Research Topics
Genomes and GenesSpecies | MARY IOVINESummaryAffiliation: Lehigh University Country: USA Publications
Research Grants
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Detail Information
Publications
Conserved mechanisms regulate outgrowth in zebrafish finsM Kathryn Iovine
Lehigh University Department of Biological Sciences, 111 Research Drive, Iacocca B217, Bethlehem, Pennsylvania 18015, USA
Nat Chem Biol 3:613-8. 2007..Future perspectives describe opportunities using the zebrafish fin to reveal mechanisms underlying the regulation of final size...- Mutations in connexin43 (GJA1) perturb bone growth in zebrafish finsM Kathryn Iovine
Lehigh University, 111 Research Drive, Iacocca B 217, Bethlehem, PA 18015, USA
Dev Biol 278:208-19. 2005.... - Cx23, a connexin with only four extracellular-loop cysteines, forms functional gap junction channels and hemichannelsM Kathryn Iovine
Department of Biological Sciences, Lehigh University, 111 Research Drive, Bethlehem, PA 18015, USA
FEBS Lett 582:165-70. 2008..Functional assays reveal that the Cx23 gap junctions are capable of sharing neurobiotin, and further, that Cx23 connexins form hemichannels in vitro... - Cx40.8, a Cx43-like protein, forms gap junction channels inefficiently and may require Cx43 for its association at the plasma membraneSarah V Gerhart
Lehigh University, Department of Biological Sciences, 111 Research Drive, Iacocca B 217, Bethlehem, PA 18015, United States
FEBS Lett 583:3419-24. 2009..Together, these data suggest the possibility that Cx40.8 may functionally interact with Cx43 to regulate cell proliferation in vivo... - Connexin43 regulates joint location in zebrafish finsKenneth Sims
Lehigh University, Department of Biological Sciences, 111 Research Drive, Iacocca B 217, Bethlehem, PA 18015, USA
Dev Biol 327:410-8. 2009..One possibility is that communication between the Cx43-positive mesenchyme and the overlying ZNS5-positive cells regulates joint location, and upregulation of Cx43 in joint-forming cells contributes to joint morphogenesis... - Zebrafish short fin mutations in connexin43 lead to aberrant gap junctional intercellular communicationAngela D Hoptak-Solga
Lehigh University, Department of Biological Sciences, Iacocca B 217, Bethlehem, PA 18015, USA
FEBS Lett 581:3297-302. 2007..Therefore, measurable differences in Cx43 function may be correlated with the severity of defects in bone length... - Connexin43 (GJA1) is required in the population of dividing cells during fin regenerationAngela D Hoptak-Solga
Lehigh University, Department of Biological Sciences, 111 Research Drive, Iacocca B 217, Bethlehem, PA 18015, USA
Dev Biol 317:541-8. 2008..We hypothesize that the level of gap junctional intercellular communication among dividing cells regulates the level of cell proliferation and ultimately regulates bone growth... - Fin-mutant female zebrafish (Danio rerio) exhibit differences in association preferences for male fin lengthJennifer M Gumm
Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA
Behav Processes 80:35-8. 2009..These results suggest that the single gene long fin mutation that results in altered fin morphological may also be involved in a related female association preference... - Osteoblast maturation occurs in overlapping proximal-distal compartments during fin regeneration in zebrafishAndrew M Brown
Lehigh University, Department of Biological Science, Bethlehem, Pennsylvania 18015, USA
Dev Dyn 238:2922-8. 2009.... - Bone growth in zebrafish fins occurs via multiple pulses of cell proliferationIsha Jain
Lehigh University, Department of Biological Sciences, Bethlehem, Pennsylvania 18015, USA
Dev Dyn 236:2668-74. 2007..These results indicate that segment lengthening requires multiple pulses of cell proliferation... - Phylogenetic analysis of three complete gap junction gene families reveals lineage-specific duplications and highly supported gene classesStephen D Eastman
Department of Biological Sciences, Lehigh University, 111 Research Drive, Iacocca B-217, Bethlehem, PA 18015, USA
Genomics 87:265-74. 2006..The identification of a third complete connexin gene family provides novel insight into the evolution of connexins, and sheds light into the phenotypic evolution of intercellular communication via gap junctions... - A developmental transition in growth control during zebrafish caudal fin developmentMatthew I Goldsmith
Department of Pediatrics, Washington University School of Medicine, 660 S Euclid Avenue, Campus Box 8208, St Louis, MO 63110, USA
Dev Biol 296:450-7. 2006.... - A genetic, deletion, physical, and human homology map of the long fin region on zebrafish linkage group 2M Kathryn Iovine
Genomics 79:756-9. 2002....
Research Grants
- Dermal Bone Growth in the ZebrafishMARY IOVINE; Fiscal Year: 2006..By completing these aims, this proposal will provide new insights of direct relevance for understanding the biology of human malformations. ..
- Gap junctional communication during zebrafish fin growthMARY IOVINE; Fiscal Year: 2009..Furthermore, these insights will directly facilitate future understanding of the biology of human bone malformations. ..