Research Topics
| Mandi J LopezSummaryAffiliation: Louisiana State University Country: USA Publications
Research Grants
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Detail Information
Publications
Acceleration of spinal fusion using syngeneic and allogeneic adult adipose derived stem cells in a rat modelMandi J Lopez
Laboratory for Equine and Comparative Orthopedic Research, Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Skip Bertman Drive, Louisiana State University, Baton Rouge, Louisiana 70803, USA
J Orthop Res 27:366-73. 2009..3 +/- 0.85%; allogeneic = 23.5 +/- 2.33%) versus scaffold alone (46.8 +/- 11.8%) 4 weeks after surgery. Results of this study support syngeneic and allogeneic ASC acceleration of posterior lumbar spinal fusion in a rat model...- In vivo evaluation of intra-articular protection in a novel model of canine cranial cruciate ligament mid-substance elongation injuryMandi J Lopez
Laboratory for Equine and Comparative Orthopedic Research, Veterinary Clinical Sciences Department, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA
Vet Surg 35:711-20. 2006..To evaluate the effects of intra-articular protection (IAP) on the canine cranial cruciate ligament (CrCL) and stifle in a CrCL midsubstance elongation injury model... - Monopolar radiofrequency energy application to the dorsal extensor tendon apparatus in a canine model of tendon injuryMandi J Lopez
Laboratory for Equine and Comparative Orthopedic Research, School of Veterinary Medicine, Louisiana State University, Baton Rouge, 70803, USA
J Hand Surg Am 31:1296-302. 2006..To evaluate the use of monopolar radiofrequency energy (MRFE) to shorten stretched dorsal extensor tendon apparatus (DETA) tissues in a canine model... - Associations between canine juvenile weight gain and coxofemoral joint laxity at 16 weeks of ageMandi J Lopez
Comparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA
Vet Surg 35:214-8. 2006..Evaluation of the relationship between canine weight gain from 6 to 15 weeks of age and passive coxofemoral joint (CFJ) laxity at 16 weeks of age... - Instrumented measurement of in vivo anterior-posterior translation in the canine knee to assess anterior cruciate integrityMandi J Lopez
Comparative Orthopaedic Research Laboratory, Department of Medical Sciences, Veterinary Medical Teaching Hospital, University of Wisconsin Madison, Madison, WI 53706, USA
J Orthop Res 22:949-54. 2004..This precise non-invasive technique to assess canine knee translational stability and ACL integrity permits repetitive, objective measurements for diagnostic use and to assess therapeutic intervention efficacy... - Interobserver repeatability of measurements on computed tomography images of lax canine hip joints from youth to maturityMandi J Lopez
Laboratory for Equine and Comparative Orthopedic Research, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA
Vet Surg 38:920-6. 2009..To determine interobserver repeatability of measurements on computed tomography (CT) images of lax canine hip joints at different ages and in the presence of degenerative joint disease at maturity... - Biomechanical characteristics of an implant used to secure semitendinosus-gracilis tendon grafts in a canine model of extra-articular anterior cruciate ligament reconstructionMandi J Lopez
Laboratory for Equine and Comparative Orthopedic Research, School of Veterinary Medicine, and the Department of Biological and Agricultural Engineering, Louisiana State University and AgCenter, Baton Rouge, LA 70803 8410, USA
Vet Surg 36:599-604. 2007..To compare initial femoral fixation properties of a new implant, Graftgrab (GG), with 2 established methods of extra-articular femoral graft fixation, spiked washers (SW) and bone staples (ST)... - Characterization of equine adipose tissue-derived stromal cells: adipogenic and osteogenic capacity and comparison with bone marrow-derived mesenchymal stromal cellsMartin A Vidal
Equine Health Studies Program, Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA
Vet Surg 36:613-22. 2007..To characterize equine adipose tissue-derived stromal cell (ASC) frequency and growth characteristics and assess of their adipogenic and osteogenic differentiation potential... - In vitro adult canine adipose tissue-derived stromal cell growth characteristicsNakia D Spencer
Laboratory for Equine and Comparative Orthopedic Research, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA
Methods Mol Biol 702:47-60. 2011..In order to optimize the use of stromal cell therapy in the dog as a patient or disease model, a comprehensive characterization of the cells is required... - Comparison of chondrogenic potential in equine mesenchymal stromal cells derived from adipose tissue and bone marrowMartin A Vidal
Equine Health Studies Program, Laboratory for Equine and Comparative Orthopedic Research, Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA
Vet Surg 37:713-24. 2008..To compare the chondrogenic potential of adult equine mesenchymal stem cells derived from bone marrow (MSCs) or adipose tissue (ASCs)... - Ex vivo comparison of three surgical techniques to stabilize canine cranial cruciate ligament deficient stiflesLynne A Snow
Laboratory for Equine and Comparative Orthopedic Research, Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA
Vet Surg 39:195-207. 2010..To quantify and compare canine stifle stability after 3 stabilization techniques... - Impaired expansion and multipotentiality of adult stromal cells in a rat chronic alcohol abuse modelNan K Huff
Department of Veterinary Clinical Sciences, Laboratory for Equine and Comparative Orthopedic Research, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA
Alcohol 45:393-402. 2011..Maintenance of the effects through multiple cell passages in vitro suggests cells may be permanently compromised... - Evaluation of gait kinetics in puppies with coxofemoral joint laxityMandi J Lopez
Laboratory for Equine and Comparative Orthopedic Research, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA
Am J Vet Res 67:236-41. 2006..The GRFs and elucidation of the relationship between GRFs and DI may be useful for future studies in immature dogs... - Effects of athletic conditioning on horses with degenerative suspensory ligament desmitis: a preliminary reportLin Xie
Laboratory for Equine and Comparative Orthopedic Research, Equine Health Studies Program, Department of Veterinary Clinical Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
Vet J 189:49-57. 2011..Insulin levels significantly decreased from baseline in all horses after 4 and 8 weeks of exercise. Exercise did not seem to exacerbate and may have improved signs of DSLD in mild to moderate cases... - Hamstring graft technique for stabilization of canine cranial cruciate ligament deficient stiflesMandi J Lopez
Comparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA
Vet Surg 32:390-401. 2003..CLINICAL RELEVANCE: Hamstring grafts may be an alternative technique for canine CrCL reconstruction. Further study is needed before clinical application... - Adipogenic differentiation of adult equine mesenchymal stromal cellsMartin A Vidal
JD Wheat Veterinary Orthopedic Research Laboratory, School of Veterinary Medicine, University of California Davis, Davis, CA, USA
Methods Mol Biol 702:61-75. 2011..The reader is also directed to other reported methods of adipogenesis for ASCs and mesenchymal stem cells (MSCs) from other tissues... - Anterior cruciate ligament rupture after thermal treatment in a canine modelMandi J Lopez
Comparative Orthopaedic Research Laboratory, Department of Medical Sciences, Veterinary Medical Teaching Hospital, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA
Am J Sports Med 31:164-7. 2003..Use of this modality should be followed by adherence to a highly conservative rehabilitation protocol... - Mesenchymal stromal cells: past, present, and futureNakia D Spencer
Laboratory for Equine and Comparative Orthopedic Research, Louisiana State University, School of Veterinary Medicine, Veterinary Clinical Sciences, Baton Rouge, LA 70803, USA
Vet Surg 40:129-39. 2011..Positive results from a number of recent investigations support the use of adult mesenchymal stromal cells for clinical application. This review article provides a brief overview of past, present, and future stromal cell technology... - In vitro adult rat adipose tissue-derived stromal cell isolation and differentiationMandi J Lopez
Laboratory for Equine and Comparative Orthopedic Research, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA
Methods Mol Biol 702:37-46. 2011..Isolation and expansion techniques for rat ASCs continue to change with advances in technology and ASC biology. The information presented in this chapter is a summary of rat ASC harvest, isolation, quantification, and in vitro expansion... - Adipose tissue as a stem cell source for musculoskeletal regenerationJeffrey M Gimble
Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
Front Biosci (Schol Ed) 3:69-81. 2011..We discuss the utility of ASCs for musculo-skeletal tissue repair and some of the technologies that can be implemented to unlock the full regenerative potential of these highly valuable cells... - A comparison of joint stability between anterior cruciate intact and deficient knees: a new canine model of anterior cruciate ligament disruptionMandi J Lopez
Department of Medical Sciences, University of Wisconsin, 2015 Linden Drive, Madison, WI 53076, USA
J Orthop Res 21:224-30. 2003..This model may also be useful for insight into the pathologic changes that occur in the knee as the ACL undergoes degeneration prior to rupture... - Relationships of hip joint volume ratios with degrees of joint laxity and degenerative disease from youth to maturity in a canine population predisposed to hip joint osteoarthritisLaura L D'Amico
Laboratory for Equine and Comparative Orthopedic Research, Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA
Am J Vet Res 72:376-83. 2011.... - Effect of rhBMP-2 on tibial plateau fractures in a canine modelSusan L Schaefer
Comparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
J Orthop Res 27:466-71. 2009..This study demonstrated that rhBMP-2/CPX accelerated healing of articular fractures with subchondral defect compared to ABG in most of the parameters evaluated, and had less subsynovial inflammation than the CPX alone in a canine model... - Effects of extracorporeal shock wave therapy on desmitis of the accessory ligament of the deep digital flexor tendon in the horseR Wayne Waguespack
Department of Veterinary Clinical Sciences, Louisiana State University, Baton Rouge, LA, USA
Vet Surg 40:450-6. 2011..To evaluate the effects of extracorporeal shock wave therapy (ESWT) on collagenase-induced lesions in the accessory ligament of the deep digital flexor tendon (ALDDFT) of horses... - Characterization of normal canine anterior cruciate ligament-associated synoviocytesSunil C Vasanjee
Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Skip Bertman Drive, Louisiana State University, Baton Rouge, Louisiana 70803, USA
J Orthop Res 26:809-15. 2008..Identification and quantification of ACL synoviocytes may serve as the foundation for future studies involving ACL disease or reconstruction... - Relationships among measurements obtained by use of computed tomography and radiography and scores of cartilage microdamage in hip joints with moderate to severe joint laxity of adult dogsMandi J Lopez
School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA
Am J Vet Res 69:362-70. 2008..To evaluate correlations among measurements on radiographic and computed tomography (CT) images with articular cartilage microdamage in lax hip joints of dogs... - In vitro expansion and differentiation of fresh and revitalized adult canine bone marrow-derived and adipose tissue-derived stromal cellsNakia D Spencer
Laboratory for Equine and Comparative Orthopedic Research, Louisiana State University, School of Veterinary Medicine, Skip Bertman Drive, Baton Rouge, LA 70803, USA
Vet J 191:231-9. 2012..Protein was significantly greater in P3 versus P6 ASC chondrogenic pellets. Based on these findings, fresh and revitalized canine ASCs are viable alternatives to BMSCs for stromal cell applications... - Cell growth characteristics and differentiation frequency of adherent equine bone marrow-derived mesenchymal stromal cells: adipogenic and osteogenic capacityMartin A Vidal
Equine Health Studies Program, Department of Veterinary Clinical Sciences, School of Veterinary Medicine and the Stem Cell Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA
Vet Surg 35:601-10. 2006..To characterize equine bone marrow (BM)-derived mesenchymal stem cell (MSC) growth characteristics and frequency as well as their adipogenic and osteogenic differentiation potential... - Molecular identification of Phialophora oxyspora as the cause of mycetoma in a horseMandi J Lopez
Laboratory for Equine and Comparative Orthopedic Research, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA
J Am Vet Med Assoc 230:84-8. 2007..An 18-year-old mare was evaluated for an oral mass that developed after extraction of a broken incisor... - Fully 2'-deoxy-2'-fluoro substituted nucleic acids induce RNA interference in mammalian cell cultureRichard A Blidner
Department of Biological and Agricultural Engineering, Louisiana State University and Agricultural Center, Baton Rouge, LA 70803, USA
Chem Biol Drug Des 70:113-22. 2007....
Research Grants
- Prevention of Hip Dysplasia with Thermal EnergyMANDI LOPEZ; Fiscal Year: 2005..The University of Wisconsin provides an exceptional environment for interaction with experts in a variety of fields, and it is well known for its exceptional research programs, especially in the medical sciences. ..