85. 2010
    ....
  2. ncbi Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system
    Ruolan Han
    Department of Biomedical Genetics and University of Rochester Stem Cell and Regenerative Medicine Institute, University of Rochester Medical Center, Elmwood Avenue, Rochester, NY 14642, USA
    J Biol 7:12. 2008
    ..Nor are there any animal models that could enable the study of this important problem...
  3. ncbi Mechanisms of Disease: the role of stem cells in the biology and treatment of gliomas
    Jörg Dietrich
    Department of Neurology, Brigham and Women s Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA
    Nat Clin Pract Oncol 5:393-404. 2008
    ..This Review summarizes recent advances in the basic understanding of neural stem cell and cancer stem cell biology and the progress towards translating these novel concepts into the clinic...
  4. ncbi CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo
    Joerg Dietrich
    Department of Biomedical Genetics, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Biol 5:22. 2006
    ..The underlying cellular basis for these adverse effects is poorly understood...
  5. ncbi Glioma stem cell signaling: therapeutic opportunities and challenges
    Jörg Dietrich
    Massachusetts General Hospital, 55 Fruit Street, Yawkey 9E, Boston, MA 02114, USA
    Expert Rev Anticancer Ther 10:709-22. 2010
    ..This review summarizes important signaling pathways employed by both normal and cancer stem cells and highlights promising molecular-targeted therapies interfering with those signaling pathways in malignant gliomas...
  6. ncbi Clinical patterns and biological correlates of cognitive dysfunction associated with cancer therapy
    Jörg Dietrich
    Department of Neurology, Division of Neuro Oncology, Stephen E and Catherine Pappas Center for Neuro Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Oncologist 13:1285-95. 2008
    ....
  7. ncbi Mathematical and experimental approaches to identify and predict the effects of chemotherapy on neuroglial precursors
    Ollivier Hyrien
    Department of Biostatistics and Computational Biology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Cancer Res 70:10051-9. 2010
    ..These analyses also provide novel tools that apply broadly to identify effects of chemotherapeutic agents and other physiological stressors...
  8. ncbi EIF2B5 mutations compromise GFAP+ astrocyte generation in vanishing white matter leukodystrophy
    Jörg Dietrich
    Department of Biomedical Genetics, Aab Institute, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Nat Med 11:277-83. 2005
    ..This raises the possibility that a deficiency in astrocyte function may contribute to the loss of white matter in VWM leukodystrophy...
  9. ncbi Cediranib: profile of a novel anti-angiogenic agent in patients with glioblastoma
    Jörg Dietrich
    Stephen E and Catherine Pappas Center for Neuro Oncology, Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA
    Expert Opin Investig Drugs 18:1549-57. 2009
    ..Treatment strategies targeting angiogenesis have revealed promising results in preclinical studies and early clinical trials in patients with glioblastomas...
  10. ncbi Developing concepts in neural stem cells
    Joerg Dietrich
    Dept of Biomedical Genetics, University of Rochester, 601 Elmwood Avenue, Box 633, Rochester, NY 14642, USA
    Trends Neurosci 25:129-31. 2002
    ..Stem Cells in the Mammalian Brain: the 4th Brain Research Interactive Symposium, at the 2001 Annual Conference of the Society for Neuroscience, San Diego, CA, USA from November 8-10 2001...
  11. ncbi Cognitive side effects of cancer therapy demonstrate a functional role for adult neurogenesis
    Michelle Monje
    Department of Neurology, Division of Child Neurology, Stanford University Medical Center, 750 Welch Road, Suite 317, Palo Alto, CA 94304, USA
    Behav Brain Res 227:376-9. 2012
    ....
  12. ncbi Emerging antiangiogenic treatments for gliomas - efficacy and safety issues
    Jörg Dietrich
    Division of Neuro Oncology, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Neurol 21:736-44. 2008
    ..To review the rationale and recent experience of angiogenesis inhibitors in malignant gliomas and to highlight both the promise and potential complications of these agents...
  13. ncbi Corticosteroids in brain cancer patients: benefits and pitfalls
    Jörg Dietrich
    MGH Cancer Center and Center for Regenerative Medicine, Harvard Medical School, Boston, MA, USA
    Expert Rev Clin Pharmacol 4:233-42. 2011
    ..This article summarizes current concepts of using corticosteroids in brain cancer patients and highlights potential pitfalls in their effects on both tumor and neural progenitor cells...
  14. ncbi Infection with an endemic human herpesvirus disrupts critical glial precursor cell properties
    Joerg Dietrich
    Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Neurosci 24:4875-83. 2004
    ....
  15. ncbi Characterization of A2B5+ glial precursor cells from cryopreserved human fetal brain progenitor cells
    Joerg Dietrich
    Department of Biomedical Genetics, University of Rochester, Rochester, New York 14642, USA
    Glia 40:65-77. 2002
    ....
  16. ncbi Intersections between neurobiology and oncology: tumor origin, treatment and repair of treatment-associated damage
    Mark Noble
    Dept of Biomedical Genetics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 633, Rochester, NY 14642, USA
    Trends Neurosci 25:103-7. 2002
    ....
  17. ncbi The complex identity of brain tumors: emerging concerns regarding origin, diversity and plasticity
    Mark Noble
    Department of Biomedical Genetics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 633, Rochester, NY 14642, USA
    Trends Neurosci 27:148-54. 2004
    ....
  18. ncbi Glutamate transporter expression and function in human glial progenitors
    Nicholas J Maragakis
    Department of Neurology and Neuroscience, Johns Hopkins University, Meyer 6-109, 600 N. Wolfe Street, Baltimore, MD 21287-5953, USA
    Glia 45:133-43. 2004
    ....