Research Topics
Species | Sharon L HaleSummaryAffiliation: Mansoura University Country: USA Publications
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Publications
Mild hypothermia as a cardioprotective approach for acute myocardial infarction: laboratory to clinical applicationSharon L Hale
The Heart Institute of Good Samaritan Hospital, Los Angeles, CA 90017, USA
J Cardiovasc Pharmacol Ther 16:131-9. 2011....- Improved left ventricular function and reduced necrosis after myocardial ischemia/reperfusion in rabbits treated with ranolazine, an inhibitor of the late sodium channelSharon L Hale
The Heart Institute, Good Samaritan Hospital, 1225 Wilshire Blvd, and the Keck School of Medicine, Division of Cardiovascular Medicine, University of Southern California, Los Angeles, CA 90017, USA
J Pharmacol Exp Ther 318:418-23. 2006..Ranolazine treatment led to better ejection fraction, stroke volume and less wall motion abnormality after reperfusion, and less myocardial necrosis... - Administration of erythropoietin fails to improve long-term healing or cardiac function after myocardial infarction in the ratSharon L Hale
The Heart Institute of Good Samaritan Hospital and the Keck School of Medicine, Division of Cardiovascular Medicine, University of Southern California, Los Angeles, California 90017, USA
J Cardiovasc Pharmacol 46:211-5. 2005..Thus, in our model, treatment with epo had no long-term beneficial effect on LV remodeling after myocardial infarction but may have exerted some positive effect on LV function... - Acetaminophen and myocardial stunning after transient ischemia in rabbit heartsSharon L Hale
The Heart Institute of Good Samaritan Hospital, Los Angeles, CA 90017, USA
J Cardiovasc Pharmacol Ther 10:121-9. 2005..This study was conducted to determine whether treatment with acetaminophen results in enhanced myocardial tolerance to transient ischemia-reperfusion by improving left ventricular function and decreasing stunning in an in vivo model... - Postconditioning fails to improve no reflow or alter infarct size in an open-chest rabbit model of myocardial ischemia-reperfusionSharon L Hale
Heart Institute, Good Samaritan Hospital, 1225 Wilshire Boulevard, Los Angeles, CA 90017, USA
Am J Physiol Heart Circ Physiol 294:H421-5. 2008..PoC did not reduce infarct size in this model, nor did it reduce the extent of the anatomic zone of no reflow, suggesting that this intervention may not impact postreperfusion microvascular damage due to ischemia... - The antianginal agent, ranolazine, reduces myocardial infarct size but does not alter anatomic no-reflow or regional myocardial blood flow in ischemia/reperfusion in the rabbitSharon L Hale
Good Samaritan Hospital, Los Angeles, California 90017, USA
J Cardiovasc Pharmacol Ther 13:226-32. 2008.... - Mesenchymal stem cell administration at coronary artery reperfusion in the rat by two delivery routes: a quantitative assessmentSharon L Hale
The Heart Institute of Good Samaritan Hospital, Los Angeles, CA 90017, United States
Life Sci 83:511-5. 2008..However, MSC may not remain in the heart, but instead relocate to other areas. We investigated quantitatively the distribution of labeled rat MSC, given by two routes after coronary artery occlusion/reperfusion in rats... - Ranolazine, an inhibitor of the late sodium channel current, reduces postischemic myocardial dysfunction in the rabbitSharon L Hale
Heart Institute of Good Samaritan Hospital and the Keck School of Medicine, Division of Cardiovascular Medicine, University of Southern California, Los Angeles 90017, USA
J Cardiovasc Pharmacol Ther 11:249-55. 2006..Ranolazine treatment reduced myocardial stunning following brief ischemia/reperfusion suggesting that inhibiting the late sodium channel current may be a novel approach to treating stunning independent of effects on hemodynamics... - Diannexin reduces no-reflow after reperfusion in rabbits with large ischemic myocardial risk zonesSharon L Hale
The Heart Institute of Good Samaritan Hospital, Los Angeles, CA 90017, USA
Cardiovasc Ther 29:e42-52. 2011..In a secondary analysis, rabbits were divided into two groups based on the overall average risk zone size of 29% of the left ventricle (LV): small (<29% of LV) and large (>29% of LV)... - Cardioprotection with adenosine-regulating agent, GP531: effects on no-reflow, infarct size, and blood flow following ischemia/ reperfusion in the rabbitSharon L Hale
The Heart Institute of Good Samaritan Hospital, Los Angeles, CA 90017, USA
J Cardiovasc Pharmacol Ther 15:60-7. 2010.... - Ranolazine as a cardioplegia additive improves recovery of diastolic function in isolated rat heartsHyosook Hwang
The Heart Institute, Good Samaritan Hospital, Los Angles, CA 90017, USA
Circulation 120:S16-21. 2009..Ranolazine (Ran), an antianginal agent, inhibits late Na(+) current. The purpose of this study was to determine whether there was an added benefit of adding Ran to cardioplegia (CP) in a model of global ischemia/reperfusion... - Allogeneic mesenchymal stem cell transplantation in postinfarcted rat myocardium: short- and long-term effectsWangde Dai
The Heart Institute, Good Samaritan Hospital, Division of Cardiovascular Medicine of Keck School of Medicine at University of Southern California, Los Angeles, CalifA 90017, USA
Circulation 112:214-23. 2005..MSCs improved global LV function at 4 weeks; however, this benefit was transient, which suggests a possible early paracrine effect... - Delivering stem cells to the heart in a collagen matrix reduces relocation of cells to other organs as assessed by nanoparticle technologyWangde Dai
The Heart Institute, Good Samaritan Hospital, Division of Cardiovascular Medicine of the Keck School of Medicine at University of Southern California, 90017, USA
Regen Med 4:387-95. 2009..We determined whether retention of mesenchymal stem cells (MSCs) in the infarcted myocardium could be improved by implanting the cells in a collagen matrix... - Cardioprotective effects of angiotensin II type 1 receptor blockade with olmesartan on reperfusion injury in a rat myocardial ischemia-reperfusion modelWangde Dai
The Heart Institute of Good Samaritan Hospital, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Cardiovasc Ther 28:30-7. 2010..3 +/- 1.6% (P= 0.0018). Olmesartan significantly reduced myocardial infarct size and improved LV contractility at a dose (3 mg/kg) with systemic vasodilating effects but not at a lower dose (0.3 mg/kg) without hemodynamic effects... - Hypothermia during reperfusion limits 'no-reflow' injury in a rabbit model of acute myocardial infarctionSharon L Hale
The Heart Institute of Good Samaritan Hospital, Los Angeles, CA 90017, USA
Cardiovasc Res 59:715-22. 2003..This study tests the effects of regional hypothermia, initiated late during ischemia and maintained for 2 h of reperfusion, on the no-reflow phenomenon... - Late sodium current inhibition as a new cardioprotective approachSharon L Hale
The Heart Institute of Good Samaritan Hospital, Los Angeles, CA 90017, USA
J Mol Cell Cardiol 44:954-67. 2008..This article reviews published data describing the role of late sodium current and its inhibition by ranolazine in clinical and experimental studies of myocardial ischemia... - Role of a paracrine action of mesenchymal stem cells in the improvement of left ventricular function after coronary artery occlusion in ratsWangde Dai
The Heart Institute, Good Samaritan Hospital, Division of Cardiovascular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90017 2395, USA
Regen Med 2:63-8. 2007..We aimed to determine whether soluble factors released by cultured mesenchymal stem cells (MSCs) improved cardiac function in an experimental model of myocardial infarction... - Development of a spontaneously beating vein by cardiomyocyte transplantation in the wall of the inferior vena cava in a rat: a pilot studyWangde Dai
The Heart Institute, Good Samaritan Hospital, Division of Cardiovascular Medicine of the Keck School of Medicine at University of Southern California, Los Angeles, CA 90017, USA
J Vasc Surg 45:817-20. 2007..This study was conducted to determine whether it is feasible to develop a vein that rhythmically beats by implanting immature cardiomyocytes in its wall... - No-reflow phenomenon persists long-term after ischemia/reperfusion in the rat and predicts infarct expansionThorsten Reffelmann
The Heart Institute, Good Samaritan Hospital, University of Southern California, 1225 Wilshire Blvd, Los Angeles, CA 90017, USA
Circulation 108:2911-7. 2003.... - Elevated body temperature during myocardial ischemia/reperfusion exacerbates necrosis and worsens no-reflowSharon L Hale
Heart Institute of Good Samaritan Hospital and Department of Medicine, University of Southern California, Los Angeles, California 90017, USA
Coron Artery Dis 13:177-81. 2002..The effects of an elevated body temperature on infarct size were tested in a rabbit model of ischemia/reperfusion... - Transplantation of neonatal cardiomyocytes after permanent coronary artery occlusion increases regional blood flow of infarcted myocardiumThorsten Reffelmann
The Heart Institute, Good Samaritan Hospital, University of Southern California, 1225 Wilshire Boulevard, CA 90017-2395, Los Angeles, USA
J Mol Cell Cardiol 35:607-13. 2003..CONCLUSIONS: Transplantation of neonatal cardiomyocytes induced neo-angiogenesis in zones of successful cell engraftment within the scar, which effectively enhanced tissue perfusion... - Long-term outcome of fetal cell transplantation on postinfarction ventricular remodeling and functionMu Yao
Heart Institute, Good Samaritan Hospital, 1225 Wilshire Boulevard, CA 90017, Los Angeles, USA
J Mol Cell Cardiol 35:661-70. 2003..Thus, fetal cell-transplant therapy mitigated the longer-term adverse effects of LV remodeling following a myocardial infarction... - Acetaminophen and experimental acute myocardial infarctionSharon L Hale
The Heart Institute of Good Samaritan Hospital, and the University of Southern California, Department of Medicine, Division of Cardiovascular Medicine, Los Angeles, CA 90017, USA
Cardiovasc Drugs Ther 18:121-5. 2004..We conclude that acetaminophen has a neutral effect in this experimental model of ischemia/reperfusion and appears to be safe in the course of experimental myocardial infarction... - Relationship between no reflow and infarct size as influenced by the duration of ischemia and reperfusionThorsten Reffelmann
The Heart Institute, Good Samaritan Hospital, University of Southern California, Los Angeles, California 90017-2395, USA
Am J Physiol Heart Circ Physiol 282:H766-72. 2002..Thus microvascular reperfusion injury led to a striking decrease in RMBF within the first 2 h of reperfusion, with infarct size as the major determinant of reflow at a given time point of reperfusion... - Ranolazine as an adjunct to cardioplegia: a potential new therapeutic applicationHyosook Hwang
Heart Institute, Good Samaritan Hospital, Los Angeles, California 90017, USA
J Cardiovasc Pharmacol Ther 14:125-33. 2009..05). These results suggest that addition of ranolazine during hyperkalemic ischemic cardioplegic arrest is beneficial and provides further protection against contracture... - Cardiac cells implanted within the outer aortic wall of rats generate measurable contractile forceWangde Dai
University of Southern California, The Heart Institute, Good Samaritan Hospital, Los Angeles, California 90017-2395, USA
Regen Med 1:119-24. 2006..This study may serve as a useful model for studying the growth and response of the grafted cardiomyocytes to various stimuli in an extra-cardiac environment in vivo... - Effects of zoledronate in the repair of chronically infarcted rat myocardiumHyosook Hwang
The Heart Institute, Good Samaritan Hospital, 1225 Wilshire Boulevard, Los Angeles, CA 90017, USA
J Cardiovasc Pharmacol 56:604-9. 2010..These results suggest that treatment of Zol given before the onset of myocardial infarction does not cause worsening of infarct repair... - Survival and maturation of human embryonic stem cell-derived cardiomyocytes in rat heartsWangde Dai
The Heart Institute, Good Samaritan Hospital, University of Southern California, 1225 Wilshire Boulevard, Los Angeles, CA 90017 2395, USA
J Mol Cell Cardiol 43:504-16. 2007..However, hESC-derived cells did not escape immune surveillance in the xenograft setting in that they elicited a rejection phenomenon in immune competent rats... - Implantation of immature neonatal cardiac cells into the wall of the aorta in rats: a novel model for studying morphological and functional development of heart cells in an extracardiac environmentWangde Dai
The Heart Institute, Good Samaritan Hospital, Division of Cardiovascular Medicine, University of Southern California, Los Angeles, California, USA
Circulation 110:324-9. 2004..CONCLUSIONS: Grafted neonatal cardiomyocytes survive, differentiate, grow, develop a blood supply, and spontaneously contract within the wall of the aorta in rats... - Metabolic mechanism by which mild regional hypothermia preserves ischemic tissueBoris Z Simkhovich
Heart Institute, Good Samaritan Hospital, Los Angeles, California 90017, USA
J Cardiovasc Pharmacol Ther 9:83-90. 2004..We hypothesized that a moderate reduction in regional myocardial temperature could preserve cardiac energy metabolism and thus protect the myocardium from sustained ischemic insult... - Granulocyte colony-stimulating factor and stem cell factor improve contractile reserve of the infarcted left ventricle independent of restoring muscle massCasilde Sesti
Heart Institute, Good Samaritan Hospital, Cardiovascular Division, Keck School of Medicine at the University of Southern California, Los Angeles, California 90017-2395, USA
J Am Coll Cardiol 46:1662-9. 2005..CONCLUSIONS: Because we did not find evidence of new muscle cells in the infarct area, our conclusion is that G-CSF and SCF enhanced the LV functional reserve of the heart without replacing scar tissue... - Stem cell therapy for the heartLoren E Wold
The Heart Institute, Good Samaritan Hospital, 1225 Wilshire Boulevard, Los Angeles, CA 90017, USA
Congest Heart Fail 10:293-301. 2004..Several questions must be answered, however, before stem cells can be used routinely in the clinic. Once these questions have been addressed, the use of stem cells in clinical practice can be realized... - Gene activity changes in ischemically preconditioned rabbit heart gene: discovery array studyBoris Z Simkhovich
Heart Institute, Good Samaritan Hospital, Los Angeles, California 90017, USA
Heart Dis 4:63-9. 2002..None of the identified genes had been previously reported to be involved in ischemic preconditioning... - Real-time intravascular shear stress in the rabbit abdominal aortaLisong Ai
Department of Biomedical Engineering and Cardiovascular Medicine, University of Southern California, Los Angeles, CA 90089 1111, USA
IEEE Trans Biomed Eng 56:1755-64. 2009..9% in peak systolic shear stress. Despite the difference between CD and experimental results, the flexible coaxial-wire-based MEMS sensors provided a possibility to assess real-time ISS in the abdominal aorta of NZW rabbits... - ATL 313, A Selective A(2A) Adenosine Receptor Agonist, Reduces Myocardial Infarct Size in a Rat Ischemia/Reperfusion ModelWangde Dai
The Heart Institute of Good Samaritan Hospital, And Division of Cardiovascular Medicine of the Keck School of Medicine, University of Southern California, Los Angeles, California 90017 2395, USA
Open Cardiovasc Med J 3:166-72. 2009..We investigated whether ATL 313, a new selective A(2A)AR agonist, could reduce myocardial infarct size in a rat ischemia/reperfusion model...