R C Rubenstein

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi In vitro pharmacologic restoration of CFTR-mediated chloride transport with sodium 4-phenylbutyrate in cystic fibrosis epithelial cells containing delta F508-CFTR
    R C Rubenstein
    Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    J Clin Invest 100:2457-65. 1997
  2. ncbi A pilot clinical trial of oral sodium 4-phenylbutyrate (Buphenyl) in deltaF508-homozygous cystic fibrosis patients: partial restoration of nasal epithelial CFTR function
    R C Rubenstein
    Eudowood Division of Pediatric Respiratory Sciences, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Am J Respir Crit Care Med 157:484-90. 1998
  3. ncbi Mutation in the gene responsible for cystic fibrosis and predisposition to chronic rhinosinusitis in the general population
    X Wang
    McKusick Nathans Institute of Genetic Medicine, CMSC 1004, Baltimore, MD 21287, USA
    JAMA 284:1814-9. 2000

Detail Information

Publications3

  1. ncbi In vitro pharmacologic restoration of CFTR-mediated chloride transport with sodium 4-phenylbutyrate in cystic fibrosis epithelial cells containing delta F508-CFTR
    R C Rubenstein
    Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    J Clin Invest 100:2457-65. 1997
    ..These data indicate that 4PBA is a promising pharmacologic agent for inducing correction of the CF phenotype in CF patients carrying the delta F508 mutation...
  2. ncbi A pilot clinical trial of oral sodium 4-phenylbutyrate (Buphenyl) in deltaF508-homozygous cystic fibrosis patients: partial restoration of nasal epithelial CFTR function
    R C Rubenstein
    Eudowood Division of Pediatric Respiratory Sciences, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Am J Respir Crit Care Med 157:484-90. 1998
    ..Side effects due to drug therapy were minimal and comparable in the two groups. These data are consistent with 4PBA therapy inducing CFTR function in the nasal epithelia of deltaF508-homozygous CF patients...
  3. ncbi Mutation in the gene responsible for cystic fibrosis and predisposition to chronic rhinosinusitis in the general population
    X Wang
    McKusick Nathans Institute of Genetic Medicine, CMSC 1004, Baltimore, MD 21287, USA
    JAMA 284:1814-9. 2000
    ..Chronic rhinosinusitis is a consistent feature of the autosomal recessive disorder cystic fibrosis (CF)...