Debasish Sinha

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi betaA3/A1-crystallin in astroglial cells regulates retinal vascular remodeling during development
    Debasish Sinha
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Bunting Blaustein Cancer Research Building II, 1550 Orleans St, Room 146, Baltimore, MD 21231, USA
    Mol Cell Neurosci 37:85-95. 2008
  2. ncbi A spontaneous mutation affects programmed cell death during development of the rat eye
    Debasish Sinha
    Department of Ophthalmology, School of Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21287, USA
    Exp Eye Res 80:323-35. 2005
  3. ncbi A potential role for beta- and gamma-crystallins in the vascular remodeling of the eye
    Cheng Zhang
    Department of Ophthalmology, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Dev Dyn 234:36-47. 2005
  4. ncbi Expression of ?A3/A1-crystallin in the developing and adult rat eye
    Geetha Parthasarathy
    Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 400 N Broadway, Smith Research Building, M035, Baltimore, MD 21287, USA
    J Mol Histol 42:59-69. 2011
  5. ncbi A developmental defect in astrocytes inhibits programmed regression of the hyaloid vasculature in the mammalian eye
    Cheng Zhang
    The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, MD 21231, USA
    Eur J Cell Biol 90:440-8. 2011
  6. ncbi Mutation in the ?A3/A1-crystallin gene impairs phagosome degradation in the retinal pigmented epithelium of the rat
    J Samuel Zigler
    The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
    J Cell Sci 124:523-31. 2011
  7. ncbi Neuroprotection of photoreceptors by minocycline in light-induced retinal degeneration
    Cheng Zhang
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9238, USA
    Invest Ophthalmol Vis Sci 45:2753-9. 2004
  8. ncbi A novel rat model to study the functions of macrophages during normal development and pathophysiology of the eye
    Stacey Hose
    Department of Ophthalmology, School of Medicine, The Johns Hopkins University, 600 North Wolfe Street/Jefferson 3-127A, Baltimore, MD 21287, USA
    Immunol Lett 96:299-302. 2005
  9. ncbi Cannabinoid receptors in conjunctival epithelium: identification and functional properties
    María Iribarne
    Facultad de Ciencias Biomedicas, Universidad Austral, Pilar, Buenos Aires, Argentina
    Invest Ophthalmol Vis Sci 49:4535-44. 2008
  10. ncbi Downregulation of class II transactivator (CIITA) expression by synthetic cannabinoid CP55,940
    Celine Gongora
    Institut de Biotechnologie et Pharmacologie, CNRS UMR 5094, Montpellier, Cedex 5, France
    Immunol Lett 91:11-6. 2004

Research Grants

  1. MODULATION OF CIITA BY CANNABINOIDS IN HUMAN MICROGLIA
    Debasish Sinha; Fiscal Year: 2004
  2. A novel bA3/A1-crystallin gene mutation results in persistent fetal vasculature
    Debasish Sinha; Fiscal Year: 2009
  3. A novel bA3/A1-crystallin gene mutation results in persistent fetal vasculature
    Debasish Sinha; Fiscal Year: 2009
  4. A CRYSTALLIN MUTATION WITH ABNORMAL ASTROCYTES AND RETINAL VESSELS
    Debasish Sinha; Fiscal Year: 2010
  5. A novel bA3/A1-crystallin gene mutation results in persistent fetal vasculature
    Debasish Sinha; Fiscal Year: 2010

Collaborators

Detail Information

Publications10

  1. ncbi betaA3/A1-crystallin in astroglial cells regulates retinal vascular remodeling during development
    Debasish Sinha
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Bunting Blaustein Cancer Research Building II, 1550 Orleans St, Room 146, Baltimore, MD 21231, USA
    Mol Cell Neurosci 37:85-95. 2008
    ..Our data implicate betaA3/A1-crystallin as an important regulatory factor mediating vascular patterning and remodeling in the retina...
  2. ncbi A spontaneous mutation affects programmed cell death during development of the rat eye
    Debasish Sinha
    Department of Ophthalmology, School of Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21287, USA
    Exp Eye Res 80:323-35. 2005
    ..The transient layer of Chievitz persists in adult Nuc1 retina, indicative of delayed development. Hence, Nuc1 is a novel mutation that could be an eye-specific regulator of apoptosis...
  3. ncbi A potential role for beta- and gamma-crystallins in the vascular remodeling of the eye
    Cheng Zhang
    Department of Ophthalmology, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Dev Dyn 234:36-47. 2005
    ..Interestingly, in human PFV (persistent fetal vasculature) disease, where the hyaloid vasculature abnormally persists after birth, we show that astrocytes express both VEGF and crystallins...
  4. ncbi Expression of ?A3/A1-crystallin in the developing and adult rat eye
    Geetha Parthasarathy
    Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 400 N Broadway, Smith Research Building, M035, Baltimore, MD 21287, USA
    J Mol Histol 42:59-69. 2011
    ....
  5. ncbi A developmental defect in astrocytes inhibits programmed regression of the hyaloid vasculature in the mammalian eye
    Cheng Zhang
    The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, MD 21231, USA
    Eur J Cell Biol 90:440-8. 2011
    ..This abnormal association of astrocytes with the hyaloid artery may impede the normal macrophage-mediated remodeling and regression of the hyaloid system...
  6. ncbi Mutation in the ?A3/A1-crystallin gene impairs phagosome degradation in the retinal pigmented epithelium of the rat
    J Samuel Zigler
    The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
    J Cell Sci 124:523-31. 2011
    ..A3/A1-crystallin is a novel lysosomal protein in RPE, essential for degradation of phagocytosed material...
  7. ncbi Neuroprotection of photoreceptors by minocycline in light-induced retinal degeneration
    Cheng Zhang
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9238, USA
    Invest Ophthalmol Vis Sci 45:2753-9. 2004
    ..This study was conducted to evaluate the neuroprotective effect of minocycline and the role of microglia in light-induced retinal degeneration...
  8. ncbi A novel rat model to study the functions of macrophages during normal development and pathophysiology of the eye
    Stacey Hose
    Department of Ophthalmology, School of Medicine, The Johns Hopkins University, 600 North Wolfe Street/Jefferson 3-127A, Baltimore, MD 21287, USA
    Immunol Lett 96:299-302. 2005
    ..Inflammation is known to have an enhanced influx of phagocytic cells. Our data suggests that subpopulations of macrophages perform distinct functions in inducing apoptosis and phagocytic activity during normal conditions and in disease...
  9. ncbi Cannabinoid receptors in conjunctival epithelium: identification and functional properties
    María Iribarne
    Facultad de Ciencias Biomedicas, Universidad Austral, Pilar, Buenos Aires, Argentina
    Invest Ophthalmol Vis Sci 49:4535-44. 2008
    ..The endocannabinoid system may be regulating these processes. Therefore, the authors explored the presence and properties of cannabinoid receptors (CB1 and CB2) in conjunctival epithelial cells...
  10. ncbi Downregulation of class II transactivator (CIITA) expression by synthetic cannabinoid CP55,940
    Celine Gongora
    Institut de Biotechnologie et Pharmacologie, CNRS UMR 5094, Montpellier, Cedex 5, France
    Immunol Lett 91:11-6. 2004
    ..These data suggests that cannabinoids affect MHC class II expression through actions on CIITA at the transcriptional level...

Research Grants7

  1. MODULATION OF CIITA BY CANNABINOIDS IN HUMAN MICROGLIA
    Debasish Sinha; Fiscal Year: 2004
    ..Microglia form the first line of defense during infection in the CNS and are involved in various immune diseases including AIDS. ..
  2. A novel bA3/A1-crystallin gene mutation results in persistent fetal vasculature
    Debasish Sinha; Fiscal Year: 2009
    ..Our data (published and unpublished) indicate that mutant 2A3/A1-crystallin plays a role in PFV. The proposed studies may help elucidate mechanisms underlying PFV that would have potential therapeutic implications. ..
  3. A novel bA3/A1-crystallin gene mutation results in persistent fetal vasculature
    Debasish Sinha; Fiscal Year: 2009
    ..Our data (published and unpublished) indicate that ?A3/A1- crystallin plays a role in PFV. The proposed studies may help elucidate mechanisms that lead to PFV and would have potential therapeutic implications. ..
  4. A CRYSTALLIN MUTATION WITH ABNORMAL ASTROCYTES AND RETINAL VESSELS
    Debasish Sinha; Fiscal Year: 2010
    ..We believe that studies on the Nuc1 rat will provide new insights into the cellular and molecular mechanisms that regulate vascular development including the molecular interactions among neurons, astrocytes and endothelial cells. ..
  5. A novel bA3/A1-crystallin gene mutation results in persistent fetal vasculature
    Debasish Sinha; Fiscal Year: 2010
    ..Our data (published and unpublished) indicate that mutant 2A3/A1-crystallin plays a role in PFV. The proposed studies may help elucidate mechanisms underlying PFV that would have potential therapeutic implications. ..