Research Topics
| B A SimonSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Detail Information
Publications
Augmentation of Pulmonary Epithelial Cell IL-8 Expression and Permeability by Pre-B-cell Colony Enhancing FactorHailong Li
Department of Surgery, University of Missouri School of Medicine, Columbia, MO 65212, USA
J Inflamm (Lond) 5:15. 2008..The molecular mechanism of PBEF involvement in the pathogenesis of ALI is still incompletely understood. This study examined the role of PBEF in regulating pulmonary alveolar epithelial cell IL-8 expression and permeability...- In vitro identification and in silico utilization of interspecies sequence similarities using GeneChip technologyDmitry N Grigoryev
Division of Pulmonary and Critical Care Medicine, Center for Translational Respiratory Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
BMC Genomics 6:62. 2005..The Affymetrix platform probe redundancy offers flexibility in selecting individual probes with high sequence similarities between related species for gene expression analysis... - Computed tomography studies of lung mechanicsBrett A Simon
Department of Anesthesiology, Tower 711, Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287 8711, USA
Proc Am Thorac Soc 2:517-21, 506-7. 2005.... - Regional ventilation and lung mechanics using X-Ray CTBrett A Simon
Department of Anesthesiology, Johns Hopkins Hospital, Baltimore, MD 21287 8711, USA
Acad Radiol 12:1414-22. 2005.... - Recirculation of inhaled xenon does not alter lung CT densityJeffrey B Hoag
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Tower 711, The Johns Hopkins University, 600 N Wolfe Street, Baltimore, MD 21287 8711, USA
Acad Radiol 14:81-4. 2007..Because Xe is moderately soluble, vascular uptake and redistribution has been proposed as a confounding phenomenon. We propose that the redistribution of Xe via the circulation is negligible, and correction is unwarranted... - Microarray analysis of regional cellular responses to local mechanical stress in acute lung injuryBrett A Simon
Department of Anesthesiology and Critical Medicine, Tower 711, Johns Hopkins Hospital, Baltimore, MD 21287 8711, USA
Am J Physiol Lung Cell Mol Physiol 291:L851-61. 2006.... - Non-invasive imaging of regional lung function using x-ray computed tomographyB A Simon
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
J Clin Monit Comput 16:433-42. 2000..This communication will review recent advances in CT based techniques for the measurement of regional lung function... - Sphingosine 1-phosphate reduces vascular leak in murine and canine models of acute lung injuryBryan J McVerry
Division of Pulmonary and Critical Care Medicine, Center for Translational Respiratory Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Am J Respir Crit Care Med 170:987-93. 2004..Together, these results indicate that Sph 1-P represents a novel therapeutic intervention for the prevention of pulmonary edema related to inflammatory injury and increased vascular permeability... - Pressure-volume curve does not predict steady-state lung volume in canine lavage lung injuryJohn M Downie
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Am J Respir Crit Care Med 169:957-62. 2004..These results support the interpretation of Pflex as pressure threshold for recruitment, but otherwise do not suggest a role for the pressure-volume curve in predicting steady-state lung volume... - CT-measured regional specific volume change reflects regional ventilation in supine sheepMatthew K Fuld
Department of Anesthesiology, Johns Hopkins Hospital, Baltimore, MD 21287, USA
J Appl Physiol 104:1177-84. 2008..Regional sVol, which involves significantly reduced exposure to radiation and Xe gas compared with the Xe-CT method, represents a safe and efficient surrogate for measuring regional ventilation in experimental studies and patients... - Selective endothelial dysfunction in conscious dogs after cardiopulmonary bypassP Zanaboni
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 8711, USA
J Appl Physiol 82:1776-84. 1997..The normal response to sodium nitroprusside indicates that cGMP-mediated vasodilation is unchanged post-CPB... - Regional aeration and perfusion distribution in a sheep model of endotoxemic acute lung injury characterized by functional computed tomography imagingAna Fernandez-Bustamante
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Crit Care Med 37:2402-11. 2009.... - Parameter estimation and confidence intervals for Xe-CT ventilation studies: a Monte Carlo approachB A Simon
Department of Anesthesia and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
J Appl Physiol 84:709-16. 1998..Finally, a simulation was performed to compare the performance of three imaging protocols in estimating model parameters... - Volumetric xenon-CT imaging of conventional and high-frequency oscillatory ventilationDaniel G Mulreany
Departments of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, MD 21287 8711, USA
Acad Radiol 16:718-25. 2009..We used volumetric, dynamic imaging of Xenon (Xe) washout of the canine lung during both HFOV and CV to compare regional ventilation in the two modalities... - Tidal volume delivery during high-frequency oscillatory ventilation in adults with acute respiratory distress syndromeDavid N Hager
Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
Crit Care Med 35:1522-9. 2007.... - Total and regional lung volume changes during high-frequency oscillatory ventilation (HFOV) of the normal lungR Blaine Easley
Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, MD, United States
Respir Physiol Neurobiol 165:54-60. 2009..These finding provide additional insight into the impact of HFOV settings on the distribution of V(L) and suggest that there is low risk of occult regional over-distention during HFOV in normal lungs... - Reliability of estimating stochastic lung tissue heterogeneity from pulmonary impedance spectra: a forward-inverse modeling studyDavid W Kaczka
Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, MD 21287, USA
Ann Biomed Eng 35:1722-38. 2007..These data demonstrate that inverse modeling approaches applied to noninvasive measures of Z(L) may provide reliable and accurate assessments of lung tissue heterogeneity as well as insight into distributed lung mechanical properties... - Mechanism of hypoxemia in acute lung injury evaluated by multidetector-row CTR Blaine Easley
Department of Anesthesiology and Critical Care Medicine, Blalock 941, Johns Hopkins Hospital, 600 N Wolfe Street, The Johns Hopkins University, Baltimore, MD 21287 8711, USA
Acad Radiol 13:916-21. 2006..We present the use of computed tomographic (CT) volume and perfusion imaging to show differences in the mechanisms of hypoxemia from alterations in blood flow distribution within different animal models of acute lung injury (ALI)... - Redistribution of pulmonary blood flow impacts thermodilution-based extravascular lung water measurements in a model of acute lung injuryR Blaine Easley
Department of Anesthesiology, Johns Hopkins Medical Institutes, Baltimore, Maryland 21287, USA
Anesthesiology 111:1065-74. 2009..The authors hypothesized that redistribution of pulmonary blood flow can cause increased apparent EVLW secondary to increased perfusion of thermally silent tissue, not increased lung edema... - Pre-B-cell colony-enhancing factor as a potential novel biomarker in acute lung injuryShui Q Ye
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, 5200 Eastern Avenue, MFL Building Center Tower 664, Baltimore, MD 21224, USA
Am J Respir Crit Care Med 171:361-70. 2005..Together, these results strongly indicate that PBEF is a potential novel biomarker in ALI and demonstrate the successful application of robust genomic technologies in the identification of candidate genes in complex lung disease... - Molecular cloning and characterization of canine pre-B-cell colony-enhancing factorJames R McGlothlin
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Mason F Lord Memorial Building, Center Tower, Rm 665, 5200 Eastern Avenue, Baltimore, Maryland 21224, USA
Biochem Genet 43:127-41. 2005..Isolation of the canine PBEF cDNA and expression of its recombinant protein may provide molecular tools to study the molecular mechanism of ALI in the canine model and to elucidate the potential role of PBEF as an ALI biomarker... - Quantifying mechanical heterogeneity in canine acute lung injury: impact of mean airway pressureDavid W Kaczka
Department of Anesthesiology and Critical Care Medicine and Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Anesthesiology 103:306-17. 2005..Such a technique may be of use in optimizing mechanical ventilatory parameters such as rate, tidal volume, or positive end-expiratory pressure... - Pulmonary vascular endothelial responses are differentially modulated after cardiopulmonary bypassD Nyhan
Department of Anesthesiology Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Cardiovasc Pharmacol 34:518-25. 1999..These results suggest that CPB causes a selective impairment in endothelial dilator function without changing the vascular smooth-muscle response to vasodilator or vasoconstrictor stimuli... - Effects of acid aspiration-induced acute lung injury on kidney functionJeffrey B Hoag
Dept of Medicine and Anesthesiology, The Johns Hopkins Univ, 600 North Wolfe St, Tower 711, Baltimore, MD 21287 8711, USA
Am J Physiol Renal Physiol 294:F900-8. 2008..Kidney injury in large animal models may be more similar to humans and may differ from results seen in small animal models... - Four methods of measuring tidal volume during high-frequency oscillatory ventilationDavid N Hager
Division of Pulmonary and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
Crit Care Med 34:751-7. 2006.... - Totally endoscopic robot-assisted transmyocardial revascularizationDavid D Yuh
Division of Cardiac Surgery, Johns Hopkins Hospital, 600 North Wolfe Street, Blalock 618, Baltimore, MD 21827 4618, USA
J Thorac Cardiovasc Surg 130:120-4. 2005..In this pilot study, we sought to combine the advantages of a dexterous robotic surgical platform with a flexible fiberoptic laser to develop a minimally invasive approach toward transmyocardial revascularization... - Anesthetic management of patients with pulmonary hypertensionBrenda MacKnight
Department of Anesthesiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 8711, USA
Semin Cardiothorac Vasc Anesth 12:91-6. 2008..With an understanding of the underlying pathophysiology of the disease and pharmacology of these new therapies, combined with careful perioperative planning and care, these patients can safely undergo elective surgical procedures... - State of the Art. A structural and functional assessment of the lung via multidetector-row computed tomography: phenotyping chronic obstructive pulmonary diseaseEric A Hoffman
Department of Radiology, University of Iowa, 200 Hawkins Drive, CC701 GH, Iowa City, 52242, USA
Proc Am Thorac Soc 3:519-32. 2006.... - Characterization of the interstitial lung diseases via density-based and texture-based analysis of computed tomography images of lung structure and functionEric A Hoffman
Department of Radiology, University of Iowa, Iowa City, IA, USA
Acad Radiol 10:1104-18. 2003..Furthermore, there is the growing need for scanner manufacturers to focus on not just visually pleasing images, but on quantitatifiably accurate images... - Effect of low-xenon and krypton supplementation on signal/noise of regional CT-based ventilation measurementsDeokiee Chon
Department of Radiology, University of Iowa, Iowa City, Iowa 52242, USA
J Appl Physiol 102:1535-44. 2007..The 30% Xe/30% Kr mixture was comparable to that of 40% Xe, providing an important agent for CT-based assessment of regional ventilation in humans... - The comprehensive imaging-based analysis of the lung: a forum for team scienceEric A Hoffman
Department of Radiology, University of Iowa, 200 Hawkins Dr, Iowa City, IA 52242, USA
Acad Radiol 11:1370-80. 2004 - Differences in regional wash-in and wash-out time constants for xenon-CT ventilation studiesDeokiee Chon
Departments of Radiology and Biomedical Engineering, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
Respir Physiol Neurobiol 148:65-83. 2005.... - Relationship between dynamic respiratory mechanics and disease heterogeneity in sheep lavage injuryCarissa L Bellardine Black
Department of Biomedical Engineering, Boston University, Boston, MA, USA
Crit Care Med 35:870-8. 2007.... - Imaging inflammation in acute lung injuryBrett A Simon
Anesthesiology 106:656-8. 2007