Research Topics
| Sharon L WalshSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Modulation of intravenous cocaine effects by chronic oral cocaine in humansS L Walsh
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224 6823, USA
Psychopharmacology (Berl) 150:361-73. 2000..Agonist therapies have proven effective for the treatment of substance dependence disorders; limited data is available on their feasibility for treating cocaine dependence...- Enadoline and butorphanol: evaluation of kappa-agonists on cocaine pharmacodynamics and cocaine self-administration in humansS L Walsh
Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
J Pharmacol Exp Ther 299:147-58. 2001..These data suggest that these kappa-agonists may be safely administered in the presence of cocaine but do not produce significant attenuation of cocaine's direct effects or self-administration under these acute dosing conditions... - Enadoline, a selective kappa opioid agonist: comparison with butorphanol and hydromorphone in humansS L Walsh
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 157:151-62. 2001.... - The clinical pharmacology of buprenorphine: extrapolating from the laboratory to the clinicSharon L Walsh
Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, John Hopkins University, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
Drug Alcohol Depend 70:S13-27. 2003.... - Evaluation of the effects of lofexidine and clonidine on naloxone-precipitated withdrawal in opioid-dependent humansSharon L Walsh
Behavioral Pharmacology Research Unit, Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
Addiction 98:427-39. 2003..To examine the efficacy of lofexidine, an alpha2 adrenergic agonist, to suppress opioid withdrawal symptoms in opioid-dependent humans under in-patient laboratory conditions by using a naloxone challenge procedure... - Acute effects of intramuscular and sublingual buprenorphine and buprenorphine/naloxone in non-dependent opioid abusersAngela N Duke
Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 211:303-12. 2010..However, the addition of naloxone may not limit abuse potential of this medication when taken by individuals without opioid physical dependence... - Effects associated with double-blind omission of buprenorphine/naloxone over a 98-h periodChristopher J Correia
Behavioral Pharmacology Research Unit, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 189:297-306. 2006..However, withdrawal did not differ as a function of B/N maintenance dose. CONCLUSIONS: These findings suggest that B/N doses greater than 8/2 mg provide minimal incremental value in terms of opioid blockade and withdrawal suppression... - Modest opioid withdrawal suppression efficacy of oral tramadol in humansMichelle R Lofwall
Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Psychopharmacology (Berl) 194:381-93. 2007..Tramadol is in an unscheduled atypical analgesic with low rates of diversion and abuse and mixed pharmacologic actions, including modest opioid agonist activity... - Methadone doses of 100 mg or greater are more effective than lower doses at suppressing heroin self-administration in opioid-dependent volunteersEric C Donny
Behavioral Pharmacology Research Unit, Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD, USA
Addiction 100:1496-509. 2005..CONCLUSIONS: These results support other clinical and laboratory-based research indicating that persistent heroin use may be reduced by providing larger methadone maintenance doses that produce more effective cross-tolerance to heroin... - Blockade of hydromorphone effects by buprenorphine/naloxone and buprenorphineEric C Strain
Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 159:161-6. 2002..Naloxone has been combined with buprenorphine to decrease the parenteral abuse potential of buprenorphine. This addition of naloxone may also confer further opioid blockade efficacy... - Assessment of agonist and antagonist effects of tramadol in opioid-dependent humansC Patrick Carroll
Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Exp Clin Psychopharmacol 14:109-20. 2006..In contrast, tramadol's pattern of effects was more similar to that of hydromorphone and suggestive of mild opioid-agonist effects (withdrawal suppression), though not to a statistically significant degree... - Open-label trial of an injection depot formulation of buprenorphine in opioid detoxificationBai-Fang X Sobel
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224-6823, USA
Drug Alcohol Depend 73:11-22. 2004..Results from the present study suggest that depot buprenorphine offers significant promise for enhancing the delivery of effective opioid agonist treatment while minimizing risk for abuse of the medication... - Sublingual buprenorphine/naloxone precipitated withdrawal in subjects maintained on 100mg of daily methadoneJames Rosado
Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
Drug Alcohol Depend 90:261-9. 2007..Acute doses of buprenorphine can precipitate withdrawal in opioid dependent persons. The likelihood of this withdrawal increases as a function of the level of physical dependence... - High-dose methadone produces superior opioid blockade and comparable withdrawal suppression to lower doses in opioid-dependent humansEric C Donny
Behavioral Pharmacology Research Unit, Department of Psychiatry, Johns Hopkins School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 161:202-12. 2002..The efficacy of methadone for treating heroin dependence derives, in part, from suppression of opiate withdrawal and attenuation of the effects of heroin... - Choosing to take cocaine in the human laboratory: effects of cocaine dose, inter-choice interval, and magnitude of alternative reinforcementEric C Donny
Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
Drug Alcohol Depend 69:289-301. 2003..Inter-choice interval did not affect cocaine choices. These results illustrate the persistence of cocaine self-administration once cocaine-taking has been initiated... - Assessing the initiation of cocaine self-administration in humans during abstinence: effects of dose, alternative reinforcement, and primingEric C Donny
Behavioral Pharmacology Research Unit, Johns Hopkins School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 172:316-23. 2004..One potential trigger of cocaine-taking is exposure to cocaine (i.e. priming)... - Experimentally-induced spontaneous opiate withdrawal: relationship to cigarette craving and expired air carbon monoxideMichelle R Lofwall
Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Addict 16:310-5. 2007..Interestingly, craving was only reduced for items related to the positive reinforcing effects of smoking. These preliminary results suggest that OW may be a favorable context to initiate smoking cessation treatment interventions... - Efficacy of continuing medical education to reduce the risk of buprenorphine diversionMichelle R Lofwall
Department of Psychiatry, University of Kentucky, Lexington, KY 40509, USA
J Subst Abuse Treat 41:321-9. 2011..Mandatory CME targeting OBOT-certified physicians could have a positive impact on patient and public health outcomes... - Relative bioavailability of different buprenorphine formulations under chronic dosing conditionsEric C Strain
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
Drug Alcohol Depend 74:37-43. 2004..This study compared the relative buprenorphine bioavailability of these different formulations... - Effect of repeated cocaine administration on detection times in oral fluid and urineRebecca Jufer
Office of the Chief Medical Examiner, Baltimore, Maryland, USA
J Anal Toxicol 30:458-62. 2006.... - Comparing the physiological and subjective effects of self-administered vs yoked cocaine in humansEric C Donny
Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA
Psychopharmacology (Berl) 186:544-52. 2006..Studies with laboratory animals demonstrating different effects of self- vs experimenter-administered drug suggest that the ability to control or predict drug delivery may be an important determinant of drug action... - Ketoconazole, a cytochrome P450 3A4 inhibitor, markedly increases concentrations of levo-acetyl-alpha-methadol in opioid-naive individualsDavid E Moody
Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112 9437, USA
Clin Pharmacol Ther 76:154-66. 2004..No previous studies have been conducted to determine the effect of in vivo inhibition of CYP3A on the pharmacokinetics and pharmacodynamics of LAAM... - Detection and time course of cocaine N-oxide and other cocaine metabolites in human plasma by liquid chromatography/tandem mass spectrometryShen Nan Lin
University of Utah Center for Human Toxicology, 20S 2030E, Room 490, Salt Lake City, Utah 84112 9457, USA
Anal Chem 75:4335-40. 2003..The resulting time course data provide additional information into kinetic interrelationships between cocaine N-oxidation and cocaine hydrolysis...