Robert Siliciano

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi Viral suppression of multiple escape mutants by de novo CD8(+) T cell responses in a human immunodeficiency virus-1 infected elite suppressor
    Karen A O'Connell
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Retrovirology 8:63. 2011
  2. ncbi Evolution of the HIV-1 nef gene in HLA-B*57 positive elite suppressors
    Maria Salgado
    Department of Medicine, Johns Hopkins University School of Medicine, 733 N, Broadway, Baltimore, MD 21205, USA
    Retrovirology 7:94. 2010
  3. ncbi Low-level HIV-1 replication and the dynamics of the resting CD4+ T cell reservoir for HIV-1 in the setting of HAART
    Ahmad R Sedaghat
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore Maryland 21205, USA
    BMC Infect Dis 8:2. 2008
  4. ncbi Stability of the latent reservoir for HIV-1 in patients receiving valproic acid
    Janet D Siliciano
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA
    J Infect Dis 195:833-6. 2007
  5. ncbi Biomarkers of HIV replication
    Janet D Siliciano
    Johns Hopkins University School of Medicine, Howard Hughes Medical Institute, Baltimore, Maryland 21205, USA
    Curr Opin HIV AIDS 5:491-7. 2010
  6. ncbi Disulfiram reactivates latent HIV-1 in a Bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation
    Sifei Xing
    Department of Medicine, Johns Hopkins University School of Medicine, 720 Rutland Ave, Baltimore, MD 21205, USA
    J Virol 85:6060-4. 2011
  7. ncbi Influence of host gene transcription level and orientation on HIV-1 latency in a primary-cell model
    Liang Shan
    Department of Medicine, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
    J Virol 85:5384-93. 2011
  8. ncbi Consistent inhibition of HIV-1 replication in CD4+ T cells by acyclovir without detection of human herpesviruses
    Moira A McMahon
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Virol 85:4618-22. 2011

Research Grants

  1. Latent Viral Reservoirs in HIV 1 Infection
    Robert F Siliciano; Fiscal Year: 2010
  2. SIGNIFICANCE OF LOW LEVEL VIREMIA IN PATIENTS ON HAART
    Robert Siliciano; Fiscal Year: 2006
  3. Latent Viral Reservoirs in HIV 1 Infection
    Robert Siliciano; Fiscal Year: 2007
  4. Intermolecular cooperativity in the action of antiviral agents
    Robert F Siliciano; Fiscal Year: 2010
  5. CYTOLYTIC T CELL RESPONSES IN AIDS VACCINE RECIPIENTS
    Robert Siliciano; Fiscal Year: 1993
  6. CYTOLYTIC T CELL RESPONSE IN AIDS VACCINE RECIPENTS
    Robert Siliciano; Fiscal Year: 2001
  7. LATENT VIRAL RESERVOIRS IN HIV1 INFECTION
    Robert Siliciano; Fiscal Year: 2002
  8. Latent Viral Reservoirs in HIV 1 Infection
    Robert Siliciano; Fiscal Year: 2009

Collaborators

  • Joseph Cofrancesco
  • Joel E Gallant
  • Janet D Siliciano
  • Liang Shan
  • Karen A O'Connell
  • Joseph B Margolick
  • Hao Zhang
  • Moira A McMahon
  • Neeta S Shroff
  • Hung Chih Yang
  • Sifei Xing
  • Joel N Blankson
  • Maria Salgado
  • Ahmad R Sedaghat
  • S Alireza Rabi
  • Hector C Bravo
  • Shridhar Bhat
  • Lin Shen
  • Thomas C Quinn
  • Cynthia K Bullen
  • Jordyn L Manucci
  • Rafael A Irizarry
  • Teresa L Parsons
  • Robert W Hegarty
  • David M Margolis
  • Stuart C Ray
  • Timothy P Brennan
  • Justin R Bailey
  • Claus O Wilke
  • Richard D Moore
  • Stephen J Gange
  • Eleanor Pitt
  • Marc Callender
  • Jun Lai

Detail Information

Publications8

  1. ncbi Viral suppression of multiple escape mutants by de novo CD8(+) T cell responses in a human immunodeficiency virus-1 infected elite suppressor
    Karen A O'Connell
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Retrovirology 8:63. 2011
    ..These responses, in combination with low viral fitness of each variant, may contribute to sustained elite control in this ES...
  2. ncbi Evolution of the HIV-1 nef gene in HLA-B*57 positive elite suppressors
    Maria Salgado
    Department of Medicine, Johns Hopkins University School of Medicine, 733 N, Broadway, Baltimore, MD 21205, USA
    Retrovirology 7:94. 2010
    ..The results provide further evidence of ongoing viral replication in ES and suggest that the nef and gag genes in these patients respond similarly to selective pressure from the host...
  3. ncbi Low-level HIV-1 replication and the dynamics of the resting CD4+ T cell reservoir for HIV-1 in the setting of HAART
    Ahmad R Sedaghat
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore Maryland 21205, USA
    BMC Infect Dis 8:2. 2008
    ..However, the mechanism underlying the long half-life of the latent reservoir is unknown. The most likely potential mechanisms are low-level viral replication and the intrinsic stability of latently infected cells...
  4. ncbi Stability of the latent reservoir for HIV-1 in patients receiving valproic acid
    Janet D Siliciano
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA
    J Infect Dis 195:833-6. 2007
    ..We conclude that the clinical use of VA has no ancillary effect on the decay of the latent reservoir...
  5. ncbi Biomarkers of HIV replication
    Janet D Siliciano
    Johns Hopkins University School of Medicine, Howard Hughes Medical Institute, Baltimore, Maryland 21205, USA
    Curr Opin HIV AIDS 5:491-7. 2010
    ....
  6. ncbi Disulfiram reactivates latent HIV-1 in a Bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation
    Sifei Xing
    Department of Medicine, Johns Hopkins University School of Medicine, 720 Rutland Ave, Baltimore, MD 21205, USA
    J Virol 85:6060-4. 2011
    ..The extent to which disulfiram reactivates latent HIV-1 in patient cells is unclear, but the drug alone or in combination may be useful in future eradication strategies...
  7. ncbi Influence of host gene transcription level and orientation on HIV-1 latency in a primary-cell model
    Liang Shan
    Department of Medicine, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
    J Virol 85:5384-93. 2011
    ..Our findings suggest that disrupting the negative control of HIV-1 transcription by upstream host promoters could facilitate the reactivation of latent HIV-1 in some resting CD4(+) T cells...
  8. ncbi Consistent inhibition of HIV-1 replication in CD4+ T cells by acyclovir without detection of human herpesviruses
    Moira A McMahon
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Virol 85:4618-22. 2011
    ..The data support acyclovir as an inhibitor of HIV-1 replication in herpesvirus-negative cells...

Research Grants32

  1. Latent Viral Reservoirs in HIV 1 Infection
    Robert F Siliciano; Fiscal Year: 2010
    ..Curing HIV infection will require new ways to eliminate this latent reservoir. The studies proposed here are designed to find new drugs that can eliminate this latent reservoir. ..
  2. SIGNIFICANCE OF LOW LEVEL VIREMIA IN PATIENTS ON HAART
    Robert Siliciano; Fiscal Year: 2006
    ....
  3. Latent Viral Reservoirs in HIV 1 Infection
    Robert Siliciano; Fiscal Year: 2007
    ..Together, these studies should help to elucidate how HIV-1 latency operates in vivo. ..
  4. Intermolecular cooperativity in the action of antiviral agents
    Robert F Siliciano; Fiscal Year: 2010
    ..The method incorporates a previously unappreciated factor that contributes enormously to the ability of drugs and vaccines to inhibit HIV. The goal is to facilitate the design of drugs and vaccines that maximally inhibit HIV. ..
  5. CYTOLYTIC T CELL RESPONSES IN AIDS VACCINE RECIPIENTS
    Robert Siliciano; Fiscal Year: 1993
    ....
  6. CYTOLYTIC T CELL RESPONSE IN AIDS VACCINE RECIPENTS
    Robert Siliciano; Fiscal Year: 2001
    ..nonresponders. Antigen processing and presentation will then be studied using cells from non-responders. Finally the ability of HIV-1 specific CTL to lyse newly or chronically infected resting CD4 T cells will be examined. ..
  7. LATENT VIRAL RESERVOIRS IN HIV1 INFECTION
    Robert Siliciano; Fiscal Year: 2002
    ..Finally, the investigators will develop an experimental system for identifying stimuli that could be used to mobilize the latent reservoir for elimination. ..
  8. Latent Viral Reservoirs in HIV 1 Infection
    Robert Siliciano; Fiscal Year: 2009
    ..Curing HIV infection will require new ways to eliminate this latent reservoir. The studies proposed here are designed to find new drugs that can eliminate this latent reservoir. ..