Research Topics
| Thomas D NolinSummaryAffiliation: Maine Medical Center Country: USA Publications
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Detail Information
Publications
Altered nonrenal drug clearance in ESRDThomas D Nolin
Division of Nephrology and Transplantation, Department of Medicine, Maine Medical Center, Portland, ME 04102, USA
Curr Opin Nephrol Hypertens 17:555-9. 2008..The present review summarizes these studies and critically assesses the proposed mechanisms and clinical implications of altered nonrenal clearance in ESRD...- Simultaneous determination of total homocysteine, cysteine, cysteinylglycine, and glutathione in human plasma by high-performance liquid chromatography: application to studies of oxidative stressThomas D Nolin
Division of Nephrology and Transplantation, Department of Medicine, Maine Medical Center, 22 Bramhall Street, Portland, ME 04102, USA
J Chromatogr B Analyt Technol Biomed Life Sci 852:554-61. 2007..This assay is well suited for high-throughput quantitative determination of aminothiols in clinical studies, and is currently being used to support investigations of oxidative stress in patients with chronic kidney disease... - Antimicrobial-associated QT interval prolongation: pointes of interestRobert C Owens
Department of Clinical Pharmacy Services, Maine Medical Center, Portland, ME 04102, USA
Clin Infect Dis 43:1603-11. 2006..Additionally, because TdP remains a difficult-to-measure adverse event, we must rely upon multiple data sources to determine the risk versus the benefit for newly approved drugs... - Hemodialysis acutely improves hepatic CYP3A4 metabolic activityThomas D Nolin
Division of Nephrology and Transplantation, Department of Medicine, Maine Medical Center, 22 Bramhall Street, Portland, ME 04102, USA
J Am Soc Nephrol 17:2363-7. 2006..50, P = 0.012), but not to several middle molecules. This is the first study in humans characterizing uremia as a state in which hepatic CYP3A4 activity is acutely improved by hemodialysis... - Are biomarkers useful for assessing cardiovascular risk in patients with chronic kidney disease?Clifford Rubin
Division of Nephrology and Transplantation, Department of Medicine, Maine Medical Center, Portland, Maine 04102, USA
Curr Opin Nephrol Hypertens 16:506-11. 2007..This review will summarize these studies and critically assess the utility of cardiovascular risk biomarkers for clinical practice... - Nocturia and aging: diagnosis and treatmentSarinya Boongird
Department of Medicine, University of Pittsburgh Medical Center Shadyside, PA, USA
Adv Chronic Kidney Dis 17:e27-40. 2010..This review will provide an overview of the effect of aging on the kidneys and urinary system, the pathophysiology, clinical assessment, and treatment strategies of nocturia, and its effect on health-related quality of life... - Hepatic drug metabolism and transport in patients with kidney diseaseThomas D Nolin
Department of Pharmacy Services and Division of Nephrology and Renal Transplantation, Maine Medical Center, Portland, ME, USA
Am J Kidney Dis 42:906-25. 2003..Knowledge of the impact and nature of these alterations associated with kidney disease may facilitate the individualization of medication management in this patient population... - Primary care of the renal transplant patientGaurav Gupta
Nephrology Division, Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
J Gen Intern Med 25:731-40. 2010..In this narrative review, we examine the common medical problems seen in KTR from the PCP's perspective. Medical management issues related to immunosuppressive medications are also briefly discussed... - Stability of atropine sulfate prepared for mass chemical terrorismJackie Dix
Department of Pharmacy and Therapeutics, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania, USA
J Toxicol Clin Toxicol 41:771-5. 2003..A 1 mg/mL solution is stable for at least 3 days, allowing for use during the most critical treatment periods after exposure... - Impaired 6-hydroxychlorzoxazone elimination in patients with kidney disease: Implication for cytochrome P450 2E1 pharmacogenetic studiesThomas D Nolin
Pharmacodynamic Research Center, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA
Clin Pharmacol Ther 74:555-68. 2003..The results of this study show that the commonly used plasma-based chlorzoxazone metabolic ratio is dependent on renal function and, therefore, does not provide a reliable index of CYP2E1-mediated metabolism... - Stereoselective determination of the CYP2C19 probe drug mephenytoin in human urine by gas chromatography-mass spectrometryThomas D Nolin
Pharmacodynamic Research Center, Center for Pharmacogenetics, Department of Pharmaceutical Sciences, University of Pittsburgh, 15261, Pittsburgh, PA, USA
J Chromatogr B Analyt Technol Biomed Life Sci 783:265-71. 2003..This method is well suited for the phenotypic evaluation of CYP2C19 activity using mephenytoin... - Rapid microtiter plate assay for determination of inulin in human plasma and dialysateThomas D Nolin
Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA
J Pharm Biomed Anal 28:209-15. 2002..This method is well suited for the rapid analysis of large numbers of samples and is currently being used for in vitro investigations of solute removal by hemodialysis...