Research Topics
Species | Sevil YasarSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Metabolic transformation plays a primary role in the psychostimulant-like discriminative-stimulus effects of selegiline [(R)-(-)-deprenyl]Sevil Yasar
Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
J Pharmacol Exp Ther 317:387-94. 2006....- Evaluation of the novel antiepileptic drug, AWD 131-138, for benzodiazepine-like discriminative stimulus and reinforcing effects in squirrel monkeysSevil Yasar
Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Eur J Pharmacol 465:257-65. 2003..The failure of AWD 131-138 to produce benzodiazepine-like discriminative effects and the absence of drug self-administration behavior when substituted for cocaine suggest that its abuse liability is low... - The use of angiotensin-converting enzyme inhibitors and diuretics is associated with a reduced incidence of impairment on cognition in elderly womenS Yasar
Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
Clin Pharmacol Ther 84:119-26. 2008..Therefore, the use of ACE-Is or diuretics was associated with reduced incidence of impairment of both global and domain-specific cognition in elderly women, and may help delay progression to dementia... - Calcium channel blockers and risk of AD: the Baltimore Longitudinal Study of AgingS Yasar
Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins School of Medicine, 5505 Hopkins Bayview Circle, Baltimore, MD 21224, USA
Neurobiol Aging 26:157-63. 2005..Previous reports suggest a possible role for CCB in the treatment of AD. However, there are some indications that CCB increase mortality in patients with cardiac disease... - A comparison of drug-seeking behavior maintained by D-amphetamine, L-deprenyl (selegiline), and D-deprenyl under a second-order schedule in squirrel monkeysSevil Yasar
Preclinical Pharmacology Section, Behavioral Neurosciences Research Branch, DHHS NIH NIDA Intramural Research Program, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 183:413-21. 2006..Under conditions where drug-seeking and drug-taking behaviors are actively maintained by D-amphetamine, L-deprenyl, at doses that specifically inhibit type B monoamine oxidase, may not be effective as a treatment... - Reinforcing and neurochemical effects of cannabinoid CB1 receptor agonists, but not cocaine, are altered by an adenosine A2A receptor antagonistZuzana Justinova
Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health DHHS, Bethesda, MD 20892, USA
Addict Biol 16:405-15. 2011..Adenosine A(2A) antagonists with more selectivity for presynaptic versus postsynaptic receptors could be potential medications for treatment of cannabis abuse... - Discriminative stimulus and reinforcing effects of p-fluoro-L-deprenyl in monkeysSevil Yasar
Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 182:95-103. 2005..It also appears to function as a relatively limited reinforcer of intravenous self-administration behavior in monkeys trained to self-administer i.v. cocaine... - Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptorsPaola Mascia
Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Medications Discovery Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
Biol Psychiatry 69:633-41. 2011..Here, we evaluated whether directly acting PPAR-? agonists can modulate reward-related effects of nicotine... - Fatty acid amide hydrolase inhibition heightens anandamide signaling without producing reinforcing effects in primatesZuzana Justinova
Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA
Biol Psychiatry 64:930-7. 2008..To address this question, we assessed the effects of URB597, a selective anandamide deactivation inhibitor, as a reinforcer of drug-seeking and drug-taking behavior in squirrel monkeys... - Inhibition of anandamide hydrolysis by cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester (URB597) reverses abuse-related behavioral and neurochemical effects of nicotine in ratsMaria Scherma
Preclinical Pharmacology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
J Pharmacol Exp Ther 327:482-90. 2008..These findings suggest that FAAH inhibition can counteract the addictive properties of nicotine and that FAAH may serve as a new target for development of medications for treatment of tobacco dependence... - Anandamide-induced behavioral disruption through a vanilloid-dependent mechanism in ratsLeigh V Panlilio
Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, NIDA, NIH, DHHS, 05A711, 251 Bayview Blvd, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 203:529-38. 2009..In the five-choice serial reaction-time task, exogenous cannabinoids have been found to alter attention, but endocannabinoids such as anandamide have not been studied... - Blockade of THC-seeking behavior and relapse in monkeys by the cannabinoid CB(1)-receptor antagonist rimonabantZuzana Justinova
Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Department of Health and Human Services, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA
Neuropsychopharmacology 33:2870-7. 2008..Thus, rimonabant and related medications might be effective as treatments for cannabinoid dependence... - The endogenous cannabinoid 2-arachidonoylglycerol is intravenously self-administered by squirrel monkeysZuzana Justinova
Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
J Neurosci 31:7043-8. 2011.... - Fatty acid amide hydrolase (FAAH) inhibition enhances memory acquisition through activation of PPAR-alpha nuclear receptorsCarmen Mazzola
Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, NIDA, NIH, DHHS, Baltimore, Maryland 21224, USA
Learn Mem 16:332-7. 2009..These findings demonstrate novel mechanisms for memory enhancement by activation of PPAR-alpha, either directly by administering a PPAR-alpha agonist or indirectly by administering a FAAH inhibitor... - Human cocaine-seeking behavior and its control by drug-associated stimuli in the laboratoryLeigh V Panlilio
Preclinical Pharmacology Section, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA
Neuropsychopharmacology 30:433-43. 2005..The similarity of the response patterns in humans and animals also supports the use of second-order schedules in animals as a valid model of human drug seeking... - Automatic recording of mediating behavior in delayed matching- and nonmatching-to-position procedures in ratsLeigh V Panlilio
Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 251 Bayview Blvd, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 214:495-504. 2011..The ubiquitous nature of mediating behavior suggests it might be analogous to rehearsal, an important component of learning and memory in humans... - The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibitionMaria Scherma
Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD, USA
Neuropharmacology 54:129-40. 2008..Thus, additive interactions between the effects of anandamide on brain reward processes and on anxiety may account for its aversive effects when intravenously administered during FAAH inhibition with URB597... - Nicotine serves as an effective reinforcer of intravenous drug-taking behavior in human cigarette smokersDeon M Harvey
Clinical Pharmacology and Therapeutics Branch, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 175:134-42. 2004..Subjects adjusted their responding to response requirements in a way that maintained relatively constant levels of nicotine injections per session... - Lack of persistent changes in the dopaminergic system of rats withdrawn from methamphetamine self-administrationRoman Stefanski
Preclinical Pharmacology Section, National Institutes of Health, National Institute on Drug Abuse, Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Eur J Pharmacol 439:59-68. 2002.... - Effects of endocannabinoid system modulation on cognitive and emotional behaviorClaudio Zanettini
Department of Health and Human Services, Preclinical Pharmacology Section, Behavioral Neurosciences Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health Baltimore, MD, USA
Front Behav Neurosci 5:57. 2011..Recent findings are reviewed that raise the possibility that endocannabinoid signaling may change the impact of environmental influences on emotional and cognitive behavior rather than selectively affecting any specific behavior... - Physical and cognitive performance and burden of anticholinergics, sedatives, and ACE inhibitors in older womenY J Cao
National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA
Clin Pharmacol Ther 83:422-9. 2008.... - Using drug-discrimination techniques to study the abuse-related effects of psychoactive drugs in ratsMarcello Solinas
Centre National de la Recherche Scientifique UMR 6187, University of Poitiers, 40 Avenue du Recteur Pineau, 86022 Poitiers Cedex, France
Nat Protoc 1:1194-206. 2006.... - The endogenous cannabinoid anandamide produces delta-9-tetrahydrocannabinol-like discriminative and neurochemical effects that are enhanced by inhibition of fatty acid amide hydrolase but not by inhibition of anandamide transportMarcello Solinas
Laboratoire de Biologie et Physiologie Cellulaires, CNRS 6187, Universite de Poitiers, Poitiers, France
J Pharmacol Exp Ther 321:370-80. 2007.... - Albuminuria and dementia in the elderly: a community studyJoshua I Barzilay
Kaiser Permanente of Georgia, Tucker, GA 30084, USA
Am J Kidney Dis 52:216-26. 2008..In this study, we examine whether cognitive status (normal cognition, mild cognitive impairment, and dementia) is associated with albuminuria, a microvascular disorder of the kidney... - Endocannabinoid system involvement in brain reward processes related to drug abuseMarcello Solinas
Institut de Physiologie et Biologie Cellulaires, University of Poitiers, Centre National de la Recherche Scientifique UMR 6187, 40 Avenue du Recteur Pineau, 86022 Poitiers Cedex, France
Pharmacol Res 56:393-405. 2007..Altogether, evidence points to the endocannadinoid system as a promising target for the development of medications for the treatment of drug abuse...