Research Topics
| James W ChanSummaryAffiliation: Lawrence Livermore National Laboratory Country: USA Publications
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Detail Information
Publications
Micro-Raman spectroscopy detects individual neoplastic and normal hematopoietic cellsJames W Chan
Lawrence Livermore National Laboratory, Livermore, California 94551, USA
Biophys J 90:648-56. 2006....- An integrated optofluidic platform for Raman-activated cell sortingAdrian Y Lau
Applied Physics and Biophysics Division, Lawrence Livermore National Laboratory, P O Box 808, L 211, Livermore, CA 94550, USA
Lab Chip 8:1116-20. 2008..This functional prototype lays the foundation for the development of a label-free cell sorting platform based on intrinsic Raman markers for automated sampling and sorting of a large number of individual cells in solution... - Label-free biochemical characterization of stem cells using vibrational spectroscopyJames W Chan
NSF Center for Biophotonics Science and Technology, University of California, Davis, 2700 Stockton Blvd Suite 1400, Sacramento, CA 95817, USA
J Biophotonics 2:656-68. 2009..A discussion of the potential for these methods to address some of the major challenges in stem cell research is presented, as well as the technological and scientific advancements that are needed to progress the knowledge in the field... - Label-free separation of human embryonic stem cells and their cardiac derivatives using Raman spectroscopyJames W Chan
Applied Physics and Biophysics Division, Physical Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California 94550, USA
Anal Chem 81:1324-31. 2009.... - The effect of cell fixation on the discrimination of normal and leukemia cells with laser tweezers Raman spectroscopyJames W Chan
Applied Physics and Biophysics Division, Lawrence Livermore National Laboratory, CA 94550, USA
Biopolymers 91:132-9. 2009.... - Nondestructive identification of individual leukemia cells by laser trapping Raman spectroscopyJames W Chan
Applied Physics and Biophysics Division, Physical Sciences Directorate, Lawrence Livermore National Laboratory, P O Box 808, L 211, Livermore, California 94551, USA
Anal Chem 80:2180-7. 2008..We also provide evidence that these markers are unique to cancer cells and not purely a function of differences in their cellular activation... - Monitoring dynamic protein expression in living E. coli. Bacterial cells by laser tweezers Raman spectroscopyJames W Chan
Applied Physics and Biophysics Division, Physics and Advanced Technologies Directorate, Lawrence Livermore National Laboratory, Livermore, California 94551, USA
Cytometry A 71:468-74. 2007..Here, we demonstrate its use to monitor changes in a population of E. coli cells that occur during overexpression of a protein, the extracellular domain of myelin oligodendrocyte glycoprotein [MOG(1-120)]... - Evaluation of Escherichia coli cell response to antibiotic treatment by use of Raman spectroscopy with laser tweezersTobias J Moritz
Biophysics Graduate Group, University of California, Davis, Davis, California 95616, USA
J Clin Microbiol 48:4287-90. 2010..Time-dependent intensity changes of several Raman peaks at 729, 1,245, and 1,660 cm(-1) enabled untreated cells and cells treated with the different antibiotic drugs to be distinguished... - Label-free identification and characterization of human pluripotent stem cell-derived cardiomyocytes using second harmonic generation (SHG) microscopySamir Awasthi
NSF Center for Biophotonics Science and Technology, University of California, Davis, 2700 Stockton Blvd, Suite 1400, Sacramento, CA 95817, USA
J Biophotonics 5:57-66. 2012..Our study demonstrates the feasibility of developing a SHG-activated flow cytometer for the non-invasive purification of PSC-CMs... - Effect of cefazolin treatment on the nonresonant Raman signatures of the metabolic state of individual Escherichia coli cellsTobias J Moritz
Biophysics Graduate Group, University of California, Davis, California 95616, USA
Anal Chem 82:2703-10. 2010..These results suggest that potential Raman markers exist that can be used to identify E. coli cell response to antibiotic drug treatment... - Optical coherence tomography and Raman spectroscopy of the ex-vivo retinaJulia W Evans
Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore 94550, USA
J Biophotonics 2:398-406. 2009..We present our first results and discuss the challenges to further development of this dual-mode instrument and limitations for future in-vivo retinal imaging... - Parallel analysis of individual biological cells using multifocal laser tweezers Raman spectroscopyRui Liu
NSF Center for Biophotonics Science and Technology, University of California, Davis, Sacramento, California 95817, USA
Appl Spectrosc 64:1308-10. 2010..By improving the rate of single-cell analysis, M-LTRS is expected to be a valuable method for studying single-cell dynamics of cell populations and for the development of high-throughput Raman based cytometers... - Growth, differentiation, and biochemical signatures of rhesus monkey mesenchymal stem cellsBrandon S Kim
California National Primate Research Center, University of California, Davis, CA 95616 8542, USA
Stem Cells Dev 17:185-98. 2008....