Emma Heart

Summary

Affiliation: Marine Biological Laboratory
Country: USA

Publications

  1. ncbi Glucose-dependent increase in mitochondrial membrane potential, but not cytoplasmic calcium, correlates with insulin secretion in single islet cells
    Emma Heart
    Department of Medicine, Obesity Research Center, Boston University School of Medicine, Boston, MA 02118, USA
    Am J Physiol Endocrinol Metab 290:E143-E148. 2006
  2. ncbi Role for malic enzyme, pyruvate carboxylation, and mitochondrial malate import in glucose-stimulated insulin secretion
    Emma Heart
    BioCurrents Research Center, Marine Biological Laboratory, 7 MBL St, Lillie 219, Woods Hole, MA 02543, USA
    Am J Physiol Endocrinol Metab 296:E1354-62. 2009
  3. ncbi Rhythm of the beta-cell oscillator is not governed by a single regulator: multiple systems contribute to oscillatory behavior
    Emma Heart
    BioCurrents Research Center, Molecular Physiology Program, Marine Biological Laboratory, Woods Hole, Massachusetts 02543, USA
    Am J Physiol Endocrinol Metab 292:E1295-300. 2007
  4. ncbi Plasma membrane electron transport in pancreatic ?-cells is mediated in part by NQO1
    Joshua P Gray
    United States Coast Guard Academy, New London, Connecticut, USA
    Am J Physiol Endocrinol Metab 301:E113-21. 2011
  5. ncbi The level of menadione redox-cycling in pancreatic ?-cells is proportional to the glucose concentration: role of NADH and consequences for insulin secretion
    Emma Heart
    Cellular Dynamics Program, Marine Biological Laboratory, Woods Hole, MA 02543, United States
    Toxicol Appl Pharmacol 258:216-25. 2012
  6. ncbi beta-Cell mitochondria exhibit membrane potential heterogeneity that can be altered by stimulatory or toxic fuel levels
    Jakob D Wikstrom
    Tufts University, Department of Pharmacology and Experimental Therapeutics, 136 Harrison Ave, Boston, MA 02111, USA
    Diabetes 56:2569-78. 2007
  7. ncbi Ca2+, NAD(P)H and membrane potential changes in pancreatic beta-cells by methyl succinate: comparison with glucose
    Emma Heart
    Obesity Research Center, Evans Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Biochem J 403:197-205. 2007
  8. ncbi Synchronizing Ca2+ and cAMP oscillations in pancreatic beta-cells: a role for glucose metabolism and GLP-1 receptors? Focus on "regulation of cAMP dynamics by Ca2+ and G protein-coupled receptors in the pancreatic beta-cell: a computational approach&
    George G Holz
    Am J Physiol Cell Physiol 294:C4-6. 2008
  9. ncbi Insulin-like and non-insulin-like selenium actions in 3T3-L1 adipocytes
    Emma Heart
    Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California 90089-9142, USA
    J Cell Biochem 88:719-31. 2003
  10. ncbi Glucose transport by osmotic shock and vanadate is impaired by glucosamine
    Emma Heart
    Department of Physiology and Biophysics, University of Southern California, Los Angeles, California 90089-9142, USA
    Biochem Biophys Res Commun 292:308-11. 2002

Collaborators

Detail Information

Publications10

  1. ncbi Glucose-dependent increase in mitochondrial membrane potential, but not cytoplasmic calcium, correlates with insulin secretion in single islet cells
    Emma Heart
    Department of Medicine, Obesity Research Center, Boston University School of Medicine, Boston, MA 02118, USA
    Am J Physiol Endocrinol Metab 290:E143-E148. 2006
    ....
  2. ncbi Role for malic enzyme, pyruvate carboxylation, and mitochondrial malate import in glucose-stimulated insulin secretion
    Emma Heart
    BioCurrents Research Center, Marine Biological Laboratory, 7 MBL St, Lillie 219, Woods Hole, MA 02543, USA
    Am J Physiol Endocrinol Metab 296:E1354-62. 2009
    ..These data suggest that although ME1 overexpression augments anaplerosis and GSIS in INS-1 832/13 cells, it is not likely involved in MSSIS and GSIS in pancreatic islets...
  3. ncbi Rhythm of the beta-cell oscillator is not governed by a single regulator: multiple systems contribute to oscillatory behavior
    Emma Heart
    BioCurrents Research Center, Molecular Physiology Program, Marine Biological Laboratory, Woods Hole, Massachusetts 02543, USA
    Am J Physiol Endocrinol Metab 292:E1295-300. 2007
    ..This supports the hypothesis that a high-fat environment might contribute to loss of regular oscillatory pattern in diabetic subjects, acting, at least in part, at the level of the single beta-cell...
  4. ncbi Plasma membrane electron transport in pancreatic ?-cells is mediated in part by NQO1
    Joshua P Gray
    United States Coast Guard Academy, New London, Connecticut, USA
    Am J Physiol Endocrinol Metab 301:E113-21. 2011
    ..We propose a model for the role of PMET as a regulator of glycolytic flux and an important component of the metabolic machinery in ?-cells...
  5. ncbi The level of menadione redox-cycling in pancreatic ?-cells is proportional to the glucose concentration: role of NADH and consequences for insulin secretion
    Emma Heart
    Cellular Dynamics Program, Marine Biological Laboratory, Woods Hole, MA 02543, United States
    Toxicol Appl Pharmacol 258:216-25. 2012
    ..These data may explain the apparent dichotomy between the stimulatory and inhibitory effects of H(2)O(2) and menadione on insulin secretion...
  6. ncbi beta-Cell mitochondria exhibit membrane potential heterogeneity that can be altered by stimulatory or toxic fuel levels
    Jakob D Wikstrom
    Tufts University, Department of Pharmacology and Experimental Therapeutics, 136 Harrison Ave, Boston, MA 02111, USA
    Diabetes 56:2569-78. 2007
    ..This study offers insight into the different metabolic states of beta-cell mitochondria...
  7. ncbi Ca2+, NAD(P)H and membrane potential changes in pancreatic beta-cells by methyl succinate: comparison with glucose
    Emma Heart
    Obesity Research Center, Evans Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Biochem J 403:197-205. 2007
    ..The data are consistent with the common intermediates being pyruvate, cytosolic NADPH or both, and suggest that cytosolic NADPH production could account for the more rapid onset of MeS-induced secretion compared with glucose stimulation...
  8. ncbi Synchronizing Ca2+ and cAMP oscillations in pancreatic beta-cells: a role for glucose metabolism and GLP-1 receptors? Focus on "regulation of cAMP dynamics by Ca2+ and G protein-coupled receptors in the pancreatic beta-cell: a computational approach&
    George G Holz
    Am J Physiol Cell Physiol 294:C4-6. 2008
  9. ncbi Insulin-like and non-insulin-like selenium actions in 3T3-L1 adipocytes
    Emma Heart
    Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California 90089-9142, USA
    J Cell Biochem 88:719-31. 2003
    ..In summary, selenium stimulates glucose transport and antilipolysis in a PI3K-dependent manner, but independent of insulin receptor activation. Selenium exerts both insulin-like and non-insulin-like actions in cells...
  10. ncbi Glucose transport by osmotic shock and vanadate is impaired by glucosamine
    Emma Heart
    Department of Physiology and Biophysics, University of Southern California, Los Angeles, California 90089-9142, USA
    Biochem Biophys Res Commun 292:308-11. 2002
    ..These data suggest that an Akt-independent mechanism is operative in glucosamine-induced insulin resistance and glucosamine impairs glucose transport stimulated by various stimuli involving and not involving Akt activation...