Research Topics
| H A BartonSummaryAffiliation: Massachusetts Institute of Technology Country: USA Publications
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Detail Information
Publications
Metabolism of myclobutanil and triadimefon by human and rat cytochrome P450 enzymes and liver microsomesH A Barton
National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Xenobiotica 36:793-806. 2006..These data identify CYP enzymes important for the metabolization of these two triazoles. Estimated hepatic clearances suggest that CYP induction may have limited impact in vivo...- Computational pharmacokinetics during developmental windows of susceptibilityHugh A Barton
U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
J Toxicol Environ Health A 68:889-900. 2005..g., lactational versus placental transfer). Pharmacodynamic modeling could similarly address changes with age, but few such models currently exist. The growth of systems biology is anticipated to change this over the coming decade... - Family approach for estimating reference concentrations/doses for series of related organic chemicalsH A Barton
K S Crump Group, ICF Kaiser, Research Triangle Park, North Carolina 27709, USA
Toxicol Sci 54:251-61. 2000..Implementation of the family approach using pharmacokinetic modeling to obtain tissue dose metrics is described and its applications are evaluated... - Evaluating noncancer effects of trichloroethylene: dosimetry, mode of action, and risk assessmentH A Barton
K S Crump Group, Inc, ICF Consulting, Research Triangle Park, NC, USA
Environ Health Perspect 108:323-34. 2000..Incorporation of pharmacokinetics and pharmacodynamics can result in values that differ significantly from those obtained with the default methods... - Regional hepatic CYP1A1 and CYP1A2 induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin evaluated with a multicompartment geometric model of hepatic zonationM E Andersen
ICF Kaiser Engineers, Research Triangle Park, North Carolina 27709, USA
Toxicol Appl Pharmacol 144:145-55. 1997..No previous model has incorporated regional variations in induction. The PBPK analysis based on the multicompartment liver model suggests that the low-dose behavior for hepatic CYP1A1/CYP1A2 induction by TCDD is highly non-linear... - Pharmacodynamic model of the rat estrus cycle in relation to endocrine disruptorsM E Andersen
ICF Kaiser Engineers, Inc, Research Triangle Park, North Carolina 27709, USA
J Toxicol Environ Health 52:189-209. 1997..With further development these pharmacodynamic estrus cycle models should be useful in aiding risk assessments for compounds causing mammary-tissue tumors associated with persistent estrus states... - Dose-response characteristics of uterine responses in rats exposed to estrogen agonistsH A Barton
K S Crump Group, ICF Kaiser, 3200 Chapel Hill Nelson Hwy, Suite 101, Research Triangle Park, North Carolina, 27709, USA
Regul Toxicol Pharmacol 28:133-49. 1998.... - The use of biochemical and molecular parameters to estimate dose-response relationships at low levels of exposureM E Andersen
ICF Kaiser Engineers, Inc, Research Triangle Park, NC 27709, USA
Environ Health Perspect 106:349-55. 1998.... - Biological regulation of receptor-hormone complex concentrations in relation to dose-response assessments for endocrine-active compoundsM E Andersen
K S Crump Group, Inc, North Carolina 27709, USA
Toxicol Sci 48:38-50. 1999..These nonlinear mechanisms involve amplification of response, rather than multimeric molecular interactions as in conventional Hill relationships... - A multicompartment geometric model of the liver in relation to regional induction of cytochrome P450sM E Andersen
ICF Kaiser Engineers, Inc, Research Triangle Park, North Carolina 27709, USA
Toxicol Appl Pharmacol 144:135-44. 1997..Because of the high n values, the low-dose induction characteristics predicted with the multicompartment liver model differ significantly from those predicted with a model that considers the liver as a single homogeneous compartment... - Dichloroacetate (DCA) dosimetry: interpreting DCA-induced liver cancer dose response and the potential for DCA to contribute to trichloroethylene-induced liver cancerH A Barton
The K S Crump Group, Inc, ICF Kaiser, Research Triangle Park, NC 27709, USA
Toxicol Lett 106:9-21. 1999..In addition, the predicted levels of DCA would be too small to produce the observed liver cancers following corn oil gavage exposure of mice to TCE... - Predicting maternal rat and pup exposures: how different are they?Miyoung Yoon
National Research Council Research Associateship Program at U S Environmental Protection Agency, Research Triangle Park, North Carolina 27709, USA
Toxicol Sci 102:15-32. 2008..The present model demonstrated pup exposures do not always parallel the mother's. The model predictions can be used to help design early life toxicity and pharmacokinetic studies and better interpret study findings... - Evaluation of physiologically based pharmacokinetic models for use in risk assessmentWeihsueh A Chiu
National Center for Environmental Assessment, Office of Research and Development, U S Environmental Protection Agency, 1200 Pennsylvania Avenue, NW, Washington, DC 20460, USA
J Appl Toxicol 27:218-37. 2007..Finally, the predictive capacity and sensitivity, variability and uncertainty of the model are analysed so that the applicability of a model for risk assessment can be determined. Published in 2007 by John Wiley & Sons, Ltd... - Biomonitoring Equivalents (BE) dossier for toluene (CAS No. 108-88-3)Lesa L Aylward
Summit Toxicology, LLP, 6343 Carolyn Drive, Falls Church, VA 22044, USA
Regul Toxicol Pharmacol 51:S27-36. 2008.... - Guidelines for the communication of Biomonitoring Equivalents: report from the Biomonitoring Equivalents Expert WorkshopJudy S LaKind
LaKind Associates, LLC, 106 Oakdale Avenue, Catonsville, MD 21228, USA
Regul Toxicol Pharmacol 51:S16-26. 2008..Communication of BEs will require outreach, education, and development of communication materials specific to several audiences including the lay public and health care providers... - Development of good modelling practice for physiologically based pharmacokinetic models for use in risk assessment: the first stepsGeorge Loizou
Health and Safety Laboratory, Harpur Hill, Buxton, SK17 9JN, UK
Regul Toxicol Pharmacol 50:400-11. 2008.... - Application of PBPK modeling in support of the derivation of toxicity reference values for 1,1,1-trichloroethaneYasong Lu
Quantitative and Computational Toxicology Group, Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523 1681, USA
Regul Toxicol Pharmacol 50:249-60. 2008..Toxicol. 11, 611-625] were selected to simulate appropriate internal dosimetry data from which to derive reference value points of departure. Duration, route, and species extrapolations were performed based on internal dose metrics... - Characterizing uncertainty and variability in physiologically based pharmacokinetic models: state of the science and needs for research and implementationHugh A Barton
US EPA, ORD, National Center for Computational Toxicology, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 99:395-402. 2007.... - Guidelines for the derivation of Biomonitoring Equivalents: report from the Biomonitoring Equivalents Expert WorkshopSean M Hays
Summit Toxicology, LLP, 165 Valley Road, Lyons, CO 80540, USA
Regul Toxicol Pharmacol 51:S4-15. 2008..The findings from this Expert Panel Workshop on BE derivation are presented and provide a set of guidelines and considerations for use in BE derivation... - Mathematical model for the androgenic regulation of the prostate in intact and castrated adult male ratsLaura K Potter
Curriculum in Toxicology, University of North Carolina, Chapel Hill, NC, USA
Am J Physiol Endocrinol Metab 291:E952-64. 2006..This model provides a framework for quantifying the kinetics and effects of environmental and pharmaceutical endocrine active compounds on the prostate... - The acquisition and application of absorption, distribution, metabolism, and excretion (ADME) data in agricultural chemical safety assessmentsHugh A Barton
U.S. Environmental Protection Agency, National Centerfor Computational Toxicology, Research Triangle Park, North Carolina, USA
Crit Rev Toxicol 36:9-35. 2006..Subsequent tiers provide additional information in an iterative manner, depending on pharmacokinetic properties, toxicity study results, and the intended uses of the compound... - A consistent approach for the application of pharmacokinetic modeling in cancer and noncancer risk assessmentHarvey J Clewell
ENVIRON International Corp, Ruston, Louisiana 71270, USA
Environ Health Perspect 110:85-93. 2002..In this paper we describe the uses of this ratio concept and discuss the advantages of a pharmacokinetic-based approach as compared to the use of default dosimetry... - The metabolic rate constants and specific activity of human and rat hepatic cytochrome P-450 2E1 toward toluene and chloroformJohn C Lipscomb
U S Environmental Protection Agency, Office of Research and Development, National Center for Environmental Assessment, Cincinnati, OH 45268, USA
J Toxicol Environ Health A 67:537-53. 2004..These results demonstrate that differences in CYP2E1 content of MSP among individuals and between species are largely responsible for observed differences in toluene and CHCl3 metabolism in vitro... - Computational modeling of serum-binding proteins and clearance in extrapolations across life stages and species for endocrine active compoundsJustin G Teeguarden
ENVIRON Health Sciences Institute, Ruston, LA 71270, USA
Risk Anal 24:751-70. 2004..The examples illustrate the utility of this approach for integrating available experimental data from in vitro and in vivo studies to estimate the relative potency of these compounds... - Framework for evaluation of physiologically-based pharmacokinetic models for use in safety or risk assessmentLeona H Clark
U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Experimental Toxicology Division, Research Triangle Park, NC 27711, USA
Risk Anal 24:1697-717. 2004..The process also helps to define the kinds of documentation that would be needed for a model to facilitate its evaluation and implementation... - Evaluation of oral and intravenous route pharmacokinetics, plasma protein binding, and uterine tissue dose metrics of bisphenol A: a physiologically based pharmacokinetic approachJustin G Teeguarden
Biological Monitoring and Modeling, Pacific Northwest National Laboratory, 902 Battelle Boulevard, P7 56, Richland, Washington 99352, USA
Toxicol Sci 85:823-38. 2005.... - Interspecies dose extrapolation for inhaled dimethyl sulfate: a PBPK model-based analysis using nasal cavity N7-methylguanine adductsRamesh Sarangapani
ICF Consulting, Research Triangle Park, North Carolina, USA
Inhal Toxicol 16:593-605. 2004..The model-based interspecies dose comparison, using N7 mG adduct levels in the nasal respiratory tissue as the appropriate dose metrics, predicts a dose rate seven times higher in rats compared to humans... - Assessing susceptibility from early-life exposure to carcinogensHugh A Barton
Office of Research and Development, National Center for Computational Toxicology, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA
Environ Health Perspect 113:1125-33. 2005..These analyses suggest increased susceptibility to cancer from early-life exposure, particularly for chemicals acting through a mutagenic mode of action... - Agricultural chemical safety assessment: A multisector approach to the modernization of human safety requirementsNeil G Carmichael
Bayer CropScience, Sophia-Antipolis, France
Crit Rev Toxicol 36:1-7. 2006.... - Approaches for applications of physiologically based pharmacokinetic models in risk assessmentChad M Thompson
National Center for Environmental Assessment, Office of Research and Development, U S Environmental Protection Agency, Washington, DC, USA
J Toxicol Environ Health B Crit Rev 11:519-47. 2008....