Y H Ko

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi Glucose catabolism in the rabbit VX2 tumor model for liver cancer: characterization and targeting hexokinase
    Y H Ko
    Department of Biological Chemistry, Johns Hopkins University, School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205-2185, USA
    Cancer Lett 173:83-91. 2001
  2. ncbi Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP
    Young H Ko
    The Russell H Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2185, USA
    Biochem Biophys Res Commun 324:269-75. 2004
  3. ncbi Cystic fibrosis: a brief look at some highlights of a decade of research focused on elucidating and correcting the molecular basis of the disease
    Y H Ko
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2185, USA
    J Bioenerg Biomembr 33:513-21. 2001
  4. ncbi Mitochondrial F(0)F(1) ATP synthase. Subunit regions on the F1 motor shielded by F(0), Functional significance, and evidence for an involvement of the unique F(0) subunit F(6)
    Y H Ko
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2185, USA
    J Biol Chem 275:32931-9. 2000
  5. ncbi ATP synthases in the year 2000: defining the different levels of mechanism and getting a grip on each
    P L Pedersen
    Department of Biological Chemistry, Johns Hopkins University, School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205 2185, USA
    J Bioenerg Biomembr 32:423-32. 2000
  6. ncbi ATP synthase motor components: proposal and animation of two dynamic models for stator function
    D J Blum
    Department of Biological Chemistry, Johns Hopkins University, School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205-2185, USA
    Biochem Biophys Res Commun 287:801-7. 2001
  7. ncbi ATP synthases in the year 2000: evolving views about the structures of these remarkable enzyme complexes
    P L Pedersen
    Department of Biological Chemistry, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205 2185, USA
    J Bioenerg Biomembr 32:325-32. 2000
  8. ncbi Delta subunit of rat liver mitochondrial ATP synthase: molecular description and novel insights into the nature of its association with the F1-moiety
    W Pan
    Department of Biological Chemistry, Johns Hopkins University, School of Medicine, Baltimore 21205 2185, USA
    Biochemistry 37:6911-23. 1998
  9. ncbi CHOP followed by involved field radiation: is it optimal for localized nasal natural killer/T-cell lymphoma?
    W S Kim
    Division of Hematology/Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Kangnam-ku, Seoul, Korea
    Ann Oncol 12:349-52. 2001
  10. ncbi Use of chemical modification in the crystallization of isocitrate lyase from Escherichia coli
    S I Abeysinghe
    Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, University of Sheffield, U K
    J Mol Biol 220:13-6. 1991

Collaborators

  • P L Pedersen
  • W Pan
  • M Torbenson
  • L M Amzel
  • W S Kim
  • D J Blum
  • H J Lee
  • H G Lee
  • C H Baek
  • Y C Ahn
  • C H Park
  • S Hong
  • K Park
  • D Y Kim
  • S S Yoon
  • S Y Song
  • W K Kang
  • D A Rini
  • S I Abeysinghe
  • T J Stillman
  • D W Rice
  • P J Baker
  • H F Rodgers
  • B A McFadden
  • H G Nimmo

Detail Information

Publications10

  1. ncbi Glucose catabolism in the rabbit VX2 tumor model for liver cancer: characterization and targeting hexokinase
    Y H Ko
    Department of Biological Chemistry, Johns Hopkins University, School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205-2185, USA
    Cancer Lett 173:83-91. 2001
    ..Finally, when tested on hepatoma cells in culture both inhibitors facilitated cell death. These studies underscore the usefulness of the VX2 tumor model for the study of advanced liver cancer and for selecting anti-hepatoma agents...
  2. ncbi Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP
    Young H Ko
    The Russell H Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2185, USA
    Biochem Biophys Res Commun 324:269-75. 2004
    ..In all 19 treated animals advanced cancers were eradicated without apparent toxicity or recurrence. These findings attest to the feasibility of completely destroying advanced, highly glycolytic cancers...
  3. ncbi Cystic fibrosis: a brief look at some highlights of a decade of research focused on elucidating and correcting the molecular basis of the disease
    Y H Ko
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2185, USA
    J Bioenerg Biomembr 33:513-21. 2001
    ....
  4. ncbi Mitochondrial F(0)F(1) ATP synthase. Subunit regions on the F1 motor shielded by F(0), Functional significance, and evidence for an involvement of the unique F(0) subunit F(6)
    Y H Ko
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2185, USA
    J Biol Chem 275:32931-9. 2000
    ..The significance of the studies reported here, in relation to current views about ATP synthase structure and function in animal mitochondria, is discussed...
  5. ncbi ATP synthases in the year 2000: defining the different levels of mechanism and getting a grip on each
    P L Pedersen
    Department of Biological Chemistry, Johns Hopkins University, School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205 2185, USA
    J Bioenerg Biomembr 32:423-32. 2000
    ..Nevertheless, in order to get a better grip in this new century on how ATP synthases make ATP and then release it, we must take on the difficult challenge of elucidating each of the three levels of mechanism...
  6. ncbi ATP synthase motor components: proposal and animation of two dynamic models for stator function
    D J Blum
    Department of Biological Chemistry, Johns Hopkins University, School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205-2185, USA
    Biochem Biophys Res Commun 287:801-7. 2001
    ..Both models have been designed to maintain chemical equivalency among the three alphabeta pairs during ATP synthesis and both have been animated...
  7. ncbi ATP synthases in the year 2000: evolving views about the structures of these remarkable enzyme complexes
    P L Pedersen
    Department of Biological Chemistry, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205 2185, USA
    J Bioenerg Biomembr 32:325-32. 2000
    ....
  8. ncbi Delta subunit of rat liver mitochondrial ATP synthase: molecular description and novel insights into the nature of its association with the F1-moiety
    W Pan
    Department of Biological Chemistry, Johns Hopkins University, School of Medicine, Baltimore 21205 2185, USA
    Biochemistry 37:6911-23. 1998
    ..These novel findings on a higher eukaryotic F1-delta subunit are discussed in relationship to earlier studies on the related epsilon subunits from both chloroplasts and E. coli...
  9. ncbi CHOP followed by involved field radiation: is it optimal for localized nasal natural killer/T-cell lymphoma?
    W S Kim
    Division of Hematology/Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Kangnam-ku, Seoul, Korea
    Ann Oncol 12:349-52. 2001
    ..05). The present study suggests that four cycles of CHOP followed by IF RT is not satisfactory for treating patients with localized nasal NK/T-cell lymphoma, and that further exploration for improved therapy is needed...
  10. ncbi Use of chemical modification in the crystallization of isocitrate lyase from Escherichia coli
    S I Abeysinghe
    Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, University of Sheffield, U K
    J Mol Biol 220:13-6. 1991
    ..Considerations of the values of Vm and measurements on the crystal density indicate that the asymmetric unit of both crystals contains four subunits...