J Bressler

Summary

Affiliation: Kennedy Krieger Institute
Country: USA

Publications

  1. ncbi Molecular mechanisms of lead neurotoxicity
    J Bressler
    Dept of Neurology, The Johns Hopkins University School of Public Health and Hygiene and The Kennedy Krieger Research Institute, Baltimore, MD 21205, USA
    Neurochem Res 24:595-600. 1999
  2. ncbi Divalent metal transporter 1 in lead and cadmium transport
    Joseph P Bressler
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    Ann N Y Acad Sci 1012:142-52. 2004
  3. ncbi Metal transporters in intestine and brain: their involvement in metal-associated neurotoxicities
    Joseph P Bressler
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Hum Exp Toxicol 26:221-9. 2007
  4. ncbi Involvement of DMT1 in uptake of Cd in MDCK cells: role of protein kinase C
    L Olivi
    Department of Neurology, Kennedy Krieger Research Institute, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Am J Physiol Cell Physiol 281:C793-800. 2001
  5. ncbi Effect of DMT1 knockdown on iron, cadmium, and lead uptake in Caco-2 cells
    Desmond I Bannon
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Am J Physiol Cell Physiol 284:C44-50. 2003
  6. ncbi Uptake of lead and iron by divalent metal transporter 1 in yeast and mammalian cells
    Desmond I Bannon
    Kennedy Krieger Research Institute, 21205, Baltimore, MD, USA
    Biochem Biophys Res Commun 295:978-84. 2002
  7. ncbi Mitochondrial toxin 3-nitropropionic acid induces cardiac and neurotoxicity differentially in mice
    K L Gabrielson
    Division of Comparative Medicine, School of Medicine, School of Medicine, The Johns Hopkins University, Baltimore, Maryland, USA
    Am J Pathol 159:1507-20. 2001
  8. ncbi Relation of alleles of the sodium-potassium adenosine triphosphatase alpha 2 gene with blood pressure and lead exposure
    B S Glenn
    Department of Neurology, Kennedy Krieger Research Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Am J Epidemiol 153:537-45. 2001
  9. ncbi Protein kinase C activity and the relations between blood lead and neurobehavioral function in lead workers
    Kyu-Yoon Hwang
    Division of Occupational and Environmental Health, Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Environ Health Perspect 110:133-8. 2002
  10. ncbi Aluminum stimulates uptake of non-transferrin bound iron and transferrin bound iron in human glial cells
    Yongbae Kim
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, USA
    Toxicol Appl Pharmacol 220:349-56. 2007

Research Grants

  1. SIGNAL TRANSDUCTION MECHANISMS AND LEAD TOXICITY
    Joseph Bressler; Fiscal Year: 2001

Collaborators

  • B S Schwartz
  • Walter F Stewart
  • Desmond I Bannon
  • M Aschner
  • Yongbae Kim
  • Luisa Olivi
  • Xun Song
  • Desmond I Bannon
  • Kyu-Yoon Hwang
  • L Olivi
  • K L Gabrielson
  • B S Glenn
  • Alex Maertens
  • Jae Hoon Cheong
  • Jamaluddin Shaikh
  • Carey Pope
  • Bachchu Lal
  • Ramesh Murthy
  • Matthew E Portnoy
  • Valeria C Culotta
  • Byung-Kook Lee
  • Karen I Bolla
  • Peter S J Lees
  • A J Cardounel
  • B A Hogue
  • J L Zweier
  • L J Martin
  • W Nakajima
  • E R Rodriguez
  • N C de Souza-Pinto
  • V A Bohr
  • J Kofler
  • J Sisk

Detail Information

Publications12

  1. ncbi Molecular mechanisms of lead neurotoxicity
    J Bressler
    Dept of Neurology, The Johns Hopkins University School of Public Health and Hygiene and The Kennedy Krieger Research Institute, Baltimore, MD 21205, USA
    Neurochem Res 24:595-600. 1999
    ..We propose that the learning deficits caused by lead are due to events regulated by protein kinase C that most likely occur at the synapse...
  2. ncbi Divalent metal transporter 1 in lead and cadmium transport
    Joseph P Bressler
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    Ann N Y Acad Sci 1012:142-52. 2004
    ..It also suggests that diets rich in iron-containing food could be protective against heavy metal poisoning...
  3. ncbi Metal transporters in intestine and brain: their involvement in metal-associated neurotoxicities
    Joseph P Bressler
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Hum Exp Toxicol 26:221-9. 2007
    ..Accordingly, exposure to toxicants that affect the activity of transporters potentially could contribute to the aetiology/progression of neurodegenerative diseases...
  4. ncbi Involvement of DMT1 in uptake of Cd in MDCK cells: role of protein kinase C
    L Olivi
    Department of Neurology, Kennedy Krieger Research Institute, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Am J Physiol Cell Physiol 281:C793-800. 2001
    ..Our results suggest that Fe and Cd are transported in MDCK cells by a transporter with biochemical properties similar to those of DMT1...
  5. ncbi Effect of DMT1 knockdown on iron, cadmium, and lead uptake in Caco-2 cells
    Desmond I Bannon
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Am J Physiol Cell Physiol 284:C44-50. 2003
    ..These results show that DMT1 is important in iron and cadmium transport in Caco-2 cells but that lead enters these cells through an independent hydrogen-driven mechanism...
  6. ncbi Uptake of lead and iron by divalent metal transporter 1 in yeast and mammalian cells
    Desmond I Bannon
    Kennedy Krieger Research Institute, 21205, Baltimore, MD, USA
    Biochem Biophys Res Commun 295:978-84. 2002
    ..These results show that DMT1 transports lead and iron with similar affinity in a yeast model suggesting that DMT1 is a transporter for lead...
  7. ncbi Mitochondrial toxin 3-nitropropionic acid induces cardiac and neurotoxicity differentially in mice
    K L Gabrielson
    Division of Comparative Medicine, School of Medicine, School of Medicine, The Johns Hopkins University, Baltimore, Maryland, USA
    Am J Pathol 159:1507-20. 2001
    ....
  8. ncbi Relation of alleles of the sodium-potassium adenosine triphosphatase alpha 2 gene with blood pressure and lead exposure
    B S Glenn
    Department of Neurology, Kennedy Krieger Research Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Am J Epidemiol 153:537-45. 2001
    ..However, because the number of subjects (especially African Americans) with the susceptible genotype in this study was small, these observations should be considered preliminary...
  9. ncbi Protein kinase C activity and the relations between blood lead and neurobehavioral function in lead workers
    Kyu-Yoon Hwang
    Division of Occupational and Environmental Health, Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Environ Health Perspect 110:133-8. 2002
    ..We hypothesize that subjects with higher PKC activity in the presence of lead may be more susceptible to the health effects of lead...
  10. ncbi Aluminum stimulates uptake of non-transferrin bound iron and transferrin bound iron in human glial cells
    Yongbae Kim
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, USA
    Toxicol Appl Pharmacol 220:349-56. 2007
    ..These results suggest that aluminum disrupts iron homeostasis in the brain by several mechanisms including the transferrin receptor, a nontransferrin iron transporter, and ferritin...
  11. ncbi Interactive effects of paraoxon and pyridostigmine on blood-brain barrier integrity and cholinergic toxicity
    Xun Song
    Neurotoxicology Laboratory, Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, Oklahoma 74078, USA
    Toxicol Sci 78:241-7. 2004
    ..Also, PYR pre-exposure appears to protect the BBB from the paraoxon-induced alterations...
  12. ncbi Blood-brain barrier and cell-cell interactions: methods for establishing in vitro models of the blood-brain barrier and transport measurements
    Michael Aschner
    Department of Pediatrics Pharmacology and The Kennedy Center, Vanderbilt University School of Medicine, Nashville, TN, USA
    Methods Mol Biol 341:1-15. 2006
    ..These in vitro methods will complement many of the in vivo techniques, and they may be used as screening for more timely and expensive experiments, and also reducing the need for experimental animals...

Research Grants6

  1. SIGNAL TRANSDUCTION MECHANISMS AND LEAD TOXICITY
    Joseph Bressler; Fiscal Year: 2001
    ..Ultimately, a protein that is phosphorylated in rats with elevated levels of Pb2+ may provide a biomarker to monitor Pb2+. ..