Research Topics
| A L FolpeSummaryAffiliation: Kathleen D. Schaum and Associates Country: USA Publications
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Publications
Expression of Fli-1, a nuclear transcription factor, distinguishes vascular neoplasms from potential mimicsA L Folpe
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA
Am J Surg Pathol 25:1061-6. 2001..As the first nuclear, rather than cytoplasmic or membranous marker of endothelium, Fli-1 immunostaining also generally lacks cytoplasmic staining artifacts that are the result of endogenous peroxidases or biotin...
MyoD1 and myogenin expression in human neoplasia: a review and updateAndrew L Folpe
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA
Adv Anat Pathol 9:198-203. 2002..Special attention is given to technical and interpretative issues critical to the use of these antibodies in diagnostic pathology...
Sclerosing rhabdomyosarcoma in adults: report of four cases of a hyalinizing, matrix-rich variant of rhabdomyosarcoma that may be confused with osteosarcoma, chondrosarcoma, or angiosarcomaAndrew L Folpe
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
Am J Surg Pathol 26:1175-83. 2002..Study of additional cases will be necessary to more fully elucidate its place among RMS and its prognostic significance...
Clear cell myomelanocytic tumor of the thigh: report of a unique caseAndrew L Folpe
Department of Pathology, Emory University, Atlanta, Georgia 30322, USA
Am J Surg Pathol 26:809-12. 2002..Histologic examination showed the classic features of CCMMT, and immunohistochemical studies confirmed co-expression of smooth muscle actin, HMB-45, and microphthalmia transcription factor...
Lipoleiomyosarcoma (well-differentiated liposarcoma with leiomyosarcomatous differentiation): a clinicopathologic study of nine cases including one with dedifferentiationAndrew L Folpe
Department of Pathology, Emory University, Atlanta, Georgia 30322, USA
Am J Surg Pathol 26:742-9. 2002..LMS in L-LMS should not be misconstrued as evidence of low-grade dedifferentiation, a phenomenon that identifies a more unstable and potentially metastasizing lesion...
Immunohistochemical detection of FLI-1 protein expression: a study of 132 round cell tumors with emphasis on CD99-positive mimics of Ewing's sarcoma/primitive neuroectodermal tumorA L Folpe
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA
Am J Surg Pathol 24:1657-62. 2000..It is not surprising that some ES/ PNET are FLI-1-negative, because not all ES/PNET have the classic EWS/FLI-1, and some cases of ES/PNET may produce either low levels of protein or idiotypically different protein...
Vascular endothelial growth factor receptor-3 (VEGFR-3): a marker of vascular tumors with presumed lymphatic differentiation, including Kaposi's sarcoma, kaposiform and Dabska-type hemangioendotheliomas, and a subset of angiosarcomasA L Folpe
Department of Pathology, Emory University, Atlanta, Georgia, USA
Mod Pathol 13:180-5. 2000..However, the expression of VEGFR-3 by certain AS having Kaposi-like areas, a prominent lymphocytic infiltrate, or hobnail endothelium may define subset(s) having phenotypic, if not pathogenetic and biologic, differences...
Microphthalmia transcription factor and melanoma cell adhesion molecule expression distinguish desmoplastic/spindle cell melanoma from morphologic mimicsM B Koch
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
Am J Surg Pathol 25:58-64. 2001..These markers may also be helpful in certain other differential diagnoses, such as distinguishing clear cell sarcomas from epithelioid malignant peripheral nerve sheath tumors...
Consultative (expert) second opinions in soft tissue pathology. Analysis of problem-prone diagnostic situationsZ K Arbiser
Department of Pathology and Laboratory Medicine, Emory University Hospital, 1364 Clifton Rd, Atlanta, GA 30322, USA
Am J Clin Pathol 116:473-6. 2001..Lack of familiarity with rare or unusual lesions is probably more significant in explaining diagnostic discrepancies than is the increasing use of needle biopsy or the failure to perform immunohistochemical analysis...
Microphthalmia transcription factor immunohistochemistry: a useful diagnostic marker in the diagnosis and detection of cutaneous melanoma, sentinel lymph node metastases, and extracutaneous melanocytic neoplasmsD J Brat
Department of Dermatology, Emory University School of Medicine, 5309 Woodruff Memorial Bldg, Atlanta, GA 30322, USA
J Am Acad Dermatol 45:414-9. 2001..Use of this stain may facilitate detection of micrometastases in sentinel lymph nodes...
Diagnostic utility of microphthalmia transcription factor in malignant melanoma and other tumorsK L Chang
Department of Pathology, City of Hope National Medical Center, Duarte, California 91010, USA
Adv Anat Pathol 8:273-5. 2001....
Thyroid transcription factor-1: immunohistochemical evaluation in pulmonary neuroendocrine tumorsA L Folpe
Department of Pathology, Emory University, Atlanta, Georgia, USA
Mod Pathol 12:5-8. 1999..The ubiquity of TTF-1 expression in pulmonary NECs demonstrated in this study also argues against its use in their subclassification...
Concurrent angiomyolipoma and renal cell neoplasia: a study of 36 casesR E Jimenez
Department of Pathology, Emory University Hospital, Atlanta, Georgia 30322, USA
Mod Pathol 14:157-63. 2001..15). Papillary neoplasia, chromophobe, and collecting-duct renal-cell carcinoma were found only in sporadic cases. All of the 22 renal-cell neoplasms studied were negative for HMB-45, whereas all 25 angiomyolipomas studied were positive...
(F-18) fluorodeoxyglucose positron emission tomography as a predictor of pathologic grade and other prognostic variables in bone and soft tissue sarcomaA L Folpe
Department of Pathology, Emory University Medical Center, Atlanta, Georgia 30322, USA
Clin Cancer Res 6:1279-87. 2000..Further follow-up will be necessary to determine whether FDG-PET provides independent prognostic information...
Clear cell myomelanocytic tumor of the falciform ligament/ligamentum teres: a novel member of the perivascular epithelioid clear cell family of tumors with a predilection for children and young adultsA L Folpe
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA
Am J Surg Pathol 24:1239-46. 2000..quot; The differential diagnosis of these tumors includes clear cell sarcoma of tendons and aponeuroses, leiomyosarcoma, and angiomyolipoma...
Low-grade fibromyxoid sarcoma and hyalinizing spindle cell tumor with giant rosettes: a clinicopathologic study of 73 cases supporting their identity and assessing the impact of high-grade areasA L Folpe
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA
Am J Surg Pathol 24:1353-60. 2000..The fact that the only three patients to develop metastatic disease were patients whose LGFMS or HSCT was identified retrospectively supports this concept...
Epithelioid sarcoma-like hemangioendotheliomaSteven D Billings
Department of Pathology, Indiana University School of Medicine, Indianapolis, USA
Am J Surg Pathol 27:48-57. 2003..Its distinction from other epithelioid vascular lesions is discussed. We think this tumor fits best into the family of "hemangioendothelioma" or vascular lesions of intermediate malignancy...
Practical applications of immunohistochemistry in the diagnosis of soft tissue neoplasmsA L Folpe
Department of Pathology, Emory University Hospital, Atlanta, GA 30322, USA
Surg Oncol 8:197-203. 1999..The limitations of immunohistochemistry and possible future directions for the application of immunohistochemistry to sarcoma diagnosis are also reviewed...
CD31 expression in intratumoral macrophages: a potential diagnostic pitfallJ K McKenney
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Am J Surg Pathol 25:1167-73. 2001..CD31 may also be useful as a nonlysosomal marker of macrophages in formalin-fixed, paraffin-embedded sections...
Do leiomyomas of deep soft tissue exist? An analysis of highly differentiated smooth muscle tumors of deep soft tissue supporting two distinct subtypesS D Billings
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA
Am J Surg Pathol 25:1134-42. 2001..We suggest that these two groups of smooth muscle tumors be diagnostically approached in a site-specific fashion...
Most osteomalacia-associated mesenchymal tumors are a single histopathologic entity: an analysis of 32 cases and a comprehensive review of the literatureAndrew L Folpe
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA
Am J Surg Pathol 28:1-30. 2004..Recognition of PMTMCT is critical, as complete resection cures intractable OO. Immunohistochemistry and RT-PCR for FGF-23 confirm the role of this protein in PMTMCT-associated OO...
Alveolar soft-part sarcoma of the urinary bladder with urethral recurrence: a unique case with emphasis on differential diagnoses and diagnostic utility of an immunohistochemical panel including TFE3Mahul B Amin
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA
Am J Surg Pathol 30:1322-5. 2006....
Expression of claudin-1, a recently described tight junction-associated protein, distinguishes soft tissue perineurioma from potential mimicsAndrew L Folpe
H 175 Department of Pathology, Emory University, 1364 Clifton Road NE, Atlanta, GA 30322, USA
Am J Surg Pathol 26:1620-6. 2002..In particular, claudin-1 is often a more robust marker than EMA in a given perineurioma. Claudin-1 is not expressed within the lesional cells of the mesenchymal tumors that enter into the differential diagnosis of perineurioma...
Heterotopic mesenteric ossification: a distinctive pseudosarcoma commonly associated with intestinal obstructionRajiv M Patel
Department of Pathology and Laboratory Medicine, 1364 Clifton Road NE, Emory University, Atlanta, GA 30222, USA
Am J Surg Pathol 30:119-22. 2006....
Activation of the mTOR pathway in sporadic angiomyolipomas and other perivascular epithelioid cell neoplasmsHeidi Kenerson
Department of Pathology, University of Washington, Seattle, WA 98195, USA
Hum Pathol 38:1361-71. 2007..This suggests the possibility that mTOR inhibitors such as rapamycin may be therapeutic for this class of disease...
Subconjunctival herniated orbital fat: A benign adipocytic lesion that may mimic pleomorphic lipoma and atypical lipomatous tumorIngo Schmack
Emory Eye Center, Emory University School of Medicine, Atlanta, GA, USA
Am J Surg Pathol 31:193-8. 2007..Multinucleated floret cells present in prolapsed orbital fat likely represent a reactive phenomenon, as they are not present in normal orbital fat...
Dual-color, break-apart fluorescence in situ hybridization for EWS gene rearrangement distinguishes clear cell sarcoma of soft tissue from malignant melanomaRajiv M Patel
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30355, USA
Mod Pathol 18:1585-90. 2005..As the studied probe can be utilized in routinely processed tissue, FISH provides an excellent alternative to reverse-transcriptase polymerase chain reaction in cases where fresh tissue is unavailable...
Cutaneous and subcutaneous fibrohistiocytic tumors of intermediate malignancy: an updateSteven D Billings
Department of Pathology, Indiana University, Indianapolis, IN, USA
Am J Dermatopathol 26:141-55. 2004..The differential diagnosis of these tumors with a variety of benign and fully malignant cutaneous soft tissue neoplasms is discussed...
Atypical and malignant glomus tumors: analysis of 52 cases, with a proposal for the reclassification of glomus tumorsA L Folpe
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
Am J Surg Pathol 25:1-12. 2001..In contrast, metastatic disease was not seen in any specimen classified as symplastic glomus tumor, glomus tumor of uncertain malignant potential, or glomangiomatosis...
P504S immunohistochemical detection in 405 prostatic specimens including 376 18-gauge needle biopsiesR Beach
Department of Pathology and Laboratory Medicine, Emory University Hospital, 1364 Clifton Road NE, Atlanta, GA 30322, USA
Am J Surg Pathol 26:1588-96. 2002..Therefore, we think that P504S is best used only in conjunction with strict light microscopic correlation and preferably with high molecular weight cytokeratin immunostaining...
Primary Ewing's sarcoma/primitive neuroectodermal tumor of the kidney: a clinicopathologic and immunohistochemical analysis of 11 casesRafael E Jimenez
Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA
Am J Surg Pathol 26:320-7. 2002..The accurate distinction between these two entities has clear prognostic and therapeutic implications...
Utility of a comprehensive immunohistochemical panel in the differential diagnosis of spindle cell lesions of the urinary bladderDanielle E Westfall
Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
Am J Surg Pathol 33:99-105. 2009....
Primary vascular tumors and tumor-like lesions of the kidney: a clinicopathologic analysis of 25 casesJeffrey G Brown
Department of Pathology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
Am J Surg Pathol 34:942-9. 2010....
C-kit expression distinguishes salivary gland adenoid cystic carcinoma from polymorphous low-grade adenocarcinomaCarla R Penner
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
Mod Pathol 15:687-91. 2002..Our finding of different patterns of c-kit expression in tubular and solid variants of ACC supports the concept of solid variant ACC as a high-grade tumor, with progression toward an entirely "inner cell" phenotype...
Well-differentiated fetal adenocarcinoma of the lung: cytomorphologic features on fine-needle aspiration with emphasis on use of beta-catenin as a useful diagnostic markerLori Proctor
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA
Diagn Cytopathol 35:39-42. 2007....
Perivascular epithelioid cell neoplasms of soft tissue and gynecologic origin: a clinicopathologic study of 26 cases and review of the literatureAndrew L Folpe
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
Am J Surg Pathol 29:1558-75. 2005..PEComas with two or more worrisome histologic features should be considered malignant. Occasional PEComas express unusual markers, such as S-100 protein, desmin, and rarely CK. The role of TFE3 in PEComas should be further studied...
Pleomorphic hyalinizing angiectatic tumor: analysis of 41 cases supporting evolution from a distinctive precursor lesionAndrew L Folpe
Department of Pathology and Laboratory Medicine Emory University, Atlanta, GA 30322, USA
Am J Surg Pathol 28:1417-25. 2004..PHAT should be considered mesenchymal tumors of intermediate malignancy, given their high rate of (sometimes aggressive) local recurrence...
Kaposiform hemangioendothelioma: a study of 33 cases emphasizing its pathologic, immunophenotypic, and biologic uniqueness from juvenile hemangiomaLisa L Lyons
Departments of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
Am J Surg Pathol 28:559-68. 2004..Given this behavior, its continued classification as a vascular tumor of intermediate malignancy is warranted...
CDX-2, a new marker for adenocarcinoma of gastrointestinal originMelissa K Li
Department of Pathology, University of Florida, Gainesville, Florida, USA
Adv Anat Pathol 11:101-5. 2004..This article reviews the previous studies of this new antibody...
National surgical patterns of care: regional lymphadenectomy of breast sarcomasNorleena Poynter Gullett
Department of Radiation Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA
Am J Clin Oncol 30:461-5. 2007..We reviewed national surgical patterns of care for regional lymphadenectomy for breast STS using the Surveillance Epidemiology & End Results (SEER) registry...
Sporadic cutaneous angiosarcomas: a proposal for risk stratification based on 69 casesAndrea T Deyrup
Department of Pathology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA
Am J Surg Pathol 32:72-7. 2008..These features seem to diminish in importance with increased tumor size and are probably most useful in tumors less than 5 cm in maximum dimension...
Potential utility of uroplakin III, thrombomodulin, high molecular weight cytokeratin, and cytokeratin 20 in noninvasive, invasive, and metastatic urothelial (transitional cell) carcinomasDouglas C Parker
Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA
Am J Surg Pathol 27:1-10. 2003..The results of the study indicate a role for an antibody panel that includes UROIII, THR, HMWCK, and CK20 in the diagnosis of urothelial tumors...
Cutaneous angiosarcoma following breast-conserving surgery and radiation: an analysis of 27 casesSteven D Billings
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Am J Surg Pathol 28:781-8. 2004..The median interval to death was 33.5 months. All 4 patients with disease have documented metastasis. CPRASB differs from Stewart-Treves AS by its shorter latency period and lack of association with lymphedema...
Ossifying fibromyxoid tumor of soft parts: a clinicopathologic study of 70 cases with emphasis on atypical and malignant variantsAndrew L Folpe
Department of Pathology H 175, Emory University Hospital, 1364 Clifton Road NE, Atlanta, GA 30322, USA
Am J Surg Pathol 27:421-31. 2003..Their line of differentiation remains unclear, although we suggest they may belong to the category of translocation-associated sarcomas, not all of which recapitulate a normal line of differentiation...
The diagnostic value of beta-catenin immunohistochemistryElizabeth Montgomery
Department of Pathology, Johns Hopkins Hospital, Baltimore, MD 21231, USA
Adv Anat Pathol 12:350-6. 2005..Immunohistochemistry for beta-catenin may be useful in the differential diagnosis of selected tumors of soft tissue, the gastrointestinal tract, including the pancreas, lung, and female genital tract...
Morphologic and immunophenotypic diversity in Ewing family tumors: a study of 66 genetically confirmed casesAndrew L Folpe
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
Am J Surg Pathol 29:1025-33. 2005....
Immunoprofile of ovarian tumors with putative transitional cell (urothelial) differentiation using novel urothelial markers: histogenetic and diagnostic implicationsSanjay Logani
Emory University School of Medicine, Atlanta, Georgia 30322, USA
Am J Surg Pathol 27:1434-41. 2003..They also indicate that the morphologic similarity between TCC-O and TCC-B does not indicate any histogenic similarity and, as others have noted, TCC-O is a variant morphology in the spectrum of surface epithelial carcinomas...
The utility of fluorescence in situ hybridization (FISH) in the diagnosis of myxoid soft tissue neoplasmsErinn Downs-Kelly
Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH 44195, USA
Am J Surg Pathol 32:8-13. 2008..FISH is capable of providing specific ancillary information useful in this often difficult differential diagnosis...
Best practices in diagnostic immunohistochemistry: pleomorphic cutaneous spindle cell tumorsAndrew L Folpe
Division of Anatomic Pathology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA
Arch Pathol Lab Med 131:1517-24. 2007..Pleomorphic cutaneous spindle cell tumors can be difficult to distinguish solely on histologic grounds. The use of ancillary immunohistochemical studies can greatly assist in this differential diagnosis...
Aberrant expression of epithelial and neuroendocrine markers in alveolar rhabdomyosarcoma: a potentially serious diagnostic pitfallArmita Bahrami
Texas Children s Hospital and Baylor College of Medicine, Houston, TX, USA
Mod Pathol 21:795-806. 2008..These findings emphasize the need to employ a panel of markers, to include desmin, myogenin/MyoD1, and genetic study in the diagnosis of primitive round cell neoplasms in all age groups and in all locations...
GLUT-1 expression in mesenchymal tumors: an immunohistochemical study of 247 soft tissue and bone neoplasmsWilliam A Ahrens
Division of Anatomic Pathology, Mayo Clinic, Rochester, MN 55905, USA
Hum Pathol 39:1519-26. 2008....
Cutaneous CD30-positive epithelioid angiosarcoma following breast-conserving therapy and irradiation: a potential diagnostic pitfallBrent R Weed
Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA
Am J Dermatopathol 30:370-2. 2008..This seems to be the first such case reported. The differential diagnosis of CD30 epithelioid angiosarcoma is discussed...
Dermatofibrosarcoma protuberans presenting as a subcutaneous mass: a clinicopathological study of 15 cases with exclusive or near-exclusive subcutaneous involvementSylvia Bague
Department of Pathology, Hospital de Sant Pau, Barcelona, Spain
Am J Dermatopathol 30:327-32. 2008..The differential diagnosis with other subcutaneous spindle cell neoplasms is emphasized. Awareness of this rare subset of DFSP should prevent its misdiagnosis as other less aggressive tumor types...
Composite hemangioendothelioma: report of 5 cases including one with associated Maffucci syndromeMasaharu Fukunaga
Department of Pathology, The Jikei University School of Medicine, Jikei Daisan Hospital, 4 11 1 Izumihoncho, Komaeshi, Tokyo 201 8601, Japan
Am J Surg Pathol 31:1567-72. 2007..We conclude that composite HE should continue to be regarded as a low-grade malignant vascular tumor (HE), with significant potential for local recurrence, but little if any potential for distant metastasis...
Diagnostically challenging spindle cell lipomas: a report of 34 "low-fat" and "fat-free" variantsSteven D Billings
Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH 44195, USA
Am J Dermatopathol 29:437-42. 2007..CD34 was diffusely positive (10/11). A high index of suspicion based on clinical context and identification of other typical features of SCL are key features to the diagnosis of low-fat and fat-free SCL...
Tenosynovial giant cell tumor and pigmented villonodular synovitisAndrew L Folpe
Skeletal Radiol 36:899-900; author reply 901. 2007
The diagnostic value of hepatocyte paraffin antibody 1 in differentiating hepatocellular neoplasms from nonhepatic tumors: a reviewLaura W Lamps
University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Adv Anat Pathol 10:39-43. 2003....
Association of the t(12;22)(q13;q12) EWS/ATF1 rearrangement with polyphenotypic round cell sarcoma of bone: a case reportAndrew L Folpe
Am J Surg Pathol 30:1057-8; author reply 1058-9. 2006
Protein gene product 9.5 (PGP 9.5) is not a specific marker of neural and nerve sheath tumors: an immunohistochemical study of 95 mesenchymal neoplasmsLucas K Campbell
University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Mod Pathol 16:963-9. 2003..It is possible that our findings reflect cross-reactivity of the 13C4 clone with epitopes present on other ubiquitin hydrolases. Alternatively, PGP 9.5 expression may be aberrantly up-regulated in a variety of mesenchymal neoplasms...
Distribution of cytokeratins and vimentin in adult renal neoplasms and normal renal tissue: potential utility of a cytokeratin antibody panel in the differential diagnosis of renal tumorsBrian F Skinnider
Department of Pathology, Vancouver General Hospital and University of British Columbia, Vancouver, British Columbia, Canada
Am J Surg Pathol 29:747-54. 2005..In conclusion, CK expression patterns may be helpful in several differential diagnostic situations when dealing with adult RENs...
