Research Topics
| DAVID RYUGOSummaryAffiliation: Johns Hopkins University Country: USA Publications
Research Grants
| Collaborators |
Detail Information
Publications
Synaptic plasticity after chemical deafening and electrical stimulation of the auditory nerve in catsD K Ryugo
Department of Otolaryngology HNS, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Comp Neurol 518:1046-63. 2010..This determination further suggests that the effects of ototoxic deafness are not identical to those of hereditary deafness...- Projections of low spontaneous rate, high threshold auditory nerve fibers to the small cell cap of the cochlear nucleus in catsD K Ryugo
Center for Hearing and Balance, Traylor Research Building, Room 510, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
Neuroscience 154:114-26. 2008..These data contribute to the concept of a high threshold feedback circuit to the inner ear, and reveal translational machinery for local control of activity-dependent synaptic modification... - Hearing molecules: contributions from genetic deafnessM D Eisen
Department of Otolaryngology Head and Neck Surgery, Center for Hearing and Balance, Baltimore, Maryland 21205, USA
Cell Mol Life Sci 64:566-80. 2007..This background will provide a context for the second part, which addresses the molecular mechanisms underlying cochlear function as elucidated by genetic causes of deafness... - Postnatal development of a large auditory nerve terminal: the endbulb of Held in catsD K Ryugo
Center for Hearing and Balance, Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Hear Res 216:100-15. 2006..Many of these observations correlate with the maturation of physiological response properties and suggest issues for further study... - Restoration of auditory nerve synapses in cats by cochlear implantsD K Ryugo
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University Center for Hearing and Balance, 720 Rutland Avenue, Baltimore, MD 21205, USA
Science 310:1490-2. 2005..This rescue of synapses is attributed to a return of spike activity in the auditory nerve and may help explain cochlear implant benefits in childhood deafness... - Activity-related features of synapse morphology: a study of endbulbs of heldD K Ryugo
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Comp Neurol 365:141-58. 1996..These structural features are hypothesized to reflect specializations that optimize synaptic transmission... - Glycine immunoreactivity of multipolar neurons in the ventral cochlear nucleus which project to the dorsal cochlear nucleusJ R Doucet
Center for Hearing Sciences, Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Comp Neurol 408:515-31. 1999..These results are consistent with the hypothesis that radiate neurons in the ventral cochlear nucleus subserve the wideband inhibition observed in the dorsal cochlear nucleus... - Differential cellular expression of isoforms of inositol 1,4,5-triphosphate receptors in neurons and glia in brainA H Sharp
Laboratory of Cellular Neurobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Comp Neurol 406:207-20. 1999..The IP3R3 may be involved in regulation of neurotransmitter or neuropeptide release in terminals within specific nuclei of the basal forebrain and limbic system... - Single unit recordings in the auditory nerve of congenitally deaf white cats: morphological correlates in the cochlea and cochlear nucleusD K Ryugo
Center for Hearing Sciences, Department Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Comp Neurol 397:532-48. 1998..Changes in endbulb structure appear to correspond to relative levels of deafness. These data suggest that endbulb structure is significantly influenced by sound-evoked auditory nerve activity... - Projections from the ventral cochlear nucleus to the dorsal cochlear nucleus in ratsJ R Doucet
Center for Hearing Sciences, Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Comp Neurol 385:245-64. 1997..This dendritic orientation suggests that radiate neurons are sensitive to a broad range of frequencies. These structural differences between planar and radiate neurons suggest that they subserve separate functions in acoustic processing... - Ultrastructural analysis of primary endings in deaf white cats: morphologic alterations in endbulbs of HeldD K Ryugo
Department of Otolaryngology Head and Neck Surgery, Center for Hearing Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Comp Neurol 385:230-44. 1997..These data reveal that early-onset, long-term deafness produces unambiguous alterations in synaptic structure and may be relevant to rehabilitation strategies that promote aural/oral communication... - Morphological changes in the cochlear nucleus of congenitally deaf white catsA A Saada
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Brain Res 736:315-28. 1996..If similar patterns of degeneration occur in humans, such pathologies may underlie reduced processing of input from cochlear implants in congenitally deaf adults... - Projections of the pontine nuclei to the cochlear nucleus in ratsM Ohlrogge
Departments of Otolaryngology-Head and Neck Surgery, Center for Hearing Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Comp Neurol 436:290-303. 2001..In an analogous way, perhaps the cerebropontocochlear nucleus projection endows the auditory system with a timing mechanism for extracting temporal information... - Revealing the molecular layer of the primate dorsal cochlear nucleusM E Rubio
Department of Physiology and Neurobiology, University of Connecticut, 75 North Eagleville Road, Storrs, CT 06269 3156, USA
Neuroscience 154:99-113. 2008..These observations are consistent with the argument that the rhesus monkey DCN has neuronal features similar to those of other nonprimate mammals...
Research Grants
- STUDIES OF THE COCHLEAR NUCLEUS GRANULE CELL DOMAINDAVID RYUGO; Fiscal Year: 2004..The data from this research will provide new knowledge on the synpatic organization of the highly integrative structure in the auditory system, and yield insights into how diverse neural systems shape the coding process for hearing. ..
- SINGLE-CELL MARKING STUDIES OF THE AUDITORY NERVEDAVID RYUGO; Fiscal Year: 2007..abstract_text> ..
- STUDIES OF THE COCHLEAR NUCLEUS GRANULE CELL DOMAINDAVID RYUGO; Fiscal Year: 2009..As we learn about how the somatosensory system modulates hearing, we will gain insight into somatic tinnitus that could contribute to the design of treatment strategies and a better understanding of tinnitus in general. ..
- STUDIES OF THE COCHLEAR NUCLEUS GRANULE CELL DOMAINDavid K Ryugo; Fiscal Year: 2010..As we learn about how the somatosensory system modulates hearing, we will gain insight into somatic tinnitus that could contribute to the design of treatment strategies and a better understanding of tinnitus in general. ..
- SINGLE CELL MARKING STUDIES OF THE AUDITORY NERVEDAVID RYUGO; Fiscal Year: 2003..abstract_text> ..
- SINGLE CELL MARKING STUDIES OF THE AUDITORY NERVEDAVID RYUGO; Fiscal Year: 1991....
- SINGLE CELL MARKING STUDIES OF THE AUDITORY NERVEDAVID RYUGO; Fiscal Year: 1993..The data will also have relevance to broader issues in sensory neurobiology and could be especially important for the design of prosthetic devices that replace nonfunctioning cochleas or auditory nerves...
- SINGLE-CELL MARKING STUDIES OF THE AUDITORY NERVEDavid K Ryugo; Fiscal Year: 2010..Lastly, the new knowledge could contribute to improved treatment strategies for users of bilateral cochlear implants and impact considerations of auditory brainstem implants. ..