Research Topics
Species | ALESSANDRO D SETTESummaryAffiliation: La Jolla Institute for Allergy and Immunology Country: USA Publications
Research Grants
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Detail Information
Publications
Epitope-based vaccines: an update on epitope identification, vaccine design and deliveryAlessandro Sette
La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
Curr Opin Immunol 15:461-70. 2003..Recent advances in understanding the mechanisms of immunodominance thus represent an opportunity to further develop the epitope-based approach...- The immune epitope database and analysis resource: from vision to blueprintBjoern Peters
La Jolla Institute of Allergy and Immunology, San Diego, California, USA
PLoS Biol 3:e91. 2005 - Identification and localization of minimal MHC-restricted CD8+ T cell epitopes within the Plasmodium falciparum AMA1 proteinMartha Sedegah
USMMVP, Malaria Department, NMRC, Silver Spring, MD 20910, USA
Malar J 9:241. 2010..Since CD8+ T cell responses have been implicated in protection against pre-erythrocytic stage malaria, this study was designed to identify MHC class I-restricted epitopes within AMA1... - Human immunome, bioinformatic analyses using HLA supermotifs and the parasite genome, binding assays, studies of human T cell responses, and immunization of HLA-A*1101 transgenic mice including novel adjuvants provide a foundation for HLA-A03 restricted CHua Cong
Departments of Surgery Ophthalmology and Visual Sciences and Pediatrics Infectious Disease, Committees on Immunology, Molecular Medicine, and Genetics, Institute of Genomics and Systems Biology, and The College, The University of Chicago, Chicago, Illinois 60637, USA
Immunome Res 6:12. 2010.... - Polyfunctional CD4+ T cell responses to a set of pathogenic arenaviruses provide broad population coverageMaya F Kotturi
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, California, 92037 USA
Immunome Res 6:4. 2010.... - Functional analysis of frequently expressed Chinese rhesus macaque MHC class I molecules Mamu-A1*02601 and Mamu-B*08301 reveals HLA-A2 and HLA-A3 supertypic specificitiesScott Southwood
Department of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
Immunogenetics 63:275-90. 2011.... - HLA class I supertypes: a revised and updated classificationJohn Sidney
Division of Vaccine Discovery, The La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
BMC Immunol 9:1. 2008..The utility of this original supertype classification, as well several other subsequent arrangements derived by others, has been demonstrated in a large number of epitope identification studies... - Predicting population coverage of T-cell epitope-based diagnostics and vaccinesHuynh Hoa Bui
La Jolla Institute for Allergy and Immunology, Division of Vaccine Discovery, 3030 Bunker Hill Street, Suite 326, San Diego, CA 92109, USA
BMC Bioinformatics 7:153. 2006..Thus, without careful consideration, a vaccine or diagnostic with ethnically biased population coverage could result... - Curation of complex, context-dependent immunological dataRandi Vita
La Jolla Institute for Allergy and Immunology, 3030 Bunker Hill Street, Suite 326, San Diego, California, USA
BMC Bioinformatics 7:341. 2006..The Immune Epitope Database and Analysis Resource (IEDB) is dedicated to capturing, housing and analyzing complex immune epitope related data http://www.immuneepitope.org... - Automating document classification for the Immune Epitope DatabasePeng Wang
The La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
BMC Bioinformatics 8:269. 2007..Like similar projects in other knowledge domains, significant effort is spent on identifying which articles are relevant for this purpose... - Peptide binding predictions for HLA DR, DP and DQ moleculesPeng Wang
La Jolla Institute for Allergy and Immunology, La Jolla, USA
BMC Bioinformatics 11:568. 2010..This reflects a significant gap in knowledge as HLA DP and DQ molecules are presumably equally important, and have only been studied less because they are more difficult to handle experimentally... - Derivation of an amino acid similarity matrix for peptide: MHC binding and its application as a Bayesian priorYohan Kim
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
BMC Bioinformatics 10:394. 2009..Our aim is to quantify this measure of similarity to improve peptide:MHC binding prediction methods. This should help compensate for holes and bias in the sequence space coverage of existing peptide binding datasets... - Development of an epitope conservancy analysis tool to facilitate the design of epitope-based diagnostics and vaccinesHuynh Hoa Bui
La Jolla Institute for Allergy and Immunology, Division of Vaccine Discovery, 9420 Athena Circle, La Jolla, CA 92037, USA
BMC Bioinformatics 8:361. 2007..In both cases, concrete information pertaining to the degree of conservancy of the epitope(s) considered is crucial... - Generating quantitative models describing the sequence specificity of biological processes with the stabilized matrix methodBjoern Peters
La Jolla Institute for Allergy and Immunology, 3030 Bunker Hill Street, Suite 326, San Diego, CA 92109, USA
BMC Bioinformatics 6:132. 2005..This method has been successfully applied to predicting peptide binding to MHC molecules, peptide transport by the transporter associated with antigen presentation (TAP) and proteasomal cleavage of protein sequences... - ElliPro: a new structure-based tool for the prediction of antibody epitopesJulia Ponomarenko
San Diego Supercomputer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
BMC Bioinformatics 9:514. 2008..The aim of this work was to implement that method as a web-tool and evaluate its performance on discontinuous epitopes known from the structures of antibody-protein complexes... - The immune epitope database and analysis resource: from vision to blueprintAlessandro Sette
La Jolla Institute for Allergy and Immunology, San Diego, California 92109, USA
Genome Inform 15:299. 2004 - Of mice and humans: how good are HLA transgenic mice as a model of human immune responses?Maya F Kotturi
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
Immunome Res 5:3. 2009.... - Classification of A1- and A24-supertype molecules by analysis of their MHC-peptide binding repertoiresJohn Sidney
La Jolla Institute for Allergy and Immunology, 3030 Bunker Hill St, Ste 326, San Diego, CA, 92109, USA
Immunogenetics 57:393-408. 2005.... - Definition of epitopes and antigens recognized by vaccinia specific immune responses: their conservation in variola virus sequences, and use as a model system to study complex pathogensAlessandro Sette
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
Vaccine 27:G21-6. 2009..Finally, we find that the vast majority of VACV epitopes are conserved in variola virus (VARV), thus suggesting that the epitopes defined herein also have relevance for the efficacy of VACV as a smallpox vaccine... - A roadmap for the immunomics of category A-C pathogensAlessandro Sette
La Jolla Institute for Allegy and Immunology, San Diego, CA 92121, USA
Immunity 22:155-61. 2005..Herein is an account of the meeting and its results... - Class I molecules with similar peptide-binding specificities are the result of both common ancestry and convergent evolutionAlessandro Sette
La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
Immunogenetics 54:830-41. 2003.... - Immune epitope mapping in the post-genomic era: lessons for vaccine developmentAlessandro Sette
La Jolla Institute for Allergy and Immunology, Division of Vaccine Discovery, 9420 Athena Circle, La Jolla, CA 92037, USA
Curr Opin Immunol 19:106-10. 2007..However, they raise the question if vaccines, which try to emulate protective natural immune responses, should elicit an equally broad range of responses to efficiently convey protection... - Vaccinia virus-specific CD4+ T cell responses target a set of antigens largely distinct from those targeted by CD8+ T cell responsesMagdalini Moutaftsi
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
J Immunol 178:6814-20. 2007..Taken together, these results highlight fundamental differences in immunodominance of CD4(+) and CD8(+) T cell responses to a complex pathogen... - HLA-A2-restricted protection against lethal lymphocytic choriomeningitisJason Botten
Molecular and Integrative Neurosciences Department, The Scripps Research Institute, SP30 2020, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
J Virol 81:2307-17. 2007.... - Simultaneous prediction of binding capacity for multiple molecules of the HLA B44 supertypeJohn Sidney
Division of Translational Immunology and Biodefense, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
J Immunol 171:5964-74. 2003..Taken together, these findings have important implications for epitope-based approaches to vaccination, immunotherapy, and the monitoring of immune responses... - Characterization of the peptide-binding specificity of Mamu-A*11 results in the identification of SIV-derived epitopes and interspecies cross-reactivityAlessandro Sette
La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
Immunogenetics 57:53-68. 2005..This is the first detailed description of mouse-macaque interspecies cross-reactivity, potentially useful in testing novel vaccines in mice and macaques... - Derivation of HLA-B*0702 transgenic mice: functional CTL repertoire and recognition of human B*0702-restricted CTL epitopesJeff Alexander
Epimmune Inc, San Diego, California 92121, USA
Hum Immunol 64:211-23. 2003.... - Detailed characterization of the peptide binding specificity of five common Patr class I MHC moleculesJohn Sidney
La Jolla Institute for Allergy and Immunology, 3030 Bunker Hill St, Ste. 326, San Diego, CA 92109, USA
Immunogenetics 58:559-70. 2006..Because the Patr alleles studied herein were found to be very common in two different chimpanzee populations, the present data should facilitate the use of chimpanzees for immunological studies... - Immune epitope database analysis resource (IEDB-AR)Qing Zhang
Immune Epitope Database and Analysis Resource IEDB AR, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA
Nucleic Acids Res 36:W513-8. 2008..New functionalities have been added to most of the previously implemented tools, and a total of eight new tools were added, including two B-cell epitope prediction tools, four T-cell epitope prediction tools and two analysis tools... - Selective CD4+ T cell help for antibody responses to a large viral pathogen: deterministic linkage of specificitiesAlessandro Sette
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology LIAI, La Jolla, CA 92037, USA
Immunity 28:847-58. 2008..Therefore, MHC restriction is a key selective event for the antiviral antibody response and is probably important for vaccine development to large pathogens... - HLA class I-restricted responses to vaccinia recognize a broad array of proteins mainly involved in virulence and viral gene regulationCarla Oseroff
La Jolla Institute for Allergy and Immunology, 3030 Bunker Hill Street, Suite 326, San Diego, CA 92109, USA
Proc Natl Acad Sci U S A 102:13980-5. 2005..Finally, most epitopes were highly conserved among vaccinia virus Western Reserve, variola major and modified vaccinia Ankara, supporting their potential use in vaccine and diagnostic applications... - Classification of the universe of immune epitope literature: representation and knowledge gapsVince Davies
La Jolla Institute for Allergy and Immunology, Vaccine Discovery, La Jolla, California, United States of America
PLoS ONE 4:e6948. 2009..The IEDB is maintained and continually updated by monitoring PubMed for new, potentially relevant references... - Five HLA-DP molecules frequently expressed in the worldwide human population share a common HLA supertypic binding specificityJohn Sidney
La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
J Immunol 184:2492-503. 2010..Taken together, these DP supertype molecules are found in >90% of the human population. Thus, these findings have important implications for epitope-identification studies and monitoring of human class II-restricted immune responses... - Dissociation between epitope hierarchy and immunoprevalence in CD8 responses to vaccinia virus western reserveCarla Oseroff
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
J Immunol 180:7193-202. 2008..Together, these findings have clear implications for the design of CD8(+) T cell subunit vaccines and in particular raise the exciting prospect of being able to choose subunits without reference to MHC restriction... - A multivalent and cross-protective vaccine strategy against arenaviruses associated with human diseaseMaya F Kotturi
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
PLoS Pathog 5:e1000695. 2009..In conclusion, the set of identified epitopes allows broad, non-ethnically biased coverage of all 7 viral species targeted by our studies... - A systematic assessment of MHC class II peptide binding predictions and evaluation of a consensus approachPeng Wang
La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America
PLoS Comput Biol 4:e1000048. 2008..We show that this consensus approach achieved best overall performance. Finally, we make the large datasets used publicly available as a benchmark to facilitate further development of MHC class II binding peptide prediction methods... - CD4+ T cells are not required for the induction of dengue virus-specific CD8+ T cell or antibody responses but contribute to protection after vaccinationLauren E Yauch
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
J Immunol 185:5405-16. 2010..These findings suggest inducing anti-DENV CD4(+) T cell responses by vaccination may be beneficial... - A consensus epitope prediction approach identifies the breadth of murine T(CD8+)-cell responses to vaccinia virusMagdalini Moutaftsi
La Jolla Institute for Allergy and Immunology, 3030 Bunker Hill Street, Suite 326, San Diego, California 92109, USA
Nat Biotechnol 24:817-9. 2006..This approach reveals the breadth of T-cell responses to vaccinia, a widely studied murine viral infection model, and may provide a tool for developing comprehensive antigenic maps of any complex pathogen... - A quantitative analysis of the variables affecting the repertoire of T cell specificities recognized after vaccinia virus infectionErika Assarsson
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
J Immunol 178:7890-901. 2007..This suggested that additional factors, including immunoregulatory mechanisms, restrict the repertoire of T cell specificities after vaccinia infection by a factor of at least 10... - Integrating epitope data into the emerging web of biomedical knowledge resourcesBjoern Peters
La Jolla Institute for Allergy and Immunology, Division of Vaccine Discovery, 9420 Athena Circle, La Jolla, California 92037, USA
Nat Rev Immunol 7:485-90. 2007.... - Identification of protective Lassa virus epitopes that are restricted by HLA-A2Jason Botten
Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
J Virol 80:8351-61. 2006.... - Correlates of protection efficacy induced by vaccinia virus-specific CD8+ T-cell epitopes in the murine intranasal challenge modelMagdalini Moutaftsi
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA
Eur J Immunol 39:717-22. 2009..However, binding affinity partially predicted protection efficacy and ultimately epitope immunogenicity and recognition of infected cells offered the best correlation... - HLA-A*0201, HLA-A*1101, and HLA-B*0702 transgenic mice recognize numerous poxvirus determinants from a wide variety of viral gene productsValerie Pasquetto
La Jolla Institute for Allergy and Immunology, San Diego, CA 92109, USA
J Immunol 175:5504-15. 2005..These findings have implications for the design of new smallpox vaccines and the understanding of immune responses to large DNA viruses in general... - Automated generation and evaluation of specific MHC binding predictive tools: ARB matrix applicationsHuynh-Hoa Bui
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 3030 Bunker Hill Street, Suite 326, San Diego, CA 92109, USA
Immunogenetics 57:304-14. 2005..MHC binding predictions based on ARB matrices were made available at http://epitope.liai.org:8080/matrix web server... - Immunogenic HLA-B7-restricted peptides of hTRTXochitl Cortez-Gonzalez
Laboratory of Immunology, Department of Medicine and Moores Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0837, USA
Int Immunol 18:1707-18. 2006.... - A decaepitope polypeptide primes for multiple CD8+ IFN-gamma and Th lymphocyte responses: evaluation of multiepitope polypeptides as a mode for vaccine deliveryJeff Alexander
Epimmune, San Diego, CA 92121, USA
J Immunol 168:6189-98. 2002..These studies support further evaluation of multiepitope polypeptide vaccines for induction of CD8(+) IFN-gamma and HTL responses... - Design and utilization of epitope-based databases and predictive toolsNima Salimi
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
Immunogenetics 62:185-96. 2010..Taken together, the results highlight the growing impact and utility of immunological databases for the scientific community... - Pre-existing immunity against swine-origin H1N1 influenza viruses in the general human populationJason A Greenbaum
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 106:20365-70. 2009..These results are consistent with reports about disease incidence, severity, and mortality rates associated with human S-OIV... - Immunogenicity and tolerogenicity of hepatitis B virus structural and nonstructural proteins: implications for immunotherapy of persistent viral infectionsKazuhiro Kakimi
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
J Virol 76:8609-20. 2002..Immunotherapeutic strategies to control HBV infection by inducing virus-specific CTL responses in chronically infected subjects should be evaluated in light of this observation... - IMMUNOCAT-a data management system for epitope mapping studiesJo L Chung
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
J Biomed Biotechnol 2010:856842. 2010..This provides a case study for the use of bioinformatics and information management techniques to track and analyze data produced in a translational research study aimed at epitope identification... - Molecular determinants of T cell epitope recognition to the common Timothy grass allergenCarla Oseroff
La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
J Immunol 185:943-55. 2010..Consistent with this notion, different Phl p Ags were associated with distinct patterns of IL-5, IFN-gamma, IL-10, and IL-17 production... - Meta-analysis of all immune epitope data in the Flavivirus genus: inventory of current immune epitope data status in the context of virus immunity and immunopathologyKerrie Vaughan
La Jolla Institute of Allergy and Immunology, La Jolla, CA 92037, USA
Viral Immunol 23:259-84. 2010..Through this work we hope to provide useful data to those working in the area of Flavivirus research... - TiArA: a virtual appliance for the analysis of Tiling Array dataJason A Greenbaum
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America
PLoS ONE 5:e9993. 2010..Genomic tiling arrays have been described in the scientific literature since 2003, yet there is a shortage of user-friendly applications available for their analysis... - Reverse vaccinology: developing vaccines in the era of genomicsAlessandro Sette
La Jolla Institute for Allergy and Immunology, San Diego, CA 92130, USA
Immunity 33:530-41. 2010.... - The design and implementation of the immune epitope database and analysis resourceBjoern Peters
La Jolla Institute of Allergy and Immunology, 3030 Bunker Hill Street, Suite 326, San Diego, CA 92109, USA
Immunogenetics 57:326-36. 2005..quot; We describe how we plan to capture, structure, and store this information, what query interfaces we will make available to the public, and what additional predictive and analytical tools we will provide... - The CD8+ T-cell response to lymphocytic choriomeningitis virus involves the L antigen: uncovering new tricks for an old virusMaya F Kotturi
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
J Virol 81:4928-40. 2007..Taken together, these findings illustrate that the LCMV-specific CD8(+) T-cell response is more complex than previously appreciated... - A community resource benchmarking predictions of peptide binding to MHC-I moleculesBjoern Peters
La Jolla Institute for Allergy and Immunology, San Diego, California, USA
PLoS Comput Biol 2:e65. 2006.... - Analysis of epitope information related to Bacillus anthracis and Clostridium botulinumLaura M Zarebski
Immune Epitope Database and Analysis Resource, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 9203, 7 USA
Expert Rev Vaccines 7:55-74. 2008..Despite this, several distinct structures at the epitope and fragment level are described herein, which could be potential additions to future vaccines or targets of novel immunotherapeutics and diagnostic reagents... - Cutting edge: murine cytomegalovirus induces a polyfunctional CD4 T cell responseRamon Arens
Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
J Immunol 180:6472-6. 2008..In total, this study reveals that the MCMV-specific CD4 T cell response is complex and functionally diverse, highlighting its important role in controlling this persistent pathogen... - Lymphocytic choriomeningitis virus infection yields overlapping CD4+ and CD8+ T-cell responsesCourtney Dow
The La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA
J Virol 82:11734-41. 2008..These findings demonstrate that immunodominance is a complex phenomenon in the context of helper responses... - Preferential use of B7.2 and not B7.1 in priming of vaccinia virus-specific CD8 T cellsShahram Salek-Ardakani
Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, San Diego, CA 92037, USA
J Immunol 182:2909-18. 2009..2 is the major ligand for the CD28 receptor on VACV-specific CD8 T cells, that B7.2 can promote efficient CD8 T cell priming without B7.1, and that B7.1 and B7.2 can be differentially utilized during antiviral responses... - Naive precursor frequencies and MHC binding rather than the degree of epitope diversity shape CD8+ T cell immunodominanceMaya F Kotturi
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
J Immunol 181:2124-33. 2008..Thus, our results indicate that an intrinsic property of the epitope (MHC binding affinity) and an intrinsic property of the host (naive precursor frequency) jointly dictate the immunodominance hierarchy of CD8(+) T cell responses... - The smallpox vaccine induces an early neutralizing IgM responseJuan E Moyron-Quiroz
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
Vaccine 28:140-7. 2009.... - Universal influenza DNA vaccine encoding conserved CD4+ T cell epitopes protects against lethal viral challenge in HLA-DR transgenic miceJeff Alexander
Pharmexa Epimmune, Inc, San Diego, CA 92121, USA
Vaccine 28:664-72. 2010..These studies demonstrate the utility of this vaccine format and the contribution of CD4(+) T cell responses to protection against influenza infection... - The immune epitope database 2.0Randi Vita
La Jolla Institute for Allergy and Immunology, Center for Infectious Disease, Allergy and Asthma Research, 9420 Athena Circle, La Jolla, CA 92037, USA
Nucleic Acids Res 38:D854-62. 2010..The database structure, as well as its querying, browsing and reporting interfaces, was completely redesigned for the IEDB 2.0 release, which became publicly available in early 2009... - Tumor-associated carbohydrate antigens: a possible avenue for cancer preventionYanfei Xu
Torrey Pines Institute for Molecular Studies, San Diego, California, USA
Immunol Cell Biol 83:440-8. 2005..Our results have suggested that CTL derived from normal donors respond with high efficiency to glycopeptides in vitro, opening a new avenue for the design of prospective vaccines for cancer prevention... - Towards a consensus on datasets and evaluation metrics for developing B-cell epitope prediction toolsJason A Greenbaum
Immune Epitope Database and Analysis Resource IEDB, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
J Mol Recognit 20:75-82. 2007..By developing common datasets, standardized data formats, and the means with which to consolidate information, we hope to greatly enhance the development of B-cell epitope prediction tools...
Research Grants
- DOMINANCE IN T CELL RESPONSES TO SMALLPOX VACCINATIONAlessandro Sette; Fiscal Year: 2003..These variola virus-derived epitopes would be incorporated in an optimized multi-determinant vaccine construct, inserted in the currently available vaccinia vaccine. ..
- DOMINANCE IN T CELL RESPONSES TO SMALLPOX VACCINATIONAlessandro Sette; Fiscal Year: 2006..These variola virus-derived epitopes would be incorporated in an optimized multi-determinant vaccine construct, inserted in the currently available vaccinia vaccine. ..
- Immunogenetic characterization of MHC molecules as a tool for biomedical researchAlessandro Sette; Fiscal Year: 2007..These experiments will validate the approach and tools developed and also identify epitopes that can be utilized to monitor responses in these A-C pathogen systems. ..
- The Immunogenetics of Macaques Used in Biodefense ResearchALESSANDRO D SETTE; Fiscal Year: 2010..This proposal is focused on developing technology and tools to evaluate cell-mediated immunity in these animal models. ..