Walter C Hubbard

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi Detection and quantitation of fatty acid acyl conjugates of triamcinolone acetonide via gas chromatography-electron-capture negative-ion mass spectrometry
    Walter C Hubbard
    Division of Allergy and Clinical Immunology, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Anal Biochem 322:243-50. 2003
  2. ncbi Combined liquid chromatography-tandem mass spectrometry as an analytical method for high throughput screening for X-linked adrenoleukodystrophy and other peroxisomal disorders: preliminary findings
    Walter C Hubbard
    Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Osler 527, Baltimore, MD 21287, USA
    Mol Genet Metab 89:185-7. 2006
  3. ncbi Newborn screening for X-linked adrenoleukodystrophy (X-ALD): validation of a combined liquid chromatography-tandem mass spectrometric (LC-MS/MS) method
    Walter C Hubbard
    Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Osler 527, Baltimore, MD 21287, USA
    Mol Genet Metab 97:212-20. 2009
  4. ncbi Quantitative analysis of sphingoid base-1-phosphates as bisacetylated derivatives by liquid chromatography-tandem mass spectrometry
    Evgeny V Berdyshev
    Division of Pulmonary Critical Care Medicine, Johns Hopkins University, MFL Building, Center Tower, Room 683, 5200 Eastern Avenue, Baltimore, MD 21224, USA
    Anal Biochem 339:129-36. 2005
  5. ncbi Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice
    Irina Petrache
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, JHAAC, 4B 65, Baltimore, Maryland 21224, USA
    Nat Med 11:491-8. 2005
  6. ncbi A highly sensitive ultra performance liquid chromatography-tandem mass spectrometric (UPLC-MS/MS) technique for quantitation of protein free and bound efavirenz (EFV) in human seminal and blood plasma
    Lindsay B Avery
    Department of Pharmacology and Molecular Sciences, Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Osler 527, Baltimore, MD 21287, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 878:3217-24. 2010
  7. ncbi Apoptotic sphingolipid signaling by ceramides in lung endothelial cells
    Terry R Medler
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Respir Cell Mol Biol 38:639-46. 2008
  8. ncbi Combined extraction of acyl carnitines and 26:0 lysophosphatidylcholine from dried blood spots: prospective newborn screening for X-linked adrenoleukodystrophy
    Yana Sandlers
    Department of Pediatrics at Johns Hopkins University, Baltimore, MD 21205, USA
    Mol Genet Metab 105:416-20. 2012
  9. ncbi Intermittent hypoxia induces hyperlipidemia in lean mice
    Jianguo Li
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
    Circ Res 97:698-706. 2005
  10. ncbi Superoxide dismutase protects against apoptosis and alveolar enlargement induced by ceramide
    Irina Petrache
    Division of Pulmonary, Allergy, Critical Care, and Occupational Medicine, Indiana University, Indianapolis, Indiana 46202 5120, USA
    Am J Physiol Lung Cell Mol Physiol 295:L44-53. 2008

Research Grants

  1. Micromass Quattro API TSQ For LC-MS/MS Quantitation
    Walter Hubbard; Fiscal Year: 2002

Collaborators

Detail Information

Publications10

  1. ncbi Detection and quantitation of fatty acid acyl conjugates of triamcinolone acetonide via gas chromatography-electron-capture negative-ion mass spectrometry
    Walter C Hubbard
    Division of Allergy and Clinical Immunology, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Anal Biochem 322:243-50. 2003
    ....
  2. ncbi Combined liquid chromatography-tandem mass spectrometry as an analytical method for high throughput screening for X-linked adrenoleukodystrophy and other peroxisomal disorders: preliminary findings
    Walter C Hubbard
    Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Osler 527, Baltimore, MD 21287, USA
    Mol Genet Metab 89:185-7. 2006
    ..There was no overlap between normal subjects versus affected subjects...
  3. ncbi Newborn screening for X-linked adrenoleukodystrophy (X-ALD): validation of a combined liquid chromatography-tandem mass spectrometric (LC-MS/MS) method
    Walter C Hubbard
    Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Osler 527, Baltimore, MD 21287, USA
    Mol Genet Metab 97:212-20. 2009
    ..These studies clearly show that the method is highly sensitive and accurate in identifying individuals with a defect in peroxisomal beta-oxidation such as X-ALD...
  4. ncbi Quantitative analysis of sphingoid base-1-phosphates as bisacetylated derivatives by liquid chromatography-tandem mass spectrometry
    Evgeny V Berdyshev
    Division of Pulmonary Critical Care Medicine, Johns Hopkins University, MFL Building, Center Tower, Room 683, 5200 Eastern Avenue, Baltimore, MD 21224, USA
    Anal Biochem 339:129-36. 2005
    ..6+/-0.2 pmol/ml, respectively. The addition of sphingosine (1 microM) to human pulmonary artery endothelial cells in culture resulted in a more than 20-fold increase in the cellular level of S1P, whereas the level of DHS1P was unchanged...
  5. ncbi Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice
    Irina Petrache
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, JHAAC, 4B 65, Baltimore, Maryland 21224, USA
    Nat Med 11:491-8. 2005
    ..Finally, increased lung ceramides in individuals with smoking-induced emphysema suggests that ceramide upregulation may be a crucial pathogenic element and a promising target in this disease that currently lacks effective therapies...
  6. ncbi A highly sensitive ultra performance liquid chromatography-tandem mass spectrometric (UPLC-MS/MS) technique for quantitation of protein free and bound efavirenz (EFV) in human seminal and blood plasma
    Lindsay B Avery
    Department of Pharmacology and Molecular Sciences, Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Osler 527, Baltimore, MD 21287, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 878:3217-24. 2010
    ..0>244.1 and m/z 298.0>227.9. The time required for the analysis of each sample was 8.0min. The analytical technique is capable of a reliable detection limit of ?15-20fmol of EFV injected on column...
  7. ncbi Apoptotic sphingolipid signaling by ceramides in lung endothelial cells
    Terry R Medler
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Respir Cell Mol Biol 38:639-46. 2008
    ..The serine palmitoyl synthase-regulated ceramides synthesis may contribute to the amplification of pulmonary vascular injury induced by excessive ceramides...
  8. ncbi Combined extraction of acyl carnitines and 26:0 lysophosphatidylcholine from dried blood spots: prospective newborn screening for X-linked adrenoleukodystrophy
    Yana Sandlers
    Department of Pediatrics at Johns Hopkins University, Baltimore, MD 21205, USA
    Mol Genet Metab 105:416-20. 2012
    ..It successfully combines the existing method for acyl carnitine analysis and 26:0 lysophosphatidyl choline that can be applied for prospective X-ALD newborn screening...
  9. ncbi Intermittent hypoxia induces hyperlipidemia in lean mice
    Jianguo Li
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
    Circ Res 97:698-706. 2005
    ....
  10. ncbi Superoxide dismutase protects against apoptosis and alveolar enlargement induced by ceramide
    Irina Petrache
    Division of Pulmonary, Allergy, Critical Care, and Occupational Medicine, Indiana University, Indianapolis, Indiana 46202 5120, USA
    Am J Physiol Lung Cell Mol Physiol 295:L44-53. 2008
    ..This work implicates excessive lung ceramides as amplifiers of lung injury through redox-dependent mechanisms...

Research Grants1

  1. Micromass Quattro API TSQ For LC-MS/MS Quantitation
    Walter Hubbard; Fiscal Year: 2002
    ..abstract_text> ..