Research Topics
Species | RAYMOND CHARLES KOEHLERSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Poly(ADP-ribose) (PAR) polymer is a death signalShaida A Andrabi
Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 103:18308-13. 2006..These results reveal PAR polymer as a signaling molecule that induces cell death and suggests that interference with PAR polymer signaling may offer innovative therapeutic approaches for the treatment of cellular injury...- Relative contribution of cyclooxygenases, epoxyeicosatrienoic acids, and pH to the cerebral blood flow response to vibrissal stimulationXiaoguang Liu
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland
Am J Physiol Heart Circ Physiol 302:H1075-85. 2012..An unidentified mechanism apparently is responsible for the rapid, residual cortical vasodilation during vibrissal stimulation... - Cerebrovascular effects of carbon monoxideRaymond C Koehler
Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, MD 21287 4961, USA
Antioxid Redox Signal 4:279-90. 2002.... - Astrocytes and the regulation of cerebral blood flowRaymond C Koehler
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
Trends Neurosci 32:160-9. 2009..Thus, astrocytes have a pivotal role in dynamic signaling within the neurovascular unit. Important questions remain on how this signaling is integrated with other pathways in health and disease... - Role of astrocytes in cerebrovascular regulationRaymond C Koehler
Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, Maryland 21287, USA
J Appl Physiol 100:307-17. 2006..Future work using in vivo imaging and genetic manipulation will be required to provide more direct evidence for a role of astrocytes in neurovascular coupling... - Insensitivity of cerebral oxygen transport to oxygen affinity of hemoglobin-based oxygen carriersRaymond C Koehler
Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, Maryland 21287, USA
Biochim Biophys Acta 1784:1387-94. 2008..Cell-free hemoglobins do not require a P50 as high as red blood cell hemoglobin to facilitate oxygen delivery... - Hypothermia for 24 hours after asphyxic cardiac arrest in piglets provides striatal neuroprotection that is sustained 10 days after rewarmingDawn M Agnew
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Hospital, Blalock 1404, 600 N Wolfe Street, Baltimore, MD 21287 U S A
Pediatr Res 54:253-62. 2003.... - Epoxyeicosatrienoic acid-dependent cerebral vasodilation evoked by metabotropic glutamate receptor activation in vivoXiaoguang Liu
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, USA
Am J Physiol Heart Circ Physiol 301:H373-81. 2011..Epoxide hydrolase activity and 20-HETE synthesis limit the duration of the response to prolonged mGluR activation... - Continuous time-domain analysis of cerebrovascular autoregulation using near-infrared spectroscopyKen M Brady
Johns Hopkins University School of Medicine, Department of Anesthesiology, Division of Pediatric Anesthesiology and Critical Care Medicine, 600 North Wolfe Street, Blalock 904, Baltimore, MD 21287, USA
Stroke 38:2818-25. 2007.... - Development of zero-link polymers of hemoglobin, which do not extravasate and do not induce pressure increases upon infusionEnrico Bucci
Department of Biochemistry and Molecular Biology, University of Maryland Medical School, Baltimore, Maryland, USA
Artif Cells Blood Substit Immobil Biotechnol 35:11-8. 2007..It was also proven that cell free hemoglobins are more efficient than red cells in delivering oxygen to tissues... - Dopamine receptor modulation of hypoxic-ischemic neuronal injury in striatum of newborn pigletsZeng Jin Yang
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Cereb Blood Flow Metab 27:1339-51. 2007..Furthermore, mechanisms of D1 receptor toxicity may involve DARPP-32-dependent phosphorylation of NMDA receptor NR1 and Na(+),K(+)-ATPase... - Salvage of focal cerebral ischemic damage by transfusion of high O2-affinity recombinant hemoglobin polymers in mouseMasaaki Nemoto
Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
J Appl Physiol 100:1688-91. 2006..The assumption that the P50 of blood substitutes should be similar to that of blood might not be warranted when used during ischemic conditions... - Stroke outcomes in mice lacking the genes for neuronal heme oxygenase-2 and nitric oxide synthaseKhodadad Namiranian
Johns Hopkins School of Medicine, Baltimore MD, USA
Curr Neurovasc Res 2:23-7. 2005..The results suggest that the deleterious action of nNOS would counteract the role of HO-2 in neuroprotection... - Recombinant hemoglobins as artificial oxygen carriersClara Fronticelli
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Artif Cells Blood Substit Immobil Biotechnol 35:45-52. 2007.... - Estradiol augments peri-infarct cerebral vascular density in experimental strokeAgnieszka A Ardelt
University of Alabama at Birmingham, Department of Neurology, Comprehensive Stroke Center, 1813 6th Avenue South, Suite M226 RWUH, Birmingham, AL 35294, USA
Exp Neurol 206:95-100. 2007..Loss of estradiol may limit repair in the peri-infarct region by limiting angiogenesis, but functional significance in stroke recovery requires further investigation... - Role of nitric oxide in cerebrovascular reactivity to NMDA and hypercapnia during prenatal development in sheepAndrew P Harris
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
Int J Dev Neurosci 26:47-55. 2008..Hence, cerebrovascular reactivities to different stimuli do not mature concurrently... - Rapid NMDA receptor phosphorylation and oxidative stress precede striatal neurodegeneration after hypoxic ischemia in newborn piglets and are attenuated with hypothermiaDawn Mueller-Burke
School of Nursing, University of Maryland at Baltimore, Baltimore, MD 21201, USA
Int J Dev Neurosci 26:67-76. 2008..Postasphyxic, mild whole body hypothermia provides neuroprotection by suppressing N-methyl-d-aspartate receptor phosphorylation and protein oxidation... - Delayed tolerance with repetitive transient focal ischemic preconditioning in the mouseJian Zhang
Department of Neurosurgery, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Blalock 1404, Baltimore, MD 21287, USA
Stroke 39:967-74. 2008..The present objective was to develop an ischemic preconditioning (IPC) model of delayed tolerance in the mouse based on repetitive, transient middle cerebral artery occlusion (MCAO)... - Interaction of nitric oxide, 20-HETE, and EETs during functional hyperemia in whisker barrel cortexXiaoguang Liu
Dept of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, 600 North Wolfe St Blalock 1404, Baltimore, MD 21287 4961, USA
Am J Physiol Heart Circ Physiol 295:H619-31. 2008..With the chronic loss of neuronal NOS in mice, other mechanisms apparently suppress 20-HETE synthesis or signaling... - Continuous measurement of autoregulation by spontaneous fluctuations in cerebral perfusion pressure: comparison of 3 methodsKen M Brady
Department of Anesthesiology, Division of Pediatric Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, 600 N Wolfe St, Blalock 904, Baltimore MD 21287, USA
Stroke 39:2531-7. 2008..We characterized the accuracy of 3 continuous monitors of autoregulation in a piglet model of hypotension... - Role of heme oxygenase-2 in pial arteriolar response to acetylcholine in mice with and without transfusion of cell-free hemoglobin polymersXinyue Qin
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, 600 North Wolfe St, Blalock 1404, Baltimore, MD 21205, USA
Am J Physiol Regul Integr Comp Physiol 295:R498-504. 2008.... - Neuroprotective effect of selective kappa opioid receptor agonist is gender specific and linked to reduced neuronal nitric oxideEmil Zeynalov
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Cereb Blood Flow Metab 26:414-20. 2006..Neuroprotective effects of BRL 52537 are lost in the male when nNOS is not present; therefore, BRL 52537 likely acts upstream from NO generation and its subsequent neurotoxicity... - Regional cerebral blood flow in cats with cross-linked hemoglobin transfusion during focal cerebral ischemiaAnnette Rebel
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
Am J Physiol Heart Circ Physiol 282:H832-41. 2002..Moreover, an end-artery region such as the caudate nucleus is less likely to benefit from hemodilution... - A recombinant polymeric hemoglobin with conformational, functional, and physiological characteristics of an in vivo O2 transporterKevin M Bobofchak
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, 600 N. Wolfe St, Baltimore, MD 21287, USA
Am J Physiol Heart Circ Physiol 285:H549-61. 2003..Polymerization maintains physiologically relevant oxygen and heme affinity, stability toward denaturation and oxidation, and effective oxygen delivery as indicated by reduced cerebral ischemic damage... - Characterization of a new double-filament model of focal cerebral ischemia in heme oxygenase-2-deficient miceShozo Goto
Dept of Anesthesiology Critical Care Medicine, The Johns Hopkins Medical Institutions, 600 N Wolfe St, Blalock 1404, Baltimore, MD 21287 4961, USA
Am J Physiol Regul Integr Comp Physiol 285:R222-30. 2003..The double-filament model may be of use as an alternative in other murine knockout strains in which the standard filament model does not yield consistent infarcts... - Prolonged opportunity for ischemic neuroprotection with selective kappa-opioid receptor agonist in ratsTsung-Ying Chen
Department of Anesthesiology/Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Stroke 35:1180-5. 2004.... - Cerebrovascular response to decreased hematocrit: effect of cell-free hemoglobin, plasma viscosity, and CO2Annette Rebel
Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, 600 N. Wolfe St, Baltimore, MD 21205, USA
Am J Physiol Heart Circ Physiol 285:H1600-8. 2003.... - Distinct protective mechanisms of HO-1 and HO-2 against hydroperoxide-induced cytotoxicityYun Sook Kim
Department of Anesthesiology Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
Free Radic Biol Med 38:85-92. 2005..The differences in subcellular localization of HO-1 and HO-2 could explain some of the discrepancies in their cellular activity and enzymatic protective mechanisms... - Potent sigma 1-receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine provides ischemic neuroprotection without altering dopamine accumulation in vivo in ratsToru Goyagi
Department of Anesthesiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Anesth Analg 96:532-8, table of contents. 2003..Therefore, PPBP provides significant ischemic neuroprotection in the CP complex without altering the acute accumulation of dopamine in vivo during transient focal ischemia in the rat... - Vascular response to infusions of a nonextravasating hemoglobin polymerBarbara Matheson
Department of Physiology, Dental School, University of Maryland, Baltimore 21201, Maryland, USA
J Appl Physiol 93:1479-86. 2002..Constriction observed in the cerebrovascular bed with a nonextravasating hemoglobin polymer at low hematocrit is presumably a regulatory response to prevent overoxygenation at low blood viscosity... - Role of nitric oxide scavenging in vascular response to cell-free hemoglobin transfusionKenji Sampei
Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, 600 N. Wolfe St, Blalock 1404, Baltimore, MD 21287, USA
Am J Physiol Heart Circ Physiol 289:H1191-201. 2005..The data support increasing the molecular size of Hb by polymerization or conjugation to limit extravasation in all vascular beds to preserve normal vascular reactivity... - Ischemic neuroprotection with selective kappa-opioid receptor agonist is gender specificChih-Hung Chen
Department of Anesthesiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Stroke 36:1557-61. 2005.... - Neuroprotective kappa-opioid receptor agonist BRL 52537 attenuates ischemia-evoked nitric oxide production in vivo in ratsToru Goyagi
Department of Anesthesiology/Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Stroke 34:1533-8. 2003.... - Suppression of cortical functional hyperemia to vibrissal stimulation in the rat by epoxygenase inhibitorsXinqi Peng
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, 600 North Wolfe Street/Blalock 1404-E, Baltimore, MD 21287, USA
Am J Physiol Heart Circ Physiol 283:H2029-37. 2002..The marked reduction of the cortical flow response to whisker stimulation with two different types of epoxygenase inhibitors indicates that EETs play an important role in the physiological coupling of blood flow to neural activation... - Role of 20-HETE in the pial arteriolar constrictor response to decreased hematocrit after exchange transfusion of cell-free polymeric hemoglobinXinyue Qin
Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, Maryland 21287, USA
J Appl Physiol 100:336-42. 2006.... - Metabotropic glutamate receptor activation enhances the activities of two types of Ca2+-activated k+ channels in rat hippocampal astrocytesDebebe Gebremedhin
Department of Physiology and Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee 53226, USA
J Neurosci 23:1678-87. 2003.... - Potential mechanism by which resveratrol, a red wine constituent, protects neuronsHean Zhuang
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
Ann N Y Acad Sci 993:276-86; discussion 287-8. 2003..All together, increased heme oxygenase activity by resveratrol is a unique pathway by which this compound can exert its neuroprotective actions... - Interaction of mechanisms involving epoxyeicosatrienoic acids, adenosine receptors, and metabotropic glutamate receptors in neurovascular coupling in rat whisker barrel cortexYanrong Shi
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland 21287 4961, USA
J Cereb Blood Flow Metab 28:111-25. 2008.... - Kappa-opioid receptor selectivity for ischemic neuroprotection with BRL 52537 in ratsZhizheng Zhang
Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, Oregon, USA
Anesth Analg 97:1776-83. 2003..IMPLICATIONS: The neuroprotective effect of selective kappa-opioid agonists in transient focal ischemia is via a selective action at the kappa-opioid receptors... - Dependency of cortical functional hyperemia to forepaw stimulation on epoxygenase and nitric oxide synthase activities in ratsXinqi Peng
Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Cereb Blood Flow Metab 24:509-17. 2004.... - Cytosolic phospholipase A alpha modulates NMDA neurotoxicity in mouse hippocampal culturesKen M Brady
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
Eur J Neurosci 24:3381-6. 2006.... - In situ immunoradiographic method for quantification of specific proteins in normal and ischemic brain regionsAnnette Rebel
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Neurosci Methods 143:227-35. 2005..The disadvantage of the falsely positive overestimation of protein immunoreactivity after stroke with the immunoperoxidase method has to be weighted with the advantage of the cellular resolution... - Glutamine-dependent inhibition of pial arteriolar dilation to acetylcholine with and without hyperammonemia in the ratTetsu Kawaguchi
Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, 600 North Wolfe St./Blalock 1404-E, Baltimore, MD 21287-4961, USA
Am J Physiol Regul Integr Comp Physiol 288:R1612-9. 2005.... - Dependence of acetylcholine and ADP dilation of pial arterioles on heme oxygenase after transfusion of cell-free polymeric hemoglobinAnnette Rebel
Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, Maryland 21287, USA
Am J Physiol Heart Circ Physiol 290:H1027-37. 2006..e., ADP) in a another species (rat)... - Estradiol alters only GAD67 mRNA levels in ischemic rat brain with no consequent effects on GABAHung Dong Joh
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Cereb Blood Flow Metab 26:518-26. 2006..It may be that estradiol under ischemic conditions is attenuating GABA metabolism rather than enhancing synthesis or is augmenting other aspects of GABAergic transmission such as GABA transporters and receptors...
Research Grants
- Therapeutic Strategies for Neonatal Hypoxic-Ischemic EncephalopathyRaymond Koehler; Fiscal Year: 2009....
- Therapeutic Strategies for Neonatal Hypoxic-Ischemic EncephalopathyRAYMOND CHARLES KOEHLER; Fiscal Year: 2010....
- Cell Free O2 Carriers: Cerebrovascular Control and StrokeRAYMOND CHARLES KOEHLER; Fiscal Year: 2010....
- Cell-Free O2 Carriers: Cerebrovascular Control & StrokeRaymond Koehler; Fiscal Year: 2007..Therefore, this proposal will provide new mechanistic insights into how cell-free Hb polymers can be used to promote 02 delivery during stroke and shock. ..
- CELL-FREE 02 CARRIERS: CEREBROVASCULAR CONTROL & STROKERaymond Koehler; Fiscal Year: 2003..These studies will render new insights into cerebrovascular regulation during anemia and into novel methodologies for hemodynamically ameliorating injury from stroke. ..
- Cell Free O2 Carriers: Cerebrovascular Control and StrokeRAYMOND CHARLES KOEHLER; Fiscal Year: 2010....