Xiaobing Yu

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi Notch signaling activation in human embryonic stem cells is required for embryonic, but not trophoblastic, lineage commitment
    Xiaobing Yu
    Stem Cell Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell Stem Cell 2:461-71. 2008
  2. ncbi Trophoblast differentiation defect in human embryonic stem cells lacking PIG-A and GPI-anchored cell-surface proteins
    Guibin Chen
    Stem Cell Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell Stem Cell 2:345-55. 2008
  3. ncbi Improved efficiency and pace of generating induced pluripotent stem cells from human adult and fetal fibroblasts
    Prashant Mali
    Stem Cell Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Broadway Research Building, Room 747, 733 North Broadway, Baltimore, Maryland 21205, USA
    Stem Cells 26:1998-2005. 2008
  4. ncbi HES1 inhibits cycling of hematopoietic progenitor cells via DNA binding
    Xiaobing Yu
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Bunting-Blaustein Cancer Research Building, Room 2M44, 1650 Orleans Street, Baltimore, Maryland 21231, USA
    Stem Cells 24:876-88. 2006
  5. ncbi FLT3/ITD expression increases expansion, survival and entry into cell cycle of human haematopoietic stem/progenitor cells
    Li Li
    Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
    Br J Haematol 137:64-75. 2007
  6. ncbi Serial imaging of human embryonic stem-cell engraftment and teratoma formation in live mouse models
    Martin G Pomper
    Department of Radiology and Radiological Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    Cell Res 19:370-9. 2009
  7. ncbi Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas
    Farzad Esni
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Development 131:4213-24. 2004
  8. ncbi Kruppel-like factor 4 is essential for inflammatory monocyte differentiation in vivo
    Jonathan K Alder
    Divisions of Immunology and Hematopoiesis, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Immunol 180:5645-52. 2008
  9. ncbi Lentiviral gene transduction of mouse and human stem cells
    Zhaohui Ye
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD
    Methods Mol Biol 430:243-53. 2008
  10. ncbi Defining the role of Wnt/beta-catenin signaling in the survival, proliferation, and self-renewal of human embryonic stem cells
    Gautam Dravid
    The Institute for Cell Engineering, Department of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Stem Cells 23:1489-501. 2005

Collaborators

Detail Information

Publications12

  1. ncbi Notch signaling activation in human embryonic stem cells is required for embryonic, but not trophoblastic, lineage commitment
    Xiaobing Yu
    Stem Cell Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell Stem Cell 2:461-71. 2008
    ..These new insights into the roles of Notch in hESC-fate determination may help to efficiently direct hESC differentiation into therapeutically relevant cell types...
  2. ncbi Trophoblast differentiation defect in human embryonic stem cells lacking PIG-A and GPI-anchored cell-surface proteins
    Guibin Chen
    Stem Cell Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell Stem Cell 2:345-55. 2008
    ..These data reveal that GPI-AP-enhanced full activation of BMP signaling is required for human trophoblast formation...
  3. ncbi Improved efficiency and pace of generating induced pluripotent stem cells from human adult and fetal fibroblasts
    Prashant Mali
    Stem Cell Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Broadway Research Building, Room 747, 733 North Broadway, Baltimore, Maryland 21205, USA
    Stem Cells 26:1998-2005. 2008
    ..Using this improved approach, we also generated hES-like cells from homozygous fibroblasts containing the sickle cell anemia mutation Hemoglobin Sickle. Disclosure of potential conflicts of interest is found at the end of this article...
  4. ncbi HES1 inhibits cycling of hematopoietic progenitor cells via DNA binding
    Xiaobing Yu
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Bunting-Blaustein Cancer Research Building, Room 2M44, 1650 Orleans Street, Baltimore, Maryland 21231, USA
    Stem Cells 24:876-88. 2006
    ..Our data characterize the complex, cell context-dependent actions of HES1 as a major downstream Notch signaling regulator of HSPC function...
  5. ncbi FLT3/ITD expression increases expansion, survival and entry into cell cycle of human haematopoietic stem/progenitor cells
    Li Li
    Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
    Br J Haematol 137:64-75. 2007
    ..CEP-701 may act as a potent therapeutic agent for AML stem cells harbouring FLT3/ITD mutations...
  6. ncbi Serial imaging of human embryonic stem-cell engraftment and teratoma formation in live mouse models
    Martin G Pomper
    Department of Radiology and Radiological Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    Cell Res 19:370-9. 2009
    ..Noninvasive imaging methods such as these may enable us to monitor the presence and distribution of transplanted human stem cells repetitively within live recipients over a long term through the expression of a reporter gene...
  7. ncbi Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas
    Farzad Esni
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Development 131:4213-24. 2004
    ..These results define a normal inhibitory role for Notch in the regulation of exocrine pancreatic differentiation...
  8. ncbi Kruppel-like factor 4 is essential for inflammatory monocyte differentiation in vivo
    Jonathan K Alder
    Divisions of Immunology and Hematopoiesis, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Immunol 180:5645-52. 2008
    ....
  9. ncbi Lentiviral gene transduction of mouse and human stem cells
    Zhaohui Ye
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD
    Methods Mol Biol 430:243-53. 2008
    ..These cells maintained stable transgene expression after engraftment in mice and in vivo differentiation. Human ESCs can also be transduced with a high efficiency, and transgene is expressed stably after hematopoietic differentiation...
  10. ncbi Defining the role of Wnt/beta-catenin signaling in the survival, proliferation, and self-renewal of human embryonic stem cells
    Gautam Dravid
    The Institute for Cell Engineering, Department of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Stem Cells 23:1489-501. 2005
    ..Thus, Wnt/beta-catenin activation does not suffice to maintain the undifferentiated and pluripotent state of hESCs. We propose a new model for the role of Wnt/beta-catenin signaling in undifferentiated hESCs...
  11. ncbi Lentiviral vectors with two independent internal promoters transfer high-level expression of multiple transgenes to human hematopoietic stem-progenitor cells
    Xiaobing Yu
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Baltimore, Maryland 21231, USA
    Mol Ther 7:827-38. 2003
    ..Thus, such dual-promoter LVs can coexpress multiple transgenes efficiently in a single target cell and will enable many gene transfer applications...
  12. ncbi Id1 delays senescence of primary human melanocytes
    Staci D Cummings
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231 1000, USA
    Mol Carcinog 47:653-9. 2008
    ....