Research Topics
Genomes and Genes
| Shau Ku HuangSummaryAffiliation: Johns Hopkins University Country: USA Publications
Research Grants
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Detail Information
Publications
Genetic variants in mannose receptor gene (MRC1) confer susceptibility to increased risk of sarcoidosisTakeshi Hattori
First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Hokkaido, Japan
BMC Med Genet 11:151. 2010..The aim of this study was to investigate potential associations of genetic variants in the MRC1 gene with sarcoidosis...- Evidence for asthma susceptibility genes on chromosome 11 in an African-American populationShau Ku Huang
Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, MD 21224 6801, Baltimore, USA
Hum Genet 113:71-5. 2003..8 cM with a confidence interval spanning the linkage peak. Evidence from both linkage and association analyses suggest that this region of chromosome 11 contains one or more susceptibility genes for asthma in these AA families... - Antigen coupled with Lewis-x trisaccharides elicits potent immune responses in miceShih Chang Hsu
Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
J Allergy Clin Immunol 119:1522-8. 2007..Glycoproteins containing Lewis-x (Le(x)) trisaccharides are often associated with the host's adaptive T(H)2-type immunity, but the mechanisms underlying the T(H)2-biased response are at present unclear... - Associations between total serum IgE levels and the 6 potentially functional variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy StudyXin Liu
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
J Allergy Clin Immunol 112:382-8. 2003.... - Oral tolerance to food-induced systemic anaphylaxis mediated by the C-type lectin SIGNR1Yufeng Zhou
Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland, USA
Nat Med 16:1128-33. 2010..The Tr1-like cells could transfer tolerance. These results suggest that sugar-modified antigens might be used to induce oral tolerance by targeting SIGNR1 and LPDCs... - Regulatory role of DC-derived osteopontin in systemic allergen sensitizationMasatsugu Kurokawa
Johns Hopkins Asthma and Allergy Center, Baltimore, MD, USA
Eur J Immunol 39:3323-30. 2009..These results indicate that DC-derived OPN plays a regulatory role in the development of systemic allergen sensitization, which is mediated, at least in part, through the production of endogenous IL-12... - Functional interaction of common allergens and a C-type lectin receptor, dendritic cell-specific ICAM3-grabbing non-integrin (DC-SIGN), on human dendritic cellsShih Chang Hsu
Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224, USA
J Biol Chem 285:7903-10. 2010..These results suggest that allergens are able to interact with DC-SIGN and induce tumor necrosis factor-alpha expression in MDDCs via, in part, Raf-1 signaling pathways... - Regulation of TH2 responses by the pulmonary Clara cell secretory 10-kd proteinChih Hsing Hung
Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224 6801, USA
J Allergy Clin Immunol 114:664-70. 2004..Pulmonary Clara cell secretory 10-kd protein (CC10) is a steroid-inducible and potentially anti-inflammatory cytokine, but its direct involvement in the regulation of T-cell responses remains unknown... - Chemokine transcripts as targets of the RNA-binding protein HuR in human airway epitheliumJinshui Fan
Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
J Immunol 186:2482-94. 2011..HuR-mediated regulation in airway epithelium appears broader than previously appreciated, coordinating numerous inflammatory genes through multiple posttranscriptional mechanisms... - Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy StudyXin Liu
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
J Allergy Clin Immunol 113:489-95. 2004..SNPs were commonly considered individually, and therefore the true effect could be masked by other genes or environmental factors... - Activation of extracellular signal-regulated kinase (ERK)1/2, but not p38 and c-Jun N-terminal kinase, is involved in signaling of a novel cytokine, ML-1Mio Kawaguchi
Johns Hopkins Asthma and Allergy Center and Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
J Biol Chem 277:15229-32. 2002..These findings suggest that ML-1-induced IL-6 and IL-8 production is mediated through the activation of ERK1/2 in both cell types... - Genetic variants of the T-cell immunoglobulin mucin 1 but not the T-cell immunoglobulin mucin 3 gene are associated with asthma in an African American populationPei Song Gao
Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Allergy Clin Immunol 115:982-8. 2005..The T-cell immunoglobulin mucin ( TIM ) proteins and their genetic variants have been suggested to play a role in regulating allergic diseases... - Interleukin-17F induces pulmonary neutrophilia and amplifies antigen-induced allergic responseNaruhito Oda
Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
Am J Respir Crit Care Med 171:12-8. 2005..These results suggest a role for IL-17F in the induction of neutrophilia in the lungs and in the exacerbation of Ag-induced pulmonary inflammation... - Survey of immune-related, mannose/fucose-binding C-type lectin receptors reveals widely divergent sugar-binding specificitiesReiko T Lee
Department of Biology, T he Johns Hopkins University, Baltimore, MD, USA
Glycobiology 21:512-20. 2011..BDCA-2, dectin-2, Langerin, MCL and mannose receptor did not bind Le(x) at all... - Posttranscriptional regulation of IL-13 in T cells: role of the RNA-binding protein HuRVincenzo Casolaro
Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Allergy Clin Immunol 121:853-9.e4. 2008..IL-13, a critical cytokine in allergy, is regulated by as-yet-elusive mechanisms... - Interferons modulate Fc epsilon RI-dependent production of autoregulatory IL-10 by circulating human monocytoid dendritic cellsTrong Le
Department of Pediatrics, Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
J Allergy Clin Immunol 123:217-23. 2009..Immature human blood monocytoid dendritic cells (mDCs) express high-affinity receptors for IgE (Fc epsilon RI), yet their exact function and regulation remain poorly understood... - Modulation of antigen-induced anaphylaxis in mice by a traditional chinese medicine formula, Guo Min KangXiu Min Li
Johns Hopkins University School of Medicine, Johns Hopkins Asthma and Allergy Center, Baltimore, MD, USA
Am J Chin Med 37:113-25. 2009..No effect of GMK was observed on the levels of total IgE and plasma histamine in naive mice. These results provide a basis for the modulation effect of GMK and suggest a potential utility of GMK as a prophylactic and therapeutic agent... - Sequence variants of the gene encoding chemoattractant receptor expressed on Th2 cells (CRTH2) are associated with asthma and differentially influence mRNA stabilityJing Long Huang
The Division of Allergy, Asthma and Rheumatology, Department of Pediatrics, Chang Gung Children s Hospital, Taoyuan, Taiwan
Hum Mol Genet 13:2691-7. 2004..11q is a strong candidate gene for asthma... - A graphical assessment of p-values from sliding window haplotype tests of association to identify asthma susceptibility loci on chromosome 11qRasika A Mathias
Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Balitmore, USA
BMC Genet 7:38. 2006..While efficient in screening a region of dense genotyping, this approach does create some problems: high numbers of tests, assimilating thousands of results, and questions about setting priorities on regions with association signals... - Infant frequent wheezing correlated to Clara cell protein 10 (CC10) polymorphism and concentration, but not allergy sensitization, in a perinatal cohort studyKuender D Yang
Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University, Kaohsiung, Taiwan
J Allergy Clin Immunol 120:842-8. 2007..Wheezing episodes are common in young infants. However, the molecular mechanism of wheezing is unclear, and very few therapeutic regimens are effective... - Expression of interleukin-17F in a mouse model of allergic asthmaShintaro Suzuki
First Department of Internal Medicine, Showa University School of Medicine, Shinagawa, Tokyo, Japan
Int Arch Allergy Immunol 143:89-94. 2007..However, its involvement in airway inflammation has not been well understood. To this end, the expression of IL-17F and the inhibitory effects of glucocorticoids on its expression in a mouse model of asthma were examined... - Interleukin-10 and Th2 cytokines differentially regulate osteopontin expression in human monocytes and dendritic cellsSatoshi Konno
Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
J Interferon Cytokine Res 26:562-7. 2006..These results demonstrate a novel role of IL-10 and Th2 cytokines in the regulation of DC function through their contrasting regulatory activities on the expression of OPN... - IL-17 cytokine familyMio Kawaguchi
Johns Hopkins University, Asthma and Allergy Center, Baltimore, MD 21224, USA
J Allergy Clin Immunol 114:1265-73; quiz 1274. 2004.... - Endotoxin contamination contributes to the in vitro cytokine-inducing activity of osteopontin preparationsSatoshi Konno
Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
J Interferon Cytokine Res 25:277-82. 2005..These results suggest the questionable evidence of the ability of OPN to induce several cytokines in human PBMCs and draw attention to the exquisite sensitivity of PBMCs/monocytes to endotoxin contaminants... - IL-17F sequence variant (His161Arg) is associated with protection against asthma and antagonizes wild-type IL-17F activityMio Kawaguchi
First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
J Allergy Clin Immunol 117:795-801. 2006..Upregulated IL17F gene expression has been observed at sites of allergen challenge in the airways of patients with asthma, suggesting that IL-17F is involved in the pathophysiology of asthma... - Intranasal gene transfer by chitosan-DNA nanospheres protects BALB/c mice against acute respiratory syncytial virus infectionMukesh Kumar
Division of Allergy and Immunology-Joy McCann Culverhouse Airway Disease Center, James A. Haley Veterans Administration Hospital and University of South Florida College of Medicine, Tampa, FL 33612, USA
Hum Gene Ther 13:1415-25. 2002..Together, these results demonstrate the potential of IGT against acute RSV infection... - Current understanding and therapy of asthma workshop summaryKuender D Yang
Chang Gung Children Hospital at Kaohsiung, Taiwan, ROC
Cell Mol Immunol 1:436-9. 2004..This article highlights the issues presented and discussed in this ground-breaking symposium emphasizing this important public health problem in the Chinese population... - Functional SNPs in the distal promoter of the ST2 gene are associated with atopic dermatitisMakiko Shimizu
Laboratory for Genetics of Allergic Diseases, SNP Research Center, RIKEN, Yokohama, Japan
Hum Mol Genet 14:2919-27. 2005..Our findings will contribute to the evaluation of one of the genetic risk factors for AD...
Research Grants
- Immunogenetic Analysis of Human Immune Response to AllergensShau Ku Huang; Fiscal Year: 2009....
- Role of C-type lectin receptors in food allergyShau Ku Huang; Fiscal Year: 2007..Moreover, binding and functional assays will be performed to investigate the ability of food allergens to target CLRs and modulate DC functions. ..
- Immunogenetic Analysis of Immune Response to AllergensShau Ku Huang; Fiscal Year: 2007..1 Description, ..
- Immunogenetic Analysis of Immune Response to AllergensShau Ku Huang; Fiscal Year: 2006..It is anticipated that the accomplishment of these studies will greatly facilitate the efforts to uncover the genetic basis of IgE responsiveness and atopic diseases. ..
- Immunogenetic Analysis of Human Immune Response to AllergensShau Ku Huang; Fiscal Year: 2010....