N H Prins

Summary

Affiliation: Johnson and Johnson Pharmaceutical Research and Development
Country: USA

Publications

  1. ncbi An improved in vitro bioassay for the study of 5-HT(4) receptors in the human isolated large intestinal circular muscle
    N H Prins
    Department of Gastrointestinal Pharmacology, Janssen Research Foundation, Beerse, Belgium
    Br J Pharmacol 129:1601-8. 2000
  2. ncbi Characterization of the receptors involved in the 5-HT-induced excitation of canine antral longitudinal muscle
    N H Prins
    Department of Gastrointestinal Pharmacology, Janssen Research Foundation, Beerse, Belgium
    Br J Pharmacol 134:1351-9. 2001
  3. ncbi 5-HT(4) receptors mediating enhancement of contractility in canine stomach; an in vitro and in vivo study
    N H Prins
    Department of Gastrointestinal Pharmacology, Janssen Research Foundation, Beerse Belgium
    Br J Pharmacol 132:1941-7. 2001
  4. ncbi 5-HT(4) receptors on cholinergic nerves involved in contractility of canine and human large intestine longitudinal muscle
    N H Prins
    Department of Gastrointestinal Pharmacology, Janssen Research Foundation, Beerse, Belgium
    Br J Pharmacol 131:927-32. 2000
  5. ncbi The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound
    M R Briejer
    Department of Gastrointestinal Pharmacology, Janssen Research Foundation, Turnhoutseweg 30, 2340 Beerse, Belgium
    Eur J Pharmacol 423:71-83. 2001
  6. ncbi Effects of the enterokinetic prucalopride (R093877) on colonic motility in fasted dogs
    M R Briejer
    Department of Gastrointestinal Pharmacology, Janssen Research Foundation, Beerse, Belgium
    Neurogastroenterol Motil 13:465-72. 2001
  7. ncbi Pharmacological characterization of the 5-HT receptors mediating contraction and relaxation of canine isolated proximal stomach smooth muscle
    P Janssen
    Heymans Institute of Pharmacology, Ghent University, Gent, Belgium
    Br J Pharmacol 136:321-9. 2002
  8. ncbi Smooth muscle 5-HT2A receptors mediating contraction of porcine isolated proximal stomach strips
    P Janssen
    Heymans Institute of Pharmacology, Ghent University, Ghent, Belgium
    Br J Pharmacol 137:1217-24. 2002
  9. ncbi In vivo characterization of 5-HT1A receptor-mediated gastric relaxation in conscious dogs
    P Janssen
    Heymans Institute of Pharmacology, Ghent University, Ghent, Belgium
    Br J Pharmacol 140:913-20. 2003
  10. ncbi 5-HT4 receptors located on cholinergic nerves in human colon circular muscle
    P G Leclere
    Heymans Institute of Pharmacology, Ghent University, Ghent, Belgium
    Neurogastroenterol Motil 17:366-75. 2005

Collaborators

  • R A Lefebvre
  • P Janssen
  • M R Briejer
  • P G Leclere
  • J A Schuurkes
  • J A J Schuurkes
  • J P Bosmans
  • L Heylen
  • M Jurzak
  • P Van Daele
  • J E Leysen

Detail Information

Publications10

  1. ncbi An improved in vitro bioassay for the study of 5-HT(4) receptors in the human isolated large intestinal circular muscle
    N H Prins
    Department of Gastrointestinal Pharmacology, Janssen Research Foundation, Beerse, Belgium
    Br J Pharmacol 129:1601-8. 2000
    ..This new bioassay allows the focused, pharmacological characterization of human colonic 5-HT(4) receptors in vitro...
  2. ncbi Characterization of the receptors involved in the 5-HT-induced excitation of canine antral longitudinal muscle
    N H Prins
    Department of Gastrointestinal Pharmacology, Janssen Research Foundation, Beerse, Belgium
    Br J Pharmacol 134:1351-9. 2001
    ..3 microM). 8. In conclusion, dog antral longitudinal muscle is endowed with (1) excitatory neuronal 5-HT4 receptors and 5-HT2B receptors and (2) inhibitory smooth muscle 5-HT7 receptors...
  3. ncbi 5-HT(4) receptors mediating enhancement of contractility in canine stomach; an in vitro and in vivo study
    N H Prins
    Department of Gastrointestinal Pharmacology, Janssen Research Foundation, Beerse Belgium
    Br J Pharmacol 132:1941-7. 2001
    ..1 microM) (124%). In conclusion, the effects of 5-HT(4) receptor agonists on proximal stomach motor activity in vivo can be explained by an effect on 5-HT(4) receptors on cholinergic nerves within the gastric muscle wall...
  4. ncbi 5-HT(4) receptors on cholinergic nerves involved in contractility of canine and human large intestine longitudinal muscle
    N H Prins
    Department of Gastrointestinal Pharmacology, Janssen Research Foundation, Beerse, Belgium
    Br J Pharmacol 131:927-32. 2000
    ....
  5. ncbi The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound
    M R Briejer
    Department of Gastrointestinal Pharmacology, Janssen Research Foundation, Turnhoutseweg 30, 2340 Beerse, Belgium
    Eur J Pharmacol 423:71-83. 2001
    ....
  6. ncbi Effects of the enterokinetic prucalopride (R093877) on colonic motility in fasted dogs
    M R Briejer
    Department of Gastrointestinal Pharmacology, Janssen Research Foundation, Beerse, Belgium
    Neurogastroenterol Motil 13:465-72. 2001
    ..It induces GMCs and causes proximal colon stimulation and distal colon inhibition of contractile motility patterns by stimulating 5-HT4 receptors...
  7. ncbi Pharmacological characterization of the 5-HT receptors mediating contraction and relaxation of canine isolated proximal stomach smooth muscle
    P Janssen
    Heymans Institute of Pharmacology, Ghent University, Gent, Belgium
    Br J Pharmacol 136:321-9. 2002
    ..75+/-0.14 respectively), indicative of 5-HT(7) receptor involvement. 5. It is concluded that 5-HT induces dog proximal stomach (LM) contraction via smooth muscle 5-HT(2A) receptors and relaxation via smooth muscle 5-HT(7) receptors...
  8. ncbi Smooth muscle 5-HT2A receptors mediating contraction of porcine isolated proximal stomach strips
    P Janssen
    Heymans Institute of Pharmacology, Ghent University, Ghent, Belgium
    Br J Pharmacol 137:1217-24. 2002
    ..A ketanserin-insensitive phase of contractions could not be characterized between the actually known classes of 5-HT receptors with the pharmacological tools that were used...
  9. ncbi In vivo characterization of 5-HT1A receptor-mediated gastric relaxation in conscious dogs
    P Janssen
    Heymans Institute of Pharmacology, Ghent University, Ghent, Belgium
    Br J Pharmacol 140:913-20. 2003
    ..It is concluded that flesinoxan induces proximal gastric relaxation in conscious dogs via 5-HT1A receptors. The response is mediated through a vagal pathway without involvement of nitrergic nerves...
  10. ncbi 5-HT4 receptors located on cholinergic nerves in human colon circular muscle
    P G Leclere
    Heymans Institute of Pharmacology, Ghent University, Ghent, Belgium
    Neurogastroenterol Motil 17:366-75. 2005
    ..All effects of prucalopride were antagonized by the selective 5-HT4 receptor antagonist GR113808. The results obtained indicate the presence of excitatory 5-HT4 receptors on cholinergic nerves within the CM of human colon...