Research Topics
| Raimond WinslowSummaryAffiliation: Johns Hopkins University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Merging microarray data from separate breast cancer studies provides a robust prognostic testLei Xu
The Institute for Computational Medicine and Center for Cardiovascular Bioinformatics and Modeling, Johns Hopkins University, Baltimore, MD 21218, USA
BMC Bioinformatics 9:125. 2008..Integrating microarray data from multiple studies in order to increase sample size is therefore a promising approach to the development of more robust prognostic tests...- Large-scale integration of cancer microarray data identifies a robust common cancer signatureLei Xu
The Institute for Computational Medicine and Center for Cardiovascular Bioinformatics and Modeling, Johns Hopkins University, Baltimore, MD 21218, USA
BMC Bioinformatics 8:275. 2007..DNA microarrays provide a means for measuring gene expression signatures which can then be used as components of genomic-based diagnostic tests to determine the presence of cancer... - Cardiac myocytes and local signaling in nano-domainsRaimond L Winslow
The Institute for Computational Medicine and Department of Biomedical Engineering, The Johns Hopkins University, School of Medicine and Whiting School of Engineering, Baltimore, MD 21218, USA
Prog Biophys Mol Biol 107:48-59. 2011.... - Integrative modeling of the cardiac ventricular myocyteRaimond L Winslow
Institute of Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA
Wiley Interdiscip Rev Syst Biol Med 3:392-413. 2011..We describe key advances and limitations of the models as well as point to new directions for future modeling research. WIREs Syst Biol Med 2011 3 392-413 DOI: 10.1002/wsbm.122.. - Multiscale modeling of calcium signaling in the cardiac dyadRaimond L Winslow
Institute for Computational Medicine and Center for Cardiovascular Bioinformatics and Modeling, The Johns Hopkins University School of Medicine and Whiting School of Engineering, Baltimore, MD 21218, USA
Ann N Y Acad Sci 1080:362-75. 2006..The simplified model may be solved many orders of magnitude faster than can either of the more detailed models, thus enabling incorporation into tissue-level simulations... - An integrative model of the cardiac ventricular myocyte incorporating local control of Ca2+ releaseJoseph L Greenstein
Department of Biomedical Engineering, Center for Computational Medicine and Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Biophys J 83:2918-45. 2002..The local control myocyte model provides a means for studying the interrelationship between microscopic and macroscopic behaviors in a manner that would not be possible in experiments... - Role of sodium-calcium exchanger in modulating the action potential of ventricular myocytes from normal and failing heartsAntonis A Armoundas
The Johns Hopkins University, School of Medicine, Institute of Molecular Cardiobiology, 844 Ross Bldg, 720 Rutland Ave, Baltimore, Md 21205-219, USA
Circ Res 93:46-53. 2003.... - CaMKII-induced shift in modal gating explains L-type Ca(2+) current facilitation: a modeling studyYasmin L Hashambhoy
Institute for Computational Medicine, Center for Cardiovascular Bioinformatics and Modeling, and the Whitaker Biomedical Engineering Institute, The Johns Hopkins University, Baltimore, Maryland, USA
Biophys J 96:1770-85. 2009..The model therefore serves as a powerful tool for interpreting I(CaL) experiments... - A computational model of the human left-ventricular epicardial myocyteVivek Iyer
The Center for Cardiovascular Bioinformatics and Modeling and The Whitaker Biomedical Engineering Institute, The Johns Hopkins University School of Medicine and Whiting School of Engineering, Baltimore, Maryland 21093, USA
Biophys J 87:1507-25. 2004..The model therefore serves as a useful tool for investigating mechanisms of arrhythmia and consequences of drug-channel interactions in the human left-ventricular myocyte... - A computational model integrating electrophysiology, contraction, and mitochondrial bioenergetics in the ventricular myocyteSonia Cortassa
The Johns Hopkins University, Institute for Computational Medicine, and Institute of Molecular Cardiobiology, Baltimore, Maryland 21218, USA
Biophys J 91:1564-89. 2006.... - Role of CaMKII in RyR leak, EC coupling and action potential duration: a computational modelYasmin L Hashambhoy
Institute for Computational Medicine, Center for Cardiovascular Bioinformatics and Modeling, The Johns Hopkins University, Baltimore, MD, USA
J Mol Cell Cardiol 49:617-24. 2010..These results suggest that LCC phosphorylation sites may be a more effective target than RyR sites in modulating diastolic RyR flux... - Key pathways associated with heart failure development revealed by gene networks correlated with cardiac remodelingZhong Gao
The Institute for Computational Medicine, The Johns Hopkins University, Baltimore, Maryland 21205, USA
Physiol Genomics 35:222-30. 2008..As the transition to overt HF is characterized by few additional transcriptional changes, posttranscriptional modifications may be more critical in regulating myocardial structure and function during later stages of HF... - Protein geometry and placement in the cardiac dyad influence macroscopic properties of calcium-induced calcium releaseAntti J Tanskanen
The Institute for Computational Medicine, Center for Cardiovascular Bioinformatics and Modeling, The Johns Hopkins University School of Medicine and Whiting School of Engineering, Baltimore, Maryland, USA
Biophys J 92:3379-96. 2007..Results suggest the hypothesis that the relative placement and shape of the RyR2 proteins helps to "funnel" Ca2+ ions to RyR2 binding sites, thus increasing excitation-contraction coupling gain... - Evidence of structural remodeling in the dyssynchronous failing heartPatrick A Helm
Centers for Cardiovascular Bioinformatics and Modeling, Johns Hopkins University, Baltimore, MD, USA
Circ Res 98:125-32. 2006..Measured changes in both fiber gradient and sheet structure will affect both the heterogeneity of passive myocardial properties as well as electrical activation of the ventricles... - MASCOT HTML and XML parser: an implementation of a novel object model for protein identification dataChunguang G Yang
Center for Cardiovascular Bioinformatics and Modeling, The Institute for Computational Medicine and The Whitaker Biomedical Engineering Institute, The Johns Hopkins University, Baltimore, MD 21218-2686, USA
Proteomics 6:5688-93. 2006..The source code is freely available at http://www.ccbm.jhu.edu and the program uses only free and open-source Java libraries... - Simple decision rules for classifying human cancers from gene expression profilesAik Choon Tan
Center for Cardiovascular Bioinformatics and Modeling, Whitaker Biomedical Engineering Institute, Baltimore, MD 21218, USA
Bioinformatics 21:3896-904. 2005..This method generates simple and accurate decision rules that only involve a small number of gene-to-gene expression comparisons, thereby facilitating follow-up studies... - Discovering robust protein biomarkers for disease from relative expression reversals in 2-D DIGE dataTroy J Anderson
Center for Cardiovascular Bioinformatics and Modeling and The Institute of Computational Medicine, Johns Hopkins University, Baltimore, MD 21218, USA
Proteomics 7:1197-207. 2007..We propose that by accounting for sources of within- and between-gel variation, RER classifiers applied to 2-D DIGE data provide a useful approach for identifying biomarkers that discriminate among protein samples of interest... - Improved reproducibility of reverse-phase protein microarrays using array microenvironment normalizationTroy Anderson
Institute for Computational Medicine, Center for Cardiovascular Bioinformatics and Modeling, Johns Hopkins University, Baltimore, MD 21218, USA
Proteomics 9:5562-6. 2009..The improved reproducibility and statistical power should facilitate clinical implementation of the platform... - The role of stochastic and modal gating of cardiac L-type Ca2+ channels on early after-depolarizationsAntti J Tanskanen
Center for Cardiovascular Bioinformatics and Modeling, The Johns Hopkins University School of Medicine and Whiting School of Engineering, Baltimore, Maryland 21218, USA
Biophys J 88:85-95. 2005..These results suggest a novel stochastic mechanism, whereby phosphorylation-induced changes in LCC gating properties contribute to EAD generation... - Computational method for identifying and quantifying shape features of human left ventricular remodelingSiamak Ardekani
Institute for Computational Medicine, Johns Hopkins University, 3400 N Charles St, Baltimore, MD 21218, USA
Ann Biomed Eng 37:1043-54. 2009..This approach may be useful in identifying differences in the remodeling process between ICM and NICM populations and possibly in differentiating the populations... - Transcriptomic profiling of the canine tachycardia-induced heart failure model: global comparison to human and murine heart failureZhong Gao
Center for Cardiovascular Bioinformatics and Modeling, The Johns Hopkins University School of Medicine and Whiting School of Engineering, Baltimore, MD 21218, USA
J Mol Cell Cardiol 40:76-86. 2006..This study provides insights into the molecular pathways leading to end-stage tachycardia-induced HF, and into global transcriptomic differences between the animal HF models and human HF... - Mechanisms of excitation-contraction coupling in an integrative model of the cardiac ventricular myocyteJoseph L Greenstein
The Center for Cardiovascular Bioinformatics and Modeling and The Whitaker Biomedical Engineering Institute, The Johns Hopkins University Whiting School of Engineering and School of Medicine, Baltimore, Maryland, USA
Biophys J 90:77-91. 2006..We also demonstrate mechanisms by which alterations in the early repolarization phase of the action potential, resulting from reduction of the transient outward potassium current, alters properties of EC coupling... - Computational cardiac anatomy using MRIMirza Faisal Beg
Center for Imaging Science, The Whitaker Biomedical Engineering Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Magn Reson Med 52:1167-74. 2004..Once heart anatomies have been registered, properties of tissue geometry and cardiac fiber orientation in corresponding regions of different hearts may be quantified... - Gene expression profiles in end-stage human idiopathic dilated cardiomyopathy: altered expression of apoptotic and cytoskeletal genesChristina K Yung
Department of Biomedical Engineering, The Johns Hopkins University School of Medicine and Whiting School of Engineering, Baltimore, MD 21218, USA
Genomics 83:281-97. 2004..These regulated genes take part in diverse cellular processes, including transcription, apoptosis, sarcomeric and cytoskeletal function, remodeling of the extracellular matrix, membrane transport, and metabolism... - Using models of the myocyte for functional interpretation of cardiac proteomic dataRaimond L Winslow
Center for Cardiovascular Bioinformatics and Modelling, The Johns Hopkins University School of Medicine and Whiting School of Engineering, Baltimore, MD, USA
J Physiol 563:73-81. 2005.... - Genome informatics: current status and future prospectsRaimond L Winslow
The Whitaker Biomedical Engineering Institute and Center for Cardiovascular Bioinformatics and Modeling, The Johns Hopkins University School of Medicine, Baltimore, MD 21218, USA
Circ Res 92:953-61. 2003..In each instance, we provide links to relevant sources of information on the World Wide Web and critical appraisals of the promises and the challenges of an expanding and diverse information landscape... - Robust prostate cancer marker genes emerge from direct integration of inter-study microarray dataLei Xu
The Whitaker Biomedical Engineering Institute, The Johns Hopkins University, Baltimore, MD 21218, USA
Bioinformatics 21:3905-11. 2005..With the rapid accumulation of microarray data, it is of great interest to integrate inter-study microarray data to increase sample size, which could lead to the discovery of more reliable markers... - Ex vivo 3D diffusion tensor imaging and quantification of cardiac laminar structurePatrick A Helm
Center for Cardiovascular Bioinformatics and Modeling, Johns Hopkins University, Baltimore, MD 21218, USA
Magn Reson Med 54:850-9. 2005.... - Large deformation diffeomorphic metric mapping of vector fieldsYan Cao
Center for Imaging Science, Johns Hopkins University, Baltimore, MD 21218, USA
IEEE Trans Med Imaging 24:1216-30. 2005..This is illustrated by numerical experiments on DT-MRI heart images... - Control and regulation of mitochondrial energetics in an integrated model of cardiomyocyte functionSonia Cortassa
Division of Cardiology, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA
Biophys J 96:2466-78. 2009..g., by a pharmacological agent) may bring about changes in processes without obvious direct mechanistic links between them... - A mitochondrial oscillator dependent on reactive oxygen speciesSonia Cortassa
The Johns Hopkins University, Institute of Molecular Cardiobiology and Center for Cardiovascular Bioinformatics and Modeling, Baltimore, Maryland 21205-2195, USA
Biophys J 87:2060-73. 2004.... - An integrated model of cardiac mitochondrial energy metabolism and calcium dynamicsSonia Cortassa
The Johns Hopkins University, Institute of Molecular Cardiobiology, Baltimore, Maryland 21205-2195, USA
Biophys J 84:2734-55. 2003..The steady-state and time-dependent behavior of the model support the hypothesis that mitochondrial matrix Ca(2+) plays an important role in matching energy supply with demand in cardiac myocytes... - Ectopic expression of KCNE3 accelerates cardiac repolarization and abbreviates the QT intervalReza Mazhari
Department of Medicine, Institute of Molecular Cardiobiology, Johns Hopkins University, 720 Rutland Avenue, Baltimore, MD 21205, USA
J Clin Invest 109:1083-90. 2002..Provided that fairly homogeneous ectopic ventricular expression of regulatory subunits can be achieved, this approach may be useful in enhancing repolarization and in treating long QT syndrome... - Modeling cardiac action potential shortening driven by oxidative stress-induced mitochondrial oscillations in guinea pig cardiomyocytesLufang Zhou
Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Biophys J 97:1843-52. 2009.... - Measuring and mapping cardiac fiber and laminar architecture using diffusion tensor MR imagingPatrick Helm
The Center for Cardiovascular Bioinformatics and Modeling, The Johns Hopkins University School of Medicine and Whiting School of Engineering, Baltimore, Maryland 21218, USA
Ann N Y Acad Sci 1047:296-307. 2005.... - Integrative systems models of cardiac excitation-contraction couplingJoseph L Greenstein
Center for Cardiovascular Bioinformatics and Modeling, Whitaker Biomedical Engineering Institute, The Johns Hopkins University, Baltimore, MD, USA
Circ Res 108:70-84. 2011..Here, we review experimentally based multiscale computational models of excitation-contraction coupling and the insights that have been gained through their application... - Modeling the actions of beta-adrenergic signaling on excitation--contraction coupling processesJoseph L Greenstein
Center for Cardiovascular Bioinformatics and Modeling, The Johns Hopkins University School of Medicine, and Whiting School of Engineering, Baltimore, MD 21218, USA
Ann N Y Acad Sci 1015:16-27. 2004.... - Identification of novel serological biomarkers for inflammatory bowel disease using Escherichia coli proteome chipChien Sheng Chen
Department of Pharmacology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Mol Cell Proteomics 8:1765-76. 2009..04). Taken together, we identified novel sets of serological biomarkers for diagnosis of CD versus healthy control and CD versus UC... - The ongoing journey to understand heart function through integrative modelingRaimond L Winslow
Circ Res 95:1135-6. 2004 - From mitochondrial ion channels to arrhythmias in the heart: computational techniques to bridge the spatio-temporal scalesGernot Plank
Institute of Biophysics, Medical University Graz, 8010 Graz, Austria
Philos Transact A Math Phys Eng Sci 366:3381-409. 2008.... - Imaging-based integrative models of the heart: closing the loop between experiment and simulationRaimond L Winslow
The Whitaker Biomedical Engineering Institute Center for Computational Medicine and Biology, Johns Hopkins University, Baltimore MD 21218, USA
Novartis Found Symp 247:129-41; discussion 141-3, 144-50, 244-52. 2002..We believe this ability to electrically map and model individual hearts will lead to enhanced understanding of the relationship between anatomical structure, and electrical conduction in the cardiac ventricles... - Candidate gene discovery in cardiovascular diseaseRaimond L Winslow
Circ Res 96:605-6. 2005
Research Grants
- The Systems Biology of Sudden Cardiac DeathRaimond Winslow; Fiscal Year: 2007..This project will test these hypotheses and the results will have major importance for our understanding of the mechanisms and treatment of arrhythmias. ..
- Short Course on Integrative Modeling of the Cardiac MyocyteRaimond Winslow; Fiscal Year: 2007....
- The CardioVascular Research GridRaimond Winslow; Fiscal Year: 2007..End of Abstract). ..
- Anatomical Remodeling and Electrical Conduction in HeartRaimond Winslow; Fiscal Year: 2005..Fifth, we will relate measured changes in fiber structure to measured changes of electrical propagation in each heart using both experimental approaches as well as computational models. ..
- Calcium Cycling and Regulation of the Cardiac APRaimond Winslow; Fiscal Year: 2005..The general goal of the proposed research is to test this hypothesis by means of experiments coupled with computational modeling. ..
- EXPERIMENTAL STUDY OF ARRHYTHMIAS IN HEART FAILURERaimond Winslow; Fiscal Year: 2000..The arrhythmogenic potential of the cellular mechanisms investigated in Aim 3 will be tested using the three-dimensional ventricular models. ..