Research Topics
| Ned C SacktorSummaryAffiliation: Johns Hopkins University Country: USA Publications
Research Grants
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Detail Information
Publications
The International HIV Dementia Scale: a new rapid screening test for HIV dementiaNed C Sacktor
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
AIDS 19:1367-74. 2005..The objective of this study was to evaluate the sensitivity and specificity of a new screening test for HIV dementia, the International HIV Dementia Scale (IHDS) in cohorts from the US and Uganda...- Depression symptoms and cognitive function among individuals with advanced HIV infection initiating HAART in UgandaNoeline Nakasujja
Department of Public Health Sciences, Karolinska Institute, Stockholm, Sweden
BMC Psychiatry 10:44. 2010..Initiation of highly active antiretroviral therapy (HAART) may have an effect on the prevalence and the change over time of depression symptoms and cognitive impairment among HIV-positive individuals... - Pattern of neuropsychological performance among HIV positive patients in UgandaKevin R Robertson
Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, NC, USA
BMC Neurol 7:8. 2007..The purpose of the current study was to evaluate the pattern of neuropsychological performance in a sample of HIV positive patients in comparison to HIV negative control subjects in Uganda... - Transdermal selegiline in HIV-associated cognitive impairment: pilot, placebo-controlled studyN Sacktor
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Neurology 54:233-5. 2000..Both selegiline and placebo were well tolerated with few adverse events. Improvements favoring the selegiline group were suggested on single tests of verbal memory and motor/psychomotor performance, warranting a larger study... - Antiretroviral therapy improves cognitive impairment in HIV+ individuals in sub-Saharan AfricaN Sacktor
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Neurology 67:311-4. 2006..Highly active antiretroviral therapy (HAART) can improve cognitive performance in some patients with HIV-associated cognitive impairment in the United States. The effect of HAART on HIV dementia in sub-Saharan Africa is largely unknown... - Minocycline treatment for HIV-associated cognitive impairment: results from a randomized trialN Sacktor
Department of Neurology, Johns Hopkins Bayview Medical Center, 4940 Eastern Ave, 301 Building, Suite 2100, Baltimore, MD 21224, USA
Neurology 77:1135-42. 2011..We conducted a study of minocycline to assess its safety, tolerability, and efficacy for the treatment of HIV-associated cognitive impairment... - Neuropsychological test profile differences between young and old human immunodeficiency virus-positive individualsNed Sacktor
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Neurovirol 13:203-9. 2007..These differences could be a result of advanced age itself or age-associated comorbidities such as coexisting cerebrovascular or neurodegenerative disease... - HIV-associated cognitive impairment in sub-Saharan Africa--the potential effect of clade diversityNed Sacktor
Department of Neurology, Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, MD 21224, USA
Nat Clin Pract Neurol 3:436-43. 2007..Further studies are needed to determine the true prevalence of HIV dementia in sub-Saharan Africa and to establish whether specific clade subtypes might influence the presentation of neurological complications... - Benefits and risks of stavudine therapy for HIV-associated neurologic complications in UgandaN Sacktor
Department of Neurology, Johns Hopkins Bayview Medical Center, Baltimore, MD 21224, USA
Neurology 72:165-70. 2009..Coformulated generic drugs, which include stavudine, are the most common regimens to treat HIV infection in Uganda and many other parts of Africa... - HIV subtype D is associated with dementia, compared with subtype A, in immunosuppressed individuals at risk of cognitive impairment in Kampala, UgandaNed Sacktor
Departments of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Clin Infect Dis 49:780-6. 2009..The objective of this study was to examine the relationship between HIV subtype and the severity of HIV-associated cognitive impairment among individuals initiating antiretroviral therapy in Uganda... - Longitudinal psychomotor speed performance in human immunodeficiency virus-seropositive individuals: impact of age and serostatusNed Sacktor
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Neurovirol 16:335-41. 2010..Mild neurocognitive changes over time among older HIV+ individuals are likely to reflect age associated pathophysiological mechanisms including cerebrovascular risk factors... - A multicenter study of two magnetic resonance spectroscopy techniques in individuals with HIV dementiaNed Sacktor
Department of Neurology, Johns Hopkins Bayview Medical Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
J Magn Reson Imaging 21:325-33. 2005..To evaluate single-voxel proton magnetic resonance spectroscopy (SV-MRS) and magnetic resonance spectroscopic imaging (MRSI) metabolite results in individuals with HIV dementia... - CSF antiretroviral drug penetrance and the treatment of HIV-associated psychomotor slowingN Sacktor
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Neurology 57:542-4. 2001..Multiple and single CSF-penetrating HAART may be equivalent for treating HIV-associated psychomotor slowing... - Novel markers of oxidative stress in actively progressive HIV dementiaNed Sacktor
Department of Neurology, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
J Neuroimmunol 157:176-84. 2004..These markers may be useful for distinguishing between different clinical phenotypes of HIV dementia... - HIV-associated cognitive impairment before and after the advent of combination therapyNed Sacktor
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
J Neurovirol 8:136-42. 2002..Even though HAART has reduced the incidence of HIV dementia, HIV-associated cognitive impairment continues to be a major clinical problem among individuals with advanced infection... - The epidemiology of human immunodeficiency virus-associated neurological disease in the era of highly active antiretroviral therapyNed Sacktor
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
J Neurovirol 8:115-21. 2002..As patients develop increasing resistance mutations to antiretroviral drugs and with subsequent decline in CD4 cell counts, in the near future, the incidence of HIV-associated neurological disease may begin to rise... - HIV-associated neurologic disease incidence changes:: Multicenter AIDS Cohort Study, 1990-1998N Sacktor
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Neurology 56:257-60. 2001..The proportion of new cases of HIV dementia with a CD4 count in a higher range (i.e., 201 to 350) since 1996 may be increasing... - Response to systemic HIV viral load suppression correlates with psychomotor speed performanceN Sacktor
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Neurology 61:567-9. 2003..Changes in plasma HIV viral load in HIV-positive individuals with cognitive slowing correlate with performance on tests of psychomotor speed... - Brain metabolism and cognitive impairment in HIV infection: a 3-T magnetic resonance spectroscopy studyMona A Mohamed
Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD 21287, USA
Magn Reson Imaging 28:1251-7. 2010..The current study was undertaken to investigate the utility of 3-T MRS for evaluating HIV+ patients with different levels of cognitive impairment with emphasis on the measurement of Glu and Glx (the sum of Glu and Gln)... - Platelet decline: an avenue for investigation into the pathogenesis of human immunodeficiency virus -associated dementiaLynn M Wachtman
Department of Molecular and Comparative Pathobiology, The Johns Hopkins University, Baltimore, Maryland 21287 7609, USA
Arch Neurol 64:1264-72. 2007..The identification of biomarkers identifying onset of human immunodeficiency virus-associated dementia (HIV-D) is critical for diagnosis and the elucidation of pathophysiologic pathways... - Incidence and epidemiology of anal cancer in the multicenter AIDS cohort studyGypsyamber D'Souza
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
J Acquir Immune Defic Syndr 48:491-9. 2008..To examine the incidence and risk factors for anal cancer in a multicenter cohort of human immunodeficiency virus (HIV) positive and HIV-negative men who have sex with men followed between 1984 and 2006 (Multicenter AIDS Cohort Study)... - Human immunodeficiency virus-associated dementia: an evolving diseaseJustin C McArthur
The Johns Hopkins University, HIV Neurology Program, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 7609, USA
J Neurovirol 9:205-21. 2003..This article reviews the changing epidemiology of HIV-associated dementia, current concepts of the different patterns of dementia under the influence of highly active antiretroviral therapy, and reviews therapeutic aspects... - Influence of highly active antiretroviral therapy on persistence of HIV in the central nervous systemAvindra Nath
Richard T Johnson Division of Neuroimmunology and Neurological Infections, Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA
Curr Opin Neurol 19:358-61. 2006..This review provides a critical analysis of the recent literature on the impact of highly actively antiretroviral therapy on HIV-related neurological complications and changes in treatment strategies... - Human immunodeficiency virus-associated neurocognitive disorders: Mind the gapJustin C McArthur
NIMH Center for Novel Therapeutics for HIV Associated Cognitive Disorders, Johns Hopkins University, Baltimore, MD, USA
Ann Neurol 67:699-714. 2010..Novel therapies aimed at persistent central nervous system inflammation will be needed to close this gap... - Attenuated central nervous system infection in advanced HIV/AIDS with combination antiretroviral therapyJustin C McArthur
Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 7609, USA
Arch Neurol 61:1687-96. 2004..Before the introduction of combination antiretroviral therapy (CART), neurological disease correlated with cerebrospinal fluid (CSF) levels of human immunodeficiency virus (HIV) RNA... - Converging roles for sphingolipids and cell stress in the progression of neuro-AIDSNorman J Haughey
Department of Neurology, Richard T Johnson Division of Neuroimmunology and Neurological Infections, The Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
Front Biosci 13:5120-30. 2008.... - Imaging glial cell activation with [11C]-R-PK11195 in patients with AIDSDima A Hammoud
Department of Radiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287-2182, USA
J Neurovirol 11:346-55. 2005..The findings of this pilot study support a role for glial cell activation in HAD, and that PET with [11C]-R-PK11195 can detect the concomitants of neuronal damage in individuals infected with HIV... - NeuroAIDS in AfricaKevin Robertson
Department of Neurology, University of North Carolina, Chapel Hill, North Carolina 27599 7025, USA
J Neurovirol 16:189-202. 2010.... - Factor analysis of proton MR spectroscopic imaging data in HIV infection: metabolite-derived factors help identify infection and dementiaMona A Mohamed
Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, 1550 Orleans St, 492 CRB II, Baltimore, MD 21231, USA
Radiology 254:577-86. 2010.... - Second assessment of NeuroAIDS in AfricaKevin Robertson
Department of Neurology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 27599 7025, USA
J Neurovirol 14:87-101. 2008..The conference presentations summarized here highlight the need for further research on neuroAIDS in Africa and methods for assessing HIV-related neurological disorders... - Evolution of HIV dementia with HIV infectionAvindra Nath
Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA
Int Rev Psychiatry 20:25-31. 2008..Oxidative stress markers appear to be predictive of active dementia. However, currently there is no specific treatment available for HIV dementia... - Cleavage of cystatin C in the cerebrospinal fluid of patients with multiple sclerosisDavid N Irani
Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA
Ann Neurol 59:237-47. 2006..The diagnosis of multiple sclerosis (MS) can be challenging because of the lack of a specific diagnostic test. Recent advances in proteomics, however, offer new opportunities for biomarker discovery and the study of disease pathogenesis... - Neuroprotective therapy for HIV dementiaJadwiga Turchan
Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA
Curr HIV Res 1:373-83. 2003..We hope that this manuscript will serve as an important guide for future approaches for clinical trials and drug development for patients with HIV dementia... - Diabetes, insulin resistance, and dementia among HIV-1-infected patientsVictor G Valcour
University of Hawaii, Neuro AIDS Specialized Neuroscience Research Program, John A Burns School of Medicine, Honolulu, HI, USA
J Acquir Immune Defic Syndr 38:31-6. 2005..The objective of this study was to examine the relationship between HIV-associated dementia (HAD) and diabetes among patients with HIV-1 infection... - Cognitive impairment in older HIV-1-seropositive individuals: prevalence and potential mechanismsVictor G Valcour
University of Hawaii, NeuroAIDS Specialized Neuroscience Research Program, John A Burns School of Medicine, Honolulu, Hawaii 96816, USA
AIDS 18:S79-86. 2004.... - Insulin resistance is associated with cognition among HIV-1-infected patients: the Hawaii Aging With HIV cohortVictor G Valcour
Office of Neurology and Aging Research, University of Hawaii, Leahi Hospital, 3675 Kilauea Avenue, Honolulu, HI 96816, USA
J Acquir Immune Defic Syndr 43:405-10. 2006..To determine if insulin resistance (IR) is associated with lower cognitive performance among HIV-1-infected adults and to determine if advanced age magnifies risk...
Research Grants
- Oxidative Stress Markers and HIV DementiaNed Sacktor; Fiscal Year: 2009..We believe that oxidative stress plays a significant role in the development of HIV-D, and strategies to decrease oxidative stress may serve as a useful therapeutic target to treat HIV-D. ..